ADMET and DMPK最新文献

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Exploring hepatic stellate cell-driven fibrosis: therapeutic advances and future perspectives. 探索肝星状细胞驱动纤维化:治疗进展和未来展望。
IF 4.3
ADMET and DMPK Pub Date : 2025-08-04 eCollection Date: 2025-01-01 DOI: 10.5599/admet.2874
Alka Singh, Ansab Akhtar, Prashant Shukla
{"title":"Exploring hepatic stellate cell-driven fibrosis: therapeutic advances and future perspectives.","authors":"Alka Singh, Ansab Akhtar, Prashant Shukla","doi":"10.5599/admet.2874","DOIUrl":"10.5599/admet.2874","url":null,"abstract":"<p><strong>Background and purpose: </strong>Liver fibrosis, a progressive liver disease arising from viral or metabolic causes, poses a major global health challenge due to its potential progression to cirrhosis and hepatocellular carcinoma. Due to the complex aetiology and epidemiology of liver fibrosis, most therapies fail in the clinic, and very few drugs have been approved by the US FDA.</p><p><strong>Approach: </strong>This review highlights the pathophysiological features of liver fibrosis, with a focus on novel targets in hepatic stellate cells (HSCs), key players in the fibrogenesis process, to develop successful therapeutic approaches using both pharmacological agents and active targeting strategies. The review also examines current therapeutic strategies targeting liver fibrosis, both in preclinical lab setups and clinical trials. Furthermore, various receptors involved in HSC-mediated liver fibrosis and active drug delivery targeting strategies are reviewed to enhance therapeutic outcomes. This article also integrates existing knowledge to identify research gaps and guide future investigations and clinical translation in liver fibrosis treatment. In addition, novel pathways pertaining to liver fibrosis, such as the RSPO3-LGR4/5-β-catenin cascade, the CD47/YAP/TEAD4 signalling axis, and HAb18G/CD147, are briefly elaborated in the context of therapeutic approaches for arresting HSC activation. Single-cell RNA sequencing of HSCs is presented to provide a clearer picture of liver fibrosis.</p><p><strong>Conclusion: </strong>The review highlights critical research gaps in liver fibrosis therapy and promising active targeting strategies and pharmacological interventions to improve therapeutic outcomes. Overall, this review provides a robust foundation for scientists and clinicians to advance active targeting of the disease pathology and to develop new pharmaceutical formulations that are pharmacologically safer and more efficacious.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"13 4","pages":"2874"},"PeriodicalIF":4.3,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bile micelle binding of structurally diverse ionized drug molecules. 胆汁胶束结合的结构不同的电离药物分子。
IF 4.3
ADMET and DMPK Pub Date : 2025-07-22 eCollection Date: 2025-01-01 DOI: 10.5599/admet.2802
Mayu Konishi, Kiyohiko Sugano
{"title":"Bile micelle binding of structurally diverse ionized drug molecules.","authors":"Mayu Konishi, Kiyohiko Sugano","doi":"10.5599/admet.2802","DOIUrl":"10.5599/admet.2802","url":null,"abstract":"<p><strong>Background and purpose: </strong>Predicting the food effect on oral drug absorption by physiologically based biopharmaceutical modelling (PBBM) remains challenging. The bile micelle unbound fraction (<i>f</i> <sub>u</sub>) is one of the primary determinants of the negative food effect for high solubility drugs. To calculate the pH-<i>f</i> <sub>u</sub> profile for PBBM, the bile micelle partition coefficients of ionized and un-ionized drug species (<i>K</i> <sub>bm,z</sub>, <i>z</i>: charge) are required. The general rules for the ratio of the partition coefficients of ionized and un-ionized drug species have been reported for the octanol/water (<i>P</i> <sub>oct</sub>) and phosphatidylcholine liposome/water partition coefficients. However, the general rule for the bile micelle partition coefficient has not yet been investigated. The purpose of the present study was to clarify the general rule for <i>K</i> <sub>bm,<i>z</i>≠0</sub>/<i>K</i> <sub>bm,0</sub>.