Advances in experimental medicine and biology最新文献_第2页

The Inflamed Bone Marrow Scenery Amongst the Symplegades of Ageing and Diseases. 在衰老和疾病的征兆中，发炎的骨髓风景。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-04-26 DOI: 10.1007/5584_2025_860

Pier Raffaele Zarro, Simona De Felice, Maria Giovanna Sabbieti, Dimitrios Agas

引用次数: 0

The Role of Aging and Senescence in Bone Marrow Transplantation Outcome. 衰老和衰老在骨髓移植结果中的作用。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-04-22 DOI: 10.1007/5584_2025_861

Babak Arjmand, Pouya Mehran, Sana Badamchizadeh, Sepideh Alavi-Moghadam, Rasta Arjmand, Mostafa Rezaei-Tavirani, Hamid Reza Aghayan, Bagher Larijani, Mohamad Vaezi, Ghasem Janbabaei, Abbas Hajifathali

{"title":"The Role of Aging and Senescence in Bone Marrow Transplantation Outcome.","authors":"Babak Arjmand, Pouya Mehran, Sana Badamchizadeh, Sepideh Alavi-Moghadam, Rasta Arjmand, Mostafa Rezaei-Tavirani, Hamid Reza Aghayan, Bagher Larijani, Mohamad Vaezi, Ghasem Janbabaei, Abbas Hajifathali","doi":"10.1007/5584_2025_861","DOIUrl":"https://doi.org/10.1007/5584_2025_861","url":null,"abstract":"Bone marrow transplantation is considered a cornerstone in the treatment of hematologic malignancies and blood disorders. While it may offer the possibility of a cure through the use of high-dose chemotherapy and radiation, outcomes are significantly impacted by biological and medical factors. Herein, aging is associated with reduced hematopoiesis, immune function, and overall regenerative capacity of tissues. Growth arrest, a crucial property of cellular senescence, inhibits bone marrow function, lowers immune surveillance in aged adults, and reduces the efficiency of bone marrow transplantation. The clinical course for older recipients is further complicated by the presence of prolonged immunosuppression, slower recovery, and higher complication rates, including life-threatening graft-versus-host disease. Accordingly, there is increasing interest in explaining how aging, cellular senescence, and transplant outcomes are interrelated. The current chapter outlines the mechanisms whereby aging and senescence contribute to the immunological dysregulation and poor bone marrow transplantation outcomes observed in elderly cancer patients. The authors' goal is to suggest therapeutic approaches that will enhance the quality of life and survival rates of elderly bone marrow transplant recipients.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid Properties and Metabolism in Response to Cold. 低温对脂质特性和代谢的影响。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-04-08 DOI: 10.1007/5584_2024_848

Thomas Enriquez, Nicholas M Teets

{"title":"Lipid Properties and Metabolism in Response to Cold.","authors":"Thomas Enriquez, Nicholas M Teets","doi":"10.1007/5584_2024_848","DOIUrl":"https://doi.org/10.1007/5584_2024_848","url":null,"abstract":"Temperature directly shapes insect physiology and has a preponderant effect on life history traits. Winter conditions in temperate and polar regions are especially challenging for insects. Extremely low temperatures can indeed compromise insect survival by promoting freezing of body fluids, but mild cold temperatures above 0 °C (i.e., chilling) can also lead to complex and severe physiological dysregulations. Among physiological damages due to freezing and chilling, insect lipids are one of the primary targets. As low temperatures tend to rigidify phospholipid bilayers, membrane functions are compromised in the cold. Lipid rigidification due to cold also decreases the accessibility of fat stores for metabolic enzymes, and therefore their availability for basal metabolism. These deleterious effects, combined with low food availability in winter, result in substantial nutritional challenges for overwintering insects. Consequently, lipid modifications such as homeoviscous adaptation of cell membranes, fluidity maintenance of fat reserves, cuticular lipid accumulation, and production of antifreeze glycolipids are essential components of the physiological response to cold stress. The aim of the present chapter is to present the physiological challenges caused by low temperatures, the lipid modifications linked with cold tolerance in insects, and the molecular regulation of lipid metabolism during cold exposure.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Niche-Based Perspective to Stem and Cancer Stem Cells of the Lung. 基于生态位的肺干细胞和肿瘤干细胞研究。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-04-04 DOI: 10.1007/5584_2025_858

