Brain & spine最新文献

{"title":"Revisiting the evidence on CT-guided biopsy and percutaneous endoscopic debridement for spondylodiscitis","authors":"Aaron Lawson McLean","doi":"10.1016/j.bas.2025.104182","DOIUrl":"10.1016/j.bas.2025.104182","url":null,"abstract":"","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"Article 104182"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in chromosomal microarray analysis: Transforming neurology and neurosurgery","authors":"Wireko Andrew Awuah ,&nbsp;Muhammad Hamza Shah ,&nbsp;Vivek Sanker ,&nbsp;Krishitha Meenu Mannan ,&nbsp;Sruthi Ranganathan ,&nbsp;Princess Afia Nkrumah-Boateng ,&nbsp;Mabel Frimpong ,&nbsp;Kwadwo Darko ,&nbsp;Joecelyn Kirani Tan ,&nbsp;Toufik Abdul-Rahman ,&nbsp;Oday Atallah","doi":"10.1016/j.bas.2025.104197","DOIUrl":"10.1016/j.bas.2025.104197","url":null,"abstract":"<div><div>Over the past two decades, genomics has transformed our understanding of various clinical conditions, with Chromosomal Microarray Analysis (CMA) standing out as a key technique. Offering unparalleled sensitivity, CMA detects submicroscopic chromosomal imbalances, enabling the examination of DNA for copy number variations, deletions, duplications, and other structural differences. In neurology, CMA has revolutionised diagnoses, personalised treatment plans, and patient outcomes. By identifying genetic anomalies linked to neurological conditions, CMA allows clinicians to tailor treatments based on individual genetic profiles, enhancing precision medicine. CMA's clinical utility spans numerous neurological conditions, providing crucial insights into neurodevelopmental disorders, CNS tumours, neurodegenerative diseases, cerebrovascular diseases, and epilepsy. In neurodevelopmental disorders, CMA aids in diagnosing autism and intellectual disabilities, facilitating early interventions that improve long-term outcomes. In epilepsy, CMA helps identify genetic causes of drug-resistant seizures, enabling more targeted therapies and reducing adverse reactions. CMA also aids in stratifying risk for cerebrovascular diseases, enabling preventive interventions that improve patient prognosis. Despite its potential, challenges remain, such as interpreting variants of uncertain significance (VOUS), the lack of standardised testing guidelines, and issues of cost and accessibility. Addressing these challenges will optimise CMA's impact, advancing personalised medicine and reshaping neurology. This review discusses CMA's pivotal role in bridging the gap between genomics and clinical practice, underscoring its potential to transform neurogenetics and ultimately improve patient care.</div></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"Article 104197"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decompressive craniectomy in subarachnoid hemorrhage compared to other etiologies: An institutional experience of 11 years","authors":"Emilia K. Pesonen ,&nbsp;Aleksi Lammi ,&nbsp;Cheng Qian,&nbsp;Mikael Von und Zu Fraunberg,&nbsp;Tommi K. Korhonen ,&nbsp;Sami Tetri","doi":"10.1016/j.bas.2025.104203","DOIUrl":"10.1016/j.bas.2025.104203","url":null,"abstract":"<div><h3>Introduction</h3><div>Decompressive craniectomy (DC) is a last-tier procedure to lower intracranial pressure in otherwise fatal brain injuries. DC significantly reduces mortality following traumatic brain injury (TBI) and ischemic stroke, but benefits in subarachnoid hemorrhage (SAH) are less clear.</div></div><div><h3>Research question</h3><div>We compared the mortality and functional outcomes in patients who underwent DC after SAH with those who underwent DC following TBI or ischemic stroke.</div></div><div><h3>Materials and methods</h3><div>All DC procedures performed in the Oulu University Hospital between January 2009 and December 2019 were retrospectively identified. Mortality and functional outcomes were assessed during a median follow-up of 20.7 months. Extended Glasgow Outcome Scale scores ≥5 were considered favorable.