Cyborg and bionic systems (Washington, D.C.)最新文献

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Noninvasive Intracranial Source Signal Localization and Decoding with High Spatiotemporal Resolution. 高时空分辨率无创颅内源信号定位与解码。
IF 10.5
Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-04-09 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0206
Hao Zhang, Xue Wang, Guowei Chen, Yanqiu Zhang, Xiqi Jian, Feng He, Minpeng Xu, Dong Ming
{"title":"Noninvasive Intracranial Source Signal Localization and Decoding with High Spatiotemporal Resolution.","authors":"Hao Zhang, Xue Wang, Guowei Chen, Yanqiu Zhang, Xiqi Jian, Feng He, Minpeng Xu, Dong Ming","doi":"10.34133/cbsystems.0206","DOIUrl":"https://doi.org/10.34133/cbsystems.0206","url":null,"abstract":"<p><p>High spatiotemporal resolution of noninvasive electroencephalography (EEG) signals is an important prerequisite for fine brain-computer manipulation. However, conventional scalp EEG has a low spatial resolution due to the volume conductor effect, making it difficult to accurately identify the intent of brain-computer manipulation. In recent years, transcranial focused ultrasound modulated EEG technology has increasingly become a research hotspot, which is expected to acquire noninvasive acoustoelectric coupling signals with a high spatial and temporal resolution. In view of this, this study established a transcranial focused ultrasound numerical simulation model and experimental platform based on a real brain model and a 128-array phased array, further constructed a 3-dimensional transcranial multisource dipole localization and decoding numerical simulation model and experimental platform based on the acoustic field platform, and developed a high-precision localization and decoding algorithm. The results show that the simulation-guided phased-array acoustic field experimental platform can achieve accurate focusing in both pure water and transcranial conditions within a safe threshold, with a modulation range of 10 mm, and the focal acoustic pressure can be enhanced by more than 200% compared with that of transducer self-focusing. In terms of dipole localization decoding results, the proposed algorithm in this study has a localization signal-to-noise ratio of 24.18 dB, which is 50.59% higher than that of the traditional algorithm, and the source signal decoding accuracy is greater than 0.85. This study provides a reliable experimental basis and technical support for high-spatiotemporal-resolution noninvasive EEG signal acquisition and precise brain-computer manipulation.</p>","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"6 ","pages":"0206"},"PeriodicalIF":10.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11981584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Remote Regulation of Molecular Diffusion in Extracellular Space of Parkinson's Disease Rat Model by Subthalamic Nucleus Deep Brain Stimulation. 丘脑下核深部脑刺激对帕金森病大鼠细胞外空间分子扩散的远程调控。
IF 10.5
Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-04-03 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0218
Dan Du, Wanyi Fu, Shaoyi Su, Xin Mao, Liu Yang, Meng Xu, Yi Yuan, Yajuan Gao, Ziyao Geng, Yanjing Chen, Mingming Zhao, Yu Fu, Feng Yin, Hongbin Han
{"title":"Remote Regulation of Molecular Diffusion in Extracellular Space of Parkinson's Disease Rat Model by Subthalamic Nucleus Deep Brain Stimulation.","authors":"Dan Du, Wanyi Fu, Shaoyi Su, Xin Mao, Liu Yang, Meng Xu, Yi Yuan, Yajuan Gao, Ziyao Geng, Yanjing Chen, Mingming Zhao, Yu Fu, Feng Yin, Hongbin Han","doi":"10.34133/cbsystems.0218","DOIUrl":"10.34133/cbsystems.0218","url":null,"abstract":"<p><p>Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective therapy for Parkinson's disease (PD). However, the therapeutic mechanisms remain incompletely understood, particularly regarding the extracellular space (ECS), a critical microenvironment where molecular diffusion and interstitial fluid (ISF) dynamics are essential for neural function. This study aims to explore the regulatory mechanisms of the ECS in the substantia nigra (SN) of PD rats following STN-DBS. To evaluate whether STN-DBS can modulate ECS diffusion and drainage, we conducted quantitative measurements using a tracer-based magnetic resonance imaging. Our findings indicated that, compared to the PD group, STN-DBS treatment resulted in a decreased diffusion coefficient (<i>D</i>*), shorted half-life (<i>T</i> <sub>1/2</sub>), and increased clearance coefficient (<i>k</i>') in the SN. To investigate the