Özge Boyacıoğlu, Berfin Deniz Kalali, Ege Tongün, Petek Korkusuz

{"title":"A Niche-Based Perspective to Stem and Cancer Stem Cells of the Lung.","authors":"Özge Boyacıoğlu, Berfin Deniz Kalali, Ege Tongün, Petek Korkusuz","doi":"10.1007/5584_2025_858","DOIUrl":"https://doi.org/10.1007/5584_2025_858","url":null,"abstract":"Lungs carry the principle function for the conduction and exchange of air through the primary, secondary, tertiary bronchi, bronchioles, and alveoli, resulting in the exchange of oxygen to carbon dioxide within the human tissues. Lung stem and progenitor cells enable differentiation of parenchymal and stromal elements and provide homeostasis and regeneration in the microenvironment against pulmonary diseases. Tumor-initiating cancer cells (TICs) refer to a subpopulation named as cancer stem cells (CSCs) of lung cancer exhibiting high self-renewal and proliferation capacity by Notch, Hippo, Hedgehog, and Wnt signaling pathways that leads to tumor development or recurrence. Lung cancer stem cells (LCSCs) are characterized by distinct genotypic or phenotypic alterations compared to healthy lung stem cells (LSCs) that provide a potential target to treat lung cancer. Therefore, understanding the cascades responsible for the transformation of healthy to CSCs is essential to develop new targeted therapy approaches. In this chapter, we precisely highlight the latest researches on LSCs and CSCs, key signaling mechanisms within the perspective of novel targeted therapy strategies.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small Molecules and Epigenetic Modifiers in Facilitating Pancreatic β-cell Formation: A Comprehensive Insight. 促进胰腺β细胞形成的小分子和表观遗传修饰因子：一个全面的见解。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-04-04 DOI: 10.1007/5584_2025_859

Naveen Raj, Asmita Karmakar, Gloria Narayan, Rajkumar P Thummer

引用次数: 0

The Art of Neuroregeneration De Novo and In Situ. 新生和原位神经再生的技术。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-03-26 DOI: 10.1007/5584_2025_856

Eumorphia Remboutsika

引用次数: 0

Organoids as 3D Models for Studying Exogenous Mitochondrial Transplantation. 类器官作为研究外源性线粒体移植的3D模型。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-03-26 DOI: 10.1007/5584_2025_857

Ismail Eş, Oner Ulger

{"title":"Organoids as 3D Models for Studying Exogenous Mitochondrial Transplantation.","authors":"Ismail Eş, Oner Ulger","doi":"10.1007/5584_2025_857","DOIUrl":"https://doi.org/10.1007/5584_2025_857","url":null,"abstract":"Mitochondria play a critical role in cellular communication, cell proliferation, and apoptosis, which make them essential to maintaining cellular health. Recently, mitochondrial transplantation has emerged as a promising therapeutic approach to treat conditions such as ischemia, neurodegenerative diseases, and cardiovascular disorders by restoring mitochondrial function in damaged cells. Despite its potential, understanding mitochondrial behavior in vivo remains challenging; however, organoid models, which are three-dimensional structures derived from stem cells that mimic human tissues, offer a solution to study mitochondrial function and transplantation strategies under controlled conditions. These models are particularly necessary in studies, as they can replicate disease conditions and consequently enable researchers to investigate mitochondrial dynamics and therapeutic integration. Developing organoid systems optimized for mitochondrial transplantation requires exploring factors that influence mitochondrial uptake, refining transplantation strategies, and understanding their role in cellular regeneration in order to advance in the field of mitochondrial research.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid Metabolism in Diapause. 滞育中的脂质代谢。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-03-19 DOI: 10.1007/5584_2025_850