</div></div><div><h3>Results</h3><div>One hundred twenty-four DCs were conducted to patients aged a median of 40 years (SD 16), of whom 88 (71%) were male. Fifty-eight (47%) DCs were due to TBI and 66 (53%) due to stroke. Of the strokes, 41 (62%) were ischemic and 21 (32%) SAH.</div><div>In multivariate models, the rates of unfavorable outcome were 48% in TBI, 78% in ischemic stroke (OR 2.73, 95% CI 0.70–10.64) and 86% in SAH (OR 3.15, 95%CI 0.67–14.77). Mortality rates were 22% in TBI, 17% in ischemic stroke (OR 0.50, 95%CI 0.11–2.31) and 33% in SAH (OR 0.97, 95%CI 0.24–3.99).</div></div><div><h3>Discussion and conclusion</h3><div>Favorable outcomes were more common in TBI compared to stroke in univariate but not in multivariate analysis. There was no statistically significant difference in the rates of favorable outcomes between SAH and ischemic stroke.</div></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"Article 104203"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simple CT score predicts early neurological disability and survival in supratentorial intracerebral hemorrhage - The intracerebral mass and brain edema score (IMBES)","authors":"Ralf Watzlawick ,&nbsp;Panagiotis Fistouris ,&nbsp;Ahmed Elbaz ,&nbsp;Pierre Scheffler ,&nbsp;Alix Bührle ,&nbsp;Marc Hohenhaus ,&nbsp;Ramy Amirah ,&nbsp;Roland Roelz ,&nbsp;Mukesch Shah ,&nbsp;Oliver Schnell ,&nbsp;Samer Elsheikh ,&nbsp;Christian Taschner ,&nbsp;Christian Fung ,&nbsp;Jürgen Beck","doi":"10.1016/j.bas.2025.104226","DOIUrl":"10.1016/j.bas.2025.104226","url":null,"abstract":"<div><h3>Introduction</h3><div>Treatment of spontaneous intracerebral hemorrhage (ICH) remains challenging, and intracerebral mass and brain edema (IMBE) are accused of being the main factors influencing patient course.</div></div><div><h3>Research question</h3><div>CT scan assessment of the space-occupying effect after initial ICH was evaluated using an IMBE-score to detect the sulcal effacement of the subarachnoid space.</div></div><div><h3>Material and methods</h3><div>Supratentorial ICH-patients within a 10 years observation period were identified. Two independent reviewers screened each CT scan in three defined axial planes. Where the combined mass effect of hemorrhage and edema showed sulcal effacement of more than half of the hemisphere, one point was assigned, resulting in an IMBES between 0 and 6. The primary endpoint was neurological outcome measured by the modified Rankin Scale (mRS) and mortality.</div></div><div><h3>Results</h3><div>We identified 762 patients, median age was 75.4 years (IQR: 64.3–81.1) and mean ICH volume was 46.1 cc. Multiple regression for mRS at discharge (mean: 12.5 days, IQR: 7.1–22.3) identified age, presence of intraventricular hemorrhage, ICH volume, renal insufficiency, intake of anticoagulants and IMBES as statistically significant variables. This was confirmed during follow-up examination, although ICH volume was not significantly associated with neurological outcome.</div></div><div><h3>Discussion and conclusion</h3><div>We observed a decreased neurological recovery and an increased mortality for patients with high IMBES during acute care and at early follow-up, indicating that IMBES had the strongest association in all regression analysis. We conclude that the fast and simple IMBES may be a useful tool to estimate patient risk for impaired neurological outcome and death.</div></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"Article 104226"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report with a literature review of trigeminal neuralgia secondary to a large posterior communicating artery aneurysm","authors":"Amer A. Alomari ,&nbsp;Fabio Boccacci ,&nbsp;Carlo Giacobbo Scavo ,&nbsp;Guido Cedrone ,&nbsp;Raffaelino Roperto ,&nbsp;Ali Zomorodi ,&nbsp;Luciano Mastronardi","doi":"10.1016/j.bas.2025.104215","DOIUrl":"10.1016/j.bas.2025.104215","url":null,"abstract":"<div><div>This is a case report of a 66-year-old female who developed atypical trigeminal neuralgia over ophthalmic-V1 and maxillary-V2 divisions secondary to a posterior communicating artery aneurysm (1.5 cm). Literature review of similar cases, description of the pain, its distribution, the aneurysm features, the pathophysiology, and the patient's management and outcome are presented.