Simultaneous determination of epinephrine and folic acid using MIL-101 (Fe)-NH2 metal-organic framework/graphene oxide nanocomposite modified electrode.

IF 4.3 Q2 CHEMISTRY, MEDICINAL
ADMET and DMPK Pub Date : 2025-06-19 eCollection Date: 2025-01-01 DOI:10.5599/admet.2762
Rasha Kareem Khundhur
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引用次数: 0

Abstract

Background and purpose: It is generally known that the majority of disorders exhibit symptoms to some degree when the quantities of two crucial substances, epinephrine and folic acid, are low or high. These two chemicals' composition variations may be tracked and utilized to identify conditions such as myocardial infarction, Parkinson's disease, and mental disorders.

Experimental approach: Using a solvothermal technique, we propose the synthesis of a novel MIL-101 (Fe)-NH2 metal-organic framework/graphene oxide nanocomposite (MOF/GO nanocomposite). The produced nanocomposite's morphology was examined using field-emission scanning electron microscopy. A straightforward, quick, and sensitive electrochemical sensing platform for epinephrine detection was then created by drop-casting the produced MOF/GO nanocomposite onto the screen-printed electrode (SPE).

Key results: Compared to unmodified SPE, cyclic voltammetry revealed that the MOF/GO/SPE considerably enhanced the epinephrine oxidation process, exhibiting a greater detection current at a lower over-potential. The synergistic combination of MOF and GO sheets may cause this discovery. With a low detection limit of 0.07 μM, the MOF/GO/SPE sensor's linear response for voltammetric measurements of epinephrine was found to be between 0.2 and 500.0 μM. A modified electrode was also utilized to measure folic acid and epinephrine simultaneously.

Conclusion: Lastly, the modified SPE effectively demonstrates its high accuracy in identifying folic acid and epinephrine in biological and pharmaceutical samples.

MIL-101 (Fe)-NH2金属-有机骨架/氧化石墨烯纳米复合修饰电极同时测定肾上腺素和叶酸。
背景和目的:众所周知,当肾上腺素和叶酸这两种关键物质的含量低或高时,大多数疾病都会在一定程度上表现出症状。这两种化学物质的成分变化可以被追踪并用于识别诸如心肌梗死、帕金森病和精神障碍等疾病。实验方法:利用溶剂热技术,我们提出了一种新的MIL-101 (Fe)-NH2金属有机骨架/氧化石墨烯纳米复合材料(MOF/GO纳米复合材料)的合成方法。利用场发射扫描电镜对制备的纳米复合材料进行形貌分析。通过将制备的MOF/GO纳米复合材料滴铸到丝网印刷电极(SPE)上,建立了一个简单、快速、灵敏的肾上腺素检测电化学传感平台。与未修饰的SPE相比,循环伏安法显示MOF/GO/SPE显著增强了肾上腺素氧化过程,在较低的过电位下表现出更大的检测电流。MOF和氧化石墨烯的协同作用可能会导致这一发现。在0.07 μM的检测限下,MOF/GO/SPE传感器对肾上腺素伏安测量的线性响应范围在0.2 ~ 500.0 μM之间。改进的电极也被用来同时测量叶酸和肾上腺素。结论:最后,改进的固相萃取法对生物和制药样品中叶酸和肾上腺素的鉴别具有较高的准确度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ADMET and DMPK
ADMET and DMPK Multiple-
CiteScore
4.40
自引率
0.00%
发文量
22
审稿时长
4 weeks
期刊介绍: ADMET and DMPK is an open access journal devoted to the rapid dissemination of new and original scientific results in all areas of absorption, distribution, metabolism, excretion, toxicology and pharmacokinetics of drugs. ADMET and DMPK publishes the following types of contributions: - Original research papers - Feature articles - Review articles - Short communications and Notes - Letters to Editors - Book reviews The scope of the Journal involves, but is not limited to, the following areas: - physico-chemical properties of drugs and methods of their determination - drug permeabilities - drug absorption - drug-drug, drug-protein, drug-membrane and drug-DNA interactions - chemical stability and degradations of drugs - instrumental methods in ADMET - drug metablic processes - routes of administration and excretion of drug - pharmacokinetic/pharmacodynamic study - quantitative structure activity/property relationship - ADME/PK modelling - Toxicology screening - Transporter identification and study
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