Current problems in cancer. Case reports最新文献

{"title":"Cryoablation as the primary treatment in a HER2 positive Stage IV breast cancer patient: 5 years term follow up case report","authors":"Kizuki Matsumoto ,&nbsp;Masaaki Sakamoto ,&nbsp;Youichi Machida ,&nbsp;Masafumi Kurosumi ,&nbsp;Eisuke Fukuma","doi":"10.1016/j.cpccr.2024.100311","DOIUrl":"https://doi.org/10.1016/j.cpccr.2024.100311","url":null,"abstract":"<div><p>We report a case of human epidermal growth factor receptor 2 (HER2)-positive Stage IV breast cancer with metastatic lung cancer treated with cryoablation as a first-line treatment. The patient, a 34-year-old woman who voluntarily screened for breast cancer, was referred to our clinic after a mammogram revealed calcification findings. The patient had a tumor in the right breast and lung metastasis. The tumor was 34×31×23 mm with internal heterogeneity in the right mammary gland. Imaging and vacuum-assisted breast tumor biopsy led to a diagnosis of invasive ductal carcinoma (estrogen receptor-positive, progesterone receptor-negative, and human epidermal growth factor receptor 2 positive). The patient received 6 cycles of trastuzumab, and paclitaxel, followed by 11 cycles of trastuzumab, pertuzumab and tamoxifen as pre-cryoablation adjuvant therapy. After chemotherapy, the patient underwent minimally invasive cryoablation treatment followed by fractionated radiation therapy to the entire right breast.</p><p>In the last follow-up, 5 years following cryoablation as a first-line treatment after anti-HER2 therapy, a complete local response was recognized, with no evidence of disease progression in the lung metastasis or recurrence of the primary breast tumor. This case report demonstrates that cryoablation is safe and effective, with favorable cosmetic results also for late-stage breast cancer.</p><p>Cryoablation, as a minimally invasive treatment for primary site control of Stage IV breast cancer, can provide a good alternative that preserves the quality of life. It can be performed under local anesthesia and be conducted jointly with chemotherapy, radiation therapy, surgery, and immunotherapy.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"15 ","pages":"Article 100311"},"PeriodicalIF":0.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666621924000346/pdfft?md5=76320a9fadc67748a0ce414ae5dd80e7&pid=1-s2.0-S2666621924000346-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinicopathologic analysis of 70 patients with mucinous breast carcinoma","authors":"Rupali Sood ,&nbsp;Karin Miller ,&nbsp;Hua-Ling Tsai ,&nbsp;Ashley Cimino-Mathews ,&nbsp;Roisin M. Connolly","doi":"10.1016/j.cpccr.2024.100304","DOIUrl":"10.1016/j.cpccr.2024.100304","url":null,"abstract":"<div><h3>Purpose</h3><p>Pure mucinous breast carcinomas (PMBC) are rare cancers that are managed per standard breast cancer treatment protocols. In this study, we review the clinicopathologic features, treatment, and outcomes of patients with PMBC treated at our academic cancer center.</p></div><div><h3>Methods</h3><p>We searched institutional pathology databases for patients with histologically confirmed PMBC over a 20-year period (January 1998 - October 2018) who received any portion of clinical care at our institution. Archival pathology slides were re-reviewed to confirm the diagnosis and record pathologic features, including the presence or absence of a micropapillary component. We estimated recurrence free survival (RFS) probabilities using the Kaplan-Meier method and evaluated prognostic factors using Cox regression.</p></div><div><h3>Results</h3><p>A total of 70 cases of PMBC were identified, including 13 with micropapillary features. Median patient age was 65 years (range, 39–94) and approximately 40 % were African American or Asian. The majority of patients had negative lymph nodes (84 %), tumors &lt; 2 cm (79 %), grade I-II (94 %), and hormone receptor positive (99 %) disease, with Ki-67 proliferation indices ≤10 % (54 %). All patients underwent surgery, 50 % received adjuvant radiation therapy, 6 % adjuvant chemotherapy, and 63 % adjuvant hormone therapy. Five-year RFS was 94 % with no identified clinicopathologic or treatment factors significantly affecting survival, including the presence of micropapillary features.</p></div><div><h3>Conclusion</h3><p>We report one of the more diverse single institution series of patients with PMBC based in the United States. This rare breast cancer subtype is associated with a favorable prognosis and may benefit from omission of aggressive standard treatment approaches.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"15 ","pages":"Article 100304"},"PeriodicalIF":0.