</div></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"Article 104215"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, interest and perspectives on Artificial Intelligence in Neurosurgery. A global survey","authors":"A. Boaro ,&nbsp;E. Mezzalira ,&nbsp;F. Siddi ,&nbsp;C. Bagattini ,&nbsp;N. Gabrovsky ,&nbsp;N. Marchesini ,&nbsp;M. Broekman ,&nbsp;F. Sala","doi":"10.1016/j.bas.2024.104156","DOIUrl":"10.1016/j.bas.2024.104156","url":null,"abstract":"<div><h3>Introduction</h3><div>Artificial Intelligence (AI) applications in healthcare are growing exponentially. The field of neurosurgery is particularly suited to implement AI solutions given its technology-driven nature. It is of paramount importance to understand the basics of AI to make informed decision on how to shape current and future applications.</div></div><div><h3>Research question</h3><div>What is the level of confidence, knowledge and the attitude of the global neurosurgical community towards AI basic concepts and applications?</div></div><div><h3>Material and methods</h3><div>A 24-item survey was designed and distributed. The survey results reported on level of knowledge, confidence and interest in AI, perspectives and attitude towards the application of AI technologies in neurosurgery. The potential influence of demographics and work-related environment features on AI knowledge was investigated.</div></div><div><h3>Results</h3><div>We received a total of 250 responses from 61 countries. The correct definition of ‘Machine Learning’, ‘Deep Learning’ and main Big Data features were identified by respectively 42%, 23% and 23% of the respondents. The survey unveiled a strong interest and a positive attitude towards the introduction of AI in the neurosurgical practice. The main concerns included trustworthiness and liability, the main barriers to implementation were considered lack of funding, infrastructure, knowledge and multidisciplinary collaboration.</div></div><div><h3>Discussion and conclusion</h3><div>There is a low familiarity with basic AI concepts in the neurosurgical community. Nevertheless, there is a strong interest and a positive attitude towards AI implementation. The systematization of training and the production of educational resources will be key in guaranteeing a successful implementation of AI in the evolving history of neurosurgery.</div></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"Article 104156"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current state and future perspectives of spinal navigation and robotics—an AO spine survey","authors":"Stefan Motov ,&nbsp;Vicki M. Butenschoen ,&nbsp;Philipp E. Krauss ,&nbsp;Anand Veeravagu ,&nbsp;Kelly H. Yoo ,&nbsp;Felix C. Stengel ,&nbsp;Nader Hejrati ,&nbsp;Martin N. Stienen","doi":"10.1016/j.bas.2024.104165","DOIUrl":"10.1016/j.bas.2024.104165","url":null,"abstract":"<div><h3>Introduction</h3><div>The use of robotics in spine surgery has gained popularity. This study aims to assess the current state of robotics and raise awareness of its educational implications.</div></div><div><h3>Research question</h3><div>What are the current adoption trends and barriers to the implementation of robotic assistance in spine surgery?</div></div><div><h3>Material and methods</h3><div>An online questionnaire comprising 27 questions was distributed to AO spine members between October 25th and November 13th, 2023, using the SurveyMonkey platform (<span><span>https://www.surveymonkey.com</span><svg><path></path></svg></span>; SurveyMonkey Inc., San Mateo, CA, USA). Statistical analyses (descriptive statistics, Pearson Chi-Square tests) and generation of all graphs were performed using SPSS Version 29.0.1.0 (IBM SPSS Statistic).