Cerebral circulation - cognition and behavior最新文献

{"title":"The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment, the Excersion-VCI randomised controlled clinical trial","authors":"Liz R. van Hout ,&nbsp;Justine Moonen ,&nbsp;Annebet E. Leeuwis ,&nbsp;Juliette van Alphen ,&nbsp;Mathijs Dijsselhof ,&nbsp;Raquel P. Amier ,&nbsp;Frederik Barkhof ,&nbsp;Esther E. Bron ,&nbsp;Doeschka A. Ferro ,&nbsp;Alexander G.J. Harms ,&nbsp;Rosalie J. Huijsmans ,&nbsp;Joost P.A. Kuijer ,&nbsp;Sanne Kuipers ,&nbsp;Matthias J.P. van Osch ,&nbsp;Niels D. Prins ,&nbsp;Marc B. Rietberg ,&nbsp;Charlotte E. Teunissen ,&nbsp;Henk Jan Mutsaerts ,&nbsp;Geert Jan Biessels ,&nbsp;Wiesje M. van der Flier","doi":"10.1016/j.cccb.2025.100386","DOIUrl":"10.1016/j.cccb.2025.100386","url":null,"abstract":"<div><div>Aerobic exercise may improve cerebral perfusion and may thereby attenuate, or delay, cognitive decline. Excersion-VCI aimed to evaluate the effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment (VCI).</div><div>This Randomized Controlled Trial included non-demented adults ≥50 years diagnosed with VCI. Patients were randomly assigned either home-based aerobic interval training (exercise group) or information sessions (control group). Primary outcome was change in Arterial Spin Labelling MRI grey matter cerebral perfusion from baseline to 14-week follow-up. Per-protocol analysis was performed in patients who completed the follow-up. Secondary outcomes were VO_2max and cognitive function. Exploratory outcomes were depression and apathy, White Matter Hyperintensities, cerebral volumes, and blood biomarkers.</div><div>Fifty-eight VCI patients (mean age 67.0 ± 6.7 years) were allocated to the exercise (<em>n</em> = 28) or control group (<em>n</em> = 30). Intention-to-treat analyses showed that change in grey matter cerebral perfusion in the exercise group did not differ from the control group (<em>p</em> = 0.38), nor were there group differences in change in VO2max (<em>p</em> = 0.17). The exercise group showed an increase in triglycerides compared to the control group (<em>p</em> = 0.04). No group differences were found for other outcomes. Per protocol analyses showed improvement in VO_2max in the exercise group compared to the control group (<em>p</em> = 0.04).</div><div>An aerobic exercise program in VCI patients improved cardiorespiratory fitness in those who adhered to the protocol, but did not show significant effects on grey matter cerebral perfusion or other outcomes. The intervention duration of 14-weeks may have been too short to measure changes in perfusion or improvements in cognitive function.</div></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"8 ","pages":"Article 100386"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From dementia prevention research to global FINGER-based multi-domain interventions and implementation strategies","authors":"Shireen Sindi ,&nbsp;Manasa Shanta Näsholm ,&nbsp;Mariagnese Barbera ,&nbsp;Charlotta Thunborg ,&nbsp;Yunfei Li ,&nbsp;Linus Jönsson ,&nbsp;Francesca Mangialasche ,&nbsp;Chengxuan Qiu ,&nbsp;Miia Kivipelto","doi":"10.1016/j.cccb.2025.100385","DOIUrl":"10.1016/j.cccb.2025.100385","url":null,"abstract":"<div><div>The demographic transition during the recent decades has resulted in an increase in older adults globally. Cognitive impairment and dementia are the leading causes of functional disability, which significantly decreases the quality of life and increases the use of healthcare resources and societal costs. The goal of this narrative review is to summarize the recent evidence on the epidemiology of cognitive disorders and dementia, their societal burdens, the potential of multidomain lifestyle interventions, the implementation of such interventions and the cost-effectiveness of dementia prevention. Our review demonstrates that although population-based studies have shown a stable or decreasing prevalence of dementia during the recent decades in Europe and North America, an opposite trend has been observed in other regions, including low- and middle-income countries where there is an increasing prevalence. Considering the multifactorial etiology of dementia, to date, multidomain lifestyle interventions simultaneously targeting several risk factors, such as the FINGER trial, have