伦伐替尼联合 Pembrolizumab 治疗重度预处理转移性胸腺癌:病例报告

IF 0.2 Q4 ONCOLOGY
Angelo Cabal , Misako Nagasaka
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引用次数: 0

摘要

胸腺瘤和胸腺癌是罕见肿瘤,对铂类药物难治性病例的治疗方案有限。最近的研究显示,来伐替尼、舒尼替尼等抗血管生成多激酶抑制剂(MKI)和包括pembrolizumab在内的免疫检查点抑制剂的阳性反应率较高,但它们尚未进行联合试验。在此,我们介绍了一例PD-L1阴性且无靶向突变的重度预处理转移性胸腺癌患者的病例,该患者在接受来伐替尼单药治疗后出现初步应答,随后病情进展,随后接受来伐替尼和pembrolizumab联合治疗。来伐替尼单药治疗后,他的肝脏出现部分反应,肿瘤负荷减轻;联合治疗后,肺部肿瘤负荷减轻。他继续接受治疗,并在9个月后病情稳定,毒性极低,继续获得临床获益。该病例是MKI和免疫疗法联合作为胸腺癌二线治疗方法的首批临床证据之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lenvatinib in combination with pembrolizumab in heavily pretreated metastatic thymic carcinoma: A case report

Thymoma and thymic carcinomas are rare tumors with limited therapeutic options for platinum-refractory cases. Recent studies have shown positive response rates in anti-angiogenic multi-kinase inhibitors (MKI) such as lenvatinib and sunitinib and immune checkpoint inhibitors including pembrolizumab, though they have yet to be tested in combination. Here, we present a case of a patient with heavily pre-treated PD-L1 negative metastatic thymic carcinoma and no targetable mutations treated with combination lenvatinib and pembrolizumab following initial response then progression from lenvatinib monotherapy. He had a partial response with decreased tumor burden in the liver with lenvatinib monotherapy and then in the lungs with combination therapy. Treatment was continued and he continues have clinical benefit with stable disease at 9 months with minimal toxicities. This case is one of the first reported clinical evidence for MKI and immunotherapy in combination as a promising second-line approach for thymic carcinomas.

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