</div></div><div><h3>Results</h3><div>We received 424 responses from AO Spine members (response rate = 9.9 %). The participants were mostly board-certified orthopedic surgeons (46 %, n = 195) and neurosurgeons (32%, n = 136). While 49% (n = 208) of the participants reported occasional or frequent use of navigation assistance, only 18 % (n = 70) indicated the use of robotic assistance for spinal instrumentation. A significant difference based on the country's median income status (p &lt; 0.001) and the respondent's number of annual instrumentation procedures (p &lt; 0.001) has been observed. While 11 % (n = 47) of all surgeons use a spinal robot frequently, 36 % (n = 153) of the participants stated they don't need a robot from a current perspective. Most participants (77%, n = 301) concluded that high acquisition costs are the primary barrier for the implementation of robotics.</div></div><div><h3>Discussion and conclusion</h3><div>Although the hype for robotics in spine surgery increased recently, robotic systems remain non-standard equipment due to cost constraints and limited usability.</div></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"Article 104165"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting the Endoscopic vs. Microscopic colloid cysts resection battle with emphasis on endoscope assisted technique","authors":"Ahmed Al Menabbawy ,&nbsp;Amr Elsamman ,&nbsp;Tamim Essawy ,&nbsp;Reem Elwy ,&nbsp;Sebastian Lehmann ,&nbsp;Loay Shoubash ,&nbsp;Ehab El Refaee ,&nbsp;Nasser M.F. El-Ghandour ,&nbsp;Mohamed Ramadan ,&nbsp;Ahmed Zohdi","doi":"10.1016/j.bas.2024.104181","DOIUrl":"10.1016/j.bas.2024.104181","url":null,"abstract":"<div><h3>Introduction</h3><div>Colloid cysts are challenging regarding their location. Surgical resection remains the therapeutic option of choice for symptomatic cysts. However, choosing the optimal surgical approach is still a subject of debate.</div></div><div><h3>Research question</h3><div>The aim of the study is to compare three surgical approaches; Pure endoscopic (PE), pure microscopic (PM) and endoscope assisted microsurgical (EA).</div></div><div><h3>Material and methods</h3><div>Retrospective data extraction from our database was done and we included patients who underwent surgical resection for colloid cysts since 2008. Patients were categorized into three groups based on the forementioned surgical techniques. Outcome measures assessed included extent of resection (EOR), morbidity using modified Rankin Scale (mRS), hospital stay duration (HSD), and complications.</div></div><div><h3>Results</h3><div>41 patients met our inclusion criteria and were divided as follows; PM 13 patients (31.7%), PE 19 patients (46.3%) and EA with 9 patients (22.0%). Mean age (SD) was 37.4 ± 12.2. Male: Female is 1:1.05 and average follow-up was 3.9 ± 2.8 years. Gross total resection(GTR) reached 92.3% (12/13) using PM, 78.9% (15/19) with PE and 100% (9/9) under EA. Morbidity was 15.4%, 10.5% and 0% respectively (mRS &gt;2). Hospital stay duration was significantly shorter in PE and EA (p = 0.012).</div></div><div><h3>Discussion and conclusion</h3><div>EA excision of colloid cysts is safe and effective. When compared to PE and PM approaches, it can combine the advantages of both tools utilizing the microscope and endoscope to achieve a safe, gross total resection while minimizing hospitalization duration. The choice of surgical approach, however, should be individualized based on the cyst's location, size, and the surgeon's expertise and preference.</div></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"Article 104181"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical symptoms and surgical outcome of colloid cysts of the third ventricle: A multicenter retrospective study","authors":"V.M. Butenschoen ,&nbsp;N. Lange ,&nbsp;A. Quiring ,&nbsp;L. Mikhina ,&nbsp;J. Gempt ,&nbsp;M. Shah ,&nbsp;J. Beck ,&nbsp;P. Evangelou ,&nbsp;V. Rohde ,&nbsp;D. Jankovic ,&nbsp;F. Ringel ,&nbsp;I. Janssen ,&nbsp;K. Schaller ,&nbsp;C.F. Freyschlag ,&nbsp;C. Thomé ,&nbsp;S. Maurer ,&nbsp;M. Czabanka ,&nbsp;P. Leissa ,&nbsp;P. Vajkoczy ,&nbsp;B. Meyer","doi":"10.1016/j.bas.2025.104196","DOIUrl":"10.1016/j.bas.2025.104196","url":null,"abstract":"<div><h3>Introduction</h3><div>Colloid cysts of the third ventricle are benign brain lesions that may obstruct cerebrospinal fluid flow within the ventricular system and cause symptoms like headaches, deterioration of vision, and acute hydrocephalus.