Short-term corticosteroid therapy consecutive to hemodialysis and charcoal hemoperfusion for methotrexate-induced acute kidney injury in an elderly lymphoma patient

IF 0.2 Q4 ONCOLOGY

Current problems in cancer. Case reports Pub Date : 2024-02-03 DOI:10.1016/j.cpccr.2024.100282

Misato Tane , Hiroki Hosoi , Hideki Kosako , Yukiko Yamano , Takayuki Hiroi , Shogo Murata , Toshiki Mushino , Shin-Ichi Araki , Takashi Sonoki

{"title":"Short-term corticosteroid therapy consecutive to hemodialysis and charcoal hemoperfusion for methotrexate-induced acute kidney injury in an elderly lymphoma patient","authors":"Misato Tane , Hiroki Hosoi , Hideki Kosako , Yukiko Yamano , Takayuki Hiroi , Shogo Murata , Toshiki Mushino , Shin-Ichi Araki , Takashi Sonoki","doi":"10.1016/j.cpccr.2024.100282","DOIUrl":null,"url":null,"abstract":"<div><p>Acute kidney injury (AKI) due to delayed methotrexate (MTX) elimination is a severe potential adverse event of high-dose (HD)-MTX treatment. However, no treatment for HD-MTX-induced AKI has been established. In addition, there are no reports of corticosteroids being administered for HD-MTX-induced AKI. Here, we report the case of a 77-year-old male with central nervous system lymphoma, who developed an AKI after the second course of HD-MTX. He underwent charcoal hemoperfusion and hemodialysis immediately after the development of the AKI. He also received short-term corticosteroid therapy due to inflammatory findings and a positive drug-induced lymphocyte stimulation test for MTX. Our case suggests that short-term corticosteroid therapy consecutive to hemodialysis and charcoal hemoperfusion may be useful for AKI induced by delayed MTX elimination even in the elderly.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266662192400005X/pdfft?md5=080e6d8d893f78355246fce604eb8a27&pid=1-s2.0-S266662192400005X-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current problems in cancer. Case reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S266662192400005X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Acute kidney injury (AKI) due to delayed methotrexate (MTX) elimination is a severe potential adverse event of high-dose (HD)-MTX treatment. However, no treatment for HD-MTX-induced AKI has been established. In addition, there are no reports of corticosteroids being administered for HD-MTX-induced AKI. Here, we report the case of a 77-year-old male with central nervous system lymphoma, who developed an AKI after the second course of HD-MTX. He underwent charcoal hemoperfusion and hemodialysis immediately after the development of the AKI. He also received short-term corticosteroid therapy due to inflammatory findings and a positive drug-induced lymphocyte stimulation test for MTX. Our case suggests that short-term corticosteroid therapy consecutive to hemodialysis and charcoal hemoperfusion may be useful for AKI induced by delayed MTX elimination even in the elderly.

查看原文本刊更多论文

一名老年淋巴瘤患者因甲氨蝶呤诱发急性肾损伤，在接受血液透析和炭化血液灌流治疗后连续接受短期皮质类固醇治疗

甲氨蝶呤（MTX）排出延迟导致的急性肾损伤（AKI）是大剂量（HD）-MTX 治疗的一个严重潜在不良反应。然而，目前还没有针对 HD-MTX 引起的急性肾损伤的治疗方法。此外，也没有关于使用皮质类固醇治疗 HD-MTX 引起的 AKI 的报道。在此，我们报告了一例 77 岁的男性中枢神经系统淋巴瘤患者，他在第二个 HD-MTX 疗程后出现了 AKI。发生 AKI 后，他立即接受了炭化血液灌流和血液透析。由于炎症结果和 MTX 药物诱导淋巴细胞刺激试验阳性，他还接受了短期皮质类固醇治疗。我们的病例表明，在进行血液透析和木炭血液灌流的同时进行短期皮质类固醇治疗可能有助于治疗因 MTX 排出延迟而诱发的 AKI，即使是老年人也不例外。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current problems in cancer. Case reports Oncology

CiteScore

0.40

自引率

0.00%

发文量

审稿时长

96 days