been most effective. Such interventions have important beneficial effects for cognition and other outcomes including physical function, reduced multimorbidity and use of healthcare resources, while proving to be cost-effective. More recent efforts have focused on tailoring and adapting multidomain lifestyle interventions to various global regions, while taking into consideration local infrastructures, cultural norms and specific needs. Such global efforts have been coordinated through the World-Wide FINGERS Network, which aims to harmonize trial methodologies to investigate the effects of FINGER-based interventions in different populations to acquire robust globally relevant evidence. Similarly, there is a need to adapt dementia risk prediction models to various geographic settings. For the wider implementation of multidomain lifestyle interventions, different societal and healthcare levels need to be included, such as the community level, primary care, and specialist (e.g. memory) clinics, and such initiatives are currently being tested in Nordic countries. Taken together, effective multidomain risk reduction programs have the potential to significantly reduce the economic and societal burdens of dementia.</div></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"9 ","pages":"Article 100385"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Post-stroke cognitive impairment and fatigue in patients with white matter hyperintensities: A prospective cohort study”","authors":"Rachana Mehta ,&nbsp;Ranjana Sah","doi":"10.1016/j.cccb.2025.100394","DOIUrl":"10.1016/j.cccb.2025.100394","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"9 ","pages":"Article 100394"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of visit-to-visit blood pressure variability on cognitive function: state-of the-art","authors":"Michiaki Nagai ,&nbsp;Isabel J Sible ,&nbsp;Phillip J. Tully ,&nbsp;Sunny S. Po ,&nbsp;Tarun W. Dasari","doi":"10.1016/j.cccb.2025.100392","DOIUrl":"10.1016/j.cccb.2025.100392","url":null,"abstract":"<div><div>Visit-to-visit blood pressure (BP) variability (VVV) is a risk factor for cognitive impairment and cognitive decline, but several studies have recently shown that VVV also increases the risk of Alzheimer's disease (AD). Although the relationship between VVV and AD has been extensively studied, its pathophysiology is instructive due to its association with vascular stiffness, cerebral circulatory failure, decreased cardiac function, and AD pathology such as amyloid β and tau-proteins. This review article focuses on the relationship between VVV and cognitive function and summarizes recent studies and the underlying pathophysiology that appears to be mediated by systemic hemodynamic disruption.</div></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"9 ","pages":"Article 100392"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144831577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden and risk factors of Alzheimer's disease and other dementias in Vietnam from 1990 to 2021 – A comprehensive analysis from global burden disease","authors":"Quynh Phuong Vo ,&nbsp;Bich Loan Dang ,&nbsp;Bao Minh Ton Luu ,&nbsp;Tri Cuong Phan ,&nbsp;Phuc Nhan Bao Le ,&nbsp;Quy Duc Ngoc Vo Nguyen ,&nbsp;Huong-Dung Thi Nguyen ,&nbsp;Thien Tan Tri Tai Truyen","doi":"10.1016/j.cccb.2025.100390","DOIUrl":"10.1016/j.cccb.2025.100390","url":null,"abstract":"<div><h3>Background</h3><div>Alzheimer’s disease (AD) is the primary cause of dementia worldwide, imposing a substantial health and economic burden. In Vietnam, an aging population and rapid socioeconomic changes have intensified concerns about AD and other dementias burden.</div></div><div><h3>Methods</h3><div>We analyzed data from the Global Burden of Disease (GBD) 2021 database to estimate age-standardized rates (ASRs) of incidence, prevalence, mortality, years lived with disability (YLDs), and years of life lost (YLLs) for AD in Vietnam from 1990 to 2021. Trends were assessed using Joinpoint regression, and risk factors were examined based on their contributions to disability-adjusted life years (DALYs) and mortality. Subgroup analysis by age and sex were also conducted.