Discover nano最新文献_第10页

Surface acoustic wave actuated plasmonic signal amplification in a plasmonic waveguide. 等离子波导中的表面声波驱动等离子信号放大。

Discover nano Pub Date : 2024-01-09 DOI: 10.1186/s11671-023-03951-0

Rohit Gupta, Kuntal Barman, Liang-Yun Lee, Anuj Chauhan, Jian-Jang Huang

{"title":"Surface acoustic wave actuated plasmonic signal amplification in a plasmonic waveguide.","authors":"Rohit Gupta, Kuntal Barman, Liang-Yun Lee, Anuj Chauhan, Jian-Jang Huang","doi":"10.1186/s11671-023-03951-0","DOIUrl":"10.1186/s11671-023-03951-0","url":null,"abstract":"Enhancement of nanoscale confinement in the subwavelength waveguide is a concern for advancing future photonic interconnects. Rigorous innovation of plasmonic waveguide-based structure is crucial in designing a reliable on-chip optical waveguide beyond the diffraction limit. Despite several structural modifications and architectural improvements, the plasmonic waveguide technology is far from reaching its maximum potential for mass-scale applications due to persistence issues such as insufficient confined energy and short propagation length. This work proposes a new method to amplify the propagating plasmons through an external on-chip surface acoustic signal. The gold-silicon dioxide (Au-SiO2) interface, over Lithium Niobate (LN) substrate, is used to excite propagating surface plasmons. The voltage-varying surface acoustic wave (SAW) can tune the plasmonic confinement to a desired signal energy level, enhancing and modulating the plasmonic intensity. From our experimental results, we can increase the plasmonic intensity gain of 1.08 dB by providing an external excitation in the form of SAW at a peak-to-peak potential swing of 3 V, utilizing a single chip.","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"19 1","pages":"10"},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10776520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139405433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prodrug-based nanomedicines for rheumatoid arthritis. 治疗类风湿性关节炎的原药纳米药物。

Discover nano Pub Date : 2024-01-05 DOI: 10.1186/s11671-023-03950-1

Pei Li, Cong Wang, Hongjie Huo, Chunyun Xu, Huijun Sun, Xinyu Wang, Li Wang, Lei Li

引用次数: 0

Development of solid lipid nanoparticles-loaded drugs in parasitic diseases. 开发用于寄生虫病的固体脂质纳米颗粒药物。

Discover nano Pub Date : 2024-01-04 DOI: 10.1186/s11671-023-03955-w

Sara Nemati, Mahsa Mottaghi, Parisa Karami, Hamed Mirjalali

引用次数: 0

Fabrication of TPGS decorated Etravirine loaded lipidic nanocarriers as a neoteric oral bioavailability enhancer for lymphatic targeting. 制备TPGS装饰的埃曲韦林脂质纳米载体，作为淋巴靶向的新型口服生物利用度增强剂。

Discover nano Pub Date : 2024-01-04 DOI: 10.1186/s11671-023-03954-x

Abdul Muheem, Mohd Wasim, Eman Aldosari, Sanjula Baboota, Javed Ali

{"title":"Fabrication of TPGS decorated Etravirine loaded lipidic nanocarriers as a neoteric oral bioavailability enhancer for lymphatic targeting.","authors":"Abdul Muheem, Mohd Wasim, Eman Aldosari, Sanjula Baboota, Javed Ali","doi":"10.1186/s11671-023-03954-x","DOIUrl":"10.1186/s11671-023-03954-x","url":null,"abstract":"Etravirine (ERVN) is a potential NNRTI (non-nucleoside reverse transcriptase inhibitor) in treating HIV infection. It possesses extremely low oral bioavailability. The present research aims to optimize the formulation and characterization of TPGS-enriched ERVN-loaded lipid-based nanocarriers (NLCs) for HIV-infected patients. The formulation, ERVN-TPGS-NLCs, was optimized by central composite rotational design using a modified-solvent emulsification process. Various characterization parameters of NLCs were evaluated, including globule size of 121.56 ± 2.174 nm, PDI of 0.172 ± 0.042, the zeta potential of - 7.32 ± 0.021 mV, %EE of 94.42 ± 8.65% of ERVN and %DL was 8.94 ± 0.759% of ERVN and spherical shape was revealed by TEM. PXRD was also performed to identify the crystallinity of the sample. In-vitro drug release showed % a cumulative drug release of 83.72 ± 8.35% at pH 1.2 and 90.61 ± 9.11% at pH 6.8, respectively, whereas the % cumulative drug release from drug suspension (ERVN-S) was found to be 21.13 ± 2.01% at pH 1.2 and 24.84 ± 2.51 at pH 6.8 at the end of 48 h. Further, the intestinal permeation study and confocal microscope showed approximately three-fold and two-fold increased permeation in ERVN-TPGS-NLCs and ERVN-NLCs across the gut sac compared to ERVN-S. Hemolysis compatibility and lipolysis studies were performed to predict the in-vivo fate of the formulation. The pharmacokinetic study revealed a 3.13-fold increment in the relative bioavailability, which agrees with the ex-vivo studies, and lymphatic uptake was validated by using cycloheximide along with designed formulation, which showed the impact of lymphatic uptake in AUC. This study ensures that ERVN-TPGS-NLCs take lymphatic uptake to minimize the first-pass metabolism followed by improved oral bioavailability of ERVN. Thus, the enhanced bioavailability of ERVN can reduce the high dose of ERVN to minimize the adverse effects related to dose-related burden.","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"19 1","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10766915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flash nanoprecipitation allows easy fabrication of pH-responsive acetalated dextran nanoparticles for intracellular release of payloads. 通过闪速纳米沉淀法，可以轻松制造出 pH 值响应型乙缩醛葡聚糖纳米颗粒，用于在细胞内释放有效载荷。