</p><p><strong>Experimental approach: </strong>The pH-<i>f</i> <sub>u</sub> profiles of 4 monovalent weak acids, 8 monovalent weak bases, 2 divalent weak bases, and 2 zwitterion drugs were measured by dynamic dialysis in the pH range about p<i>K</i> <sub>a</sub> ± 2. Bile micelles consisted of taurocholic acid (TC)/egg lecithin (15 mM/ 3.75 mM). <i>K</i> <sub>bm,<i>z</i></sub> was calculated from the pH-<i>f<sub>u</sub></i> profiles.</p><p><strong>Key results: </strong><i>K</i> <sub>bm,-1</sub>/<i>K</i> <sub>bm,0</sub> was ≤ 0.03 for all monovalent acids. <i>K</i> <sub>bm,+1</sub>/<i>K</i> <sub>bm,0</sub> ranged from 0.24 to 2.6. <i>K</i> <sub>bm,+2</sub>/<i>K</i> <sub>bm,0</sub> was about 0.3. For the two zwitterionic drugs, <i>K</i> <sub>bm,-1</sub>/<i>K</i> <sub>bm,±0</sub> was 1.1 and 2.3, and <i>K</i> <sub>bm,+1</sub>/<i>K</i> <sub>bm,±0</sub> was 3.9 and 20, respectively. <i>K</i> <sub>bm,0</sub> roughly correlated with <i>P</i> <sub>oct</sub> (r = 0.68).</p><p><strong>Conclusion: </strong>The bile micelle binding of anionic drug species (<i>z</i> = -1) is generally negligible, whereas that of cationic drug species (<i>z</i> = +1) can be significant. A general rule for <i>K</i> <sub>bm,+1</sub>/<i>K</i> <sub>bm,0</sub> was not found. <i>K</i> <sub>bm,+1</sub>/<i>K</i> <sub>bm,0</sub> can be greater than 1 in several cases, suggesting an attractive electrostatic interaction between the positive charge of a drug and the negative charge of TC. These points should be considered in food effect prediction.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"13 4","pages":"2802"},"PeriodicalIF":4.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monolayer graphene/platinum-modified 3D origami microfluidic paper-based biosensor for smartphone-assisted biomarkers detection. 用于智能手机辅助生物标志物检测的单层石墨烯/铂改性3D折纸微流控纸生物传感器。
IF 4.3
ADMET and DMPK Pub Date : 2025-07-20 eCollection Date: 2025-01-01 DOI: 10.5599/admet.2833
Arda Fridua Putra, Annisa Septyana Ningrum, Suyanto, Vania Mitha Pratiwi, Muhammad Yusuf Hakim Widianto, Irkham, Wulan Tri Wahyuni, Isnaini Rahmawati, Fu-Ming Wang, Chi-Hsien Huang, Ruri Agung Wahyuono
{"title":"Monolayer graphene/platinum-modified 3D origami microfluidic paper-based biosensor for smartphone-assisted biomarkers detection.","authors":"Arda Fridua Putra, Annisa Septyana Ningrum, Suyanto, Vania Mitha Pratiwi, Muhammad Yusuf Hakim Widianto, Irkham, Wulan Tri Wahyuni, Isnaini Rahmawati, Fu-Ming Wang, Chi-Hsien Huang, Ruri Agung Wahyuono","doi":"10.5599/admet.2833","DOIUrl":"10.5599/admet.2833","url":null,"abstract":"<p><strong>Background and purpose: </strong>Imbalances in biomarkers such as dopamine and NADH are linked to neurological and metabolic disorders, including Parkinson's disease, depression, and stroke, underscoring the need for rapid and accessible diagnostics. This study presents a smartphone-assisted, 3D origami microfluidic paper-based analytical device (μPAD) modified with photochemically synthesized graphene/platinum (G/Pt) nanocatalysts for multiplex colorimetric detection of dopamine and NADH.</p><p><strong>Experimental approach: </strong>G/Pt catalysts were prepared using 2.5 to 10 mM Pt precursors under UV irradiation. μPADs were laser-printed on commercial-grade filter paper, patterned, and folded into three layers of 3D Origami.</p><p><strong>Key results: </strong>The optimized 10 mM G/Pt catalyst significantly improved reaction rates (18× faster), leading to a rapid detection time constant of 6.69 and 4.59 s for dopamine and NADH, respectively. Furthermore, the utilization of 10 mM G/Pt catalyst increased colour intensity (2.48×) on the μPAD platform. An application for smartphones integrated with an image processing algorithm was developed using Kotlin to enable automatic quantification of colorimetric signals from saturation and hue channels for dopamine and NADH, respectively. The detection exhibited the lowest mean absolute percentage errors of 0.52 and 0.07 % as well as a limit of detection of 0.56 and 0.99 mM for dopamine and NADH, respectively.