Advances in experimental medicine and biology最新文献_第7页

Paragonimiasis. Paragonimiasis.

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-60121-7_6

David Blair

引用次数: 0

Probing Protein Complexes Composition, Stoichiometry, and Interactions by Peptide-Based Mass Spectrometry. 用基于肽的质谱法探测蛋白质复合物的组成、化学计量和相互作用。

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-52193-5_4

Gianluca Degliesposti

引用次数: 0

Nonprescription Treatment Options. 非处方治疗方案。

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-54513-9_14

Taylor Edwards, Kayla Felix, Sandy Francois, Leah Cardwell, Zakiyyah Rice

{"title":"Nonprescription Treatment Options.","authors":"Taylor Edwards, Kayla Felix, Sandy Francois, Leah Cardwell, Zakiyyah Rice","doi":"10.1007/978-3-031-54513-9_14","DOIUrl":"10.1007/978-3-031-54513-9_14","url":null,"abstract":"The pathogenesis of atopic dermatitis (AD) is complex and multifactorial. However, recent advancements in the genetics and pathophysiology of AD suggest that epidermal barrier dysfunction is paramount in the development and progression of the condition (Boguniewicz M, Leung DYM, Immunol Rev 242(1):233-246, 2011). In addition to standard therapy for AD, there are a plethora of nonprescription treatment modalities which may be employed. Over-the-counter treatments for atopic dermatitis can come in the form of topical corticosteroids, moisturizers/emollients, and oral antihistamines. Though these treatments are beneficial, prescription treatments may be quicker acting and more efficacious in patients with moderate to severe disease or during flares. OTC agents are best used for maintenance between flares and to prevent progression of mild disease. Alternative and complementary treatments lack strong efficacy evidence. However, wet wraps, bleach baths, and other treatments appear to be promising when used in conjunction with conventional treatments. With the financial burden of atopic dermatitis ranging from 364 million to 3.8 billion dollars each year in the United States, we suspect this topic will gain further research attention.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1447 ","pages":"151-167"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140896985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erythroid Krüppel-Like Factor (KLF1): A Surprisingly Versatile Regulator of Erythroid Differentiation. 红细胞克吕珀尔样因子（KLF1）：令人惊讶的红细胞分化多功能调节因子

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-62731-6_10

James J Bieker, Sjaak Philipsen

{"title":"Erythroid Krüppel-Like Factor (KLF1): A Surprisingly Versatile Regulator of Erythroid Differentiation.","authors":"James J Bieker, Sjaak Philipsen","doi":"10.1007/978-3-031-62731-6_10","DOIUrl":"10.1007/978-3-031-62731-6_10","url":null,"abstract":"Erythroid Krüppel-like factor (KLF1), first discovered in 1992, is an erythroid-restricted transcription factor (TF) that is essential for terminal differentiation of erythroid progenitors. At face value, KLF1 is a rather inconspicuous member of the 26-strong SP/KLF TF family. However, 30 years of research have revealed that KLF1 is a jack of all trades in the molecular control of erythropoiesis. Initially described as a one-trick pony required for high-level transcription of the adult HBB gene, we now know that it orchestrates the entire erythroid differentiation program. It does so not only as an activator but also as a repressor. In addition, KLF1 was the first TF shown to be directly involved in enhancer/promoter loop formation. KLF1 variants underlie a wide range of erythroid phenotypes in the human population, varying from very mild conditions such as hereditary persistence of fetal hemoglobin and the In(Lu) blood type in the case of haploinsufficiency, to much more serious non-spherocytic hemolytic anemias in the case of compound heterozygosity, to dominant congenital dyserythropoietic anemia type IV invariably caused by a de novo variant in a highly conserved amino acid in the KLF1 DNA-binding domain. In this chapter, we present an overview of the past and present of KLF1 research and discuss the significance of human KLF1 variants.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1459 ","pages":"217-242"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141625637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non B Cell-Derived Immunoglobulins in Intestinal Tract. 肠道中的非 B 细胞衍生免疫球蛋白

