Current problems in cancer. Case reports最新文献

{"title":"Refractory diarrhea in a patient with metastatic breast cancer with ABCB1 polymorphism: A case report","authors":"Moeko Iida ,&nbsp;Yoshihiko Tasaki ,&nbsp;Akiko Kato ,&nbsp;Tomoya Yasujima ,&nbsp;Hiroaki Yuasa ,&nbsp;Yasuhiro Maeda ,&nbsp;Yoshihisa Mimura ,&nbsp;Kunihiro Odagiri ,&nbsp;Yuka Kimura ,&nbsp;Nanami Ito ,&nbsp;Yasuhiro Horita ,&nbsp;Yosuke Sugiyama ,&nbsp;Yuji Hotta ,&nbsp;Tatsuya Toyama ,&nbsp;Yoko Furukawa-Hibi","doi":"10.1016/j.cpccr.2025.100367","DOIUrl":"10.1016/j.cpccr.2025.100367","url":null,"abstract":"<div><div>Although abemaciclib is an essential therapy for breast cancer, approximately 80 % of patients develop diarrhea. Abemaciclib undergoes excretion by the P-glycoprotein encoded by ATP-binding cassette subfamily B member 1 (<em>ABCB1</em>) in the small intestine during absorption. The polymorphism of this gene is associated with adverse effects such as pancytopenia. Therefore, we report a case of refractory diarrhea in which <em>ABCB1</em> polymorphisms were investigated. A Japanese 44-year-old female was diagnosed with breast cancer (estrogen receptor positive, progesterone receptor positive, and human epidermal growth factor receptor 2-negative) accompanied with bone metastasis. Although the patient was initially treated with abemaciclib, letrozole (Femara), and leuprorelin, refractory diarrhea induced by abemaciclib occurred after six days of treatment. Serum abemaciclib concentrations were measured before and after the diarrhea alleviation and the <em>ABCB1</em> (3435C&gt;<em>T</em>, 1236T&gt;<em>C</em>, and 2677G&gt;<em>T</em>/A) polymorphisms involved in delayed abemaciclib excretion were examined. <em>ABCB1</em> 3435C&gt;<em>T</em> polymorphism was also identified. The abemaciclib concentration prior to diarrhea alleviation was higher than the mean concentration in a large-scale clinical trial (current study; 326.7 ng/mL vs a large-scale clinical trial; 169–243 ng/mL). The patient discontinued abemaciclib as it was difficult for her to continue the dose (150 mg twice daily) because of the associated diarrhea, which was alleviated thereafter. The abemaciclib concentration after diarrhea alleviation was below the detection limit of 25.0 ng/mL. <em>ABCB1</em> 3435C&gt;<em>T</em> polymorphism may be involved in the induction of refractory diarrhea by abemaciclib and may be an objective indicator for managing abemaciclib dosage.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"18 ","pages":"Article 100367"},"PeriodicalIF":0.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143837932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D printed lightweight breast prostheses for a patient of breast size 38F who was unhappy with the heavy weight of their silicone prosthesis","authors":"Lyons EmmaJude ,&nbsp;Baban Chwanrow ,&nbsp;Walsh Lorraine ,&nbsp;O'Sullivan Kevin.J ,&nbsp;O'Sullivan Aidan ,&nbsp;Meany Siobhan ,&nbsp;O'Sullivan Leonard W","doi":"10.1016/j.cpccr.2025.100366","DOIUrl":"10.1016/j.cpccr.2025.100366","url":null,"abstract":"<div><div>Breast prostheses offer symmetry and femininity restoration for women post-mastectomy. They are fitted to an individual's bra size, but standard prostheses can be heavy and uncomfortable on the scar site. Custom-made breast prosthesis offers improved fit, contour matching, and reduced weight, which is beneficial to patients. We report a case of a specific patient with a large prosthesis who experienced significant comfort issues with her standard silicone prosthesis, and how a bespoke prosthesis was created from a scan of her residual contralateral breast and created using 3D printing such that it was lightweight.</div><div>Two 3D scans were taken, one of the patient's residual contralateral breast while wearing a comfortable and well-fitting bra, and the other of the mastectomy site. The scans were processed using STL file editing software Meshmixer and Nomad Sculpt, and the residual breast profile was isolated and mirrored across the centerline of the patient's body. This profile was then aligned with the mastectomy surgery site scan and combined to create the anterior side of the prosthesis. A Vat Polymerisation (VP) 3D printing technology was used to produce the breast prosthesis, which was 3D printed on a FormLabs 3B+ using the FormLabs Flexible 80A material.</div><div>The new 3d printed prosthesis design is lightweight and flexible and mirrors the existing breast to achieve anatomical symmetry. The bespoke prosthesis is 62 % lighter than the patient's previous silicone prosthesis. Additionally, the anterior of the prosthesis is a bespoke match of the mastectomy scar site, providing for a secure fit.