Advances in experimental medicine and biology最新文献

{"title":"Empathy and Burnout Among Nurses: a Cross-Sectional Study in a University Hospital in Central Greece.","authors":"Anna Patsopoulou, Vasileios Tzenetidis, Konstantinia Karathanasi, Ioanna V Papathanasiou, Maria Malliarou, Pavlos Sarafis","doi":"10.1007/978-3-032-03402-1_4","DOIUrl":"https://doi.org/10.1007/978-3-032-03402-1_4","url":null,"abstract":"<p><strong>Background: </strong>Empathy cultivates deeper interpersonal relationships; however, frequent exposure can trigger the risk of burnout. This study aims to predict empathy, burnout, and syndrome among nursing staff in a university hospital in Central Greece.</p><p><strong>Material and methods: </strong>This is a synchronic study on the nursing staff of the university general hospital in central Greece. The sample consisted of 210 nurses who took part in the study by completing a questionnaire that included demographic and social characteristics, the \"Copenhagen Burnout Inventory\" and the \"Composite Empathy Scale.\" The Pearson correlation coefficient (r) and linear regression analysis with a statistical significance of 0.05 were used for the statistical analysis. Univariate and multiple logistic regression analyses were used to determine the potential predictive factors associated with burnout and empathy.</p><p><strong>Results: </strong>The prevalence of burnout and empathy among nursing staff was 62.5%. A significant positive correlation between empathy with burnout was found in almost all dimensions. For burnout subscales, \"Personal Burnout\" was found to be at 44.1%, Operational Burnout \"at 62.5%, and in\" Burn related to patients \"the average was 58.3%. A higher level of burnout is associated with\" Workplace Burnout \"for nurses on shift work. There was a significant negative correlation between \"Cognitive Personal Empathy\" and the \"Personal Burnout.\" Also, 92.9% of the nursing staff reported suffering from a disease.</p><p><strong>Conclusion: </strong>The nurses in the university hospital are \"aged staff\" with health problems, high levels of empathy, and burnout.</p>","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1490 ","pages":"25-34"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145888515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental Health Nurses' Spiritual Well-Being, Personal Trauma History, Compassion Fatigue, and Compassion Satisfaction.","authors":"E Missouridou, P Mangoulia, E Karahaliou, E Kritsiotakis, V Pavlou, S Parissopoulos, E Stefanou, M Gremou, C Liapis, E Fradelos, Ioannis Rizavas","doi":"10.1007/978-3-032-03402-1_32","DOIUrl":"https://doi.org/10.1007/978-3-032-03402-1_32","url":null,"abstract":"<p><strong>Introduction: </strong>Mental health nursing can be highly rewarding but at the same time overwhelmingly stressful or even traumatizing. Spirituality constitutes a central element of mental health nurses' resilience while personal trauma may be activated during exposure to beneficiaries' trauma.</p><p><strong>Aim: </strong>The aim of this study is to examine the impact of sociodemographic and work-related characteristics, spirituality, and history of trauma on compassion fatigue (CF) and compassion satisfaction among psychiatric nurses in Greece.</p><p><strong>Methods: </strong>A cross-sectional survey study with a total of 91 mental health nurses selected by convenience sampling and required to complete the Professional Quality of Life Scale (ProQOL-V), the FACIT-Spiritual Well-Being Scale-12 non-illness scale, and the Traumatic Life Events Questionnaire (TLEQ).</p><p><strong>Results: </strong>More than a quarter (25.3%) of participants reported high compassion fatigue risk, while 76% expressed high to moderate potential for compassion satisfaction. Secondary traumatic stress (STS) as expected was found to correlate positively with traumatic life events and negatively with the spirituality dimension of meaning. Spiritual well-being, good physical health, high levels of cooperation, respect for teamwork and positive work climate were positively related to higher levels of compassion satisfaction.</p><p><strong>Conclusion: </strong>The findings of this study shed light on the significant prevalence of compassion fatigue and personal trauma history among nursing staff, highlighting the need for targeted interventions to improve the mental health of front-line health care nurses. Mental health care organizations must recognize the importance of fostering compassionate work environments that prioritize mental health professionals' spiritual and psychological well-being.