葡萄糖代谢中的脑-体通讯。

4区 医学 Q2 Biochemistry, Genetics and Molecular Biology
Astrid A S van Irsen, Andries Kalsbeek, Susanne E la Fleur
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引用次数: 0

摘要

葡萄糖是大脑必需的燃料,它的浓度必须保持在严格的范围内,才能达到最佳的健康状态。维持葡萄糖稳态涉及葡萄糖摄取和输出之间的平衡,以及葡萄糖浓度的日常节律管理。本章探讨了不同脑区在葡萄糖稳态中的作用,以及它们通过交感和副交感神经系统与胰腺和肝脏等外周器官的联系。下丘脑的关键核,包括弓状核和下丘脑腹内侧核,在葡萄糖调节中的作用已经得到了很好的证实。此外,皮质边缘区域,如伏隔核和杏仁核,参与糖代谢的调节。这些脑区通过自主神经通路与胰腺和肝脏沟通,影响胰岛素分泌、肝糖生成和整体代谢平衡。通过检查所涉及的神经回路和机制,本章旨在全面了解脑-体相互作用如何维持葡萄糖稳态及其对代谢健康的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Brain-Body Communication in Glucose Metabolism.

Glucose is an essential fuel for the brain, and its concentration must be maintained within strict boundaries for optimal fitness. Maintaining glucose homeostasis involves a balance between glucose uptake and output, as well as the management of daily rhythms in glucose concentrations. This chapter explores the roles of various brain regions in glucose homeostasis and their connections through the sympathetic and parasympathetic nervous systems to peripheral organs such as the pancreas and liver. Key hypothalamic nuclei, including the arcuate nucleus and the ventromedial hypothalamus, are well established in their roles in glucose regulation. Additionally, cortico-limbic areas, such as the nucleus accumbens and amygdala, contribute to the modulation of glucose metabolism. These brain regions communicate with the pancreas and liver via autonomic pathways, influencing insulin secretion, hepatic glucose production, and overall metabolic balance. By examining the neural circuits and mechanisms involved, this chapter aims to provide a comprehensive understanding of how brain-body interactions maintain glucose homeostasis and their implications for metabolic health.

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来源期刊
Advances in experimental medicine and biology
Advances in experimental medicine and biology 医学-医学:研究与实验
CiteScore
5.90
自引率
0.00%
发文量
465
审稿时长
2-4 weeks
期刊介绍: Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.
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