</div><div>The patient has worn her custom-made breast prosthesis for over one year up to the time of writing, and continues to do so. She describes the prosthesis as comfortable, lightweight, and secure in her bra. The use of 3D printing presents an opportunity to enhance the quality of breast prosthesis according to individual patient preferences.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"18 ","pages":"Article 100366"},"PeriodicalIF":0.2,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary lymphangitic carcinomatosis secondary to gastric Cancer in a Young Woman: A case report","authors":"Sijie Liu,&nbsp;Jing Wang","doi":"10.1016/j.cpccr.2025.100365","DOIUrl":"10.1016/j.cpccr.2025.100365","url":null,"abstract":"<div><h3>Background</h3><div>Pulmonary lymphangitic carcinomatosis (PLC) is a rare secondary metastatic cancer. Cough and dyspnea are the common clinical manifestations of PLC. PLC is often confused with pulmonary sarcoidosis, pulmonary edema, pneumoconiosis, and interstitial pneumonia, which leads to delayed diagnosis and poor prognosis.</div></div><div><h3>Case Presentation</h3><div>A 23-year-old female with a cough. Gastric cancer was confirmed by gastroscopy. The abnormal changes in the lung were considered to be consistent with PLC.</div></div><div><h3>Conclusion</h3><div>PCL is often misdiagnosed or delayed. PLC should be considered when cough, dyspnea, and chest CT show thickening of the peribronchovascular and interlobular septa or when pleural effusion and enlargement of mediastinal lymph nodes.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"18 ","pages":"Article 100365"},"PeriodicalIF":0.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrasplenic metastasis of appendiceal low-grade mucinous neoplasm – A case report and review of the literature","authors":"P. Meister ,&nbsp;J. Rawitzer ,&nbsp;M. Reschke ,&nbsp;H.A. Baba ,&nbsp;U. Neumann ,&nbsp;M. Kaths","doi":"10.1016/j.cpccr.2025.100364","DOIUrl":"10.1016/j.cpccr.2025.100364","url":null,"abstract":"<div><div>Low-grade appendiceal mucinous neoplasms (LAMNs) may lead to pseudomyxoma peritonei and require specialized surgical therapy. By pathological definition, these tumor entities exhibit neither invasive growth nor develop systemic or lymph node metastases. We report the case of a 43-year-old female presenting with a metachronous splenic metastasis of low-grade pseudomyxoma peritonei four years after surgical therapy. The patient was treated successfully via laparoscopic splenectomy. While the spleen itself is an extremely rare location for metastasizing colonic cancer, a LAMN metastasis in this location has not been previously described. A literature review of pseudomyxoma recurrence reveals that LAMNs might indeed recur in extraperitoneal locations, questioning their pathophysiological definition of non-metastasizing behavior.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"18 ","pages":"Article 100364"},"PeriodicalIF":0.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clear cell sarcoma of salivary gland: A case report","authors":"Saša Z. Tabaković ,&nbsp;Sonja Tabaković","doi":"10.1016/j.cpccr.2025.100359","DOIUrl":"10.1016/j.cpccr.2025.100359","url":null,"abstract":"<div><h3>Introduction</h3><div>Malignant mesenchymal tumors of the salivary glands are neoplasms whose histopathological picture represents a very big diagnostic challenge. Most tumors of the parotid glands are benign, and for malignant neoplasms, immunohistochemistry is essential for diagnosis.</div></div><div><h3>Aim</h3><div>The aim is to present a rare case of a mesenchymal malignant tumor of the parotid gland, including diagnostics and surgical therapy.</div></div><div><h3>Case presentation</h3><div>A 67-year-old patient presented with a tumor around the parotid gland. Sonographically, the change resembled an adenoma, although the differential diagnosis did not exclude a pathological entity of another etiology. The patient underwent a superficial parotidectomy, and the operative and postoperative course was without complications. Immunohistochemical analysis in combine with histopath results confirmed the final diagnosis of Clear Cell Sarcoma of the parotid gland.</div></div><div><h3>Conclusion</h3><div>Clear cell sarcoma of the parotid gland is a rare malignant neoplasm. Timely diagnosis and total parotidectomy with negative resection margins, in the first year after the operation ensure a satisfactory postoperative result without recurrence and meta-changes. Doctors should be very cautious in such situations because the histopathological examination with immunohistochemical analysis gives a clear picture of the tumor in question as a differential diagnosis.