Current problems in cancer. Case reports最新文献_第7页

Lenvatinib in combination with pembrolizumab in heavily pretreated metastatic thymic carcinoma: A case report 伦伐替尼联合 Pembrolizumab 治疗重度预处理转移性胸腺癌：病例报告

IF 0.2

Current problems in cancer. Case reports Pub Date : 2024-07-23 DOI: 10.1016/j.cpccr.2024.100315

Angelo Cabal , Misako Nagasaka

{"title":"Lenvatinib in combination with pembrolizumab in heavily pretreated metastatic thymic carcinoma: A case report","authors":"Angelo Cabal , Misako Nagasaka","doi":"10.1016/j.cpccr.2024.100315","DOIUrl":"10.1016/j.cpccr.2024.100315","url":null,"abstract":"<div><p>Thymoma and thymic carcinomas are rare tumors with limited therapeutic options for platinum-refractory cases. Recent studies have shown positive response rates in anti-angiogenic multi-kinase inhibitors (MKI) such as lenvatinib and sunitinib and immune checkpoint inhibitors including pembrolizumab, though they have yet to be tested in combination. Here, we present a case of a patient with heavily pre-treated PD-L1 negative metastatic thymic carcinoma and no targetable mutations treated with combination lenvatinib and pembrolizumab following initial response then progression from lenvatinib monotherapy. He had a partial response with decreased tumor burden in the liver with lenvatinib monotherapy and then in the lungs with combination therapy. Treatment was continued and he continues have clinical benefit with stable disease at 9 months with minimal toxicities. This case is one of the first reported clinical evidence for MKI and immunotherapy in combination as a promising second-line approach for thymic carcinomas.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"15 ","pages":"Article 100315"},"PeriodicalIF":0.2,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666621924000383/pdfft?md5=7d4e4649bddd9dc1a0f480ca54db15cb&pid=1-s2.0-S2666621924000383-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141851001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metachronous bilateral invasive breast carcinoma with low-grade adenosquamous carcinoma on one side: A case report and literature review 双侧浸润性乳腺癌并发一侧低级别腺鳞癌：病例报告和文献综述

IF 0.2

Current problems in cancer. Case reports Pub Date : 2024-07-14 DOI: 10.1016/j.cpccr.2024.100314

Wenli He , Xu Dong , Renling Hu , Qian Liu , Zhirong Yang

{"title":"Metachronous bilateral invasive breast carcinoma with low-grade adenosquamous carcinoma on one side: A case report and literature review","authors":"Wenli He , Xu Dong , Renling Hu , Qian Liu , Zhirong Yang","doi":"10.1016/j.cpccr.2024.100314","DOIUrl":"10.1016/j.cpccr.2024.100314","url":null,"abstract":"<div><p>Low-grade adenosquamous carcinoma (LGASC) is a rare variant of metaplastic breast carcinoma that consists of glandular and squamous elements in a spindle cell background. They lack distinctive imaging features and overlap with other breast neoplasm characteristics, posing a diagnostic challenge. We present the case of a 60-year-old woman with metachronous bilateral invasive breast carcinoma (MBBC). The mastectomy specimens of her left breast carcinoma revealed nests of squamous- appearing cells and “comma” glandular structures on a microscopic level. Comprehensive immunohistochemical examination of ER, PR, Her-2, p63, and CK7 CK5/6 confirmed the diagnosis of LGASC. Unlike other invasive breast carcinomas, LGASC have an indolent course and favorable prognosis. Eight years after surgery, she was diagnosed with a non-specific type of invasive breast carcinoma of the right breast via imaging, core needle biopsy and immunohistochemistry. This was a rare case of MBBC that has not been previously reported. Therefore, we report and review the relevant literature to raise awareness of this disease.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"15 ","pages":"Article 100314"},"PeriodicalIF":0.2,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666621924000371/pdfft?md5=57299d840d6ad866067bf5fe9ba7777e&pid=1-s2.0-S2666621924000371-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141623675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acquired pachydermatoglyphia: An ominous sign, two case reports 后天性畸形：一种不祥的征兆，两份病例报告

IF 0.2

Current problems in cancer. Case reports Pub Date : 2024-07-06 DOI: 10.1016/j.cpccr.2024.100312

Pedro Juan Saldarriaga-Muñoz , Carolina Arango-Buitrago , Maria del Pilar Márquez-Morón , Ana María Maya-Rico , Juan Pablo Vélez-Ramírez , Valeria Arciniegas-Grisales

引用次数: 0

Epitheliotropic monomorphic intestinal T cell lymphoma: Case report and literature review 上皮细胞性单形性肠 T 细胞淋巴瘤：病例报告和文献综述

IF 0.2

Current problems in cancer. Case reports Pub Date : 2024-07-05 DOI: 10.1016/j.cpccr.2024.100313

