Gabriel Francisco Pereira Aleixo , Holly Pederson , Nancy Dalpiaz , Jame Abraham
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引用次数: 0
摘要
无创产前检测（NIPT）分析母体血液中胎盘无细胞 DNA 的遗传异常，尤其适用于高龄产妇。它是一种高灵敏度和特异性的检测方法，用于筛查胎儿染色体 13、18、21 三体综合征、性染色体非整倍体和罕见的胎儿染色体非整倍体。很少有病例用它来诊断母体癌症。我们将讨论一例通过 NIPT 诊断出的转移性乳腺癌病例，以及目前使用该技术诊断孕期癌症的相关知识。
Noninvasive prenatal testing detecting metastatic breast cancer: Case report and literature review
Noninvasive prenatal testing (NIPT) analyzes placental cell-free DNA in maternal blood for genetic abnormalities, especially in pregnant women of advanced maternal age. It is a high-sensitivity and specificity test used for screening fetal chromosome trisomy 13, 18, 21, sex chromosome aneuploidy, and rare fetal chromosome aneuploidy. Rarely there were cases in which it was used to diagnose maternal cancer. We will discuss a case of metastatic breast cancer diagnosed by NIPT and current knowledge on the use of this technology in diagnosing cancer during pregnancy.
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