Mammary Myofibroblastoma: A mimicker of benign and low-grade malignant tumors with multipotent mesenchymal differentiation

IF 0.2 Q4 ONCOLOGY
Anthony S. Larson , Amy Song , Lacey J. Schrader , Mark Wickre , Grzegorz T Gurda
{"title":"Mammary Myofibroblastoma: A mimicker of benign and low-grade malignant tumors with multipotent mesenchymal differentiation","authors":"Anthony S. Larson ,&nbsp;Amy Song ,&nbsp;Lacey J. Schrader ,&nbsp;Mark Wickre ,&nbsp;Grzegorz T Gurda","doi":"10.1016/j.cpccr.2024.100310","DOIUrl":null,"url":null,"abstract":"<div><p>Mammary myofibroblastoma (MFB) is a rare benign spindle cell neoplasm of the breast that can exhibit both epithelial and mesenchymal elements. The histomorphologic features of MFB mimic other potentially more aggressive neoplasms of the breast that may require more involved clinical management beyond a conservative local excision. We present the case of a 71-year-old male with a mammary MFB who underwent core needle biopsy (CNB) of a well-defined, bland spindle cell neoplasm with a subsequent local excision. The case highlights triage of MFB among a broad diagnostic differential at biopsy, particularly given its multipotent differentiation potential and highly variable presentation from the standpoint of both radiology and histopathology. We also discuss the role of <em>RB1</em> deficiency in distinguishing MFB from other tumor types and non-neoplastic/reactive proliferations.</p></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666621924000334/pdfft?md5=f189716ad536dbfa2616efcee454b276&pid=1-s2.0-S2666621924000334-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current problems in cancer. Case reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666621924000334","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Mammary myofibroblastoma (MFB) is a rare benign spindle cell neoplasm of the breast that can exhibit both epithelial and mesenchymal elements. The histomorphologic features of MFB mimic other potentially more aggressive neoplasms of the breast that may require more involved clinical management beyond a conservative local excision. We present the case of a 71-year-old male with a mammary MFB who underwent core needle biopsy (CNB) of a well-defined, bland spindle cell neoplasm with a subsequent local excision. The case highlights triage of MFB among a broad diagnostic differential at biopsy, particularly given its multipotent differentiation potential and highly variable presentation from the standpoint of both radiology and histopathology. We also discuss the role of RB1 deficiency in distinguishing MFB from other tumor types and non-neoplastic/reactive proliferations.

乳腺肌纤维母细胞瘤:多能间充质分化的良性和低度恶性肿瘤的模拟者
乳腺肌纤维母细胞瘤(MFB)是一种罕见的乳腺良性纺锤形细胞瘤,可同时表现为上皮和间质成分。乳腺肌纤维母细胞瘤的组织形态学特征与其他可能更具侵袭性的乳腺肿瘤相似,除了保守的局部切除外,可能还需要更多的临床治疗。我们介绍了一例 71 岁男性乳腺 MFB 患者的病例,他接受了核心针活检(CNB),发现了一个界限清晰的平滑纺锤形细胞肿瘤,随后进行了局部切除。该病例强调了乳腺纤维瘤在活检时的广泛诊断鉴别中的分流,特别是考虑到它的多能分化潜能,以及从放射学和组织病理学角度看其表现的高度可变性。我们还讨论了 RB1 缺乏症在区分 MFB 与其他肿瘤类型和非肿瘤性/反应性增生方面的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
0.40
自引率
0.00%
发文量
0
审稿时长
96 days
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信