</div></div><div><h3>Results</h3><div>In 2021, the ASRs for AD and other dementias incidence and prevalence in Vietnam were 110.09 (95 % UI: 96.21–126.57) and 649.42 (95 % UI: 556.89–744.39) per 100,000 persons which were comparable to those in the Southeast Asia region and globally, with the burden predominantly observed in individuals aged 65 and older. Despite a declining trend in incidence and prevalence over the study period (AAPC –0.185 % and –0.199 %), both DALYs and mortality rates increased significantly (AAPC 0.155 % and 0.339 %). High fasting plasma glucose, elevated body mass index (BMI), and smoking emerged as the most significant risk factors.</div></div><div><h3>Conclusions</h3><div>Despite a decline in incidence and prevalence from 1990 to 2021, rising DALYs and mortality rates highlight the growing burden of AD and other dementias in Vietnam. High fasting plasma glucose, elevated BMI, and smoking are important risk factors.</div></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"9 ","pages":"Article 100390"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statin treatment for cerebral small vessel disease: A systematic review and meta-analysis of randomized controlled trials","authors":"David Fresnais ,&nbsp;Brynjar Fure","doi":"10.1016/j.cccb.2025.100389","DOIUrl":"10.1016/j.cccb.2025.100389","url":null,"abstract":"<div><h3>Background</h3><div>Cerebral small vessel disease (CSVD) is a chronic, progressive disorder that affects small blood vessels in the brain's white matter. This white matter damage appears on brain imaging as white matter hyperintensities (WMH). Although CSVD is often asymptomatic, it causes one fifth of strokes and nearly half of all vascular dementia cases, highlighting its clinical importance. Statins, widely used to lower lipid levels, are effective for reducing cardiovascular mortality in high-risk groups and are recommended for patients with myocardial infarction and ischemic stroke.</div></div><div><h3>Aim</h3><div>This systematic review and meta-analysis of randomized controlled trials aimed to evaluate the impact of statin therapy on CSVD.</div></div><div><h3>Method</h3><div>A literature search was performed in PubMed, Embase, the Cochrane Library and Epistemonikos resulting in the full-text review of 86 articles, of which two were used for the meta-analysis.</div></div><div><h3>Results</h3><div>A non-significant trend towards lower WMH volume in milliliters was observed in the statin group compared to controls, mean difference (MD) = -4.44 (95 % CI -10.19–1.31).</div></div><div><h3>Conclusion</h3><div>There is limited evidence available for the use of stain-treatment for CSVD, and further research is needed as well as studies on the clinical and person-centered benefits of statins on cognition and functional level in persons with CSVD.</div></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"9 ","pages":"Article 100389"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of liquiritin on the expression of BDNF, Bax, and Bcl-2 in the hippocampus of post-stroke depression rats","authors":"Gui-Liu Yan ,&nbsp;Dan Dai ,&nbsp;Qiang Zi ,&nbsp;Fu-Mei Zhang ,&nbsp;Yun Li","doi":"10.1016/j.cccb.2025.100388","DOIUrl":"10.1016/j.cccb.2025.100388","url":null,"abstract":"<div><h3>Aims</h3><div>The study intended to explore the therapeutic effect of liquiritin on PSD rats and its role in the pathogenesis of PSD.</div></div><div><h3>Methods</h3><div>The stroke model was established via middle cerebral artery occlusion, and the PSD model was created using chronic unpredictable mild stress combined with isolated feeding. The expressions of BDNF, Bax, and Bcl-2 proteins in the hippocampus of rats were detected using Western blot and immunofluorescence staining after 6 weeks of modeling.</div></div><div><h3>Results</h3><div>The weight, sucrose consumption and activity of the PSD rats decreased (<em>P</em> &lt; 0.05) compared with the normal control and stroke groups. On the contrary, the weights of the liquiritin and escitalopram groups increased and their sucrose consumption and activity increased in the open-field test (<em>P</em> &lt; 0.05) compared with the PSD and normal saline (NS) groups.The result of immunofluorescence staining and western-blot showed that BDNF and Bcl-2 increased in the liquiritin group and Bax increased significantly in the stroke and PSD groups (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Liquiritin is capable of inhibiting neuronal apoptosis in the hippocampus of PSD rats to improve depression symptoms. This improvement may be achieved by reducing the expression of Bax and increasing the expressions of Bcl-2 and BDNF in the hippocampus of PSD rats.