</p>","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1490 ","pages":"299-311"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145888518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Lived Experience of Parents Raising a Child with Autism Spectrum Disorder: \"Losing Your Way, Being on a Rollercoaster with Ups and Downs\".","authors":"Efthalia Tsagkli, Ioanna Prasini, Evdokia Missouridou, Paraskevi Apostolara, Ourania Govina, Chrysoula Tsiou, Marianna Mantzorou, Marianthi Paraskeva, Lydia Lentzari, Theodoula Adamakidou, Helen Dokoutsidou, Fiona Timmins, Stelios Parissopoulos","doi":"10.1007/978-3-032-03394-9_37","DOIUrl":"10.1007/978-3-032-03394-9_37","url":null,"abstract":"<p><strong>Introduction: </strong>Raising a child with Autism Spectrum Disorder (ASD) poses distinct challenges for the parents. The responsibilities that come with securing ongoing support are often described as daunting by them. Parents need support, guidance, and access to specialists to come to terms with the first diagnosis of ASD and to safely guide their child through the developmental stages into adulthood.</p><p><strong>Aim: </strong>To investigate the experiences of parents who are raising children diagnosed with ASD in Greece.</p><p><strong>Methods: </strong>Semi-structured interviews were conducted with eight parents of children with ASD. Interviews were analyzed according to Braun and Clarke's thematic methodology. Qualitative analysis software program ATLAS.TI version 8 was used for data organization and analysis.</p><p><strong>Findings: </strong>Data analysis resulted in one core theme, as the participants experienced raising their child with ASD as \"losing your way, being on a rollercoaster with ups and downs\". The core theme comprised of five sub-themes: (a) Experiencing loneliness, isolation, and social stigma, (b) Positive development in the long run and finding solutions to problems, (c) Advocating for their child, being the link, (d) Uncertainty, stress, fear for what the future holds, and (e) Losing themselves, identity crisis.</p><p><strong>Conclusions: </strong>The parents grappled with feelings of loneliness, isolation, and stigma. Engaging in social interactions with friends and extended family proved particularly challenging. Additionally, they made substantial life adjustments, including changing or even stopping their careers. Nevertheless, despite their many challenges, the children progressed over time. This prompted the parents to devise solutions, be proactive and keep going, for the best interest of their child.</p>","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1489 ","pages":"385-401"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145538511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Work-Related Stress and Miscarriage in Pregnant Women: A Systematic Review.","authors":"Eirini Anastasiadou, Flora Bacopoulou, Dimitrios Vlachakis, Elena Critselis, Christina Kanaka-Gantenbein","doi":"10.1007/978-3-032-03394-9_17","DOIUrl":"10.1007/978-3-032-03394-9_17","url":null,"abstract":"<p><p>Miscarriage is a naturally occurring event that can be caused by several factors, such as work-related stress. The aim of the current systematic review was to examine the association between work-related stress and miscarriage in pregnant women, and to corroborate previous findings on the subject. A systematic review was conducted using the PubMed and Scopus databases. Observational studies published in English were considered for inclusion. A total of 412 papers were identified through the database search. After removing duplicates, 302 papers were screened, and based on the inclusion and exclusion criteria, seven studies were included in the systematic review. Our results indicate that there is an increased risk of miscarriage among women with work stress. Future research in larger population samples is needed to confirm these findings.</p>","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1489 ","pages":"169-174"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145538527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Approach of Shared Decision-Making as a Factor in Improving the Quality of Care.","authors":"Aikaterini Toska, Evangelos C Fradelos, Maria Saridi, Kyriakos Souliotis","doi":"10.1007/978-3-032-03394-9_9","DOIUrl":"10.1007/978-3-032-03394-9_9","url":null,"abstract":"<p><p>The patient-physician relationship has traditionally been paternalistic, in which the physician made decisions on behalf of the patient, using his or her skills to select the necessary interventions and treatments likely to restore the patient's health. In this context, the information given to the patient is selected in such a way as to encourage him to consent to the decisions of the attending physician. This definition of asymmetric or unbalanced interaction between doctors and patients has begun to be challenged in recent years, with a shift towards a more \"complementary\" relationship where the patient is more informed, empowered, and autonomous. Shared decision-making has been shown to have a positive impact on health care, as it guides treatment plans that better reflect patient goals, improves patient-physician communication, has a positive effect on health outcomes, and can reduce costs.