{"title":"将连接蛋白生物学作为治疗视网膜疾病的靶点。","authors":"Alicia Domenech-Bendaña, Nicolle Salazar, Antonella Locascio, Alejandro Ponce-Mora, Lucía Gimeno-Mallench, Eloy Bejarano","doi":"10.1007/978-3-031-76550-6_79","DOIUrl":null,"url":null,"abstract":"<p><p>Gap junctions are intercellular channels formed by structural elements called connexins. These intercellular channels play a key role in retinal homeostasis by enabling the exchange of metabolites between neighbouring cells. Several connexins are expressed in different retinal cells, suggesting that the permeability properties of the channels and their physiological relevance could be cell-type dependent. Many studies have revealed that dysfunctional gap junction activity contributes to the development and worsening of retinal diseases. Unravelling the complexity of the retinal connexins' biology is essential to designing effective therapeutic strategies. For instance, new drugs or connexin mimetic peptides that selectively modulate connexin isoforms in each cell type are currently explored as therapeutic options for retinal diseases. To date, Cx43 mimetic peptides have been tested for the treatment of different retinal pathologies.</p>","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1468 ","pages":"485-489"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Targeting Connexins Biology as Therapeutic Strategies Against Retinal Diseases.\",\"authors\":\"Alicia Domenech-Bendaña, Nicolle Salazar, Antonella Locascio, Alejandro Ponce-Mora, Lucía Gimeno-Mallench, Eloy Bejarano\",\"doi\":\"10.1007/978-3-031-76550-6_79\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Gap junctions are intercellular channels formed by structural elements called connexins. These intercellular channels play a key role in retinal homeostasis by enabling the exchange of metabolites between neighbouring cells. Several connexins are expressed in different retinal cells, suggesting that the permeability properties of the channels and their physiological relevance could be cell-type dependent. Many studies have revealed that dysfunctional gap junction activity contributes to the development and worsening of retinal diseases. Unravelling the complexity of the retinal connexins' biology is essential to designing effective therapeutic strategies. For instance, new drugs or connexin mimetic peptides that selectively modulate connexin isoforms in each cell type are currently explored as therapeutic options for retinal diseases. To date, Cx43 mimetic peptides have been tested for the treatment of different retinal pathologies.</p>\",\"PeriodicalId\":7270,\"journal\":{\"name\":\"Advances in experimental medicine and biology\",\"volume\":\"1468 \",\"pages\":\"485-489\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in experimental medicine and biology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/978-3-031-76550-6_79\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in experimental medicine and biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/978-3-031-76550-6_79","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
Targeting Connexins Biology as Therapeutic Strategies Against Retinal Diseases.
Gap junctions are intercellular channels formed by structural elements called connexins. These intercellular channels play a key role in retinal homeostasis by enabling the exchange of metabolites between neighbouring cells. Several connexins are expressed in different retinal cells, suggesting that the permeability properties of the channels and their physiological relevance could be cell-type dependent. Many studies have revealed that dysfunctional gap junction activity contributes to the development and worsening of retinal diseases. Unravelling the complexity of the retinal connexins' biology is essential to designing effective therapeutic strategies. For instance, new drugs or connexin mimetic peptides that selectively modulate connexin isoforms in each cell type are currently explored as therapeutic options for retinal diseases. To date, Cx43 mimetic peptides have been tested for the treatment of different retinal pathologies.
期刊介绍：
Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.
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