Advances in experimental medicine and biology最新文献_第10页

Dysregulation of Retinal and Photoreceptor Structural Integrity Genes in ATF6^-/- Retinal Organoids. ATF6-/-视网膜类器官中视网膜和光感受器结构完整性基因的失调。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-76550-6_66

Allyssa Bradley, Masako Le, Soyeon Park, Heike Kroeger, R Luke Wiseman, Eun-Jin Lee, Jonathan H Lin

{"title":"Dysregulation of Retinal and Photoreceptor Structural Integrity Genes in ATF6-/- Retinal Organoids.","authors":"Allyssa Bradley, Masako Le, Soyeon Park, Heike Kroeger, R Luke Wiseman, Eun-Jin Lee, Jonathan H Lin","doi":"10.1007/978-3-031-76550-6_66","DOIUrl":"10.1007/978-3-031-76550-6_66","url":null,"abstract":"ATF6 is a key regulator of the unfolded protein response (UPR) pathway that maintains cellular homeostasis during ER stress. In people, loss of ATF6 function causes cone dysfunction, manifesting as achromatopsia (ACHM). Previously, we generated ACHM retinal organoids (ROs) from patient induced pluripotent stem cells (iPSCs) carrying mutant ATF6 variants and gene-edited ATF6-knockout (KO) human embryonic stem cells (hESCs). ACHM and ATF6-KO ROs both showed severe stunting of cone inner and outer segments. RNA-Seq analysis of ACHM 290-day-old ROs showed downregulated cone gene expression and dysregulated mitochondria and ER stress gene expression. Here, we analyzed RNA-Seq analysis of 203-day-old ATF6-KO ROs. In younger ROs, we found dysregulation of genes involved in retinal and photoreceptor structural integrity, including CRB1, EGFLAM, and VTN. In addition, we found dysregulation of ATF6 and UPR-regulated transcriptional signatures. Dysregulation of retinal and photoreceptor structural integrity genes may underlie the observed stunting of cone inner/outer segments in ATF6-achromatopsia patients.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1468 ","pages":"401-407"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Histone Modifications in Inherited Retinal Disorders. 探讨组蛋白修饰在遗传性视网膜疾病中的作用。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-76550-6_31

Luigi Mazzeo, Yvan Arsenijevic, Adeline Berger

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Periodontal Treatment to Improve General Health and Manage Systemic Diseases. 牙周治疗改善一般健康和管理全身性疾病。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-79146-8_15

Yanlin Zeng, Dongjia Lin, Aijia Chen, Yang Ning, Xiaolan Li

{"title":"Periodontal Treatment to Improve General Health and Manage Systemic Diseases.","authors":"Yanlin Zeng, Dongjia Lin, Aijia Chen, Yang Ning, Xiaolan Li","doi":"10.1007/978-3-031-79146-8_15","DOIUrl":"10.1007/978-3-031-79146-8_15","url":null,"abstract":"Periodontitis is increasingly recognized for its role in overall health and its associations with systemic conditions. Shared etiological factors, including microbiological, immunological, genetic, and environmental influences, have prompted interest in the potential impact of periodontal therapy on broader health outcomes. The oral microbiome plays a key role in the pathogenesis of periodontitis, with microbial imbalances (dysbiosis) contributing to inflammation and systemic disease progression. Additionally, immune responses to periodontal infection, such as chronic inflammation and dysregulated immune activity, are central to linking periodontitis with conditions like diabetes, cardiovascular disease, and autoimmune disorders. This chapter explores the connections between periodontal treatment and systemic diseases, such as diabetes, rheumatoid arthritis, cardiovascular disease, chronic kidney disease, Alzheimer's disease, digestive disorders, and respiratory disease. It also reviews the current research on the mechanisms, including microbial and immune factors, that underlie these associations. By emphasizing the role of periodontal health, the oral microbiome, and immune regulation in disease prevention and management, this chapter underscores the importance of integrated healthcare approaches to improve patient outcomes.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1472 ","pages":"245-260"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D-Bioprinted Skin Tissues for Improving Wound Healing: Current Status and Perspective. 用于改善伤口愈合的三维生物打印皮肤组织：现状与展望。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-01-01 DOI: 10.1007/5584_2024_817

Nikita Gopakumar, Abdulla M Ali, Sumayah Oudda, Amarnath Singam, Seungman Park

引用次数: 0

Thymus Ontogeny and Development. 胸腺个体发生与发育。

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Advances in experimental medicine and biology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-77921-3_2

Sara Montero-Herradón, Javier García-Ceca, Agustín G Zapata

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Antimicrobial Potential of Cocos nucifera (Coconut) Oil on Bacterial Isolates. 椰子油对细菌分离物的抑菌潜力。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-01-01 DOI: 10.1007/5584_2023_786

