Current problems in cancer. Case reports最新文献_第9页

Reversible cardiomyopathy after interferon-gamma for cutaneous T cell lymphoma: A report of two cases γ-干扰素治疗皮肤T细胞淋巴瘤后可逆性心肌病2例报告

Current problems in cancer. Case reports Pub Date : 2023-09-01 DOI: 10.1016/j.cpccr.2023.100255

Joseph S. Durgin , Neha N. Jariwala , Alain H. Rook , Juan M. Ortega-Legaspi

引用次数: 0

Erratum regarding missing statements in previously published articles 关于先前发表文章中遗漏陈述的勘误表

Current problems in cancer. Case reports Pub Date : 2023-09-01 DOI: 10.1016/j.cpccr.2023.100235

引用次数: 0

Sarcomatoid malignant pleural mesothelioma associated with anti-Ma2-related paraneoplastic neurological syndrome: A case report 肉瘤样恶性胸膜间皮瘤伴抗ma2相关副肿瘤神经综合征1例报告

Current problems in cancer. Case reports Pub Date : 2023-09-01 DOI: 10.1016/j.cpccr.2023.100244

Akio Tada , Kozo Kuribayashi , Kazuhiro Kitajima , Akifumi Nakamura , Michiko Yuki , Shingo Kanemura , Eisuke Shibata , Yoshiki Negi , Hirotoshi Ishigaki , Yasuhiro Nakajima , Ryo Takahashi , Takashi Yokoi , Toshiyuki Minami , Takashi Kijima

引用次数: 0

Extreme elevation of CA19-9 in patient with endometriosis-associated cancer: A brief report and review of the literature CA19-9在子宫内膜异位症相关癌症患者中的极端升高:一个简短的报告和文献回顾

Current problems in cancer. Case reports Pub Date : 2023-09-01 DOI: 10.1016/j.cpccr.2023.100254

Maia Drasin , Gregory Rumore , Elizabeth Suh-Burgmann

{"title":"Extreme elevation of CA19-9 in patient with endometriosis-associated cancer: A brief report and review of the literature","authors":"Maia Drasin , Gregory Rumore , Elizabeth Suh-Burgmann","doi":"10.1016/j.cpccr.2023.100254","DOIUrl":"10.1016/j.cpccr.2023.100254","url":null,"abstract":"<div><p>CA 19-9 (carbohydrate antigen 19-9) is used as a biomarker for hepatobiliary cancer and is generally not considered helpful in the evaluation of gynecologic cancer. Endometriosis-associated cancers are a subset of gynecologic cancers in which malignancy is found adjacent to endometriosis either within or outside the gynecologic tract. We describe a case of a woman who presented with a CA 19-9 level of 49,469 U/mL who was subsequently found to have two concurrent but separate primary endometriosis-associated cancers involving the ovary and small intestine. Although data regarding the association between CA 19-9 and endometriosis-associated malignancy is lacking, endometriosis is known to be associated with high levels of inflammation which in turn has been associated with higher CA 19-9 levels. The inflammatory response and effect on CA 19-9 levels may be particularly pronounced in cases where endometriosis-associated malignancy involves the peritoneum. The case described suggests that when cancer is suspected in a woman with an extremely high level of CA 19-9 and no apparent hepatobiliary disease, an endometriosis-associated malignancy may be a consideration.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42206256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertrophic pulmonary osteoarthropathy, secretory diarrhea and pancoast syndrome in the setting of a large cell neuroendocrine carcinoma of the lung: A case report 肺大细胞神经内分泌癌的增生性肺骨关节病、分泌性腹泻和Pancoast综合征1例报告

Current problems in cancer. Case reports Pub Date : 2023-06-01 DOI: 10.1016/j.cpccr.2023.100241