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666621924000279/pdfft?md5=7edbc9e6a64a8b6f2f1cc4b57d0ed1bb&pid=1-s2.0-S2666621924000279-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141396362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classic Hodgkin lymphoma transformation into composite lymphoma complicated with Guillain‒Barré syndrome after chemotherapy: A case report","authors":"Li He,&nbsp;Ying Bao","doi":"10.1016/j.cpccr.2024.100303","DOIUrl":"10.1016/j.cpccr.2024.100303","url":null,"abstract":"<div><p>Classic Hodgkin lymphoma rarely undergoes pathological transformation, and the transformation type is usually common non-Hodgkin lymphoma. This study describes a 71-year-old male diagnosed with stage III classic Hodgkin lymphoma positive for Epstein‒Barr virus. The disease was partially relieved soon after chemotherapy but quickly progressed with transformation into composite lymphoma with a mixture of T and B cells. Then he developed symptoms in his nervous system and was diagnosed with Guillain‒Barré syndrome. EBV remained positive throughout the course of the disease. Classic Hodgkin lymphoma may transform into composite lymphoma, and the composite lymphoma may be complicated with Guillain‒Barré syndrome after chemotherapy. We hypothesized that EBV infection may play a role in the progression of the disease.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"15 ","pages":"Article 100303"},"PeriodicalIF":0.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666621924000267/pdfft?md5=d52393ce34d5ad93c828f7bd8f6bc877&pid=1-s2.0-S2666621924000267-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141277484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenoid cystic carcinoma of the breast–A case report and review of the literature","authors":"Qing Q. Liu,&nbsp;Li J. Tang,&nbsp;Jie Yan,&nbsp;Yan Xu","doi":"10.1016/j.cpccr.2024.100309","DOIUrl":"10.1016/j.cpccr.2024.100309","url":null,"abstract":"<div><p>Adenoid cystic carcinoma (ACC) is a rare type of breast cancer, and predominant adenoid cystic carcinomas are low grade and triple-negative by histology. Unlike other triple-negative breast carcinomas, ACC of the breast generally have a low propensity for recurrence and metastasis, with complete surgical excision alone being curative in most circumstances in early-stage disease. Here, we presents a case study detailing the clinical course of a 32-year-old female patient diagnosed with ACC of the breast. We emphasized the efficacy of standardized treatment protocols and highlighted recent advancements in research pertaining to this uncommon malignancy.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"15 ","pages":"Article 100309"},"PeriodicalIF":0.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666621924000322/pdfft?md5=11b199e750b0b7eb479dfe106397b21e&pid=1-s2.0-S2666621924000322-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-flow nasal cannula combined with intravenous general anesthesia for stent implantation in right lung cancer: A case report","authors":"Hai-Yu Xie ,&nbsp;Yi Li ,&nbsp;Jiao Mo ,&nbsp;Zhi-Yong Wu ,&nbsp;Zhi-Min Hu ,&nbsp;Wei-Dong Liang ,&nbsp;Li-Feng Wang","doi":"10.1016/j.cpccr.2024.100319","DOIUrl":"10.1016/j.cpccr.2024.100319","url":null,"abstract":"<div><p>Airway blockage frequently occurs in advanced lung cancer patients, leading to breathing difficulties and oxygen deprivation. This severely impacts patients' quality of life and can even result in death. Bronchial stent insertion effectively alleviates these symptoms and is often performed with intravenous general anesthesia. Nevertheless, during anesthesia and the procedure, inadequate ventilation can lead to severe oxygen deficiency and subsequent complications. There is an urgent need for a safe and efficient intraoperative ventilation strategy to maintain sufficient oxygen levels and reduce the risk of oxygen deficiency. We present a case of successful bronchial stent placement using high-flow nasal cannula (HFNC) in conjunction with intravenous general anesthesia. The patient, a 64-year-old male with a one-year history of right peripheral lung cancer, sought treatment for persistent cough and breathing difficulties. Chest X-rays upon admission revealed a substantial increase in the size of the anterior segment of the right upper lung lobe, likely due to peripheral lung cancer complicated by obstructive pneumonia. To address the patient's airway compression symptoms, we proposed \"bronchoscopic tracheal stent insertion.