Cyborg and bionic systems (Washington, D.C.)最新文献_第3页

Amplification-Free Electrochemiluminescent Biosensor for Ultrasensitive Detection of Fusobacterium nucleatum Using Tetrahedral DNA-Based CRISPR/Cas12a. 基于四面体dna的CRISPR/Cas12a超灵敏检测核梭杆菌的无扩增电化学发光生物传感器

IF 10.5

Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-05-01 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0266

Xindan Zhang, Minkang Wu, Haoran Shi, Soochan Kim, Shixiang Lu, Ping Wang, Jieling Qin

{"title":"Amplification-Free Electrochemiluminescent Biosensor for Ultrasensitive Detection of Fusobacterium nucleatum Using Tetrahedral DNA-Based CRISPR/Cas12a.","authors":"Xindan Zhang, Minkang Wu, Haoran Shi, Soochan Kim, Shixiang Lu, Ping Wang, Jieling Qin","doi":"10.34133/cbsystems.0266","DOIUrl":"https://doi.org/10.34133/cbsystems.0266","url":null,"abstract":"Fusobacterium nucleatum, a bacterium linked to colorectal cancer, possesses a specific gene called fadA that serves as an early diagnostic biomarker. The CRISPR/Cas12a system has demonstrated marked potential for nucleic acid detection due to its satisfactory selectivity and trans-cleavage ability. However, most CRISPR/Cas-based sensors suffer from problems such as probe entanglement or local aggregation, reducing the Cas enzyme efficiency. In this study, an amplification-free biosensing platform for ultrasensitive detection of F. nucleatum was developed by integrating the highly specific CRISPR/AsCas12a with an improved electrochemiluminescence (ECL) biosensor. Different from the conventional 1- or 2-dimensional probes, the platform was constructed by tetrahedral DNA nanostructure (TDN) probes conjugated with quenchers and coralliform gold (CFAu) functionalized with luminescent agents. The TDN serves as an exceptional scaffold to modulate the recognition unit, substantially enhancing the recognition and cleavage efficiency of AsCas12a toward the probes. Furthermore, the high surface area of CFAu provides extensive landing sites for the luminescent agents, thereby improving the detection sensitivity. The prepared ECL biosensor exhibited a wider linear range (10 fM to 100 nM) and was capable of detecting F. nucleatum down to 1 colony-forming unit/ml. Additionally, the high mismatch sensitivity of AsCas12a to protospacer adjacent motifs and nearby areas provides a strategy for distinguishing mutant from wild-type sequences. Finally, by designing CRISPR RNA (crRNA), this diagnostic method can also be easily modified to detect other bacteria or biomarkers for the early diagnosis of various diseases.","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"6 ","pages":"0266"},"PeriodicalIF":10.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Progress of Soft and Bioactive Materials in Flexible Bioelectronics. 柔性生物电子学中软性和生物活性材料的研究进展。

IF 10.5

Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-04-29 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0192

Xiaojun Wu, Yuanming Ye, Mubai Sun, Yongfeng Mei, Bowen Ji, Ming Wang, Enming Song

{"title":"Recent Progress of Soft and Bioactive Materials in Flexible Bioelectronics.","authors":"Xiaojun Wu, Yuanming Ye, Mubai Sun, Yongfeng Mei, Bowen Ji, Ming Wang, Enming Song","doi":"10.34133/cbsystems.0192","DOIUrl":"https://doi.org/10.34133/cbsystems.0192","url":null,"abstract":"Materials that establish functional, stable interfaces to targeted tissues for long-term monitoring/stimulation equipped with diagnostic/therapeutic capabilities represent breakthroughs in biomedical research and clinical medicine. A fundamental challenge is the mechanical and chemical mismatch between tissues and implants that ultimately results in device failure for corrosion by biofluids and associated foreign body response. Of particular interest is in the development of bioactive materials at the level of chemistry and mechanics for high-performance, minimally invasive function, simultaneously with tissue-like compliance and in vivo biocompatibility. This review summarizes the most recent progress for these purposes, with an emphasis on material properties such as foreign body response, on integration schemes with biological tissues, and on their use as bioelectronic platforms. The article begins with an overview of emerging classes of material platforms for bio-integration with proven utility in live animal models, as high performance and stable interfaces with different form factors. Subsequent sections review various classes of flexible, soft tissue-like materials, ranging from self-healing hydrogel/elastomer to bio-adhesive composites and to bioactive materials. Additional discussions highlight examples of active bioelectronic systems that support electrophysiological mapping, stimulation, and drug delivery as treatments of related diseases, at spatiotemporal resolutions that span from the cellular level to organ-scale dimension. Envisioned applications involve advanced implants for brain, cardiac, and other organ systems, with capabilities of bioactive materials that offer stability for human subjects and live animal models. Results will inspire continuing advancements in functions and benign interfaces to biological systems, thus yielding therapy and diagnostics for human healthcare.","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"6 ","pages":"0192"},"PeriodicalIF":10.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acoustic Inspired Brain-to-Sentence Decoder for Logosyllabic Language. 声学启发脑到句子解码器的符号音节语言。