</div></div><div><h3>Research question</h3><div>What is the clinical outcome of surgical treatment of third ventricle colloid cysts, and what factors are influencing long-term complications?</div></div><div><h3>Material and methods</h3><div>In this multicenter retrospective cohort study performed between 2008 and 2023, we assessed the preoperative clinical status, the colloid cyst risk score, surgical techniques, and the clinical outcome of patients undergoing surgical cyst resection for incidental and symptomatic colloid cysts of the third ventricle. We specifically focused on long-term data such as shunt dependency and postoperative complications.</div></div><div><h3>Results</h3><div>In total, 190 patients were included. Most presented with headaches (75,3%), while 25% showed signs of acute and 36% signs of chronic hydrocephalus. In 23% of the patients, short-term memory was impaired. The surgical treatment presented a safe and definite treatment, with wound healing disorders (6.3%) and CSF leakage (4.7%) being the most frequently encountered complications. Only 5.3% showed a postoperative shunt dependency.</div></div><div><h3>Discussion and conclusion</h3><div>The surgical treatment of colloid cysts of the third ventricle represents a safe procedure. Acute hydrocephalus was observed more frequently than previously described, and shunt dependency after surgery was low. (211/250 words)</div></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"Article 104196"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome measures after anterior cervical decompression and fusion surgery –non-respondents do not bias the results: A Finnish spine register (FinSpine) study","authors":"N. Klimko ,&nbsp;N. Danner ,&nbsp;H. Salo ,&nbsp;A. Malmivaara ,&nbsp;V. Leinonen ,&nbsp;J. Huttunen","doi":"10.1016/j.bas.2024.104179","DOIUrl":"10.1016/j.bas.2024.104179","url":null,"abstract":"<div><h3>Introduction</h3><div>Comprehensive national spine registers are used in the Nordic countries. Register data is inherently incomplete, raising concerns about the derived results due to non-respondent bias. Few studies have addressed the effect of non-respondents on the integrity of patient-reported outcome data in national spine registers, suggesting that outcome measures after spine surgery may not differ between respondents and non-respondents.</div></div><div><h3>Research question</h3><div>Using the Finnish national spine register (FinSpine), we aimed to assess whether non-respondents would bias patient-reported outcomes at 12 months following anterior cervical decompression and fusion (ACDF) surgery.</div></div><div><h3>Material and methods</h3><div>FinSpine data from 5563 ACDF surgeries since 2016 were analyzed, supplemented with prescription records from the Finnish Social Insurance Institution and subcohort data from Kuopio University Hospital. Patients were grouped based on whether they completed post-operative outcome surveys. Outcomes were compared on neck and upper extremity pain, functional capacity, quality of life, sleep quality, return to work, regular use of pain medication, and opioid purchases 12 months after surgery.</div></div><div><h3>Results</h3><div>Out of 5563 ACDF patients, 1362 (24.5%) purchased opioids during the first post-operative year. There were no significant differences in the mean cumulative opioid purchases between respondents and non-respondents. In the subcohort (n = 60), all non-respondents (n = 29) were reached and interviewed. There were no differences between respondents and non-respondents in any outcome measures at 12 months.</div></div><div><h3>Discussion and conclusion</h3><div>Non-respondents do not bias the assessment of outcome measures following ACDF at 12 months, supporting the validity and reliability of national quality registers like FinSpine for clinical research.</div></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"Article 104179"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}