\" The patient exhibited an ejection fraction of 45% on cardiac ultrasound, had limited physical activity tolerance, grade III heart function, severe airway constriction, and maintained oxygen saturation (SPO₂) levels between 85% and 88%. We successfully performed the procedure using HFNC in combination with intravenous general anesthesia, resulting in a significant improvement in airway compression symptoms. In this case, it was found that HFNC could be used as a new non-invasive respiratory support therapy for bronchial stent implantation under intravenous general anesthesia to reduce the occurrence of intraoperative hypoxemia.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"15 ","pages":"Article 100319"},"PeriodicalIF":0.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666621924000425/pdfft?md5=7d6234bff30fbabb67ea1b8c3511111e&pid=1-s2.0-S2666621924000425-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141998328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant pleural schwannoma presenting as intractable coughing: A rare case report","authors":"Shrinjay Vyas ,&nbsp;Michael Brescia ,&nbsp;Heidi Fish","doi":"10.1016/j.cpccr.2024.100308","DOIUrl":"https://doi.org/10.1016/j.cpccr.2024.100308","url":null,"abstract":"<div><p>While pleural schwannomas typically exhibit a male predilection, our case enunciates a distinctive scenario wherein a pleural schwannoma manifested as persistent, uncontrollable coughing in an adult female. The confirmation of diagnosis was achieved through a comprehensive diagnostic approach encompassing X-ray, Computed Tomography (CT) scan, and immunohistochemical analysis. This novel case emphasizes the importance of meticulous diagnostic imaging and histopathological scrutiny in uncommon presentations of pleural schwannoma. Moreover, our findings underscore the significance of considering benign nerve tumors as a plausible differential diagnosis for patients enduring prolonged, unyielding coughing episodes. Ultimately, we believe that early recognition of such infrequent manifestations may facilitate more informed preoperative evaluation and surgical intervention, eventually contributing to improved patient prognoses.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"15 ","pages":"Article 100308"},"PeriodicalIF":0.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666621924000310/pdfft?md5=2a42a886843391aba6970f49e3e2dc85&pid=1-s2.0-S2666621924000310-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141484304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metachronous bilateral invasive breast carcinoma with low-grade adenosquamous carcinoma on one side: A case report and literature review","authors":"Wenli He ,&nbsp;Xu Dong ,&nbsp;Renling Hu ,&nbsp;Qian Liu ,&nbsp;Zhirong Yang","doi":"10.1016/j.cpccr.2024.100314","DOIUrl":"10.1016/j.cpccr.2024.100314","url":null,"abstract":"<div><p>Low-grade adenosquamous carcinoma (LGASC) is a rare variant of metaplastic breast carcinoma that consists of glandular and squamous elements in a spindle cell background. They lack distinctive imaging features and overlap with other breast neoplasm characteristics, posing a diagnostic challenge. We present the case of a 60-year-old woman with metachronous bilateral invasive breast carcinoma (MBBC). The mastectomy specimens of her left breast carcinoma revealed nests of squamous- appearing cells and “comma” glandular structures on a microscopic level. Comprehensive immunohistochemical examination of ER, PR, Her-2, p63, and CK7 CK5/6 confirmed the diagnosis of LGASC. Unlike other invasive breast carcinomas, LGASC have an indolent course and favorable prognosis. Eight years after surgery, she was diagnosed with a non-specific type of invasive breast carcinoma of the right breast via imaging, core needle biopsy and immunohistochemistry. This was a rare case of MBBC that has not been previously reported. Therefore, we report and review the relevant literature to raise awareness of this disease.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"15 ","pages":"Article 100314"},"PeriodicalIF":0.