mechanisms underlying these changes in molecular diffusion, we employed enzyme-linked immunosorbent assay (ELISA), Western blotting (WB), and microdialysis techniques. The results revealed that STN-DBS led to an increase in hyaluronic acid content, elevated expression of excitatory amino acid transporter 2 (EAAT2), and a reduction in extracellular glutamate concentration. Additionally, to further elucidate the mechanisms influencing ISF drainage, we employed immunofluorescence and immunohistochemical techniques for staining aquaporin-4 (AQP-4) and α-synuclein. The results demonstrated that STN-DBS restored the expression of AQP-4 while decreasing the expression of α-synuclein. In conclusion, our findings suggest that STN-DBS improves PD symptoms by modifying the ECS and enhancing ISF drainage in the SN regions. These results offer new insights into the mechanisms and long-term outcomes of DBS in ECS, paving the way for precision therapies.</p>","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"6 ","pages":"0218"},"PeriodicalIF":10.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward Hand Gesture Recognition Using a Channel-Wise Cumulative Spike Train Image-Driven Model. 基于信道累积尖峰序列图像驱动模型的手势识别研究。
IF 10.5
Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0219
Yang Yu, Zeyu Zhou, Yang Xu, Chen Chen, Weichao Guo, Xinjun Sheng
{"title":"Toward Hand Gesture Recognition Using a Channel-Wise Cumulative Spike Train Image-Driven Model.","authors":"Yang Yu, Zeyu Zhou, Yang Xu, Chen Chen, Weichao Guo, Xinjun Sheng","doi":"10.34133/cbsystems.0219","DOIUrl":"10.34133/cbsystems.0219","url":null,"abstract":"<p><p>Recognizing hand gestures from neural control signals is essential for natural human-machine interaction, which is extensively applied to prosthesis control and rehabilitation. However, establishing associations between the neural control signals of motor units and gestures remains an open question. Here, we propose a channel-wise cumulative spike train (cw-CST) image-driven model (cwCST-CNN) for hand gesture recognition, leveraging the spatial activation patterns of motor unit firings to distinguish motor intentions. Specifically, the cw-CSTs of motor units were decomposed from high-density surface electromyography using a spatial spike detection algorithm and were further reconstructed into images according to their spatial recording positions. Then, the resultant cwCST-images were fed into a customized convolutional neural network to recognize gestures. Additionally, we conducted an experiment involving 10 gestures and 10 subjects and compared the proposed method with 2 root-mean-square (RMS)-based approaches and a cw-CST-based approach, namely, RMS-image-driven convolutional neural network classification model, RMS feature with linear discrimination analysis classifier, and cw-CST discharge rate feature with linear discrimination analysis classifier. The results demonstrated that cwCST-CNN outperformed the other 3 methods with a higher classification accuracy of 96.92% ± 1.77%. Moreover, analysis of cw-CST and RMS features showed that the former had better separability across gestures and consistency considering training and testing datasets. This study provides a new solution and enhances the accuracy of gesture recognition using neural drive signals in human-machine interaction.</p>","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"6 ","pages":"0219"},"PeriodicalIF":10.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prioritized Multi-task Motion Coordination of Physically Constrained Quadruped Manipulators. 物理约束四足机器人优先多任务运动协调。
IF 10.5
Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0203
Aizhen Xie, Xuewen Rong, Guoteng Zhang, Yibin Li, Yong Fan, Zhi Li, Teng Chen
{"title":"Prioritized Multi-task Motion Coordination of Physically Constrained Quadruped Manipulators.","authors":"Aizhen Xie, Xuewen Rong, Guoteng Zhang, Yibin Li, Yong Fan, Zhi Li, Teng Chen","doi":"10.34133/cbsystems.0203","DOIUrl":"10.34133/cbsystems.0203","url":null,"abstract":"<p><p>Quadruped manipulators can use legs to mimic legged animals for crossing unstructured environments. They can also use a bionic arm to execute manipulation tasks. The increasing demands for such robots have pushed research progress. However, there remain challenging works in their usage of a high degree of freedom. To solve this redundant problem, we propose a novel motion coordination framework based on multi-task prioritization and null-space projection. The framework can adaptively generate optimal motion for different parts of the robot considering 3 prioritized tasks. The tasks include end-effector trajectory tracking, motion redistribution to meet physical constraints, and manipulability enhancement. The motion is then executed by a whole-body controller incorporating dynamics, inverse kinematics, multiobjective priorities, and force constraints. Experiments both in simulation and on the robot platform validate the advantages and effectiveness of the algorithm. The robot can finish robust and accurate operational space end-effector tracking with errors less than 3 cm.