Joseph Alburqueque-Melgarejo , Brady Beltrán Gárate , Jhony A. De la Cruz-Vargas

{"title":"Epitheliotropic monomorphic intestinal T cell lymphoma: Case report and literature review","authors":"Joseph Alburqueque-Melgarejo , Brady Beltrán Gárate , Jhony A. De la Cruz-Vargas","doi":"10.1016/j.cpccr.2024.100313","DOIUrl":"10.1016/j.cpccr.2024.100313","url":null,"abstract":"<div><p>Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare type of T-cell lymphoma of the gastrointestinal tract that presents an aggressive course. Previously, this entity was named type II T-cell lymphoma associated with enteropathy. However, in later years it was classified as a different entity due to its particular characteristics. This neoplasm usually affects the jejunum and ileum and usually has a clinical presentation with intestinal perforation, intestinal obstruction or bleeding. Its diagnosis requires histopathological evaluation and differentiation from other types of T cell lymphomas that affect the intestine. Its prognosis is usually very poor and therapeutic options are limited and are based on induction chemotherapy followed by autologous bone marrow transplant. This article presents the first case of MEITL in Peru, in an elderly patient who presented at hospital emergency with intestinal perforation and that presented multiple relapses of the neoplasm.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"15 ","pages":"Article 100313"},"PeriodicalIF":0.2,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266662192400036X/pdfft?md5=0f070fe6c4ba4e93e28b5b5ad33c6b60&pid=1-s2.0-S266662192400036X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141702818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adenoid cystic carcinoma of the breast–A case report and review of the literature 乳腺腺样囊性癌--病例报告和文献综述

IF 0.2

Current problems in cancer. Case reports Pub Date : 2024-06-30 DOI: 10.1016/j.cpccr.2024.100309

Qing Q. Liu, Li J. Tang, Jie Yan, Yan Xu

引用次数: 0

Cryoablation as the primary treatment in a HER2 positive Stage IV breast cancer patient: 5 years term follow up case report 将冷冻消融作为 HER2 阳性 IV 期乳腺癌患者的主要治疗方法：5 年随访病例报告

IF 0.2

Current problems in cancer. Case reports Pub Date : 2024-06-22 DOI: 10.1016/j.cpccr.2024.100311

Kizuki Matsumoto , Masaaki Sakamoto , Youichi Machida , Masafumi Kurosumi , Eisuke Fukuma

{"title":"Cryoablation as the primary treatment in a HER2 positive Stage IV breast cancer patient: 5 years term follow up case report","authors":"Kizuki Matsumoto , Masaaki Sakamoto , Youichi Machida , Masafumi Kurosumi , Eisuke Fukuma","doi":"10.1016/j.cpccr.2024.100311","DOIUrl":"https://doi.org/10.1016/j.cpccr.2024.100311","url":null,"abstract":"<div><p>We report a case of human epidermal growth factor receptor 2 (HER2)-positive Stage IV breast cancer with metastatic lung cancer treated with cryoablation as a first-line treatment. The patient, a 34-year-old woman who voluntarily screened for breast cancer, was referred to our clinic after a mammogram revealed calcification findings. The patient had a tumor in the right breast and lung metastasis. The tumor was 34×31×23 mm with internal heterogeneity in the right mammary gland. Imaging and vacuum-assisted breast tumor biopsy led to a diagnosis of invasive ductal carcinoma (estrogen receptor-positive, progesterone receptor-negative, and human epidermal growth factor receptor 2 positive). The patient received 6 cycles of trastuzumab, and paclitaxel, followed by 11 cycles of trastuzumab, pertuzumab and tamoxifen as pre-cryoablation adjuvant therapy. After chemotherapy, the patient underwent minimally invasive cryoablation treatment followed by fractionated radiation therapy to the entire right breast.</p><p>In the last follow-up, 5 years following cryoablation as a first-line treatment after anti-HER2 therapy, a complete local response was recognized, with no evidence of disease progression in the lung metastasis or recurrence of the primary breast tumor. This case report demonstrates that cryoablation is safe and effective, with favorable cosmetic results also for late-stage breast cancer.</p><p>Cryoablation, as a minimally invasive treatment for primary site control of Stage IV breast cancer, can provide a good alternative that preserves the quality of life. It can be performed under local anesthesia and be conducted jointly with chemotherapy, radiation therapy, surgery, and immunotherapy.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"15 ","pages":"Article 100311"},"PeriodicalIF":0.2,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666621924000346/pdfft?md5=76320a9fadc67748a0ce414ae5dd80e7&pid=1-s2.0-S2666621924000346-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant pleural schwannoma presenting as intractable coughing: A rare case report 表现为顽固性咳嗽的巨大胸膜裂孔瘤：罕见病例报告

IF 0.2

Current problems in cancer. Case reports Pub Date : 2024-06-22 DOI: 10.1016/j.cpccr.2024.100308