IF 10.5

Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-04-29 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0257

Chen Feng, Lu Cao, Di Wu, En Zhang, Ting Wang, Xiaowei Jiang, Jinbo Chen, Hui Wu, Siyu Lin, Qiming Hou, Junming Zhu, Jie Yang, Mohamad Sawan, Yue Zhang

{"title":"Acoustic Inspired Brain-to-Sentence Decoder for Logosyllabic Language.","authors":"Chen Feng, Lu Cao, Di Wu, En Zhang, Ting Wang, Xiaowei Jiang, Jinbo Chen, Hui Wu, Siyu Lin, Qiming Hou, Junming Zhu, Jie Yang, Mohamad Sawan, Yue Zhang","doi":"10.34133/cbsystems.0257","DOIUrl":"https://doi.org/10.34133/cbsystems.0257","url":null,"abstract":"Recent advances in brain-computer interfaces (BCIs) have demonstrated the potential to decode language from brain activity into sound or text, which has predominantly focused on alphabetic languages, such as English. However, logosyllabic languages, such as Mandarin Chinese, present marked challenges for establishing decoders that cover all characters, due to its unique syllable structures, extended character sets (e.g., over 50,000 characters for Mandarin Chinese), and complex mappings between characters and syllables, thus hindering practical applications. Here, we leverage the acoustic features of Mandarin Chinese syllables, constructing prediction models for syllable components (initials, tones, and finals), and decode speech-related stereoelectroencephalography (sEEG) signals into coherent Chinese sentences. The results demonstrate a high sentence-level offline decoding performance with a median character accuracy of 71.00% over the full spectrum of characters in the best participant. We also verified that incorporating acoustic-related features into the design of prediction models substantially enhances the accuracy of initials, tones, and finals. Moreover, our findings revealed that effective speech decoding also involves subcortical structures like the thalamus in addition to traditional language-related brain regions. Overall, we established a brain-to-sentence decoder for logosyllabic languages over full character set with a large intracranial electroencephalography dataset.","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"6 ","pages":"0257"},"PeriodicalIF":10.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Restoring Somatotopic Sensory Feedback in Lower Limb Amputees through Noninvasive Nerve Stimulation. 通过无创神经刺激恢复下肢截肢者的躯体感觉反馈。

IF 10.5

Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-04-29 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0243

Andrea Demofonti, Marco Germanotta, Andrea Zingaro, Gaia Bailo, Sabina Insalaco, Francesca Cordella, Irene Giovanna Aprile, Loredana Zollo