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666621924000371/pdfft?md5=57299d840d6ad866067bf5fe9ba7777e&pid=1-s2.0-S2666621924000371-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141623675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disrupted care for multiple myeloma in an amenorrheic woman due to a false-positive pregnancy test: A case report","authors":"Kaley Parchinski ,&nbsp;Kyra Urquhart-Foster ,&nbsp;Stephen Aaron Purser ,&nbsp;Charles Bodine","doi":"10.1016/j.cpccr.2024.100316","DOIUrl":"10.1016/j.cpccr.2024.100316","url":null,"abstract":"<div><p>We report the case of a 48-year-old female with a history of tubal ligation who presented to her PCP with altered mental status and back pain. Inpatient workup revealed multiple myeloma, and treatment with bortezomib and dexamethasone was initiated. Due to teratogenicity on lenalidomide, a pre-treatment urine pregnancy test was performed and returned positive. She denied sexual activity and had no history of germ cell tumor. While urine hCG remained low positive for three tests, her serum hCG remained normal (&lt;5 mIU/mL). The uncertainty in pregnancy testing caused a delay in full-dose induction therapy. With two cycles of bortezomib and dexamethasone, her M-Spike only dropped from 4.8 to 2.9 g/dL. Ultimately urine hCG normalized, and she was started on lenalidomide with cycle number three. With the addition of lenalidomide, after two cycles, her M-Spike disappeared, and bone marrow biopsy showed complete resolution of plasma cell dyscrasia. The phenomenon of positive hCG testing in multiple myeloma is discussed, highlighting the importance of provider and patient awareness in the setting of a non-gravid woman to prevent a disruption of standard of care treatment and patient distress.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"15 ","pages":"Article 100316"},"PeriodicalIF":0.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666621924000395/pdfft?md5=58903e12d97434ddec5c0757131a70e9&pid=1-s2.0-S2666621924000395-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141950832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stauffer syndrome in a tumor of the pancreatic tail: A paracrine pathogenesis, rather than an inflammatory disimmune phenomenon – a case report","authors":"Caterina Porciani ,&nbsp;Piero Colombatto ,&nbsp;Simone Guadagni ,&nbsp;Gabriele Ricco ,&nbsp;Luca Morelli ,&nbsp;Laura Caponi ,&nbsp;Daniela Campani ,&nbsp;Annalisa Comandatore ,&nbsp;Giusi Desire' Sciume' ,&nbsp;Paola Migliorini ,&nbsp;Piero Boraschi ,&nbsp;Maurizia Brunetto ,&nbsp;Giulio Di Candio","doi":"10.1016/j.cpccr.2024.100320","DOIUrl":"10.1016/j.cpccr.2024.100320","url":null,"abstract":"<div><p>Stauffer syndrome, also known as paraneoplastic intrahepatic cholestasis syndrome, is a rare reversible clinical manifestation characterized by elevation of direct bilirubin, alcaline phosphatase, transaminases and prolonged prothrombin time, without direct hepatobiliary disease, that is due to the presence of malignancy, mostly kidney cancer. In this case report, we describe a rare form of mixed acinar neuroendocrine pancreatic tail mass causing a non-obstructive form of cholestasis. We analysed the effects of metilprednisolone treatment and surgery on the levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF alpha), previously associated with this syndrome. We found that serum levels of IL-6 and TNF alpha decreased during steroid treatment, had a peak immediately after the surgical procedure, and remained stable while cholestasis resolved slowly after tumour removal. These findings showed that IL-6 and TNF alpha were not the effectors of the paraneoplastic cholestasis in our patient. Rather, the evidence of a mixed acinar neuroendocrine pancreatic tumour and non-specific cholestasis at the liver histology suggests paracrine mechanisms affecting cellular transporters implicated in bile acids excretion.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"15 ","pages":"Article 100320"},"PeriodicalIF":0.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666621924000437/pdfft?md5=abb1c6a23eb67343a69b75ff773faa98&pid=1-s2.0-S2666621924000437-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of disseminated extra-nodal natural killer (NK) cell lymphoma","authors":"Sowbharnika Arivazhagan ,&nbsp;Guru Prasad Parthiban ,&nbsp;Sukanthini Subbiah","doi":"10.1016/j.cpccr.2024.100301","DOIUrl":"10.1016/j.cpccr.2024.100301","url":null,"abstract":"<div><p>Extranodal Natural Killer (NK)/T-cell lymphoma, nasal type, is rare and frequently found in Asia and South America. It is rarely found in the United States, mainly in the immigrant population. We present a 26-year-old male from Central America who was found to have disseminated NK/T-cell lymphoma. Through this article, we explain how we manage our patient and try to consolidate the treatment modalities for different stages of the disease.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"15 ","pages":"Article 100301"},"PeriodicalIF":0.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666621924000243/pdfft?md5=6eb5903d14bb5eaf3853fd5ef41c986d&pid=1-s2.0-S2666621924000243-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141409017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}