Vibha Bhardwaj

{"title":"Antimicrobial Potential of Cocos nucifera (Coconut) Oil on Bacterial Isolates.","authors":"Vibha Bhardwaj","doi":"10.1007/5584_2023_786","DOIUrl":"10.1007/5584_2023_786","url":null,"abstract":"This study investigates the in vitro antibacterial activity of coconut oil on selected clinical and pure bacterial isolates. Clinical samples were isolated from the people of Ras Al Khaimah, United Arab Emirates. Biochemical examination of the microorganisms was done according to standard methods. Pure bacterial cultures were provided from LTA srl Italia. In this research work, an effort has been made to highlight the valuable properties of Cocos nucifera oil, in order to rationalize the use of coconut oil against bacteria. Experiments were performed by agar well diffusion method. Ciprofloxacin was used as a standard antibiotic. The assay of antibacterial activity of clinical isolate of Streptococcus species showed the highest susceptibility to coconut oil while Escherichia coli had the least. This study endorses the use of coconut oil as therapeutic agent since it contains lauric acid which is bactericidal. The utilization of coconut oil should be promoted as a functional food and the use of coconut seed flesh in our diets should be encouraged for health-supporting functions. Further studies should be done on the oil and its derivatives both in vitro and in vivo to unveil their mechanism of action.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":" ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10021809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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PI3K Signaling at the Crossroads of Lipid Metabolism and Cancer. PI3K信号在脂质代谢和癌症的十字路口。

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Advances in experimental medicine and biology Pub Date : 2025-01-01 DOI: 10.1007/5584_2024_832

Sevval Yilmaz, Onur Cizmecioglu

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Immune Microenvironment in Breast Cancer Metastasis. 乳腺癌转移中的免疫微环境

4区医学

Advances in experimental medicine and biology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-70875-6_20

Bin-Zhi Qian, Ruo-Yu Ma

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Cellular Senescence: An Emerging Player in the Pathogenesis of AMD. 细胞衰老：AMD发病机制中的一个新兴参与者。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-76550-6_6

Vilas Wagh, Nivedita Damodaren, Sharad K Mittal, Fabian L Cardenas-Diaz, Hong Sun, Alexander V Loktev, Vanessa M Peterson, Janmeet S Saini

{"title":"Cellular Senescence: An Emerging Player in the Pathogenesis of AMD.","authors":"Vilas Wagh, Nivedita Damodaren, Sharad K Mittal, Fabian L Cardenas-Diaz, Hong Sun, Alexander V Loktev, Vanessa M Peterson, Janmeet S Saini","doi":"10.1007/978-3-031-76550-6_6","DOIUrl":"10.1007/978-3-031-76550-6_6","url":null,"abstract":"Age-related macular degeneration (AMD) is the leading cause of blindness in the aged population. The accumulation of abnormal extracellular drusen deposits between the retinal pigment epithelium (RPE) and Bruch's membrane is a significant driver of AMD pathology. Drusen deposition leads to the degeneration of RPE cells and, subsequently, photoreceptors, driving the disease to its advanced stages and ultimately resulting in complete vision loss. Although the exact mechanisms underlying the AMD pathogenesis are not fully understood, it is hypothesized that the disease begins with the dysfunction of the RPE, triggering the complement and pro-inflammatory cascade. Over the last decade, new findings have implicated the involvement of cellular senescence (CS) in the pathology of age-related disorders. Specifically for AMD, evidence suggests that the senescence of RPE cells may play a role in the pathogenesis of the disease. In this review, we discuss the potential role of senescence in the onset and progression of AMD and propose potential therapeutic interventions that could be developed by targeting senescence.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1468 ","pages":"33-37"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunogenic Switch of RPE Cells. RPE细胞的免疫原性开关。

4区医学

Advances in experimental medicine and biology Pub Date : 2025-01-01 DOI: 10.1007/978-3-031-76550-6_61

Andjela Sekulic, Gerhild Wildner, Christine Skerka, Olaf Strauß

{"title":"Immunogenic Switch of RPE Cells.","authors":"Andjela Sekulic, Gerhild Wildner, Christine Skerka, Olaf Strauß","doi":"10.1007/978-3-031-76550-6_61","DOIUrl":"10.1007/978-3-031-76550-6_61","url":null,"abstract":"The barrier function of the retinal pigment epithelium (RPE) secures a highly selective exchange of molecules between the blood stream of the choroid and retina but also maintenance of the immune privilege of the retina. The latter function includes a mechanical barrier through the tight junctions and immune barrier of either membrane bound or secreted immune-suppressive factors in response to increasing inflammatory activities in the outer retina. However, in disease, both physical and immune barriers are compromised to allow accumulation of immune cells in the subretinal space or even to pass across the RPE into the retinal space. The ability of the RPE to secrete immune stimulatory factors such as MCP-1, as a response to the increased inflammation, suggests that disease goes along with an immunogenic switch. We recently found that stressed RPE cells express the transcription factor FoxP3 and its activation leads to secretion of pro-inflammatory factors. Indeed, RPE cells in either mouse models with age-related macular degeneration (AMD) relevance or in retinas from AMD patients, express FoxP3 in the RPE, which was not observed in healthy donors. FoxP3 appears first as a rescue factor for the RPE in the increasing presence of pro-inflammatory proteins such as IL1β or active complement that eventually changes the immunogenic phenotype from anti-inflammatory to pro-inflammatory.","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1468 ","pages":"369-373"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0