Joel Rivera-Concepcion , Ying-Chun Lo , Dipesh Uprety , Alex A. Adjei , Vinicius Ernani , Konstantinos Leventakos
{"title":"一例具有组织学转化和多重耐药机制的表皮生长因子受体突变肺癌 IV 期疑难病例","authors":"Joel Rivera-Concepcion , Ying-Chun Lo , Dipesh Uprety , Alex A. Adjei , Vinicius Ernani , Konstantinos Leventakos","doi":"10.1016/j.cpccr.2024.100284","DOIUrl":null,"url":null,"abstract":"<div><p>This clinical case presents a patient with NSCLC who experienced on-target resistant mutations and tumor cell transformation from adenocarcinoma to large cell neuroendocrine and small cell carcinoma. Our patient was successfully treated with a combination of targeted therapy, immunotherapy and chemotherapy based on genetic and histologic changes that occurred in a period of five years.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666621924000073/pdfft?md5=0ba2fe24f9c99e760e08461b6d035097&pid=1-s2.0-S2666621924000073-main.pdf","citationCount":"0","resultStr":"{\"title\":\"A challenging case of stage IV EGFR-mutant lung cancer with histologic transformation and multiple resistance mechanisms\",\"authors\":\"Joel Rivera-Concepcion , Ying-Chun Lo , Dipesh Uprety , Alex A. Adjei , Vinicius Ernani , Konstantinos Leventakos\",\"doi\":\"10.1016/j.cpccr.2024.100284\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This clinical case presents a patient with NSCLC who experienced on-target resistant mutations and tumor cell transformation from adenocarcinoma to large cell neuroendocrine and small cell carcinoma. Our patient was successfully treated with a combination of targeted therapy, immunotherapy and chemotherapy based on genetic and histologic changes that occurred in a period of five years.</p></div>\",\"PeriodicalId\":72741,\"journal\":{\"name\":\"Current problems in cancer. Case reports\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2024-02-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2666621924000073/pdfft?md5=0ba2fe24f9c99e760e08461b6d035097&pid=1-s2.0-S2666621924000073-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current problems in cancer. Case reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666621924000073\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current problems in cancer. Case reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666621924000073","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
A challenging case of stage IV EGFR-mutant lung cancer with histologic transformation and multiple resistance mechanisms
This clinical case presents a patient with NSCLC who experienced on-target resistant mutations and tumor cell transformation from adenocarcinoma to large cell neuroendocrine and small cell carcinoma. Our patient was successfully treated with a combination of targeted therapy, immunotherapy and chemotherapy based on genetic and histologic changes that occurred in a period of five years.
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