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-981-97-0511-5_11

Zihan Geng, Lina Wu, Qianqian Wang, Junfan Ma, Zhan Shi

{"title":"Non B Cell-Derived Immunoglobulins in Intestinal Tract.","authors":"Zihan Geng, Lina Wu, Qianqian Wang, Junfan Ma, Zhan Shi","doi":"10.1007/978-981-97-0511-5_11","DOIUrl":"https://doi.org/10.1007/978-981-97-0511-5_11","url":null,"abstract":"Intestinal epithelium constitutes a barrier to the unrestricted movement of pathogens, and other detrimental substances from the external world (gut lumen) into the interstitial environment. Intestinal epithelial cells obstruct harmful substances passing through the epithelium as a physical and chemical barrier; Moreover, the epithelial cells can express Toll-like receptors (TLRs) and cytokines to exert innate immune function. In addition, high levels of immunoglobulin A (IgA) and other antibodies exist in the intestinal mucosa, maintaining intestinal immune homeostasis in conjunction with intestinal probiotics. Traditionally, these antibodies have been deemed to be secreted by submucosal plasma cells. Nonetheless, in recent years, it has been demonstrated that intestinal epithelial cells produce a substantial amount of Igs, especially IgA or free Ig light chains, which are involved in intestinal immune homeostasis and the survival of normal epithelial cells. Furthermore, mounting evidence affirms that many human carcinoma cells, including colorectal cancer (CRC), can overexpress Igs, particularly IgG. Cancer-derived Igs exhibit a unique V(D)J rearrangement pattern distinct from B cell-derived Ig; moreover, this cancer cell-derived IgG also has a unique sialic acid modification on the 162 site of CH1 domain (SIA-IgG). The SIA-IgG plays a crucial role in promoting cancer initiation, progression, metastasis, and tumour immune escape. Simultaneously, CRC cells can also express free Ig light chains, which promote colitis, colitis-associated colon carcinogenesis, and CRC progression. Therefore, Igs expressed by CRC cells could be a potential target for diagnosing and preventing the transformation of inflammation into cancer, as well as treating CRC.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1445 ","pages":"137-149"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monocytic Phagocytes in the Immunopathogenesis of Cytokine Storm Syndromes. 细胞因子风暴综合征免疫发病机制中的单核吞噬细胞

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-59815-9_12

Pui Y Lee

引用次数: 0

Murine Models of Secondary Cytokine Storm Syndromes. 继发性细胞因子风暴综合征的小鼠模型

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-59815-9_34

Ellen Brisse, Emely L Verweyen, Amber De Visscher, Christoph Kessel, Carine H Wouters, Patrick Matthys

引用次数: 0

Other Immunomodulatory Treatment for Cytokine Storm Syndromes. 细胞因子风暴综合征的其他免疫调节治疗。

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-59815-9_40

Ezgi Deniz Batu, Seza Ozen

引用次数: 0

Bacteria-Associated Cytokine Storm Syndrome. 细菌相关细胞因子风暴综合征

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-59815-9_19

Esraa M Eloseily, Randy Q Cron

{"title":"Bacteria-Associated Cytokine Storm Syndrome.","authors":"Esraa M Eloseily, Randy Q Cron","doi":"10.1007/978-3-031-59815-9_19","DOIUrl":"https://doi.org/10.1007/978-3-031-59815-9_19","url":null,"abstract":"While viruses are considered the most common infectious triggers for cytokine storm syndromes (CSS), a growing list of bacterial pathogens, particularly intracellular organisms, have been frequently reported to be associated with this syndrome. Both familial and sporadic cases of CSS are often precipitated by acute infections. It is also important to note that an underlying precipitating infection might not be clinically obvious as the CSS clinical picture can mimic an infectious process or an overwhelming septicemia. It is important to detect such an underlying treatable condition. In addition, infections can also be acquired during the course of CSS due to the concurrent immune suppression with treatment. Optimal CSS outcomes require treating bacterial infections when recognized.CSS should always be suspected in patients presenting with a sepsis-like or multi-organ dysfunction picture. There are many criteria proposed to diagnose CSS in general, with HLH-2004 being the most commonly used. Alternatively, criteria have been proposed for CSS occurring in specific underlying conditions such as systemic lupus erythematosus (SLE) or systemic juvenile idiopathic arthritis (sJIA). However, waiting for many of these criteria to be fulfilled could lead to significant delay in diagnosis, and the physician needs a high index of suspicion for CSS in critically ill febrile hospitalized patients in order to properly recognize the condition. Thus, there should be diagnostic equipoise between CSS and infections, including bacterial, in this population. In this chapter, we discuss the more common bacterial precipitants of CSS with many of the cases being discussed in the pediatric age group.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1448 ","pages":"275-283"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of the COVID-19 Pandemic on Teaching, Learning, Assessment, and Wellbeing in Higher Education. COVID-19 大流行对高等教育教学、学习、评估和福祉的影响。

4区医学

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-61943-4_17

Alessandro Siani

引用次数: 0