</p><p><strong>Conclusion: </strong>The 3D origami structure facilitates efficient fluid handling and multiplex detection, while the nanocatalyst modification improves pore infiltration and sensitivity. This work demonstrates, for the first time, a cost-effective, portable, and high-performance biosensor for dual biomarker detection, offering substantial promise for point-of-care diagnostics in neurological and metabolic health monitoring.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"13 4","pages":"2833"},"PeriodicalIF":4.3,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrochemical sensors for anticancer drugs used in the targeted therapy of chronic myeloid leukaemia. 用于慢性髓性白血病靶向治疗抗癌药物的电化学传感器。
IF 4.3
ADMET and DMPK Pub Date : 2025-07-18 eCollection Date: 2025-01-01 DOI: 10.5599/admet.2825
Totka Dodevska
{"title":"Electrochemical sensors for anticancer drugs used in the targeted therapy of chronic myeloid leukaemia.","authors":"Totka Dodevska","doi":"10.5599/admet.2825","DOIUrl":"10.5599/admet.2825","url":null,"abstract":"<p><strong>Background and purpose: </strong>Treatment of chronic myeloid leukaemia includes targeted therapy with tyrosine kinase inhibitors (TKIs): imatinib, dasatinib, nilotinib, bosutinib, ponatinib, and asciminib. This review aims to prove that electrochemical sensors provide a reliable alternative to the conventional analytical methods for highly sensitive and cost-effective assay of TKIs in pharmaceutical formulations and biofluids. These platforms have significant advantages in fast detection and portability because they could be designed as miniaturized hand-held devices suitable for real-time point-of-care analysis, providing quick results for enabling personalized therapeutic drug monitoring.</p><p><strong>Experimental approach: </strong>The paper covers recent developments in substrate materials, various electrode designs, the advantages, and limitations of sensors for TKIs, encompassing both basic and applied research.</p><p><strong>Key results: </strong>This is a pioneering study that provides a general review on emerging trends, technologies, and practical applications of electrochemical sensors for TKIs analysis. The article provides researchers with a clear introduction and concise guide to the design and application of electrochemical sensors in the clinical analysis of TKIs.</p><p><strong>Conclusion: </strong>The review is intended to serve as a valuable resource for researchers in navigating the latest developments in TKIs' electrochemical sensing platforms. The fast response, high sensitivities and satisfactory recoveries obtained in blood serum and urine samples show the potential for application of the proposed electroanalytical systems in clinical analysis and optimization of chemotherapeutic treatments.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"13 4","pages":"2825"},"PeriodicalIF":4.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nano-modified biosensors for detection of pathogenic diseases: The prospect of smart, multiplex and point-of-care testing. 用于检测致病性疾病的纳米修饰生物传感器:智能、多重和即时检测的前景。
IF 4.3
ADMET and DMPK Pub Date : 2025-07-09 eCollection Date: 2025-01-01 DOI: 10.5599/admet.2799
Abdullahi Umar Ibrahim, Pwadubashiyi Coston Pwavodi, Mehmet Oszoz, Basil Barth Duwa, Irkham Irkham, Yeni Wahyuni Hartati
