Advances in experimental medicine and biology最新文献

The Role of Epigenetic Modifications in Enhancing Bone Marrow Transplantation Efficacy in Cancer. 表观遗传修饰在增强骨髓移植治疗癌症疗效中的作用。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-06-17 DOI: 10.1007/5584_2025_870

Babak Arjmand, Fatemeh Shahrahmani, Alieh Mirzaei, Arian Emamifar, Sepideh Alavi-Moghadam

{"title":"The Role of Epigenetic Modifications in Enhancing Bone Marrow Transplantation Efficacy in Cancer.","authors":"Babak Arjmand, Fatemeh Shahrahmani, Alieh Mirzaei, Arian Emamifar, Sepideh Alavi-Moghadam","doi":"10.1007/5584_2025_870","DOIUrl":"https://doi.org/10.1007/5584_2025_870","url":null,"abstract":"Bone marrow transplantation is an important therapeutic modality in the treatment of hematological malignancies and other hematological diseases. It is typically marred by complications like graft-versus-host disease, engraftment failure of donor cells, and recurrence of the original disease. Epigenetic modifications like DNA methylation, histone modification, and noncoding RNAs play a pivotal role in regulating gene expression and cellular function. Current advances in epigenetics studies have heightened the expectation that they have the potential to enhance the efficacy of transplantation by regulating immune response, improving donor cell engraftment, and manipulating the tumor microenvironment. The current chapter discusses the implication of epigenetic modification for the solution of the issues in bone marrow transplantation, with a special focus on how they can impact graft-versus-host disease, hematopoietic reconstitution, and relapse of cancer. By integrating epigenetic therapies and biomarkers into transplant regimens, the possibility exists to improve patient outcomes and advance personalized medicine in oncology.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosome Innovations in Ophthalmology and Sjögren's Syndrome. 眼科学和Sjögren综合征的外泌体创新。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-05-14 DOI: 10.1007/5584_2025_865

Kevin Y Wu, Archan Dave, Gurleen K Nirwal, Michel Giunta, Vincent D H Nguyen, Simon D Tran

{"title":"Exosome Innovations in Ophthalmology and Sjögren's Syndrome.","authors":"Kevin Y Wu, Archan Dave, Gurleen K Nirwal, Michel Giunta, Vincent D H Nguyen, Simon D Tran","doi":"10.1007/5584_2025_865","DOIUrl":"https://doi.org/10.1007/5584_2025_865","url":null,"abstract":"Exosomes, a subset of extracellular vesicles, have emerged as potential therapeutic agents in ophthalmology due to their ability to modulate immune responses, facilitate cellular communication, and promote tissue repair. This chapter explores the potential applications of exosome-based therapies in corneal and anterior segment disorders, retinal diseases, glaucoma, and Sjögren's syndrome. In corneal disorders, mesenchymal stem cell (MSC)-derived secretomes have shown promise in accelerating wound healing, reducing fibrosis, and modulating inflammation, with hydrogel encapsulation strategies potentially enhancing their efficacy. In retinal diseases, exosomes may provide neuroprotective effects in age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa by modulating oxidative stress and inflammation. In glaucoma, secretome-based therapies could support retinal ganglion cell survival and optic nerve regeneration, though their impact on intraocular pressure via the trabecular meshwork remains uncertain. Additionally, exosomal biomarkers in aqueous humor are being investigated as potential diagnostic tools. In Sjögren's syndrome, exosomal biomarkers may facilitate earlier detection, while stem cell-derived exosomes hold promise in modulating immune responses and restoring glandular function. Despite encouraging preclinical and early clinical findings, standardization, scalability, and long-term safety must be addressed before clinical translation. Future research will focus on optimizing exosome-based therapies and exploring their feasibility for ophthalmic applications.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging the Gap Between Bone Marrow Transplantation and CAR-T Cell Therapy in Hematological Cancers. 弥合骨髓移植和CAR-T细胞治疗血液肿瘤之间的差距。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-05-07 DOI: 10.1007/5584_2025_862

Babak Arjmand, Fatemeh Shahrahmani, Alieh Mirzaei, Sepideh Alavi-Moghadam, Rasta Arjmand, Mostafa Rezaei-Tavirani, Seyed Mohammadamin Nejati-Niyaki, Bagher Larijani, Ghasem Janbabaei, Seied Asadollah Mousavi, Abbas Hajifathali