</p>","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"6 ","pages":"0203"},"PeriodicalIF":10.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Earthworm-Inspired Multimodal Pneumatic Continuous Soft Robot Enhanced by Winding Transmission. 以蚯蚓为灵感的多模态气动连续软机器人。
IF 10.5
Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0204
Jianbin Liu, Pengcheng Li, Zhihan Huang, Haitao Liu, Tian Huang
{"title":"Earthworm-Inspired Multimodal Pneumatic Continuous Soft Robot Enhanced by Winding Transmission.","authors":"Jianbin Liu, Pengcheng Li, Zhihan Huang, Haitao Liu, Tian Huang","doi":"10.34133/cbsystems.0204","DOIUrl":"10.34133/cbsystems.0204","url":null,"abstract":"<p><p>This paper presents an earthworm-inspired multimodal pneumatic continuous soft robot enhanced by wire-winding transmission. First, a derived overlapped continuous control law based on multiple peristaltic waves is introduced to effectively improve the motion performance of the robot. Second, by applying the wire-winding transmission method, the extension of one segment is simultaneously transformed into the contraction of other segments, achieving coordinated deformation and making it more similar to real earthworms. In addition, an autonomous obstacle-avoidance control strategy based on contact force sensing is developed to enhance the environmental adaptability of the robot. Based on these methods, an earthworm-inspired soft robot that can perform multimodal movements with autonomous obstacle-avoidance ability and enhanced motion efficiency is developed. A series of experiments including in- and cross-plane crawling, obstacle avoidance steering, and pipeline crawling are conducted to validate the robot's multimodal motion capabilities. The robot can achieve a speed of 6.65 mm/s (36.0 × 10<sup>-3</sup> bl/s) during in-plane crawling movement and 1.66 mm/s (8.97 × 10<sup>-3</sup> bl/s) during pipeline crawling movement. In terms of the in-plane crawling speed, the robot surpasses other robots of the same type. In conclusion, the robot's multimodal capabilities and enhanced motion efficiency demonstrate superior overall performance, and the robot has good potential for medical and industrial applications.</p>","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"6 ","pages":"0204"},"PeriodicalIF":10.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Repetitive Mechanical Oscillation Needle-Free Injection through Electrically Induced Microbubbles. 电致微泡重复机械振荡无针注射的研究进展。
IF 10.5
Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0225
Yibo Ma, Wenjing Huang, Naotomo Tottori, Yoko Yamanishi
{"title":"Development of Repetitive Mechanical Oscillation Needle-Free Injection through Electrically Induced Microbubbles.","authors":"Yibo Ma, Wenjing Huang, Naotomo Tottori, Yoko Yamanishi","doi":"10.34133/cbsystems.0225","DOIUrl":"10.34133/cbsystems.0225","url":null,"abstract":"<p><p>We previously developed a novel needle-free reagent injection method based on electrically induced microbubbles. The system generates microbubbles and applies repetitive mechanical oscillation associated with microbubble dynamics to perforate tissue and introduce a reagent. In this paper, we propose improving the reagent injection depth by reflecting the shock wave through microbubble dynamics. Our results show that the developed shock wave reflection method improves the ability of the electrically induced microbubble injection system to introduce a reagent. The method extends the application potential of electrically induced microbubble needle-free injection.</p>","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"6 ","pages":"0225"},"PeriodicalIF":10.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward Cyborg: Exploring Long-Term Clinical Outcomes of a Multi-Degree-of-Freedom Myoelectric Prosthetic Hand. 迈向半机械人:探索多自由度肌电假手的长期临床效果。
IF 10.5
Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-03-18 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0195