Discover nano Pub Date : 2024-01-04 DOI: 10.1186/s11671-023-03947-w

Krystal A Hughes, Bishal Misra, Maryam Maghareh, Parinya Samart, Ethan Nguyen, Salik Hussain, Werner J Geldenhuys, Sharan Bobbala

{"title":"Flash nanoprecipitation allows easy fabrication of pH-responsive acetalated dextran nanoparticles for intracellular release of payloads.","authors":"Krystal A Hughes, Bishal Misra, Maryam Maghareh, Parinya Samart, Ethan Nguyen, Salik Hussain, Werner J Geldenhuys, Sharan Bobbala","doi":"10.1186/s11671-023-03947-w","DOIUrl":"10.1186/s11671-023-03947-w","url":null,"abstract":"Acetalated dextran (Ac-Dex) nanoparticles are currently of immense interest due to their sharp pH-responsive nature and high biodegradability. Ac-Dex nanoparticles are often formulated through single- or double-emulsion methods utilizing polyvinyl alcohol as the stabilizer. The emulsion methods utilize toxic organic solvents such as dichloromethane or chloroform and require multi-step processing to form stable Ac-Dex nanoparticles. Here, we introduce a simple flash nanoprecipitation (FNP) approach that utilizes a confined impinging jet mixer and a non-toxic solvent, ethanol, to form Ac-Dex nanoparticles rapidly. Ac-Dex nanoparticles were stabilized using nonionic PEGylated surfactants, D-α-Tocopherol polyethylene glycol succinate (TPGS), or Pluronic (F-127). Ac-Dex nanoparticles formed using FNP were highly monodisperse and stably encapsulated a wide range of payloads, including hydrophobic, hydrophilic, and macromolecules. When lyophilized, Ac-Dex TPGS nanoparticles remained stable for at least one year with greater than 80% payload retention. Ac-Dex nanoparticles were non-toxic to cells and achieved intracellular release of payloads into the cytoplasm. In vivo studies demonstrated a predominant biodistribution of Ac-Dex TPGS nanoparticles in the liver, lungs, and spleen after intravenous administration. Taken together, the FNP technique allows easy fabrication and loading of Ac-Dex nanoparticles that can precisely release payloads into intracellular environments for diverse therapeutic applications. pH-responsive Acetalateddextran can be formulated using nonionic surfactants, such as TPGS or F-127, for intracellular release of payloads. Highly monodisperse and stable nanoparticles can be created through the simple, scalable flash nanoprecipitation technique, which utilizes a confined impingement jet mixer.","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"19 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10766584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ionome mapping and amino acid metabolome profiling of Phaseolus vulgaris L. seeds imbibed with computationally informed phytoengineered copper sulphide nanoparticles. 用计算信息植物工程硫化铜纳米颗粒浸泡的Phaseolus vulgaris L.种子的离子组图谱和氨基酸代谢组图谱。

Discover nano Pub Date : 2024-01-04 DOI: 10.1186/s11671-023-03953-y

Nandipha L Botha, Karen J Cloete, Žiga Šmit, Kristina Isaković, Mahmood Akbari, Razieh Morad, Itani Madiba, Oladipupo Moyinoluwa David, Luis P M Santos, Admire Dube, Primoz Pelicon, Malik Maaza