</p>","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1489 ","pages":"91-100"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145538564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review on Interventions to Enhance Transition Process in Youth with Chronic Disease: Are They Crucial for Transition Outcomes?","authors":"Christina Plati, Vassiliki Mpoumpa, Alexia Papageorgiou, Maria Tsolia, Theodora Psaltopoulou, Tonia Vassilakou, Theodoros N Sergentanis, Artemis K Tsitsika","doi":"10.1007/978-3-032-03394-9_42","DOIUrl":"10.1007/978-3-032-03394-9_42","url":null,"abstract":"<p><p>To evaluate interventions designed to improve transition to adult-oriented care for youth with chronic physical health problems.</p><p><strong>Methods: </strong>Electronic searches were conducted in PubMed, Google Scholar, EMBASE, and PsycINFO focusing on patient education and preparation, and their effect on the course and the follow-up of diseases, as well as on the quality of life of young people.</p><p><strong>Results: </strong>Seventeen studies met inclusion criteria. Educational programs, either hospital-based or Internet-based, and also workshops with a cognitive-behavioral approach seem to reflect positively on transition outcomes.</p><p><strong>Conclusions: </strong>This systematic review illustrates a map of interventions that enhance a successful transition of young chronic patients to adult health care. The findings suggest that educational programs, behavioral workshops, common medical appointments with pediatric and adult healthcare providers, training of the latter, and patient families are useful to transition experience. Transition programs should be developed with a long-term perspective preparing and empowering youth for the future.</p>","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1489 ","pages":"441-456"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145538612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Orientation and Health Literacy of Individuals Coming in the Outpatient Clinic and in the Emergency Department of a Provincial Hospital in Greece.","authors":"Maria Saridi, Ioanna Dimitriadou, Aikaterini Toska, Evangelos C Fradelos, Konstantinos Togas, Christos Papadopoulos, Kyriakos Souliotis","doi":"10.1007/978-3-032-03394-9_1","DOIUrl":"10.1007/978-3-032-03394-9_1","url":null,"abstract":"<p><strong>Objective: </strong>The primary objective of this study was to assess the health orientation and health literacy of individuals seeking assistance at a provincial hospital in Greece.</p><p><strong>Design: </strong>A cross-sectional study design was employed to collect data over a four-month period, from July to October 2022. The study was conducted in the outpatient clinics and Emergency Department of the Argolis General Hospital.</p><p><strong>Setting: </strong>The study was carried out in the healthcare facilities of the Argolis General Hospital, including outpatient clinics and Emergency Department. This hospital is in the provincial region of Argos in Greece.</p><p><strong>Participants: </strong>A total of 223 individuals participated in this study. The participants were individuals who sought medical assistance at the Argolis General Hospital during the specified four-month period, encompassing a diverse range of sociodemographic and medical backgrounds.</p><p><strong>Results: </strong>The study involved participants with an average age of approximately 41 years, where the majority were females (63.2%). Most were nonsmokers (65.2%), infrequent exercisers (56.8%), and did not have chronic diseases (80.7%). A significant proportion had been both vaccinated (78.5%) and infected with COVID-19 (67.7%). The average health literacy score was 13.15%, with 69.7% having adequate health literacy, 18.5% showing problematic health literacy, and 11.8% demonstrating insufficient health literacy. Education played a role, with primary school graduates scoring lower and master's degree holders performing better in internal health control. Age correlated with various health aspects, and health literacy was positively associated with factors like private health consciousness, health esteem-confidence, and motivation for healthiness.</p><p><strong>Conclusion: </strong>Higher health literacy is linked to positive health attitudes and behaviors, including confidence in health, motivation for healthiness, and control over health decisions. In clinical practice, healthcare professionals should routinely assess health literacy and orientation to identify individuals who may need targeted interventions to improve health literacy and promote positive health behaviors.