Carley Mitchell , Leyla Bayat , Wadad Mneimneh , Debora Bruno

{"title":"Hypertrophic pulmonary osteoarthropathy, secretory diarrhea and pancoast syndrome in the setting of a large cell neuroendocrine carcinoma of the lung: A case report","authors":"Carley Mitchell , Leyla Bayat , Wadad Mneimneh , Debora Bruno","doi":"10.1016/j.cpccr.2023.100241","DOIUrl":"10.1016/j.cpccr.2023.100241","url":null,"abstract":"<div><p>Large cell neuroendocrine carcinoma of the lung is a rare and aggressive pulmonary malignancy. Given its peripheral location, patients are frequently asymptomatic at the time of diagnosis or present with non-specific complaints. Moreover, its association with paraneoplastic syndromes or structural intrathoracic complications are highly atypical. Here, we report a case involving a 57-year-old female who presented with two simultaneous paraneoplastic syndromes, including hypertrophic pulmonary osteoarthropathy and secretory diarrhea, prior to the diagnosis of an early-stage large cell neuroendocrine carcinoma of the lung. Both syndromes showcased rapid symptomatic resolution following tumor resection. Upon disease recurrence, the patient developed a presentation consistent with Pancoast syndrome, with gradual improvement following the initiation of chemoradiotherapy. Individually, these conditions are rarely reported in association with large cell neuroendocrine carcinoma of the lung making their combination highly unusual. Furthermore, related symptoms were present both before and at the time of diagnosis, and upon disease recurrence. This highlights the importance of maintaining a high clinical suspicion for atypical manifestations of malignancy.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47896967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare presentation of round cell sarcoma 一例罕见的圆细胞肉瘤

Current problems in cancer. Case reports Pub Date : 2023-06-01 DOI: 10.1016/j.cpccr.2023.100226

Emma Pedersen , Christine MG Schammel , David P Schammel , A Michael Devane , Scott Porter , Steven D Trocha

{"title":"A rare presentation of round cell sarcoma","authors":"Emma Pedersen , Christine MG Schammel , David P Schammel , A Michael Devane , Scott Porter , Steven D Trocha","doi":"10.1016/j.cpccr.2023.100226","DOIUrl":"10.1016/j.cpccr.2023.100226","url":null,"abstract":"<div><p>Undifferentiated round cell sarcomas (URCS) are an extremely rare form of cancer, comprising a heterogeneous group of bone and soft tissue tumors occurring primarily in young adults (but distributed across all ages; range 2mo-81 years) and displaying a slight male predominance. URCS are primarily identified by their genetic abnormalities, with three recurrent oncogenic fusion rearrangements associated in the literature and recently added to the WHO classifications: EWSR1-non-ETS, BCOR-CCNB3, and CIC-DUX4. We present/describe a rare case of an URCS diagnosed in a 27-year-old female following six years of non-specific symptoms including pain and swelling of the third proximal phalanx. This case is only the third reported in a digit and, based on FoundationOne genotyping, was uniquely treated with tamoxifen. This patient also received radiation therapy, surgical resection, and palliative chemotherapy. Metastases were noted in the lungs and mediastinum, and the patient died of disease 89 months after the first treatment. While diagnosis of these tumors is becoming increasingly dependent on molecular profiles, treatment remains mostly unchanged and does not largely reflect the use of genetic results in treatment plans. A comprehensive review of the literature was completed to examine URCS and assist in the development of a diagnostic/treatment algorithm.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45528893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare, life-threatening debut of pancreatic adenocarcinoma: Pulmonary tumor thrombotic microangiopathy 罕见的，危及生命的胰腺腺癌首次亮相:肺肿瘤血栓性微血管病

Current problems in cancer. Case reports Pub Date : 2023-06-01 DOI: 10.1016/j.cpccr.2023.100238

Pablo Jiménez-Labaig , Soledad Fernández Solé , Susana Gómez Varela , Jorge García Calvo , Sergio Carrera Revilla , Alberto Muñoz Llarena

引用次数: 0

Rare case of de novo EGFR L718V mutation-positive non-small cell lung cancer successfully treated with afatinib 阿法替尼治疗罕见的EGFR L718V突变阳性新发癌症