{"title":"Ionome mapping and amino acid metabolome profiling of Phaseolus vulgaris L. seeds imbibed with computationally informed phytoengineered copper sulphide nanoparticles.","authors":"Nandipha L Botha, Karen J Cloete, Žiga Šmit, Kristina Isaković, Mahmood Akbari, Razieh Morad, Itani Madiba, Oladipupo Moyinoluwa David, Luis P M Santos, Admire Dube, Primoz Pelicon, Malik Maaza","doi":"10.1186/s11671-023-03953-y","DOIUrl":"10.1186/s11671-023-03953-y","url":null,"abstract":"This study reports the effects of a computationally informed and avocado-seed mediated Phyto engineered CuS nanoparticles as fertilizing agent on the ionome and amino acid metabolome of Pinto bean seeds using both bench top and ion beam analytical techniques. Physico-chemical analysis of the Phyto engineered nanoparticles with scanning-electron microscopy, transmission electron microscopy, X-ray diffraction, and Fourier Transform Infrared Spectroscopy confirmed the presence of CuS nanoparticles. Molecular dynamics simulations to investigate the interaction of some active phytocompounds in avocado seeds that act as reducing agents with the nano-digenite further showed that 4-hydroxybenzoic acid had a higher affinity for interacting with the nanoparticle's surface than other active compounds. Seeds treated with the digenite nanoparticles exhibited a unique ionome distribution pattern as determined with external beam proton-induced X-ray emission, with hotspots of Cu and S appearing in the hilum and micropyle area that indicated a possible uptake mechanism via the seed coat. The nano-digenite also triggered a plant stress response by slightly altering seed amino acid metabolism. Ultimately, the nano-digenite may have important implications as a seed protective or nutritive agent as advised by its unique distribution pattern and effect on amino acid metabolism.","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"19 1","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10767113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-sensitivity flip chip blue Mini-LEDs miniaturized optical instrument for non-invasive glucose detection. 用于无创葡萄糖检测的高灵敏度倒装芯片蓝色 Mini-LED 微型光学仪器。

Discover nano Pub Date : 2024-01-04 DOI: 10.1186/s11671-023-03948-9

Zhi Ting Ye, Shen Fu Tseng, Shang Xuan Tsou, Chun Wei Tsai

{"title":"High-sensitivity flip chip blue Mini-LEDs miniaturized optical instrument for non-invasive glucose detection.","authors":"Zhi Ting Ye, Shen Fu Tseng, Shang Xuan Tsou, Chun Wei Tsai","doi":"10.1186/s11671-023-03948-9","DOIUrl":"10.1186/s11671-023-03948-9","url":null,"abstract":"The colorimetric detection of glucose typically involves a peroxidase reaction producing a color, which is then recorded and analyzed. However, enzyme detection has difficulties with purification and storage. In addition, replacing enzyme detection with chemical methods involves time-consuming steps such as centrifugation and purification and the optical instruments used for colorimetric detection are often bulky and not portable. In this study, ammonium metavanadate and sulfuric acid were used to prepare the detection solution instead of peroxidase to produce color. We also analyzed the effect of different concentrations of detection solution on absorbance sensitivity. Finally, a flip chip blue Mini-LEDs miniaturized optical instrument (FC blue Mini-LEDs MOI) was designed for glucose detection using optics fiber, collimating lenses, a miniaturized spectrometer, and an FC Blue Mini-LEDs with a center wavelength of 459 nm. While detecting glucose solutions in the concentration range of 0.1-10 mM by the developed MOI, the regression equation of y = 0.0941x + 0.1341, R2 of 0.9744, the limit of detection was 2.15 mM, and the limit of quantification was 7.163 mM. Furthermore, the preparation of the detection solution only takes 10 min, and the absorbance sensitivity of the optimized detection solution could be increased by 2.3 times. The detection solution remained stable with only a 0.6% decrease in absorbance compared to the original after storing it in a refrigerated environment at 3 °C for 14 days. The method proposed in this study for detecting glucose using FC blue light Mini-LEDs MOI reduces the use of peroxidase. In addition, it has a wide detection range that includes blood as well as non-invasive saliva and tear fluids, providing patients with a miniaturized, highly sensitive, and quantifiable glucose detection system.","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"19 1","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10766880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of changes in the aging process, microstructure, and mechanical properties of AA2024-AA1050 nanocomposites created by the accumulative roll bonding process, with the addition of 0.005 vol.% of alumina nanoparticles. 研究添加了 0.005 Vol.% 氧化铝纳米颗粒的 AA2024-AA1050 纳米复合材料在累积辊粘工艺中的老化过程、微观结构和机械性能的变化。

