Cerebral circulation - cognition and behavior最新文献

{"title":"Comment on “Relevance of cerebral microbleeds with leaky blood brain barrier in traumatic brain injury and protective role of interferon-gamma: A cohort study”","authors":"Sangameshwar Manikya , Varshini Vadhithala , Rajnish Kumar , Pankaj Nainwal","doi":"10.1016/j.cccb.2026.100541","DOIUrl":"10.1016/j.cccb.2026.100541","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"10 ","pages":"Article 100541"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147709810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between cardiac index and brain volume in the UK Biobank","authors":"Sarah Syed,&nbsp;Chris Moran,&nbsp;Stephanie Than,&nbsp;Jarin Herson,&nbsp;Taya Collyer,&nbsp;Richard Beare,&nbsp;Velandai Srikanth","doi":"10.1016/j.cccb.2026.100560","DOIUrl":"10.1016/j.cccb.2026.100560","url":null,"abstract":"<div><h3>Aims</h3><div>Although cardiac function is associated with cognitive impairment in end-stage heart disease, the links between cardiac function and brain structure remain unclear. We aimed to examine the association between cardiac index (CI) (a measure of cardiac output adjusting for body surface area) and brain volumes in mid-to later life and how these are affected by age, sex and cardiometabolic factors.</div></div><div><h3>Materials and methods</h3><div>We utilized brain and cardiac magnetic resonance imaging (MRI) data from a population-based cohort of people in the UK Biobank (a United Kingdom population-based cohort of people &gt; 40 years old) at mid to later life. Linear regression modelling was used to examine associations of CI with total brain volume (TBV), gray matter (GMV), white matter (WMV), white matter hyperintensity (WMHV) and total hippocampal volume (THV), and assess whether these associations were influenced by sex, age or cardiometabolic factors.</div></div><div><h3>Results</h3><div>Complete data were available for 22,199 individuals (mean age 64 years [SD 7], 64% women). In univariable analyses, lower CI was associated with lower TBV, GMV, WMV, THV and greater WMHV (p &lt; 0.001). In adjusted models, statistically significant CI × age interactions were observed for TBV, GMV, and THV (all p &lt; 0.01) indicating more pronounced associations in older individuals. No CI × sex interactions were identified.</div></div><div><h3>Conclusions</h3><div>Lower cardiac index is associated with lower brain volumes and greater vascular lesion burden in mid-to later life, with evidence of age modification for TBV, GMV and THV.</div></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"11 ","pages":"Article 100560"},"PeriodicalIF":3.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148854421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual rating versus volumetric segmentation of white matter hyperintensities for cognitive assessment: a memory clinic-based comparison and systematic review","authors":"Geke G.C.E.A. van Dijk,&nbsp;Camiel V.J. Box,&nbsp;Farog Faghir,&nbsp;Joy Martens,&nbsp;Janne M. Papma,&nbsp;Francesco U.S. Mattace Raso,&nbsp;Esther Van Den Berg,&nbsp;Meike W. Vernooij,&nbsp;Frank J. Wolters","doi":"10.1016/j.cccb.2026.100564","DOIUrl":"10.1016/j.cccb.2026.100564","url":null,"abstract":"<div><h3>Introduction</h3><div>Clinical impression of WMH commonly relies on visual rating scales (VRS), yet may improve through volumetric segmentation. Comparative studies, particularly considering clinical outcomes, are scarce.</div></div><div><h3>Methods</h3><div>We conducted a retrospective, cross-sectional study among 246 memory clinic patients. We compared WMH assessed through VRS (Fazekas) to automated volumetric segmentation (Quantib), through correlation and explained variance in neuropsychological assessment across six cognitive domains, above and beyond age, sex, and educational attainment in linear regression models. Results were contextualised through systematic literature review until 30 September 2022.</div></div><div><h3>Results</h3><div>Fazekas scores and WMH volumes were strongly correlated in the memory clinic population (ρ=0.83, p &lt; 0.001), with little overlap in volumes between Fazekas categories. This was supported by similar correlations observed in 24 studies included in the systematic review and 13 in meta-analysis. Jointly with demographics, VRS and segmentation explained 6–19% of variance in cognitive domains in the memory clinic population. Volumetrics explained at most 2% more variance than visual rating, most substantial in MMSE (2%), in contrast to executive function (-1%). The systematic review identified three other comparative studies on cognitive outcome, each reporting similar correlations with volumetrics and visual rating scales. Previously proposed cut-offs in WMH volume that approximate Fazekas categories (3.4, 9.6 and 17.1 mL) showed classification accuracies of 59%, 70% and 78% in our cohort, with optimal thresholds in our sample at 1.6, 6.0 and 19.8 mL.</div></div><div><h3>Discussion</h3><div>VRS and volumetric segmentation of WMH are highly correlated. Small improvements in explained variance in cognition with volumetrics were inconsistent across cognitive domains</div></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"11 ","pages":"Article 100564"},"PeriodicalIF":3.