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"18 ","pages":"Article 100359"},"PeriodicalIF":0.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The successful employment of Brentuximab Vedotin to a patient with peritoneal dialysis: A case report","authors":"Sunpil Hwang ,&nbsp;Sucheta Kundu ,&nbsp;Brett Barlow","doi":"10.1016/j.cpccr.2025.100363","DOIUrl":"10.1016/j.cpccr.2025.100363","url":null,"abstract":"<div><div>Brentuximab Vedotin, an antibody-drug conjugate targeting CD30, has been widely used in treating systemic anaplastic large-cell lymphoma and primary cutaneous anaplastic large-cell lymphoma. Despite its extensive use, information on its use in patients with end-stage renal disease is limited. This case report illustrates a 75-year-old male undergoing daily peritoneal dialysis, diagnosed with primary cutaneous anaplastic large-cell lymphoma. Due to extensive lesions, the patient opted for Brentuximab Vedotin following an exhaustive discussion. Remarkably, the treatment resulted in the complete resolution of cutaneous lesions, which was confirmed by a subsequent negative PET scan, indicating the absence of malignancy. Throughout the treatment course, the patient reported only weakness as a side effect, which was compounded by an acute COVID-19 infection at that time. This case report underscores the potential application of Brentuximab Vedotin in patients undergoing peritoneal dialysis, a population previously excluded, thus providing another promising therapeutic option for this particular population.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"18 ","pages":"Article 100363"},"PeriodicalIF":0.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent primary pulmonary anaplastic B-cell lymphoma in a 35-year-old patient treated with radical resection: A case report.","authors":"George Bashour ,&nbsp;Muhsen Issa ,&nbsp;Saddik Haddad ,&nbsp;Gabi Kafa ,&nbsp;Hussein Kaada ,&nbsp;Samer Rajab ,&nbsp;Ali Daoud ,&nbsp;Rabab Salloum","doi":"10.1016/j.cpccr.2025.100362","DOIUrl":"10.1016/j.cpccr.2025.100362","url":null,"abstract":"<div><h3>Background</h3><div>Primary pulmonary lymphoma (PPL) is a lymphoid proliferation in the lung parenchyma and/or bronchi of a patient with no extrapulmonary lesion within 3 months of diagnosis. Diffuse large B-cell lymphoma (DLBCL) accounts for 10 % of all PPL cases, and only a very minor number of them present with an anaplastic morphologic variant.</div></div><div><h3>Case presentation</h3><div>We report a 35-year-old female patient who presented with shortness of breath, cough, anorexia, weight loss, fever of unknown origin, and night sweats. The patient was diagnosed with primary pulmonary anaplastic DLBCL and put on rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen. She achieved remission according to the PET scan results; however, the symptoms recurred one year later, and a CT scan confirmed the regrowth of the tumor. The patient refused further chemotherapy and repeated the biopsy at another center, and she was diagnosed with Hodgkin lymphoma and was placed on ifosfamide, carboplatin, and etoposide (ICE) and rituximab, dexamethasone, cytarabine, and cysplatin (RDHAP) protocols for 9 months, which did not improve her condition. Finally, a PET scan revealed that the lesion was limited to the lung with no visible metastases or lymph node involvement, and radical surgery was performed to excise the tumor. A new IHC panel was ordered because of the conflicting reports, and it showed matching results to the first diagnosis, except for a negative CD20 result, which was attributed to rituximab in the patient's chemotherapy. A 2-year follow-up revealed no lesions or recurrence.</div></div><div><h3>Conclusion</h3><div>DLBCL is an uncommon cause for primary lung lymphomas, but high clinical suspicion must be maintained when assessing such tumors, even among younger individuals. More studies should be done to investigate the best treatment option for the anaplastic variant of DLBCL.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"17 ","pages":"Article 100362"},"PeriodicalIF":0.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary squamous cell carcinoma complicated with invasive ductal carcinoma of breast","authors":"Chen Fan ,&nbsp;Linhui Fang ,&nbsp;Li Yang ,&nbsp;Fan Wang","doi":"10.1016/j.cpccr.2025.100361","DOIUrl":"10.1016/j.cpccr.2025.100361","url":null,"abstract":"<div><h3>Background</h3><div>Primary Squamous Cell Carcinoma (SCC) of the breast, a rare subtype of metaplastic carcinoma, is estimated to occur in &lt;0.1 % of breast cancer cases. In clinical practice, the coexistence of primary SCC with Invasive Ductal Carcinoma (IDC) is exceptionally rare, presenting unique challenges in diagnosis and management.