{"title":"Nano-modified biosensors for detection of pathogenic diseases: The prospect of smart, multiplex and point-of-care testing.","authors":"Abdullahi Umar Ibrahim, Pwadubashiyi Coston Pwavodi, Mehmet Oszoz, Basil Barth Duwa, Irkham Irkham, Yeni Wahyuni Hartati","doi":"10.5599/admet.2799","DOIUrl":"10.5599/admet.2799","url":null,"abstract":"<p><strong>Introduction and background: </strong>The world has witnessed several outbreaks, emergence and re-emergence of infectious diseases throughout the 21<sup>st</sup> century as a result of climate change, urbanization and migration. Several infectious diseases caused by pathogens such as SARS-CoV-2, Ebola, Zika, Dengue, Marburg viruses, <i>Mycobacterium tuberculosis</i>, etc. have caused a devastating impact on lives and livelihoods around the world. To counter these diseases, medical experts rely on conventional techniques, which include microscopy and serological testing. However, these conventional methods are hindered by several trade-offs, including high cost, longer processing times, low sensitivity, and a likelihood of false positive results. Biomedical sensors have gained momentum in clinical diagnostics due to their low cost, portability, and sensitivity, among other advantages. To improve their performance, scientists have incorporated nanomaterials. Other techniques used to enhance the performance of nanobiosensors include multiplex testing, point-of-care testing (POCT), and smart sensing.</p><p><strong>Methodology: </strong>Thus, in this review, we present a comprehensive overview of the state-of-the-art nanobiosensors for detecting infectious diseases. The review covers key topics that are centred around the application of nanotechnology in biosensing, multiplex testing, POCT and smart nano-enhanced biosensors.</p><p><strong>Findings: </strong>The findings of this review highlighted the advantages of biosensors over conventional approaches, with a limit of detection ranging from nanomolar to attomolar concentrations and a time response ranging from 1 to 3 hours.</p><p><strong>Conclusion: </strong>Despite the prospect of nanobiosensors, several limitations exist, including complexity, extensive processing time, and others. Moreover, the integration of smart technologies in nanobiosensors can offer several benefits, including high accuracy and faster detection and prediction.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"13 4","pages":"2799"},"PeriodicalIF":4.3,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fabrication and optimization of freeze-dried isoniazid-loaded poly-ε-caprolactone nanoparticles. 冷冻干燥负载异烟肼聚ε-己内酯纳米颗粒的制备与优化。
IF 4.3
ADMET and DMPK Pub Date : 2025-07-08 eCollection Date: 2025-01-01 DOI: 10.5599/admet.2774
Eknath Kole, Yuvraj Pawara, Atul Chaudhari, Aniruddha Chatterjee, Jitendra Naik
{"title":"Fabrication and optimization of freeze-dried isoniazid-loaded poly-<i>ε</i>-caprolactone nanoparticles.","authors":"Eknath Kole, Yuvraj Pawara, Atul Chaudhari, Aniruddha Chatterjee, Jitendra Naik","doi":"10.5599/admet.2774","DOIUrl":"10.5599/admet.2774","url":null,"abstract":"<p><strong>Background: </strong>Microfluidic nanoprecipitation followed by freeze-drying would yield uniformly sized, stable nanoparticles by preserving their physicochemical property without compromising therapeutic performance. The isoniazid (INH)-loaded poly-<i>ε</i>-caprolactone (PCL) nanoparticles could be developed using a microfluidic technique for the management of tuberculosis.</p><p><strong>Experimental approach: </strong>The INH-loaded nanoparticles were fabricated via a microreactor-assisted nanoprecipitation method and optimization using a design of experiments factorial design approach. The resulting INH-PCL nanoformulation was characterized for particle size, polydispersity index (PDI), zeta potential (surface charge), Fourier-transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction analysis and field emission scanning electron microscope.