{"title":"Restoring Somatotopic Sensory Feedback in Lower Limb Amputees through Noninvasive Nerve Stimulation.","authors":"Andrea Demofonti, Marco Germanotta, Andrea Zingaro, Gaia Bailo, Sabina Insalaco, Francesca Cordella, Irene Giovanna Aprile, Loredana Zollo","doi":"10.34133/cbsystems.0243","DOIUrl":"https://doi.org/10.34133/cbsystems.0243","url":null,"abstract":"Patients with lower limb amputation experience ambulation disorders since they rely exclusively on visual information in addition to the tactile information they receive from stump-socket interface. The lack of sensory feedback in commercial lower limb prostheses is essential in their abandonment by patients with transtibial amputation (TTA) or transfemoral amputation (TFA). Recent studies have obtained promising results using invasive interfaces with peripheral nervous system presenting drawbacks related to surgery. This paper aims to (a) investigate the potential of transcutaneous electrical nerve stimulation (TENS) as noninvasive means for restoring somatotopic sensory feedback in lower limb amputees and (b) evaluate the effect of the system over a 4-week experimental protocol. The first phase of the study involved 13 participants (6 with TTA and 7 with TFA), and the second one evaluated the long-term effect of TENS on ambulation performance of 2 participants (S1 with TTA and S7 with TFA). The proposed system enhanced participant's ambulation significantly increasing the body weight distribution between legs (S1: from 134% to 143%, P < 0.0055; S7: from 66% to 72%, P < 0.0055) and gait symmetry (S1: step length symmetry index from 11% to 5%, P < 0.0055; S7: stance phase symmetry index from -4% to -2%, P < 0.0055). It led to a postamputation neuropathic pain reduction in S1 (neuropathic pain symptom inventory score diminished from 6 to 0). This demonstrates how TENS enhanced prosthesis embodiment, enabling greater load bearing and more physiological gait patterns. This study highlights TENS as noninvasive solution for restoring somatotopic sensory feedback, addressing the current limitations and paving the way for further research.","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"6 ","pages":"0243"},"PeriodicalIF":10.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Yeast-Driven and Bioimpedance-Sensitive Biohybrid Soft Robots. 酵母驱动和生物阻抗敏感的生物混合软机器人。

IF 10.5

Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-04-25 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0233

MennaAllah Soliman, Frederick Forbes, Dana D Damian

{"title":"Yeast-Driven and Bioimpedance-Sensitive Biohybrid Soft Robots.","authors":"MennaAllah Soliman, Frederick Forbes, Dana D Damian","doi":"10.34133/cbsystems.0233","DOIUrl":"https://doi.org/10.34133/cbsystems.0233","url":null,"abstract":"Biohybrid robots integrate biological components with synthetic materials to harness the unique capabilities of living systems for robotic functions. This study focuses on leveraging yeast fermentation dynamics to enable actuation and sensing in soft robotic systems. By leveraging yeast's natural ability to produce carbon dioxide and generate pressure during fermentation, we demonstrate the feasibility of creating biohybrid robots with lifelike behavior and adaptability. Our research integrates bioimpedance sensing into track yeast behavior and metabolic dynamics in real time. We developed an adjustable single-resistor oscillator circuit by using a digital potentiometer to measure impedance frequency and model the yeast growth rate. Experimental results reveal the sensitivity of the single-resistor oscillator circuit to variations in yeast concentration and demonstrate the correlation between yeast behavior and actuation power. Furthermore, we highlight the potential of yeast-driven robots for various applications by demonstrating a yeast-driven soft limb capable of rotating 140° tested at different temperatures, an inflatable membrane actuator functioning as a tactile sensor detecting forces up to 4.5 N, a palpation probe for differentiating tissue stiffness, and a gripper capable of manipulating objects. This work lays the foundation for advancing biohybrid robotics by integrating yeast fermentation dynamics with bioimpedance sensing, enhancing the functionality of robotic systems.","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"6 ","pages":"0233"},"PeriodicalIF":10.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient Hybrid Environment Expression for Look-and-Step Behavior of Bipedal Walking. 两足行走“看-步”行为的高效混合环境表达。

IF 10.5

Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-04-23 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0244

Chao Li, Qingqing Li, Junhang Lai, Xuechao Chen, Zhangguo Yu, Zhihong Jiang

{"title":"Efficient Hybrid Environment Expression for Look-and-Step Behavior of Bipedal Walking.","authors":"Chao Li, Qingqing Li, Junhang Lai, Xuechao Chen, Zhangguo Yu, Zhihong Jiang","doi":"10.34133/cbsystems.0244","DOIUrl":"https://doi.org/10.34133/cbsystems.0244","url":null,"abstract":"The look-and-step behavior of biped robots requires quickly extracting planar regions and obstacles with limited computing resources. To this end, this paper proposes an efficient method representing the environment as a hybrid of feasible planar regions and a heightmap. The feasible planar regions are used for footstep planning, preventing the body from hitting obstacles, and the heightmap is used to calculate foot trajectory to avoid foot collision during the swing process. The planar regions are efficiently extracted by leveraging the organized structure of points for nearest neighbor searches. To ensure safe locomotion, these extracted planar regions exclude areas that could cause the robot's body to collide with the environment. The proposed method completes this perception process in 0.16 s per frame using only a central processing unit, making it suitable for look-and-step behavior of biped robots. Experiments conducted in typical artificial scenarios with BHR-7P and BHR-8P demonstrate its efficiency and safety, validating its effectiveness for the look-and-step behavior of biped robots.","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"23 ","pages":"0244"},"PeriodicalIF":10.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Level-Ground and Stair Adaptation for Hip Exoskeletons Based on Continuous Locomotion Mode Perception. 基于连续运动模式感知的髋关节外骨骼的平地和楼梯适应。