Shrinjay Vyas , Michael Brescia , Heidi Fish

引用次数: 0

Mammary Myofibroblastoma: A mimicker of benign and low-grade malignant tumors with multipotent mesenchymal differentiation 乳腺肌纤维母细胞瘤：多能间充质分化的良性和低度恶性肿瘤的模拟者

IF 0.2

Current problems in cancer. Case reports Pub Date : 2024-06-19 DOI: 10.1016/j.cpccr.2024.100310

Anthony S. Larson , Amy Song , Lacey J. Schrader , Mark Wickre , Grzegorz T Gurda

{"title":"Mammary Myofibroblastoma: A mimicker of benign and low-grade malignant tumors with multipotent mesenchymal differentiation","authors":"Anthony S. Larson , Amy Song , Lacey J. Schrader , Mark Wickre , Grzegorz T Gurda","doi":"10.1016/j.cpccr.2024.100310","DOIUrl":"https://doi.org/10.1016/j.cpccr.2024.100310","url":null,"abstract":"<div><p>Mammary myofibroblastoma (MFB) is a rare benign spindle cell neoplasm of the breast that can exhibit both epithelial and mesenchymal elements. The histomorphologic features of MFB mimic other potentially more aggressive neoplasms of the breast that may require more involved clinical management beyond a conservative local excision. We present the case of a 71-year-old male with a mammary MFB who underwent core needle biopsy (CNB) of a well-defined, bland spindle cell neoplasm with a subsequent local excision. The case highlights triage of MFB among a broad diagnostic differential at biopsy, particularly given its multipotent differentiation potential and highly variable presentation from the standpoint of both radiology and histopathology. We also discuss the role of <em>RB1</em> deficiency in distinguishing MFB from other tumor types and non-neoplastic/reactive proliferations.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"15 ","pages":"Article 100310"},"PeriodicalIF":0.2,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666621924000334/pdfft?md5=f189716ad536dbfa2616efcee454b276&pid=1-s2.0-S2666621924000334-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141606336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A clinicopathologic analysis of 70 patients with mucinous breast carcinoma 70 例黏液性乳腺癌患者的临床病理分析

IF 0.2

Current problems in cancer. Case reports Pub Date : 2024-06-15 DOI: 10.1016/j.cpccr.2024.100304

Rupali Sood , Karin Miller , Hua-Ling Tsai , Ashley Cimino-Mathews , Roisin M. Connolly

{"title":"A clinicopathologic analysis of 70 patients with mucinous breast carcinoma","authors":"Rupali Sood , Karin Miller , Hua-Ling Tsai , Ashley Cimino-Mathews , Roisin M. Connolly","doi":"10.1016/j.cpccr.2024.100304","DOIUrl":"10.1016/j.cpccr.2024.100304","url":null,"abstract":"<div><h3>Purpose</h3><p>Pure mucinous breast carcinomas (PMBC) are rare cancers that are managed per standard breast cancer treatment protocols. In this study, we review the clinicopathologic features, treatment, and outcomes of patients with PMBC treated at our academic cancer center.</p></div><div><h3>Methods</h3><p>We searched institutional pathology databases for patients with histologically confirmed PMBC over a 20-year period (January 1998 - October 2018) who received any portion of clinical care at our institution. Archival pathology slides were re-reviewed to confirm the diagnosis and record pathologic features, including the presence or absence of a micropapillary component. We estimated recurrence free survival (RFS) probabilities using the Kaplan-Meier method and evaluated prognostic factors using Cox regression.</p></div><div><h3>Results</h3><p>A total of 70 cases of PMBC were identified, including 13 with micropapillary features. Median patient age was 65 years (range, 39–94) and approximately 40 % were African American or Asian. The majority of patients had negative lymph nodes (84 %), tumors < 2 cm (79 %), grade I-II (94 %), and hormone receptor positive (99 %) disease, with Ki-67 proliferation indices ≤10 % (54 %). All patients underwent surgery, 50 % received adjuvant radiation therapy, 6 % adjuvant chemotherapy, and 63 % adjuvant hormone therapy. Five-year RFS was 94 % with no identified clinicopathologic or treatment factors significantly affecting survival, including the presence of micropapillary features.</p></div><div><h3>Conclusion</h3><p>We report one of the more diverse single institution series of patients with PMBC based in the United States. This rare breast cancer subtype is associated with a favorable prognosis and may benefit from omission of aggressive standard treatment approaches.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"15 ","pages":"Article 100304"},"PeriodicalIF":0.2,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666621924000279/pdfft?md5=7edbc9e6a64a8b6f2f1cc4b57d0ed1bb&pid=1-s2.0-S2666621924000279-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141396362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunotherapy for anorectal melanoma: A case report 肛门直肠黑色素瘤的免疫疗法：病例报告

Current problems in cancer. Case reports Pub Date : 2024-06-12 DOI: 10.1016/j.cpccr.2024.100302

Nicholas L. Vitagliano , Muhammad B. Darwish , Roger W. Hsiung

引用次数: 0