</p><p><strong>Key results: </strong>The optimized nanoparticles exhibited an average particle size (248.4 ± 5.372 nm) and high encapsulation efficiency (82.26 ± 4.36 %). Thermal and spectroscopic analyses confirmed the absence of drug-polymer interactions, ensuring formulation integrity; stability studies under accelerated conditions demonstrated negligible changes in particle size, PDI, and zeta potential over the period of 6 months, indicating robust colloidal stability. A scanning electron microscopy study revealed rod-shaped nanoparticles with smooth surfaces. Lyophilization (freeze-drying) enhanced long-term stability, yielding a readily re-dispersible powder (reconstitution index ~1.066). Following diffusion-controlled kinetics, in vitro drug release studies in phosphate buffer saline (pH 7.4) showed sustained drug release (92.45 % cumulative release over 48 h).</p><p><strong>Conclusion: </strong>Our results confirm that the INH-loaded PCL nanoformulation combines excellent stability, high drug-loading capacity, and sustained release, key attributes of effective tuberculosis therapy.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"13 4","pages":"2774"},"PeriodicalIF":4.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of lipophilic and size-exclusion membranes: the effect of stirring and cyclodextrin in the donor compartment. 亲脂膜和阻粒膜的比较:搅拌和环糊精对供体隔室的影响。
IF 4.3
ADMET and DMPK Pub Date : 2025-07-05 eCollection Date: 2025-01-01 DOI: 10.5599/admet.2753
Petra Tőzsér, Szabina Kádár, Edina Szabó, Máté Dobó, Gergő Tóth, György T Balogh, Péter Sóti, Bálint Sinkó, Enikő Borbás
{"title":"Comparison of lipophilic and size-exclusion membranes: the effect of stirring and cyclodextrin in the donor compartment.","authors":"Petra Tőzsér, Szabina Kádár, Edina Szabó, Máté Dobó, Gergő Tóth, György T Balogh, Péter Sóti, Bálint Sinkó, Enikő Borbás","doi":"10.5599/admet.2753","DOIUrl":"10.5599/admet.2753","url":null,"abstract":"<p><strong>Background and purpose: </strong>The effective transport of an active pharmaceutical ingredient across various membrane systems is critical for enhancing its bioavailability, especially in formulations involving solubilizing agents. This study aims to investigate the permeability differences of carvedilol (CAR) between lipophilic and size-exclusion membranes in the presence of hydroxypropyl-beta-cyclodextrin (HP-β-CD) using <i>in vitro</i> side-by-side diffusion cell assays.</p><p><strong>Experimental approach: </strong>Solubility and permeability assays confirmed that HP-β-CD significantly enhanced the solubility of CAR, while simultaneously decreasing its permeability, indicating an interplay between the two parameters.</p><p><strong>Key results: </strong>A mathematical model based on Fick's first law of diffusion was developed to describe drug transport across the UWL, and generally through the UWL-membrane system, with a particular focus on the role of solubilizing agents.</p><p><strong>Conclusion: </strong>Results from both the UWL and membrane limited transport conditions demonstrated that the supersaturation ratio (SSR, defined as the ratio of the drug concentration present in solution to its thermodynamic solubility measured in exactly the same media) between donor and acceptor compartments is the real driving force of the transport, when the complexing agent and the drug- HP-β-CD complex does not penetrate the membrane or the permeation of the solubilizing additive through the membrane is relatively slow, so it does not affect the transport of the API substantially.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"13 4","pages":"2753"},"PeriodicalIF":4.3,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphine electrochemical determination using SnO2 nanostructure-modified glassy carbon electrode in the presence of diclofenac. 双氯芬酸存在下,SnO2纳米结构修饰玻碳电极电化学测定吗啡。
IF 4.3
ADMET and DMPK Pub Date : 2025-07-02 eCollection Date: 2025-01-01 DOI: 10.5599/admet.2803
Zainab S Hadawi, Isam Ngaimesh Taeb, Rasha N Aljabery
