Metachronous bilateral invasive breast carcinoma with low-grade adenosquamous carcinoma on one side: A case report and literature review

IF 0.2 Q4 ONCOLOGY
Wenli He , Xu Dong , Renling Hu , Qian Liu , Zhirong Yang
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引用次数: 0

Abstract

Low-grade adenosquamous carcinoma (LGASC) is a rare variant of metaplastic breast carcinoma that consists of glandular and squamous elements in a spindle cell background. They lack distinctive imaging features and overlap with other breast neoplasm characteristics, posing a diagnostic challenge. We present the case of a 60-year-old woman with metachronous bilateral invasive breast carcinoma (MBBC). The mastectomy specimens of her left breast carcinoma revealed nests of squamous- appearing cells and “comma” glandular structures on a microscopic level. Comprehensive immunohistochemical examination of ER, PR, Her-2, p63, and CK7 CK5/6 confirmed the diagnosis of LGASC. Unlike other invasive breast carcinomas, LGASC have an indolent course and favorable prognosis. Eight years after surgery, she was diagnosed with a non-specific type of invasive breast carcinoma of the right breast via imaging, core needle biopsy and immunohistochemistry. This was a rare case of MBBC that has not been previously reported. Therefore, we report and review the relevant literature to raise awareness of this disease.

双侧浸润性乳腺癌并发一侧低级别腺鳞癌:病例报告和文献综述
低级别腺鳞癌(LGASC)是移行细胞乳腺癌的一种罕见变体,由纺锤形细胞背景中的腺和鳞状细胞组成。它们缺乏明显的影像学特征,并与其他乳腺肿瘤特征重叠,给诊断带来了挑战。我们介绍了一例患有双侧浸润性乳腺癌(MBBC)的 60 岁女性病例。她的左侧乳腺癌切除标本在显微镜下显示出鳞状细胞巢和 "逗号 "腺结构。ER、PR、Her-2、p63 和 CK7 CK5/6 的免疫组化检查证实了 LGASC 的诊断。与其他浸润性乳腺癌不同,LGASC 病程缓慢,预后良好。术后八年,通过影像学、核心针活检和免疫组化检查,她被确诊为右乳非特异性浸润性乳腺癌。这是一例罕见的 MBBC 病例,以前从未报道过。因此,我们报告并回顾了相关文献,以提高人们对这种疾病的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.40
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0.00%
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96 days
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