{"title":"Bridging the Gap Between Bone Marrow Transplantation and CAR-T Cell Therapy in Hematological Cancers.","authors":"Babak Arjmand, Fatemeh Shahrahmani, Alieh Mirzaei, Sepideh Alavi-Moghadam, Rasta Arjmand, Mostafa Rezaei-Tavirani, Seyed Mohammadamin Nejati-Niyaki, Bagher Larijani, Ghasem Janbabaei, Seied Asadollah Mousavi, Abbas Hajifathali","doi":"10.1007/5584_2025_862","DOIUrl":"https://doi.org/10.1007/5584_2025_862","url":null,"abstract":"Bone marrow transplantation and chimeric antigen receptor T cell therapy have become two important treatment modalities for hematological malignancies, each having different mechanisms of action and therapeutic roles. This chapter focuses on the chronological development and obstacles of bone marrow transplantation, the paradigm-shifting impact of chimeric antigen receptor T cell therapy, and further integrative approaches. The complementary roles of these modalities are emphasized given their optimal timing, selection of patients, and the development of novel strategies to improve therapeutic outcomes. Challenges such as cytokine release syndrome, graft-versus-host disease, and immune suppression are critically scrutinized. The future perspectives highlight the development of synergistic approaches, refining patient-centered treatments, and addressing long-term quality-of-life concerns. It is with this aim that the discussion below might help bridge these modalities through interdisciplinary efforts toward more effective, personalized, and sustainable treatments for cancer.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination Therapies in Drug Repurposing: Personalized Approaches to Combatting Leukaemia and Multiple Myeloma. 药物再利用中的联合疗法：对抗白血病和多发性骨髓瘤的个性化方法。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-04-26 DOI: 10.1007/5584_2025_863

B Monchusi, P Dube, M M Takundwa, V L Kenmogne, T Malise, D B Thimiri Govinda Raj

{"title":"Combination Therapies in Drug Repurposing: Personalized Approaches to Combatting Leukaemia and Multiple Myeloma.","authors":"B Monchusi, P Dube, M M Takundwa, V L Kenmogne, T Malise, D B Thimiri Govinda Raj","doi":"10.1007/5584_2025_863","DOIUrl":"https://doi.org/10.1007/5584_2025_863","url":null,"abstract":"Despite advances in cancer research, treating malignancies remains challenging due to issues like drug resistance, disease heterogeneity, and the limited efficacy of current therapies, particularly in relapsed or refractory cases. In recent years, several drugs originally approved for non-cancer indications have shown potential in cancer treatment, demonstrating anti-proliferative, anti-metastatic, and immunomodulatory effects. Drug repurposing has shown immense promise due to well-established safety profiles and mechanisms of action of the compounds. However, the implementation is fraught with clinical, logistical, regulatory, and ethical challenges, especially in diseases such as leukaemia and multiple myeloma. This chapter examines the treatment challenges in leukaemia and multiple myeloma, focusing on the role of drug repurposing in addressing therapeutic resistance and disease variability. It highlights the potential of personalized, tailored combination therapies, using repurposed drug components, to offer more effective, targeted, and cost-efficient treatment strategies, overcoming resistance and improving patient outcomes.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Inflamed Bone Marrow Scenery Amongst the Symplegades of Ageing and Diseases. 在衰老和疾病的征兆中，发炎的骨髓风景。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-04-26 DOI: 10.1007/5584_2025_860

Pier Raffaele Zarro, Simona De Felice, Maria Giovanna Sabbieti, Dimitrios Agas

引用次数: 0

The Role of Aging and Senescence in Bone Marrow Transplantation Outcome. 衰老和衰老在骨髓移植结果中的作用。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-04-22 DOI: 10.1007/5584_2025_861

Babak Arjmand, Pouya Mehran, Sana Badamchizadeh, Sepideh Alavi-Moghadam, Rasta Arjmand, Mostafa Rezaei-Tavirani, Hamid Reza Aghayan, Bagher Larijani, Mohamad Vaezi, Ghasem Janbabaei, Abbas Hajifathali