{"title":"Morphine electrochemical determination using SnO<sub>2</sub> nanostructure-modified glassy carbon electrode in the presence of diclofenac.","authors":"Zainab S Hadawi, Isam Ngaimesh Taeb, Rasha N Aljabery","doi":"10.5599/admet.2803","DOIUrl":"10.5599/admet.2803","url":null,"abstract":"<p><p>In the present work, SnO<sub>2</sub> nanostructures were synthesized and a sensitive voltammetric sensor on a glassy carbon electrode (GCE) was constructed to estimate morphine (MP) in the presence of diclofenac (DLF).</p><p><strong>Background and purpose: </strong>Because diclofenac (DLF) is an NSAID, its administration can reduce postoperative morphine (MP) requirements in adults; for example, standard DLF dosing has been shown to decrease MP use after abdominal surgery. Hence, devising a simple, cost-effective, and swift assay for these compounds in biological and pharmaceutical specimens is indispensable.</p><p><strong>Experimental approach: </strong>SnO<sub>2</sub> nanostructures were synthesized, and a sensitive voltammetric sensor on a glassy carbon electrode (GCE) was constructed to estimate MP in the presence of DLF. Cyclic voltammetry was employed to evaluate the electrochemical response of the SnO2 nanostructures/GCE towards MP.</p><p><strong>Key results: </strong>The SnO<sub>2</sub> nanostructures exhibited a significant effect on the electrochemical reaction of the electrode toward the MP oxidation. The SnO<sub>2</sub> nanostructures/GCE further exhibited a more sensitive detection platform for MP determination with a limit of detection of 0.006 μM using differential pulse voltammetry in a linear range of 0.01 to 340.0 μM.</p><p><strong>Conclusion: </strong>The SnO<sub>2</sub> nanostructures/GCE exhibited extremely high electrochemical activities towards the simultaneous oxidation of MP and DLF. Moreover, the SnO<sub>2</sub> nanostructures/GCE provided reproducible and stable responses for MP quantitation. The platform prepared showed successful performance for MP and DLF determination in real samples. SnO<sub>2</sub> nanostructures exhibited a significant effect on the electrochemical reaction of the electrode toward the MP oxidation. The SnO<sub>2</sub> nanostructures/GCE further exhibited a more sensitive detection platform for MP determination with a limit of detection of 0.006 μM using differential pulse voltammetry in a linear range of 0.01 to 340.0 μM. Additionally, the SnO<sub>2</sub> nanostructures/GCE exhibited extremely high electrochemical activities towards the simultaneous oxidation of MP and DLF. Moreover, the SnO<sub>2</sub> nanostructures/GCE provided reproducible and stable responses for MP quantitation. The platform prepared showed successful performance for MP and DLF determination in real samples.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"13 4","pages":"2803"},"PeriodicalIF":4.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous determination of epinephrine and folic acid using MIL-101 (Fe)-NH2 metal-organic framework/graphene oxide nanocomposite modified electrode. MIL-101 (Fe)-NH2金属-有机骨架/氧化石墨烯纳米复合修饰电极同时测定肾上腺素和叶酸。
IF 3.4
ADMET and DMPK Pub Date : 2025-06-19 eCollection Date: 2025-01-01 DOI: 10.5599/admet.2762
Rasha Kareem Khundhur
{"title":"Simultaneous determination of epinephrine and folic acid using MIL-101 (Fe)-NH<sub>2</sub> metal-organic framework/graphene oxide nanocomposite modified electrode.","authors":"Rasha Kareem Khundhur","doi":"10.5599/admet.2762","DOIUrl":"10.5599/admet.2762","url":null,"abstract":"<p><strong>Background and purpose: </strong>It is generally known that the majority of disorders exhibit symptoms to some degree when the quantities of two crucial substances, epinephrine and folic acid, are low or high. These two chemicals' composition variations may be tracked and utilized to identify conditions such as myocardial infarction, Parkinson's disease, and mental disorders.</p><p><strong>Experimental approach: </strong>Using a solvothermal technique, we propose the synthesis of a novel MIL-101 (Fe)-NH<sub>2</sub> metal-organic framework/graphene oxide nanocomposite (MOF/GO nanocomposite). The produced nanocomposite's morphology was examined using field-emission scanning electron microscopy. A straightforward, quick, and sensitive electrochemical sensing platform for epinephrine detection was then created by drop-casting the produced MOF/GO nanocomposite onto the screen-printed electrode (SPE).