Cerebral circulation - cognition and behavior最新文献

{"title":"THE IMPACT OF ALZHEIMER BIOMARKERS AND VASCULAR FACTORS ON COGNITIVE DECLINE IN MEMORY CLINIC PATIENTS","authors":"Veerle van Gils , Willemijn J. Jansen , Domantė Kučikienė , Ana Sofia Costa , Jörg B. Schulz , Frans Verhey , Kathrin Reetz , Stephanie J.B. Vos","doi":"10.1016/j.cccb.2022.100051","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100051","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100051"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000162/pdfft?md5=592afaa61ea23ee723a33474d08cf2c7&pid=1-s2.0-S2666245022000162-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141478892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AGE-ASSOCIATED CHANGES IN THE RENIN-ANGIOTENSIN SYSTEM: IMPLICATIONS FOR FUTURE CLINICAL TRIALS","authors":"Robert MacLachlan, Scott Miners, Patrick Kehoe","doi":"10.1016/j.cccb.2022.100090","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100090","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100090"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000551/pdfft?md5=22acc20a62eaecff4ac9d49464db686d&pid=1-s2.0-S2666245022000551-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141479036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE RELATIONSHIP OF ACUTE DELIRIUM WITH COGNITIVE AND EMOTIONAL SYMPTOMS AFTER STROKE: A LONGITUDINAL STUDY","authors":"Vilde Nerdal , Elise Gjestad , Ragnhild Munthe-Kaas , Ingvild Saltvedt , Stian Lydersen , Ramune Grambaite","doi":"10.1016/j.cccb.2022.100088","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100088","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100088"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000538/pdfft?md5=f49aebbd1f92be51efef82918534b188&pid=1-s2.0-S2666245022000538-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141479122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astaxanthin and improvement of dementia: A systematic review of current clinical trials","authors":"Nunki Puspita Utomo,&nbsp;Rizaldy Taslim Pinzon,&nbsp;Patrick Kurniawan Latumahina,&nbsp;Kadex Reisya Sita Damayanti","doi":"10.1016/j.cccb.2024.100226","DOIUrl":"https://doi.org/10.1016/j.cccb.2024.100226","url":null,"abstract":"<div><p>Worldwide, the incidence of neurodegenerative diseases especially dementia is steadily increasing due to the aging population. Abundant research emerges on the probability of combating or preventing the degeneration process, with the most established one being to tackle the existence of oxidative stress and free radicals production due to their nature of aggravating dementia. Astaxanthin, a marine carotenoid, was proven to be a protective agent of cerebral ischemia through many animal model clinical trials. This review summarizes the evidence of Astaxanthin's benefits for cognitive function across clinical trials done in older age. The results are of interest as its supplementation does not exhibit unwanted issues on the consumer based on physical and laboratory examinations. Despite not being supported statistically, however, subjective and objective cognitive amelioration were reported according to the majority of this review's trial subjects. Although there is no clear and direct mechanism for cognitive improvement by Astaxanthin activity in the body systems, the encouragement of Astaxanthin supplementation should be considered as the elderly with dementia may highly benefit from the improved cognitive function.</p></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"7 ","pages":"Article 100226"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245024000278/pdfft?md5=5b400399b52121d9ff200c5ef1cda3a9&pid=1-s2.0-S2666245024000278-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141479314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INVESTIGATING THE RISK OF CARDIOVASCULAR RISK FACTOR SUBGROUPS IN COGNITIVELY NORMAL ELDERLY ON ALZHEIMER'S DISEASE: A LATENT CLASS APPROACH","authors":"Myuri Ruthirakuhan ,&nbsp;Hugo Cogo-Moreira ,&nbsp;Walter Swardfager ,&nbsp;Nathan Herrmann ,&nbsp;Krista Lanctot ,&nbsp;Sandra Black","doi":"10.1016/j.cccb.2022.100087","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100087","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100087"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000526/pdfft?md5=054a12aee67a7bfe38e60d19fbfd497b&pid=1-s2.0-S2666245022000526-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141480273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRAJECTORIES OF COGNITIVE CHANGE FOLLOWING STROKE: A STEPWISE DECLINE TOWARDS DEMENTIA","authors":"Joao Delgado ,&nbsp;Louise Allan ,&nbsp;Rajesh Kalaria","doi":"10.1016/j.cccb.2022.100056","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100056","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100056"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000216/pdfft?md5=df18c4c2b1bf027d3f84e12cb70f2cc4&pid=1-s2.0-S2666245022000216-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141481132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NEUROFILAMENT LIGHT LEVEL CORRELATES WITH BRAIN ATROPHY AND COGNITIVE AND MOTOR PERFORMANCE IN SUBJECTS WITH CEREBRAL WHITE MATTER HYPERINTENSITIES","authors":"Marge Kartau ,&nbsp;Susanna Melkas ,&nbsp;Joonas Kartau ,&nbsp;Anne Arola ,&nbsp;Hanna Laakso ,&nbsp;Johanna Pitkänen ,&nbsp;Matti Ahlström ,&nbsp;Juha Lempiäinen ,&nbsp;Juha Koikkalainen ,&nbsp;Jyrki Lötjönen ,&nbsp;Antti Korvenoja ,&nbsp;Sanna-Kaisa Herukka ,&nbsp;Timo Erkinjuntti ,&nbsp;Hanna Jokinen","doi":"10.1016/j.cccb.2022.100070","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100070","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100070"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000356/pdfft?md5=41365f5ef7c58a0f0e7024efae5cec75&pid=1-s2.0-S2666245022000356-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141482206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ENDOTHELIN-1-MEDIATED