Current problems in cancer. Case reports Pub Date : 2023-06-01 DOI: 10.1016/j.cpccr.2023.100228

Takanori Ito, Kohei Fujita, Zentaro Saito, Takuma Imakita, Issei Oi, Osamu Kanai, Hiromasa Tachibana, Tadashi Mio

{"title":"Rare case of de novo EGFR L718V mutation-positive non-small cell lung cancer successfully treated with afatinib","authors":"Takanori Ito, Kohei Fujita, Zentaro Saito, Takuma Imakita, Issei Oi, Osamu Kanai, Hiromasa Tachibana, Tadashi Mio","doi":"10.1016/j.cpccr.2023.100228","DOIUrl":"10.1016/j.cpccr.2023.100228","url":null,"abstract":"<div><p>Since the FLAURA trial, epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC) has generally been treated with osimertinib as a first-line therapy. However, there is still insufficient data on the therapeutic efficacy of EGFR-tyrosine kinase inhibitors in NSCLC patients with uncommon mutations. Many of these minor mutations are resistant to osimertinib; one such mutation is EGFR L718V or L718Q (L718V/Q), which may occur in combination with L858R. L718V/Q has been identified as a resistance gene to osimertinib when progressive disease occurs during treatment with osimertinib. Some reports have shown that EGFR L718V/Q with L858R is resistant to osimertinib but sensitive to afatinib. All cases of L718V/Q mutation-positive NSCLC reported in previous studies have presented with L718V/Q as the acquisition of resistance after treatment with osimertinib. In the present case report, we describe a rare case of NSCLC with de novo EGFR L718V and L858R mutations. Consistent with previous reports, the patient was resistant to osimertinib but responded well to afatinib.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47001125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osimertinib failure followed by successful treatment of afatinib in a patient with compound uncommon, G719S and V834L mutations 在一名化合物发生罕见G719S和V834L突变的患者中，奥西美替尼失败后成功治疗阿法替尼。

Current problems in cancer. Case reports Pub Date : 2023-06-01 DOI: 10.1016/j.cpccr.2023.100236

Kohei Isa, Kentaro Tanaka, Yoshimasa Shiraishi, Yasuto Yoneshima, Eiji Iwama, Isamu Okamoto

引用次数: 0

Metastatic breast cancer in patient with clinical neurofibromatosis type 1 临床1型神经纤维瘤病患者转移性癌症

Current problems in cancer. Case reports Pub Date : 2023-06-01 DOI: 10.1016/j.cpccr.2023.100240

Elīna Nadziņa , Evita Gašenko , Signe Plāte , Žanete Zvirbule , Alinta Hegmane

{"title":"Metastatic breast cancer in patient with clinical neurofibromatosis type 1","authors":"Elīna Nadziņa , Evita Gašenko , Signe Plāte , Žanete Zvirbule , Alinta Hegmane","doi":"10.1016/j.cpccr.2023.100240","DOIUrl":"10.1016/j.cpccr.2023.100240","url":null,"abstract":"<div><p>Patients with neurofibromathosis have a high risk of associated cancers and specialized cancer screening guidelines<sup>1</sup>. However for most of these cancer types early detection methods currently do not exist. For some cancer types, such as breast cancer, where screening is available, it is important to note that this patient group has increased risk of breast cancer and may present at an earlier age than general population.</p><p>Here, we describe a case of 48-year-old female with clinical diagnosis of neurofibromathosis type 1, who presented with skin color changes, itching and induration in left breast between multiple skin neurofibromas. She was diagnosed with stage IV HER2 positive breast cancer with hepatic and bilateral axillary lymph node metastasis, treated with chemotherapy and anti-HER2 antibodies. CT scan also described structural lung parenchyma alterations and scoliosis.</p><p>The aim of this case study is to emphasize the need of neurofibromathosis patient education in encouraging them to seek advice as soon as new symptoms appear and to prompt medical providers to use additional caution in this patient group.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48873381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0