</p><p><strong>Key results: </strong>Compared to unmodified SPE, cyclic voltammetry revealed that the MOF/GO/SPE considerably enhanced the epinephrine oxidation process, exhibiting a greater detection current at a lower over-potential. The synergistic combination of MOF and GO sheets may cause this discovery. With a low detection limit of 0.07 μM, the MOF/GO/SPE sensor's linear response for voltammetric measurements of epinephrine was found to be between 0.2 and 500.0 μM. A modified electrode was also utilized to measure folic acid and epinephrine simultaneously.</p><p><strong>Conclusion: </strong>Lastly, the modified SPE effectively demonstrates its high accuracy in identifying folic acid and epinephrine in biological and pharmaceutical samples.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"13 3","pages":"2762"},"PeriodicalIF":3.4,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuneable carbon dots coated iron oxide nanoparticles as superior T 1 contrast agent for multimodal imaging. 可调谐碳点包覆氧化铁纳米颗粒作为多模态成像的卓越t1造影剂。
IF 3.4
ADMET and DMPK Pub Date : 2025-06-18 eCollection Date: 2025-01-01 DOI: 10.5599/admet.2790
Anbazhagan Thirumalai, Palani Sharmiladevi, Koyeli Girigoswami, Alex Daniel Prabhu, Agnishwar Girigoswami
{"title":"Tuneable carbon dots coated iron oxide nanoparticles as superior <i>T</i> <sub>1</sub> contrast agent for multimodal imaging.","authors":"Anbazhagan Thirumalai, Palani Sharmiladevi, Koyeli Girigoswami, Alex Daniel Prabhu, Agnishwar Girigoswami","doi":"10.5599/admet.2790","DOIUrl":"10.5599/admet.2790","url":null,"abstract":"<p><strong>Background and purpose: </strong>Multifunctional hybrid nanoparticles garner heightened interest for prospective biomedical applications, including medical imaging and medication administration, owing to their synergistic benefits of constituent components. Therefore, we demonstrated an optimized protocol for synthesizing magnetofluorescent nanohybrids comprising fluorescent carbon dots with magnetic nanoparticles.</p><p><strong>Experimental approach: </strong>Carbon dot-coated iron oxide nanoparticles (CDs@Fe<sub>2</sub>O<sub>3</sub>) were synthesized with varying citric acid concentrations by a one-pot hydrothermal synthesis method for the development of a low-cost and biocompatible contrast agent (CA) for enhanced multimodal imaging (fluorescent and <i>T</i> <sub>1</sub> and <i>T</i> <sub>2</sub> weighted magnetic resonance imaging (MRI)) to replace the conventional CAs.</p><p><strong>Key results: </strong>The physicochemical characterization of the synthesized CDs@Fe<sub>2</sub>O<sub>3</sub> revealed that 3 g of citric acid used for the synthesis of nanoparticles, keeping Fe(II) and Fe(III) ratio 1:2 provides higher stability of -78 mV zeta potential, saturation magnetization of 24 emu/g, with a hydrodynamic diameter of 68 nm. Carbon coating affects surface spins on Fe<sub>2</sub>O<sub>3</sub>, resulting in fewer surface-based relaxation centres, making <i>T</i> <sub>1</sub> relaxation relatively more prominent. Furthermore, the surface-engineered iron oxide NPs are efficient in producing both <i>T</i> <sub>1</sub> and <i>T</i> <sub>2</sub> weighted MRI as well as fluorescence-based imaging. The molar relaxivity and molar radiant efficiency derived from phantom studies demonstrate their effectiveness in multimodal medical imaging. The cytotoxicity assay, haemolysis assay, haematology, and histopathology studies show that the optimized CDs@Fe<sub>2</sub>O<sub>3</sub> are biocompatible, haemocompatible, and negligibly toxic.</p><p><strong>Conclusion: </strong>We can conclude the significant potency of CDs@Fe<sub>2</sub>O<sub>3</sub> for multimodal diagnosis.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"13 3","pages":"2790"},"PeriodicalIF":3.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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