Antifungal Stewardship in Invasive Fungal Infections, a Systematic Review.

4区医学 Q2 Biochemistry, Genetics and Molecular Biology

Advances in experimental medicine and biology Pub Date : 2024-02-10 DOI:10.1007/5584_2024_798

Cataldo Procacci, Luisa Marras, Leonarda Maurmo, Grazia Vivanet, Luca Scalone, Giacomo Bertolino

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引用次数: 0

Abstract

Introduction: Invasive fungal infections (IFI) are a group of life-threatening diseases associated with significant morbidity, mortality and high healthcare costs. Some modern management programs known as AFS (antifungal stewardship programs) have now been developed. The purpose of this systematic review is to evaluate the different declinations of antifungal stewardship programs (AFPs).

Methods: Articles were systematically reviewed using the PRISMA checklist 2020. EMBASE and MEDLINE/PubMED were searched using the term "antifungal stewardship" (2012-2022 data) on 2 January 2023. Eligible studies were those that described an AFS and included an intervention, performance evaluation and outcome measures.

Results: A total of 22/796 studies were included. Approximately two-thirds (16) were published between 2018 and 2022. 16 (72.7%) stated a minimal complete AFS team. 12 (54.5%) adopted a non-compulsory AFS approach, 6(27.3%) had an Educational AFS and 4(18.2%) a compulsory AFS. Cost analyses of 12 studies showed a decrease for 7 (31.8%) compared to an increase for 5 (22.7%). In terms of outcomes, 18 studies showed a lower (10;45.5%) or the same (8;36.4%) pre-post intervention mortality rate.

Conclusion: AFS programs seem to be related to lower costs and better outcomes and should thus be implemented in tandem with antimicrobial stewardship programs.

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侵袭性真菌感染中的抗真菌管理，系统综述。

导言：侵袭性真菌感染（IFI）是一组威胁生命的疾病，具有显著的发病率、死亡率和高昂的医疗费用。目前，一些被称为 AFS（抗真菌管理计划）的现代管理计划已经开发出来。本系统性综述旨在评估抗真菌管理计划（AFPs）的不同衰减情况：方法：采用 2020 年 PRISMA 检查表对文章进行系统性综述。于 2023 年 1 月 2 日使用 "抗真菌管理 "一词（2012-2022 年数据）检索 EMBASE 和 MEDLINE/PubMED。符合条件的研究是那些描述了 AFS 并包括干预措施、绩效评估和结果测量的研究：结果：共纳入 22/796 项研究。约三分之二（16 项）的研究发表于 2018 年至 2022 年之间。16项（72.7%）阐述了一个最基本完整的AFS团队。12项（54.5%）采用非强制AFS方法，6项（27.3%）采用教育AFS，4项（18.2%）采用强制AFS。12 项研究的成本分析表明，7 项研究（31.8%）的成本有所下降，而 5 项研究（22.7%）的成本有所上升。在结果方面，18 项研究显示干预前死亡率降低（10；45.5%）或相同（8；36.4%）：AFS计划似乎与降低成本和改善疗效有关，因此应与抗菌药物管理计划同时实施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in experimental medicine and biology 医学-医学：研究与实验

CiteScore

5.90

自引率

0.00%

发文量

465

审稿时长

2-4 weeks

期刊介绍： Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.