Discover nano Pub Date : 2024-01-02 DOI: 10.1186/s11671-023-03917-2

Hamed Roghani, Ehsan Borhani, Ehsan Ahmadi, Hamid Reza Jafarian

{"title":"Study of changes in the aging process, microstructure, and mechanical properties of AA2024-AA1050 nanocomposites created by the accumulative roll bonding process, with the addition of 0.005 vol.% of alumina nanoparticles.","authors":"Hamed Roghani, Ehsan Borhani, Ehsan Ahmadi, Hamid Reza Jafarian","doi":"10.1186/s11671-023-03917-2","DOIUrl":"10.1186/s11671-023-03917-2","url":null,"abstract":"We created AA2024-AA1050 and AA2024-AA1050/0.005 vol.% Al2O3 nanocomposites by six accumulative roll bonding (ARB) process cycles. We used AA2024 and AA1050 sheets with a thickness of 0.7 mm and plate-shaped alumina nanoparticles to create a composite. The two AA1050 and one AA2024 sheets (among the two AA1050 sheets) were ARB-ed up to six cycles with and without adding alumina nanoparticles. Also, a sample of the AA1050 without composite making was ARB-ed up to six cycles. We aged some composites after the ARB process in the furnace at 110, 150, and 190 °C. This project performed SEM, TEM, and EDS-MAP analyses, tensile strength, microhardness, and Pin-on-Disc tests to study the ARB-ed sheets. The results of the tensile tests showed that the tensile strength of AA2024-AA1050 created by the six cycles ARB process was two times more than primary AA1050. Also, the wear resistance of this composite was 74% more than six cycles ARB-ed the AA1050. Using 0.005 vol.% alumina nanoparticles in AA2024-AA1050 composite improved its wear resistance by 30%. In the following, the aging process caused an improvement in tensile strength and total elongation of AA2024-AA1050/Al2O3 nanocomposites.","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"19 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10761635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139076062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro and in vivo toxicity of carbon dots with different chemical compositions. 不同化学成分碳点的体内外毒性研究。

Discover nano Pub Date : 2023-09-08 DOI: 10.1186/s11671-023-03891-9

Halyna Kuznietsova, Alain Géloën, Nataliia Dziubenko, Alexander Zaderko, Sergei Alekseev, Vladimir Lysenko, Valeriy Skryshevsky

{"title":"In vitro and in vivo toxicity of carbon dots with different chemical compositions.","authors":"Halyna Kuznietsova, Alain Géloën, Nataliia Dziubenko, Alexander Zaderko, Sergei Alekseev, Vladimir Lysenko, Valeriy Skryshevsky","doi":"10.1186/s11671-023-03891-9","DOIUrl":"10.1186/s11671-023-03891-9","url":null,"abstract":"Carbon dots (CDs) are easy-obtained nanoparticles with wide range of biological activity; however, their toxicity after prolonged exposure is poorly investigated. So, in vitro and in vivo toxicity of CDs with the surfaces enriched with hydroxylated hydrocarbon chains and methylene groups (CD_GE), carboxyl and phenol groups accompanied with nitrogen (CD_3011), trifluoromethyl (CDF19) or toluidine and aniline groups (CDN19) were aimed to be discovered. CDs' in vitro toxicity was assessed on A549 cells (real-time cell analysis of impedance, fluorescence microscopy) after 24 h of incubation, and we observed no changes in cell viability and morphology. CDs' in vivo toxicity was assessed on C57Bl6 mice after multiple dosages (5 mg/kg subcutaneously) for 14 days. Lethality (up to 50%) was observed in CDN19 and CD_3011 groups on different days of dosing, accompanied by toxicity signs in case of CD_3011. There were no changes in serum biochemical parameters except Urea (increased in CDF19 and CD_3011 groups), nor substantial kidney, liver, and spleen injuries. The most impactful for all organs were also CD_3011 and CDF19, causing renal tubule injury and liver blood supply violation. Thus, CDs with a surface enriched with oxygen- and nitrogen-containing functional groups might be toxic after multiple everyday dosing, without, however, significant damages of internal organs in survived animals.","PeriodicalId":72828,"journal":{"name":"Discover nano","volume":"18 1","pages":"111"},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10211329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The electronic properties of boron-doped germanium nanocrystals films. 掺硼锗纳米晶体薄膜的电子特性。

Discover nano Pub Date : 2023-09-07 DOI: 10.1186/s11671-023-03893-7

Dan Shan, Menglong Wang, Daoyuan Sun, Yunqing Cao

引用次数: 1