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149159035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: “Node-level inference and score construction may overstate the diagnostic utility of cervical lymph node ultrasound in Alzheimer’s disease”","authors":"Tae Hyung Kim ,&nbsp;Jin Geun Kwon ,&nbsp;Jimmy Sung-Chuan Chao ,&nbsp;Jae Woo Kim ,&nbsp;Changsik John Pak ,&nbsp;Hyunsuk Peter Suh ,&nbsp;Jae-Sung Lim ,&nbsp;Joon Pio Hong","doi":"10.1016/j.cccb.2026.100546","DOIUrl":"10.1016/j.cccb.2026.100546","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"10 ","pages":"Article 100546"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The need for post-stroke cognitive screening - the rationale behind the Hungarian adaptation of the Oxford Cognitive Screen (OCS) and its pilot study","authors":"Tímea Tünde Takács ,&nbsp;Judit Kárpáti ,&nbsp;Edina Szabó ,&nbsp;Károlyné Pálvölgyi ,&nbsp;Panna Pálinkás ,&nbsp;Orsolya Antal ,&nbsp;Júlia Baross ,&nbsp;Bernadett Bruckner ,&nbsp;Sam Webb ,&nbsp;Nele Demeyere ,&nbsp;Bence Gunda","doi":"10.1016/j.cccb.2025.100527","DOIUrl":"10.1016/j.cccb.2025.100527","url":null,"abstract":"<div><h3>Background</h3><div>Post-stroke cognitive impairment (PSCI) is a frequent yet underdiagnosed consequence of stroke, with significant implications for quality of life, functional outcomes and long-term prognosis. Despite its importance, cognitive screening remains insufficiently integrated into post-stroke care protocols, particularly in Hungary.</div></div><div><h3>Objective</h3><div>This study aimed to adapt and pilot the Oxford Cognitive Screen (OCS) for Hungarian stroke patients, addressing the urgent need for a culturally and linguistically appropriate, stroke-specific cognitive screening tool that is freely available in Hungarian.</div></div><div><h3>Methods</h3><div>The Hungarian adaptation followed a rigorous 11-step linguistic validation process, including cultural adaptation, forward and back translations, reviews, and pilot testing. Ten stroke patients at Semmelweis University were assessed using the adapted OCS within three weeks of symptom onset. Data on test performance, feasibility, and patient feedback were collected from 10 pilot patients and 6 examiners.</div></div><div><h3>Results</h3><div>The adaptation and pilot testing process, completed in approximately three months, confirmed the usability of the tool, with most patients finding it engaging. The median number of impaired tasks was two. No major issues arose, and the tool was well received by both patients and examiners.</div></div><div><h3>Conclusion</h3><div>The Hungarian version of the OCS offers a practical, user-friendly cognitive screening tool tailored for stroke patients. Its implementation could enhance early detection of PSCI, improve patient safety by supporting targeted rehabilitation, and ultimately contribute to better long-term outcomes. This initiative represents a foundational step toward integrating cognitive screening into stroke protocols in Hungary, addressing a significant gap in rehabilitation and healthcare equity.</div></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"10 ","pages":"Article 100527"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial arterial calcification and cerebrovascular function in the general aging population – A 7T MRI Study","authors":"Anna M. Streiber ,&nbsp;Carmen Kuenen ,&nbsp;Stanley D.T. Pham ,&nbsp;Julia Neitzel ,&nbsp;Daniel Bos ,&nbsp;Jeroen C.W. Siero ,&nbsp;Jaco J.M. Zwanenburg ,&nbsp;Nikki Dieleman ,&nbsp;Geert Jan Biessels ,&nbsp;Meike W. Vernooij","doi":"10.1016/j.cccb.2026.100531","DOIUrl":"10.1016/j.cccb.2026.100531","url":null,"abstract":"<div><h3>Background</h3><div>Intracranial arteriosclerosis may impair downstream cerebrovascular function, but the underlying mechanisms remain unclear. Using 7T MRI, we investigate the association between intracranial arteriosclerosis and cerebrovascular function in the middle cerebral artery (MCA) and in downstream small perforating arteries.</div></div><div><h3>Methods</h3><div>We included 195 Rotterdam Study participants (43.6% female, average age 70.8 years (± 4.52 years)) who previously underwent a non-contrast CT on which we measured intracranial carotid artery calcification (ICAC) and vertebral artery calcification (VAC) as hallmarks of intracranial arteriosclerosis. Participants underwent a 7T brain MRI to assess blood flow velocity and pulsatility in the MCA and small perforating arteries as well as whole-brain cerebrovascular reactivity (CVR). We assessed the relationship between intracranial arteriosclerosis and vessel function using linear regression and linear mixed models.</div></div><div><h3>Results</h3><div>ICAC and VAC presence and burden were associated with higher pulsatility but not blood flow velocity in the MCA (e.g. β_{ICAC presence}: 0.07 [95% Confidence interval: 0.02, 0.13]). There was no statistically significant association with CVR, pulsatility, and blood flow velocity in the small perforating arteries.</div></div><div><h3>Conclusions</h3><div>In this cohort, intracranial arterial calcification was associated with increased MCA pulsatility, suggesting a localized impact on cerebrovascular hemodynamics. Associations with CVR and perforating artery flow velocity and pulsatility did not reach statistical significance. Thus, larger studies are needed to determine whether subtle effects exist.