IF 10.5

Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-04-22 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0248

Zhaoyang Wang, Dongfang Xu, Shunyi Zhao, Zehuan Yu, Yan Huang, Lecheng Ruan, Zhihao Zhou, Qining Wang

{"title":"Level-Ground and Stair Adaptation for Hip Exoskeletons Based on Continuous Locomotion Mode Perception.","authors":"Zhaoyang Wang, Dongfang Xu, Shunyi Zhao, Zehuan Yu, Yan Huang, Lecheng Ruan, Zhihao Zhou, Qining Wang","doi":"10.34133/cbsystems.0248","DOIUrl":"https://doi.org/10.34133/cbsystems.0248","url":null,"abstract":"Hip exoskeleton can provide assistance to users to augment movements in different scenarios. The assistive control for hip exoskeleton involves the interactions among exoskeleton, user, and environment, which depends on the environment perception (to predict locomotion) to design control strategy combined with gait mode and so on. Current exoskeleton control still needs to be improved in adaptation to continuous locomotion mode and different users. To address this problem, we have employed a learning-free (i.e., non-data-driven) environment perception method to improve hip exoskeleton adaptive control toward continuous locomotion mode. The adaptive control experiments were conducted on level ground and stairs on 7 subjects. The prediction accuracy for steady locomotion mode was more than 95% for each subject (ranged from 95.7% to 99.7%). The prediction accuracy for each locomotion mode transition ranged from 87.5% to 100%, and the transition timing could be detected before the end of transition period. Compared with learning-based (data-driven) approaches, our method achieves better performances in adaptive control for hip exoskeleton and shows some generalization for subjects.","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"6 ","pages":"0248"},"PeriodicalIF":10.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuromorphic Floating-Gate Memory Based on 2D Materials. 基于二维材料的神经形态浮栅存储器。

IF 10.5

Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-04-22 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0256

Chao Hu, Lijuan Liang, Jinran Yu, Liuqi Cheng, Nianjie Zhang, Yifei Wang, Yichen Wei, Yixuan Fu, Zhong Lin Wang, Qijun Sun

{"title":"Neuromorphic Floating-Gate Memory Based on 2D Materials.","authors":"Chao Hu, Lijuan Liang, Jinran Yu, Liuqi Cheng, Nianjie Zhang, Yifei Wang, Yichen Wei, Yixuan Fu, Zhong Lin Wang, Qijun Sun","doi":"10.34133/cbsystems.0256","DOIUrl":"https://doi.org/10.34133/cbsystems.0256","url":null,"abstract":"In recent years, the rapid progression of artificial intelligence and the Internet of Things has led to a significant increase in the demand for advanced computing capabilities and more robust data storage solutions. In light of these challenges, neuromorphic computing, inspired by human brain's architecture and operation principle, has surfaced as a promising answer to the growing technological demands. This novel methodology emulates the biological synaptic mechanisms for information processing, enabling efficient data transmission and computation at the identical position. Two-dimensional (2D) materials, distinguished by their atomic thickness and tunable physical properties, exhibit substantial potential in emulating synaptic plasticity and find broad applications in neuromorphic computing. With respect to device architecture, memory devices based on floating-gate (FG) structures demonstrate robust data retention capabilities and have been widely used in the realm of flash memory. This review begins with a succinct introduction to 2D materials and FG transistors, followed by an in-depth discussion on remarkable research progress in the integration of 2D materials with FG transistors for applications in neuromorphic computing and memory. This paper offers a thorough review of the existing research landscape, encapsulating the notable progress in swiftly expanding field. In conclusion, it addresses the constraints encountered by FG transistors using 2D materials and delineates potential future trajectories for investigation and innovation within this area.","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"6 ","pages":"0256"},"PeriodicalIF":10.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soft Robots with Cy5: An "Intake and Work" Imaging Technique for Intraoperative Navigation of Gastric Lesion. Cy5软机器人：胃病变术中导航的“入口与工作”成像技术。