</div></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"9 ","pages":"Article 100388"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study on the effectiveness of individual centered goal-oriented cognitive rehabilitation in vascular dementia","authors":"Aayushi Srivastava ,&nbsp;Ashwani Bhat ,&nbsp;Vaibhav Agarwal","doi":"10.1016/j.cccb.2025.100399","DOIUrl":"10.1016/j.cccb.2025.100399","url":null,"abstract":"<div><h3>Introduction</h3><div>Dementia encompasses a range of neurological conditions that impair cognitive functions, with vascular dementia (VaD) being a prominent non-degenerative form, especially among older adults. VaD is primarily caused by cerebrovascular diseases, leading to cognitive impairments that disrupt daily life and independence. While pharmacological treatments exist, there is a growing emphasis on non-pharmacological interventions, such as cognitive rehabilitation, to manage symptoms and improve patients' quality of life.</div></div><div><h3>Methodology</h3><div>The study was conducted as a randomized controlled observational study at Swami Rama Himalayan University, involving patients diagnosed with vascular dementia. Participants were divided into two groups: one receiving individual-centered, goal-oriented cognitive rehabilitation, and the other receiving standard care. The rehabilitation program was tailored to each patient's specific cognitive challenges and personal goals, aiming to improve daily functioning and cognitive performance.</div></div><div><h3>Results</h3><div>The trial demonstrated significant improvements in the cognitive abilities and daily functioning of patients undergoing goal-oriented cognitive rehabilitation compared to those receiving standard care. Participants showed enhanced performance in tasks related to memory, executive functions, and overall cognitive health. The study highlights the effectiveness of personalized rehabilitation strategies in managing the cognitive decline associated with vascular dementia.</div></div><div><h3>Conclusion</h3><div>This study provides robust evidence for the effectiveness of individual-centered, goal-oriented cognitive rehabilitation in improving the cognitive and functional outcomes for patients with vascular dementia.</div></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"9 ","pages":"Article 100399"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introducing the IC3 study - Deep cognitive phenotyping of patients with cerebrovascular disease in relation to novel plasma and MRI brain biomarkers","authors":"Dragos-Cristian Gruia ,&nbsp;Sabia Combrie ,&nbsp;William Trender ,&nbsp;Peter Hellyer ,&nbsp;Soma Banerjee ,&nbsp;Joseph Kwan ,&nbsp;Henrik Zetterberg ,&nbsp;Adam Hampshire ,&nbsp;Fatemeh Geranmayeh","doi":"10.1016/j.cccb.2024.100328","DOIUrl":"10.1016/j.cccb.2024.100328","url":null,"abstract":"<div><h3>Introduction</h3><p>Cerebrovascular disease is a leading cause of death and disability worldwide. Identification and treatment of cognitive impairment following cerebrovascular disease (such as following stroke) remains a large unmet need. There is a growing need for in-depth scalable and cost-effective longitudinal assessment of cognitive function to better understand the range of factors that contribute to long-term cognitive outcomes after a vascular insult. To address this gap and to capitalise on the recent growth of telemedicine, we developed the IC3 online tool (Imperial College Comprehensive assessment for Cerebrovascular disease; <span><span>https://ic3study.co.uk/</span><svg><path></path></svg></span>) combined with MRI brain imaging and plasma biomarkers to identify novel multimodal predictors of recovery after stroke (Figure 1).<figure><img></figure><figure><img></figure></p><p><strong>Figure 1:</strong> Study Timeline.