</p>","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1489 ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145538790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Involvement in the Development and Maintenance of Oral and Craniofacial Bones.","authors":"Takehito Ono","doi":"10.1007/978-3-032-03176-1_25","DOIUrl":"10.1007/978-3-032-03176-1_25","url":null,"abstract":"<p><p>The oral and craniofacial bones are essential for determining individual appearance and enabling mastication, respiration, and phonation. The cranium exhibits a complex architecture composed of multiple small bones. The development of this structured organization is a consequence of the well-coordinated functions of various bone cells, such as chondrocytes, osteoblasts, osteoclasts, and osteocytes. These cells contribute to both the development and maintenance of bone, known as the modeling and remodeling phases, respectively. The differentiation and function of these bone cells can be influenced by intrinsic and extrinsic stimuli, resulting in the adaptation of bone morphology and functions when stimulation occurs within physiological ranges. In contrast, excessive or abnormal stimuli, including genetic mutations, endocrine disorders, abnormal mechanical loading, tumor formation, and aberrant immune responses, can lead to bone malformations and dysfunction. The immune system, originally developed as a defense mechanism against non-self entities, can disrupt the physiological structures and functions of organs when dysregulated. Bone metabolism can be influenced by the immune system, both directly and indirectly via other biological systems, and irregular activation of the immune system can cause inflammatory bone diseases as well as bone diseases of other categories. A precise understanding of these bone diseases requires insights into the involvement of the immune system. This chapter summarizes our knowledge of how the immune system functions during the development and maintenance of oral and craniofacial bones.</p>","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1492 ","pages":"529-545"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145501407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innate Immunity Gene Variants Affect Periodontitis Susceptibility.","authors":"Martin Levine, Zsolt M Lohinai","doi":"10.1007/978-3-032-03176-1_23","DOIUrl":"10.1007/978-3-032-03176-1_23","url":null,"abstract":"<p><p>Periodontitis is a chronic bacterial infection that destroys the epithelial attachment, forming a crevice beneath the gingival margins. The bacteria form dentally attached biofilms that enter the crevice and cause systemic inflammatory diseases (comorbidities). Susceptibility to moderate or severe (established) periodontitis is associated with smoking, diabetes, inadequate oral hygiene, and a genetic factor related to innate immunity function. One key factor in innate immunity function and its significance for periodontitis is related to the essential amino acid lysine. While lysine is absent in saliva, it is present in gingival crevicular fluid (GCF), an inflammatory exudate from the gingival crevice that permeates dental biofilms. After 16 periodontally healthy adults refrained from oral hygiene for 1 week, nine exhibited strong and seven exhibited weak GCF exudation, despite similar biofilm lysine concentrations. Strong responders, who effectively moved biofilm bacteria back into saliva, possess the adenine (A) single nucleotide polymorphism (SNP) at site -511 of the interleukin-1β (IL1B) gene instead of guanine (G). Weak responders possess thymidine (T) SNP at site +3877 of IL1B instead of cytidine (C), leading to bacterial retention in gingival crevices where lysine promotes periodontopathic biofilm development. If both IL1B + 3877(T) and IL1B-511(A) are present, an SNP in IL6, IL10, or CD14 determines the GCF response. These genetic profiles identify 40% of the US population as susceptible to periodontitis and comorbidities, causing bacterially driven systemic inflammation.</p>","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1492 ","pages":"485-507"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145501486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serendipitous Discoveries in Biomedical Sciences (Revisited).","authors":"Yuan Chuan Lee","doi":"10.1007/978-3-032-04153-1_1","DOIUrl":"10.1007/978-3-032-04153-1_1","url":null,"abstract":"<p><p>Serendipity is to come across a nice coincidence or to discover something unexpected. Also, it is to look for something and happen to find something of value other than what you are looking for. In simple, it is to seize upon good fortune by a random chance. I described examples of serendipity in scientific discoveries in the glycoscience field and their background in the 2011 publication of MICC-3 under the title \"Serendipity in scientific discoveries: some examples in glycosciences.\" We have learned that the progress in the scientific field has been remarkable, and many discoveries have been made, including some discoveries by serendipity. In this chapter, I filled the gaps in serendipitous discoveries in the biomedical sciences left by the MICC-3 as follows: (i) the discovery of intramolecular lactonization of sialic acids, (ii) the discovery of ancient Chinese script (), (iii) the discovery of oriental beauty oolong tea, and (iv) Yamanaka's Nobel Prize-winning discovery of induced pluripotent stem (iPS) cells. Finally, the planning for serendipity was discussed.</p>","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1491 ","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}