</div></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"10 ","pages":"Article 100531"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146167950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Node-level inference and score construction may overstate the diagnostic utility of cervical lymph node ultrasound in Alzheimer’s disease","authors":"Yaohui Liu","doi":"10.1016/j.cccb.2026.100545","DOIUrl":"10.1016/j.cccb.2026.100545","url":null,"abstract":"<div><div>None.</div></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"10 ","pages":"Article 100545"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Reflections on the Hungarian oxford cognitive screen in post-stroke cognitive care”","authors":"Tímea Tünde Takács,&nbsp;Panna Pálinkás,&nbsp;Bence Gunda","doi":"10.1016/j.cccb.2026.100557","DOIUrl":"10.1016/j.cccb.2026.100557","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"11 ","pages":"Article 100557"},"PeriodicalIF":3.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148769868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain raspberries: a microvascular finding, seen with anti-collagen 4 staining","authors":"Hannah Storbråten Edstam,&nbsp;Henric Ek Olofsson,&nbsp;Elisabet Englund","doi":"10.1016/j.cccb.2026.100559","DOIUrl":"10.1016/j.cccb.2026.100559","url":null,"abstract":"<div><h3>Introduction</h3><div>A brain raspberry is a microvascular formation of yet insufficiently known origin and significance, defined histologically as three or more transversally sectioned vascular lumen surrounded by a common perivascular space. Previous reports on the prevalence of this structure have been based mainly on histopathological routine staining with haematoxylin-eosin (HE). The aim of this study was to compare the detectability of raspberries between HE and immunohistochemical vessel staining with anti-collagen 4 (col4).</div></div><div><h3>Materials and methods</h3><div>We used 50 pairs of tissue sections from the cerebral cortex of 40 deceased individuals who had undergone a diagnostic neuropathological examination at the Department of Pathology, Lund, Sweden, during 2019–2022. Raspberries were manually quantified on digitally scanned cortical sections stained with HE and col4, respectively.</div></div><div><h3>Results</h3><div>Staining with col4 showed a higher detectability of cortical raspberries than staining with HE, with an absolute difference of 12.1 raspberries/cm² and a relative difference of 252.1%. The difference between the two staining methods was statistically significant (P &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>This study reveals that staining with col4 provides a substantially higher detectability of raspberries compared with HE staining. Immunohistochemical detection is recommended for future studies on the pathogenesis and prevalence of brain raspberries.</div></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"11 ","pages":"Article 100559"},"PeriodicalIF":3.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148854422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in documented clinical features of memory clinic patients: a natural language processing study","authors":"Sanne Kuipers ,&nbsp;L. Malin Overmars ,&nbsp;Bram van Es ,&nbsp;Sander C. Tan ,&nbsp;Jet M.J. Vonk ,&nbsp;Majon Muller ,&nbsp;Mark C.H. de Groot ,&nbsp;Wouter W. van Solinge ,&nbsp;Saskia Haitjema ,&nbsp;Michiel L. Bots ,&nbsp;Geert Jan Biessels ,&nbsp;Lieza G. Exalto","doi":"10.1016/j.cccb.2026.100544","DOIUrl":"10.1016/j.cccb.2026.100544","url":null,"abstract":"<div><h3>Introduction</h3><div>Sex differences in signs and symptoms of cognitive impairment are well described in research cohorts, but whether they are reflected in routine clinical documentation is unknown.</div></div><div><h3>Methods</h3><div>We applied natural language processing to clinical letters from 915 memory clinic patients in the Utrecht Patient-Oriented Database. Sex differences in documented clinical features were assessed with logistic regression, with and without age adjustment. Benjamini–Hochberg correction was applied for multiple comparisons.</div></div><div><h3>Results</h3><div>We included 1036 clinical letters from 915 patients (47% women; mean age 66 ± 14 vs. 67 ± 13 years, p = 0.6). The most common clinical features were memory problems (56.5% overall) and forgetting intended actions (49.6%). After correction for multiple comparisons, no significant sex differences remained. At the nominal level, women more often had documentation of stress (OR 0.39), headache (OR 0.63), and calendar use for memory support (OR 0.66); men more often had documentation of getting angry easily (OR 1.72) and short-term memory problems (OR 1.70).</div></div><div><h3>Discussion</h3><div>This exploratory study identified suggestive but non-significant sex differences in documented clinical features in memory clinic practice. Differences may reflect variation in occurrence, reporting, or documentation habits, and warrant replication in larger, diagnosis-stratified samples.</div></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"10 ","pages":"Article 100544"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147802182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}