</p></div><div><h3>Methods</h3><p>The IC3 platform is a web-based digital technology, designed to detect both domain-general and domain-specific cognitive deficits prevalent in cerebrovascular disease (Figure 2). Demographic, socio-economic, and neuropsychiatric information is collected alongside 22 short, computerised cognitive tests, with minimal input from a health professional, at 0-, 3-, 6-, and 12-months post- stroke. These are related to structural and functional brain MRI and plasma biomarkers (such as plasma brain-derived tau, neurofilament light, glial fibrillary acidic protein and amyloid entities).</p></div><div><h3>Results</h3><p>We present IC3 assessment results from N&gt;5000 older adults. We outline the cognitive performance of a modest sample of patients with stroke against a gender-, age- and education- matched control sample. Furthermore, we present an overview of our validation studies which examine the battery's specificity and sensitivity, and test-retest reliability. Finally, as the assessment has been designed to be self-administered remotely, we also present validation against face-to-face supervised delivery of the battery and discuss the effect of several technical confounds affecting a patient's performance (such as device type, operating system, and motoric impairments).</p></div><div><h3>Discussion</h3><p>The IC3 tool is the first assessment to offer a an in-depth relatively unsupervised cognitive phenotyping of patients with cerebrovascular disease, facilitating scalable and cost-efficient longitudinal monitoring of cognition in this group. The assessment fares very well against various validation methods, making it an attractive tool for understanding the mechanisms of recovery in relation to novel brain and plasma biomarkers in a plethora of cerebrovascular disorders.</p></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100328"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245024001296/pdfft?md5=a246292685f15352bb5de6fee2b8d1e5&pid=1-s2.0-S2666245024001296-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Post-stroke Cognitive Impairment Using Machine Learning Approach","authors":"Minwoo Lee","doi":"10.1016/j.cccb.2024.100286","DOIUrl":"10.1016/j.cccb.2024.100286","url":null,"abstract":"<div><h3>Introduction</h3><p>Post-stroke cognitive impairment (PSCI) occurs in up to 50% of patients with acute ischemic stroke (AIS). Thus, the prediction of cognitive outcomes in AIS may be useful for treatment decisions. This PSCI cohort study aimed to determine the applicability of a machine learning approach for predicting PSCI after stroke.</p></div><div><h3>Methods</h3><p>This retrospective study used a prospective PSCI cohort of patients with AIS. Demographic features, clinical characteristics, and brain imaging variables previously known to be associated with PSCI were included in the analysis. The primary outcome was PSCI at 3–6 months, defined as an adjusted z-score of less than -2.0 standard deviation in at least one of the four cognitive domains (memory, executive/frontal, visuospatial, and language), using the Korean version of the Vascular Cognitive Impairment Harmonization Standards neuropsychological protocol (VCIHS-NP). We developed four machine learning models (logistic regression, support vector machine, extreme gradient boost, and artificial neural network) and compared their accuracies for outcome variables.</p></div><div><h3>Results</h3><p>A total of 1047 patients (mean age 65.7±11.9; male 61.5%) with AIS were included in this study. The area under the curve for the extreme gradient boost and the artificial neural network was the highest (0.7919 and 0.7365, respectively) among the four models for predicting PSCI according to the VCIHS-NP definition. The most important features for predicting PSCI include the presence of cortical infarcts, mesial temporal lobe atrophy, initial stroke severity, stroke history, and strategic lesion infarcts.</p></div><div><h3>Discussion</h3><p>Our findings indicate that machine-learning algorithms, particularly the extreme gradient boost and the artificial neural network models, can best predict cognitive outcomes after ischemic stroke.</p></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100286"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245024000874/pdfft?md5=fd3582808b3d37d8edb6167163dfac28&pid=1-s2.0-S2666245024000874-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142122049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}