IF 10.5

Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-04-11 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0212

Lifeng He, Yu Pan, Wei Jin, Rong Tan, Yanan Xue, Danying Sun, Jingyu Zhang, Pingyu Xiang, Qin Fang, Yue Wang, Rong Xiong, Haojian Lu, Songmei Lou

{"title":"Soft Robots with Cy5: An \"Intake and Work\" Imaging Technique for Intraoperative Navigation of Gastric Lesion.","authors":"Lifeng He, Yu Pan, Wei Jin, Rong Tan, Yanan Xue, Danying Sun, Jingyu Zhang, Pingyu Xiang, Qin Fang, Yue Wang, Rong Xiong, Haojian Lu, Songmei Lou","doi":"10.34133/cbsystems.0212","DOIUrl":"https://doi.org/10.34133/cbsystems.0212","url":null,"abstract":"Locating tumors during laparoscopic surgery for early gastric cancers poses an important challenge because they lack involvement with the serosal layer and remain invisible within the peritoneal cavity. To address this issue, various techniques such as preoperative dye injection and magnetic clip detection systems have been introduced to aid in intraoperative tumor localization. However, these existing techniques are often intricate and lack intuition and endurance. In this study, we propose a novel approach utilizing fluorescent soft robots to accurately locate tumors within the stomach. The methodology involved placing a metal clip at the tumor site, followed by administering several soft robots labeled with Cy5. These soft robots were designed to autonomously converge around the metal clip. To validate their efficacy, we conducted animal experiments by implanting clips into the stomachs of rats and subsequently administering capsules containing the soft robots. By detecting the resulting fluorescence, we successfully identified the location of the clips within the stomach. Our findings indicate that these soft robots hold great promise as a viable alternative for localizing gastric lesions during laparoscopic surgery, which has better persistence and intuitiveness than other markup methods. Their implementation could significantly enhance the accuracy and efficiency of tumor identification in a technologically advanced and clinically accessible manner.","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"6 ","pages":"0212"},"PeriodicalIF":10.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CrystalTac: Vision-Based Tactile Sensor Family Fabricated via Rapid Monolithic Manufacturing. CrystalTac：通过快速单片制造制造的基于视觉的触觉传感器系列。

IF 10.5

Cyborg and bionic systems (Washington, D.C.) Pub Date : 2025-04-10 eCollection Date: 2025-01-01 DOI: 10.34133/cbsystems.0231

Wen Fan, Haoran Li, Dandan Zhang

{"title":"CrystalTac: Vision-Based Tactile Sensor Family Fabricated via Rapid Monolithic Manufacturing.","authors":"Wen Fan, Haoran Li, Dandan Zhang","doi":"10.34133/cbsystems.0231","DOIUrl":"https://doi.org/10.34133/cbsystems.0231","url":null,"abstract":"Recently, vision-based tactile sensors (VBTSs) have gained popularity in robotics systems. The sensing mechanisms of most VBTSs can be categorized based on the type of tactile features they capture. Each category requires specific structural designs to convert physical contact into optical information. The complex architectures of VBTSs pose challenges for traditional manufacturing techniques in terms of design flexibility, cost-effectiveness, and quality stability. Previous research has shown that monolithic manufacturing using multimaterial 3-dimensional printing technology can address these challenges but fails to bridge the gap between the design phase and creation phase of VBTSs. Thereby, in this study, we introduce the CrystalTac family, a series of VBTSs designed with on-demand sensing mechanisms and fabricated through rapid monolithic manufacturing. Case studies on the CrystalTac family demonstrate their efficiency in targeted tasks involving tactile perception, along with impressive cost-effectiveness and design flexibility. The CrystalTac family aims to highlight the potential of rapid monolithic manufacturing techniques in VBTS development and inspire further research in tactile sensing and manipulation.","PeriodicalId":72764,"journal":{"name":"Cyborg and bionic systems (Washington, D.C.)","volume":"6 ","pages":"0231"},"PeriodicalIF":10.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0