Yuki Kuroda, Yusuke Yamanoi, Hai Jiang, Yoshiko Yabuki, Yuki Inoue, Dianchun Bai, Yinlai Jiang, Jinying Zhu, Hiroshi Yokoi
{"title":"Toward Cyborg: Exploring Long-Term Clinical Outcomes of a Multi-Degree-of-Freedom Myoelectric Prosthetic Hand.","authors":"Yuki Kuroda, Yusuke Yamanoi, Hai Jiang, Yoshiko Yabuki, Yuki Inoue, Dianchun Bai, Yinlai Jiang, Jinying Zhu, Hiroshi Yokoi","doi":"10.34133/cbsystems.0195","DOIUrl":"10.34133/cbsystems.0195","url":null,"abstract":"<p><p>Recent advancements in robotics and sensor technology have facilitated the development of myoelectric prosthetic hands (MPHs) featuring multiple degrees of freedom and heightened functionality, but their practical application has been limited. In response to this situation, formulating a control theory ensuring the hand dexterity of highly functional MPHs has garnered marked attention. Progress in this field has been directed toward employing machine-learning algorithms to process electromyogram patterns, enabling a broad spectrum of hand movements. In particular, the practical application of 5-finger-driven MPHs with such control functions to real users remains limited, and their attributes and challenges have not been thoroughly examined. In this study, we developed a 5-finger MPH equipped with pattern recognition capabilities. Through a long-term clinical trial, encompassing task assessments and subjective evaluations via questionnaires, we explored the MPH's range of applications. The task assessments revealed an expanded range of achievable tasks as the variety of motions increased. However, this enhanced adaptability was paralleled by a decrease in control reliability. Additionally, findings from the questionnaires indicated that enhancements in task performance with MPHs might be more effective in reducing workplace-related disability than in improving activities in everyday life. This study offers valuable insights into the long-term clinical prospects and constraints associated with multi-degree-of-freedom MPHs incorporating pattern recognition functionality.</p>","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"6 ","pages":"0195"},"PeriodicalIF":10.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnetic Shaftless Propeller Millirobot with Multimodal Motion for Small-Scale Fluidic Manipulation. 基于多模态运动的磁力无轴螺旋桨微机器人。
IF 10.5
Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-03-12 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0235
Yaozhen Hou, Shihao Zhong, Zhiqiang Zheng, Jiabao Du, Ruhao Nie, Qing Shi, Qiang Huang, Huaping Wang
{"title":"Magnetic Shaftless Propeller Millirobot with Multimodal Motion for Small-Scale Fluidic Manipulation.","authors":"Yaozhen Hou, Shihao Zhong, Zhiqiang Zheng, Jiabao Du, Ruhao Nie, Qing Shi, Qiang Huang, Huaping Wang","doi":"10.34133/cbsystems.0235","DOIUrl":"10.34133/cbsystems.0235","url":null,"abstract":"<p><p>Magnetic miniature robots have shown great potential in biomedical applications in recent years. However, a challenge remains in which it is difficult for magnetic miniature robots to achieve balanced capabilities for multimodal locomotion and fluidic manipulation in various environments. Here, we report a magnetic shaftless propeller-like millirobot (MSPM) that possesses the capabilities of rotating-based multimodal 3-dimensional motion and cargo transportation with untethered manipulation. The MSPM utilizes the propulsion and pumping capabilities of the propeller structure to achieve fluidic manipulation. The shaftless propeller structures are designed to achieve omnidirectional locomotion through rolling, propelling, and tumbling. Additionally, the shaftless 3-blade propeller is used to perform a pumping function to achieve controllable transportation of fluids and particles. We anticipate that the MSPM holds great potential as a minimally invasive device for thrombosis treatment and targeted medicine delivery.</p>","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"6 ","pages":"0235"},"PeriodicalIF":10.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Coupled Wing Motion on the Aerodynamic Performance during Different Flight Stages of Pigeon. 耦合翼运动对鸽子不同飞行阶段气动性能的影响。
IF 10.5
Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-03-11 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0200
Yishi Shen, Yi Xu, Weimin Huang, Chengrui Shang, Qing Shi