CONTRACTION OF HUMAN BRAIN PERICYTES IS DYSREGULATED IN THE PRESENCE OF Aβ1-40","authors":"Elliott Hibbs,&nbsp;Seth Love,&nbsp;Scott Miners","doi":"10.1016/j.cccb.2022.100076","DOIUrl":"https://doi.org/10.1016/j.cccb.2022.100076","url":null,"abstract":"","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100076"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245022000411/pdfft?md5=fae4467c4c8267cb8e27c9565dfc27eb&pid=1-s2.0-S2666245022000411-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141482293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The promise of molecular science in brain health. What breakthroughs are anticipated in the next 20 years?","authors":"Atticus H Hainsworth ,&nbsp;Thomas P Blackburn ,&nbsp;Elizabeth M Bradshaw ,&nbsp;Fanny M Elahi ,&nbsp;Philip B Gorelick ,&nbsp;Jeremy D Isaacs ,&nbsp;Anders Wallin ,&nbsp;Steven CR Williams","doi":"10.1016/j.cccb.2024.100364","DOIUrl":"10.1016/j.cccb.2024.100364","url":null,"abstract":"<div><p>Brain health means optimal physiological brain function across the normal life-course. It encompasses not only healthy brain aging but also brain diseases, their diagnosis and treatment. In all these areas, molecular science has advanced our understanding.</p><p>This multi-disciplinary review combines viewpoints from laboratory science, clinical medicine and the bioscience industry. First, we review the advances that molecular science has brought to brain health in the past twenty years. These include therapeutic antibodies for CNS diseases (multiple sclerosis, Alzheimer disease) and the dramatic introduction of RNA-targeted therapeutics. Second, we highlight areas where greater molecular understanding is needed. Salient examples are the relation of brain structure to cognitive symptoms, and molecular biomarkers for diagnosis, target discovery and testing of interventions. Finally, we speculate on aspects of molecular science that are likely to advance brain health in the next twenty years. These include: cell senescence and chronobiology; gene editing (notably, CRISPR) and RNA targeting (RNA interference, miRNA manipulation); brain-immune interactions; novel drug targets (AQP4, HIF1, Toll-like receptors); and novel chemistry to make new drugs (molecular machines, quantum molecular modelling and “click” chemistry). Early testing of the relationships between molecular pathways and clinical manifestations will drive much-needed breakthroughs in neurology and psychiatry.</p></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"7 ","pages":"Article 100364"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266624502400165X/pdfft?md5=dc9dbcd733c7dbe90cfc2a71d52cc479&pid=1-s2.0-S266624502400165X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Alzheimer's disease markers and MRI load of vascular pathology and neurodegeneration: the SMART-MR Study","authors":"Emma Twait ,&nbsp;Lotte Gerritsen ,&nbsp;Justine Moonen ,&nbsp;Inge Verberk ,&nbsp;Charlotte Teunissen ,&nbsp;Pieter Jelle Visser ,&nbsp;Wiesje van der Flier ,&nbsp;Mirjam Geerlings","doi":"10.1016/j.cccb.2024.100263","DOIUrl":"10.1016/j.cccb.2024.100263","url":null,"abstract":"<div><h3>Introduction</h3><p>Two of the main causes for dementia are Alzheimer's disease (AD) pathology and vascular pathology. Plasma biomarkers for AD pathology have recently emerged, including amyloid-beta, p-tau, neurofilament light (NfL), and glial fibrillary acidic protein (GFAP). Vascular pathology can be assessed on MRI via white matter hyperintensities (WMH) and infarcts. Our aim was to estimate the relationship between plasma AD biomarkers and MRI markers of vascular pathology and neurodegeneration in non-demented individuals with manifest arterial disease.</p></div><div><h3>Methods</h3><p>Data from 594 individuals (mean (SD) age: 64 (8) years; 17% female) were included from the SMART-MR Study, a prospective cohort study from the UMC Utrecht in the Netherlands. Vascular and neurodegenerative MRI markers included WMH volume, presence of infarcts (yes/no), total brain volume (TBV), and hippocampal volume (HV) assessed on 1.5T MRI. AD plasma markers (amyloid-beta 42/40 ratio, ptau-181, NfL, and GFAP) were assessed using Single Molecular Array (Simoa; Quanterix) assays. Linear regressions were performed for each plasma marker with WMH volume, TBV, and HV, correcting for age, sex, education, and ICV. Additionally, logistic regressions were performed for the presence of lacunar and cortical infarcts. Plasma AD levels were converted to z-scores.</p></div><div><h3>Results</h3><p>Higher ptau-181 was associated with larger WMH volume (β=0.16, 95% CI=0.06; 0.26, p=0.001). Higher NfL (β=-5.63, 95% CI=-8.95; -2.31, p=0.001) was associated with lower TBV. Higher NfL levels (.R=1.58, 95% CI=1.20; 2.08, p=0.001) and higher GFAP levels (OR=1.45, 95% CI=1.09; 1.92, p=0.010) were associated with cortical infarcts.</p></div><div><h3>Discussion</h3><p>In our sample of patients with manifest arterial disease, NfL was related to both brain volume and infarcts. Further, an association between ptau-181 and WMH was found, as well as between GFAP and cortical infarcts. Plasma biomarkers offer the potential to easily measure a wider range of pathophysiological processes related to cognitive decline.</p></div>","PeriodicalId":72549,"journal":{"name":"Cerebral circulation - cognition and behavior","volume":"6 ","pages":"Article 100263"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666245024000643/pdfft?md5=15c686bbb984f7fff67d2086d70d5f13&pid=1-s2.0-S2666245024000643-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}