{"title":"The Role of Aging and Senescence in Bone Marrow Transplantation Outcome.","authors":"Babak Arjmand, Pouya Mehran, Sana Badamchizadeh, Sepideh Alavi-Moghadam, Rasta Arjmand, Mostafa Rezaei-Tavirani, Hamid Reza Aghayan, Bagher Larijani, Mohamad Vaezi, Ghasem Janbabaei, Abbas Hajifathali","doi":"10.1007/5584_2025_861","DOIUrl":"https://doi.org/10.1007/5584_2025_861","url":null,"abstract":"Bone marrow transplantation is considered a cornerstone in the treatment of hematologic malignancies and blood disorders. While it may offer the possibility of a cure through the use of high-dose chemotherapy and radiation, outcomes are significantly impacted by biological and medical factors. Herein, aging is associated with reduced hematopoiesis, immune function, and overall regenerative capacity of tissues. Growth arrest, a crucial property of cellular senescence, inhibits bone marrow function, lowers immune surveillance in aged adults, and reduces the efficiency of bone marrow transplantation. The clinical course for older recipients is further complicated by the presence of prolonged immunosuppression, slower recovery, and higher complication rates, including life-threatening graft-versus-host disease. Accordingly, there is increasing interest in explaining how aging, cellular senescence, and transplant outcomes are interrelated. The current chapter outlines the mechanisms whereby aging and senescence contribute to the immunological dysregulation and poor bone marrow transplantation outcomes observed in elderly cancer patients. The authors' goal is to suggest therapeutic approaches that will enhance the quality of life and survival rates of elderly bone marrow transplant recipients.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid Properties and Metabolism in Response to Cold. 低温对脂质特性和代谢的影响。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-04-08 DOI: 10.1007/5584_2024_848

Thomas Enriquez, Nicholas M Teets

{"title":"Lipid Properties and Metabolism in Response to Cold.","authors":"Thomas Enriquez, Nicholas M Teets","doi":"10.1007/5584_2024_848","DOIUrl":"https://doi.org/10.1007/5584_2024_848","url":null,"abstract":"Temperature directly shapes insect physiology and has a preponderant effect on life history traits. Winter conditions in temperate and polar regions are especially challenging for insects. Extremely low temperatures can indeed compromise insect survival by promoting freezing of body fluids, but mild cold temperatures above 0 °C (i.e., chilling) can also lead to complex and severe physiological dysregulations. Among physiological damages due to freezing and chilling, insect lipids are one of the primary targets. As low temperatures tend to rigidify phospholipid bilayers, membrane functions are compromised in the cold. Lipid rigidification due to cold also decreases the accessibility of fat stores for metabolic enzymes, and therefore their availability for basal metabolism. These deleterious effects, combined with low food availability in winter, result in substantial nutritional challenges for overwintering insects. Consequently, lipid modifications such as homeoviscous adaptation of cell membranes, fluidity maintenance of fat reserves, cuticular lipid accumulation, and production of antifreeze glycolipids are essential components of the physiological response to cold stress. The aim of the present chapter is to present the physiological challenges caused by low temperatures, the lipid modifications linked with cold tolerance in insects, and the molecular regulation of lipid metabolism during cold exposure.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Niche-Based Perspective to Stem and Cancer Stem Cells of the Lung. 基于生态位的肺干细胞和肿瘤干细胞研究。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-04-04 DOI: 10.1007/5584_2025_858

Özge Boyacıoğlu, Berfin Deniz Kalali, Ege Tongün, Petek Korkusuz

{"title":"A Niche-Based Perspective to Stem and Cancer Stem Cells of the Lung.","authors":"Özge Boyacıoğlu, Berfin Deniz Kalali, Ege Tongün, Petek Korkusuz","doi":"10.1007/5584_2025_858","DOIUrl":"https://doi.org/10.1007/5584_2025_858","url":null,"abstract":"Lungs carry the principle function for the conduction and exchange of air through the primary, secondary, tertiary bronchi, bronchioles, and alveoli, resulting in the exchange of oxygen to carbon dioxide within the human tissues. Lung stem and progenitor cells enable differentiation of parenchymal and stromal elements and provide homeostasis and regeneration in the microenvironment against pulmonary diseases. Tumor-initiating cancer cells (TICs) refer to a subpopulation named as cancer stem cells (CSCs) of lung cancer exhibiting high self-renewal and proliferation capacity by Notch, Hippo, Hedgehog, and Wnt signaling pathways that leads to tumor development or recurrence. Lung cancer stem cells (LCSCs) are characterized by distinct genotypic or phenotypic alterations compared to healthy lung stem cells (LSCs) that provide a potential target to treat lung cancer. Therefore, understanding the cascades responsible for the transformation of healthy to CSCs is essential to develop new targeted therapy approaches. In this chapter, we precisely highlight the latest researches on LSCs and CSCs, key signaling mechanisms within the perspective of novel targeted therapy strategies.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small Molecules and Epigenetic Modifiers in Facilitating Pancreatic β-cell Formation: A Comprehensive Insight. 促进胰腺β细胞形成的小分子和表观遗传修饰因子：一个全面的见解。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-04-04 DOI: 10.1007/5584_2025_859

Naveen Raj, Asmita Karmakar, Gloria Narayan, Rajkumar P Thummer

引用次数: 0

The Art of Neuroregeneration De Novo and In Situ. 新生和原位神经再生的技术。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-03-26 DOI: 10.1007/5584_2025_856

Eumorphia Remboutsika

引用次数: 0