Umut Toprak, Nicholas M Teets, Doga Cedden, Gözde Güney

{"title":"Lipid Metabolism in Diapause.","authors":"Umut Toprak, Nicholas M Teets, Doga Cedden, Gözde Güney","doi":"10.1007/5584_2025_850","DOIUrl":"https://doi.org/10.1007/5584_2025_850","url":null,"abstract":"Organisms living in temperate and polar environments encounter seasonal fluctuations that entail changes in temperature, resource availability, and biotic interactions. Thus, adaptations for synchronizing the life cycle with essential resources and persisting through unfavorable conditions are critical. Diapause, a programmed period of developmental arrest and metabolic depression, is widely used by insects to survive winter and synchronize the life cycle. In some cases, insects spend over half the year (or in some cases, multiple years) in a nonfeeding diapause state. Thus, diapause is energetically challenging, and insects accumulate surplus energy stores and/or suppress metabolism to make it through the winter. As the most energy-dense, and often most abundant, energy reserve in insects, lipids play a central role in diapause energetics. In this chapter, we provide an overview of lipid metabolism in the context of diapause. First, as this is the only chapter in this book that covers diapause, we present some of the general features of diapause. We then discuss the role of lipids as an essential energy store during diapause, focusing on patterns of lipid accumulation before diapause and patterns of utilization during diapause. In the next section, we outline some other roles of lipids during diapause in addition to their role as an energy store. Finally, we end the chapter by discussing the molecular regulation of lipid metabolism in diapause, which has received increased attention in recent years.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insect Flight and Lipid Metabolism: Beyond the Classic Knowledge. 昆虫飞行和脂质代谢：超越经典知识。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-03-19 DOI: 10.1007/5584_2024_849

Leonardo L Fruttero, Jimena Leyria, Lilián E Canavoso

{"title":"Insect Flight and Lipid Metabolism: Beyond the Classic Knowledge.","authors":"Leonardo L Fruttero, Jimena Leyria, Lilián E Canavoso","doi":"10.1007/5584_2024_849","DOIUrl":"https://doi.org/10.1007/5584_2024_849","url":null,"abstract":"Insects are the most successful animal group by various ecological and evolutionary metrics, including species count, adaptation diversity, biomass, and environmental influence. This book delves into the underlying reasons behind insects' dominance on Earth. Lipids play pivotal roles in insect biology, serving as fuel for physiological processes, signaling molecules, and structural components of biomembranes and providing waterproofing against dehydration, among other functions. The study of insect flight has been instrumental in advancing our understanding of insect metabolism, with the migratory locust (Locusta migratoria) and the tobacco hornworm (Manduca sexta) serving as prominent models. Throughout the 1980s and 1990s, numerous studies shed light on the role of adipokinetic hormone (AKH), a crucial neuropeptide in lipid mobilization, to support the extraordinary energy demands of insect flight. Remarkably, AKH was the first identified peptide hormone in insects. These pioneering works linking lipids and flight laid the groundwork for subsequent research characterizing the physiological roles of other neuroendocrine factors in energy substrate mobilization across diverse insect species. However, in the omics era, one may be surprised by the limited understanding of the complex cascade of events governing lipid supply to insect flight muscles. Thus, this chapter aims to provide a concise overview of the evolutionary significance of insect flight, emphasizing key advancements that expand our classical knowledge in this field. Ultimately, we hope this chapter serves as a modest tribute to the pioneering researchers of one of the most captivating areas in insect biology, inspiring further exploration into the myriad roles of lipids in insect biology.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptide Nanofibers and Skin Regeneration. 肽纳米纤维与皮肤再生。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-01-23 DOI: 10.1007/5584_2024_845

Sarah H Tekinay, Ayse B Tekinay

引用次数: 0