</div></div><div><h3>Case report</h3><div>We report a patient with primary SCC complicated with IDC of the breast. This patient underwent operation, adjuvant chemotherapy and endocrine therapy according to the Breast Cancer Guidelines.</div></div><div><h3>Conclusion</h3><div>Primary SCC of the breast is recognized for its highly aggressive nature and resistance to treatment, often associated with a poor prognosis. Currently, there are no specific guidelines dedicated to the management of primary SCC of the breast. When primary SCC coexists with IDC of the breast, the prognosis becomes even more uncertain due to the complex interplay between these two distinct pathological entities. In this case, we have adopted a treatment strategy targeting the IDC component, following established guidelines for breast cancer management. We anticipate that this approach will contribute to a favorable prognosis for the patient.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"17 ","pages":"Article 100361"},"PeriodicalIF":0.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible secondary angiosarcoma following subcutaneous mastectomy with primary reconstruction without subsequent radiotherapy: A case report and literature review","authors":"David Ibsen Dadash-Khanlou ,&nbsp;Hanne Rønning ,&nbsp;Helga Fibiger Munch-Petersen ,&nbsp;Ida Lolle ,&nbsp;Sandra Duvnjak ,&nbsp;Bodil Elisabeth Engelmann ,&nbsp;Elisabeth Ida Specht Stovgaard","doi":"10.1016/j.cpccr.2025.100358","DOIUrl":"10.1016/j.cpccr.2025.100358","url":null,"abstract":"<div><div>Angiosarcoma is a rare aggressive tumor of the endothelial cells, that in its secondary form can be seen in breast cancer patients 5–10 years following radiation therapy or radical mastectomy with chronic lymphedema. In this article, we report a rare case of a breast cancer patient developing possible secondary angiosarcoma following surgery while having received no subsequent radiation therapy.</div><div>A 66-year-old female presented in 2016 with invasive ductal carcinoma (IDC) and ductal carcinoma in situ (DCIS) in her right breast. She was treated with a subcutaneous mastectomy and primary reconstruction using a DIEP-flap (deep inferior epigastric perforator flap). She received postoperative adjuvant chemotherapy combined with HER2 targeted therapy, but no radiation therapy. In 2023, the patient presented with yellowish marks on the reconstructed breast and a history of trauma to the right side of her body, suggestive of hematoma. Clinical mammography and fine needle aspiration showed only reactive changes. In the following months the cutaneous changes worsened with ulceration, discoloration, and bleeding in the reconstructed breast. A core needle biopsy was taken and angiosarcoma with high malignancy grade was found.</div><div>Microscopically, the tumor was composed of malignant mesenchymal spindle cells in a hypercellular and slit-like pattern with numerous mitotic figures and nuclear pleomorphism with oval and enlarged nucleoli. Immunohistochemical stain was strongly positive of CD34, CD31 and, remarkably, c-Myc. There was no expression of D240, cytokeratin or S-100.</div><div>The case highlights that angiosarcoma cannot be excluded in patients following extensive surgery and that we must be aware of this risk in the future.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"17 ","pages":"Article 100358"},"PeriodicalIF":0.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143600763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unanticipated recurrence of muscle-invasive bladder cancer: A case report","authors":"Farzad Allameh ,&nbsp;Afshin Moradi ,&nbsp;Azadeh Rakhshan ,&nbsp;Sina Samenezhad ,&nbsp;Amir Alinejad Khorram","doi":"10.1016/j.cpccr.2025.100357","DOIUrl":"10.1016/j.cpccr.2025.100357","url":null,"abstract":"<div><div>Muscle-invasive bladder cancer management often involves radical cystectomy, but bladder preservation protocols have gained recognition as a low-morbidity alternative for the management of carefully selected patients. However, close follow-up is crucial for prompt diagnosis of cancer recurrence. We report a case of muscle-invasive bladder cancer managed using a bladder preservation approach. Although cystoscopy and random biopsy findings appeared unremarkable during follow-up, tumor recurrence occurred in the muscular propria without involving the bladder mucosa. This case underscores the importance of revising follow-up protocols to ensure optimal patient care.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"17 ","pages":"Article 100357"},"PeriodicalIF":0.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}