{"title":"Effect of Coupled Wing Motion on the Aerodynamic Performance during Different Flight Stages of Pigeon.","authors":"Yishi Shen, Yi Xu, Weimin Huang, Chengrui Shang, Qing Shi","doi":"10.34133/cbsystems.0200","DOIUrl":"10.34133/cbsystems.0200","url":null,"abstract":"<p><p>Birds achieve remarkable flight performance by flexibly morphing their wings during different flight stages. However, due to the lack of experimental data on the free morphing of wings and the complexity of coupled motion in aerodynamics studies, the intricate kinematic changes and aerodynamic mechanisms of wings during various flight stages still need to be explored. To address this issue, we collected comprehensive data on free-flight pigeons (<i>Columba livia</i>). We categorized the wing kinematic parameters during the takeoff, leveling flight, and landing stages into 5 kinematics parameters: flap, twist, sweep, fold, and bend. Based on this, we established a 3-dimensional pigeon wing model, defined its coupled motion using rotation matrices, and then used the computational fluid dynamics method to simulate the coupled motion in the 3 flight stages. We analyzed and compared the kinematic parameter changes, aerodynamic forces, and flow structures. It is found that, within a wingbeat cycle, pigeons during the takeoff stage cause the leading-edge vortex to attach earlier, enhancing instantaneous lift to overcome gravity and achieve ascending. During the leveling flight stage, the pigeon's average lift becomes stable, ensuring a steady flight posture. In the landing stage, the pigeon increases the wing area facing the airflow to maintain a stable landing posture, achieving a more minor, consistent average lift while increasing drag. This study enhances our understanding of birds' flight mechanisms and provides theoretical guidance for developing efficient bio-inspired flapping-wing aerial vehicles.</p>","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"6 ","pages":"0200"},"PeriodicalIF":10.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of Ultrasound Localization Microscopy in Evaluating the Type 2 Diabetes Progression. 超声定位显微镜在评估2型糖尿病进展中的应用。
IF 10.5
Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-03-10 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0117
Tao Zhang, Jipeng Yan, Xinhuan Zhou, Bihan Wu, Chao Zhang, Mengxing Tang, Pintong Huang
{"title":"Application of Ultrasound Localization Microscopy in Evaluating the Type 2 Diabetes Progression.","authors":"Tao Zhang, Jipeng Yan, Xinhuan Zhou, Bihan Wu, Chao Zhang, Mengxing Tang, Pintong Huang","doi":"10.34133/cbsystems.0117","DOIUrl":"10.34133/cbsystems.0117","url":null,"abstract":"<p><p>Type 2 diabetes is considered as a chronic inflammatory disease in which the dense microvasculature reorganizes with disease progression and is highly correlated with β cell mass and islet function. In this study, we constructed rat models of type 2 diabetes and used ultrasound localization microscopy (ULM) imaging to noninvasively map the pancreatic microvasculature at microscopy resolution in vivo to reflect β cell loss and islet function deterioration, and evaluate the efficacy after anti-cytokine immunotherapy. It was unveiled that ULM morphological and hemodynamic parameters have a strong link with β cell loss and deterioration of pancreatic islet function. This correlation aligns with the observed pathological alterations in the microvessels of islet and demonstrated that ULM can effectively mirror the functionality of β cells during rapid fluctuations in blood glucose levels by observing changes in mean velocity. Furthermore, it was revealed that treatment with anti-cytokine immunotherapy enhances the function and health of β cells by restoring the microvascular environment. Remarkable improvements in vessel morphology (measured by fractal dimension) and hemodynamics (indicated by mean velocity and vessel density) were noted following the anti-cytokine immunotherapy, signifying a significant enhancement at the treatment's conclusion (<i>P</i> < 0.05). These observations suggested that ULM technology holds promise as a visible and efficient tool for monitoring the effectiveness of anti-cytokine immunotherapy in managing type 2 diabetes. Pancreatic microvessel-based ULM may serve as a novel noninvasive method to assess β cells, providing a valuable clinical tool for tracking the progression of type 2 diabetes.</p>","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"6 ","pages":"0117"},"PeriodicalIF":10.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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