Brain & spine最新文献

{"title":"Consensus on the management of traumatic brain injury in older adults: Results from a Delphi study.","authors":"Alfonso Lagares, Bart Depreitere, Niklas Marklund, Ana María Castano Leon, Jussi P Posti, Alexander Younsi, Sam Klein","doi":"10.1016/j.bas.2025.104319","DOIUrl":"10.1016/j.bas.2025.104319","url":null,"abstract":"<p><strong>Introduction: </strong>As the world population is rapidly becoming older, the incidence of traumatic brain injury (TBI) is increasing among older adults with vast implications for brain health of older adults in Europe. Due to differences from younger patients, there are areas of uncertainty in the assessment, diagnosis and management of TBI in older adults.</p><p><strong>Research question: </strong>To reach a consensus among experts on statements regarding the definition of old age, assessment, diagnosis and management of traumatic brain injury in older adults.</p><p><strong>Materials and methods: </strong>A modified Delphi method consisting of two online rounds was organised, followed by an in-person meeting. Consensus was defined as >75 % agreement. In the second online round the experts were able to view their first assessment and the average of the group. Some statements were rephrased and presented again in the in-person meeting. Questions with numerical data could not be assessed by consensus and descriptive and non-parametric statistics were used to analyze them.</p><p><strong>Results: </strong>Experts (n = 72), from different nationalities (Europe, United States, Latin America, Africa and Asia) and specialities (Neurosurgery, Emergency Medicine, Intensive care medicine) responded on 62 statements. Consensus was finally reached on 44 statements regarding the definition of older adulthood, as well as the assessment, surgical and intensive care management, discharge, and rehabilitation of patients.</p><p><strong>Discussion and conclusions: </strong>This consensus reinforces the importance of this area for physicians and researchers interested in traumatic brain injury. It signals important areas of agreement as well as future topics for research and specific knowledge gaps.</p>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"104319"},"PeriodicalIF":2.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of early decompression surgery and injury characteristics on neurological recovery following traumatic cervical spinal cord injury.","authors":"Ngo Dinh Trung, Hoang Xuan Su, Dao Trong Chinh, Nguyen Chi Tam, Le Nam Khanh, Do Van Nam","doi":"10.1016/j.bas.2025.104326","DOIUrl":"10.1016/j.bas.2025.104326","url":null,"abstract":"<p><strong>Introduction: </strong>Traumatic cervical spinal cord injury (SCI) frequently leads to severe neurological deficits. Early decompressive surgery, when performed shortly after the injury, is believed to improve outcomes. However, the impact of surgical timing, calculated from the moment of injury, and injury characteristics on neurological recovery remains poorly understood.</p><p><strong>Research question: </strong>This study aims to assess the impact of early decompressive surgery and injury characteristics on neurological recovery in traumatic cervical SCI patients.</p><p><strong>Material and methods: </strong>A retrospective case-control study was conducted at the 108 Central Military Hospital in Hanoi, Vietnam, between January 2018 and June 2023. Data collected included demographics, injury characteristics, time from injury to decompression surgery, and clinical outcomes at the 1-year follow-up.</p><p><strong>Results: </strong>Among the 193 patients initially screened, 156 met the inclusion criteria. Neurological recovery was observed in 44.2 % of patients. Early decompression within 24 h significantly improved recovery outcomes (OR = 3.12, p = 0.006). Injury at C1-C3 levels, longer spinal cord injury length, and severe spinal canal stenosis were associated with poorer recovery (OR = 0.34, p = 0.015; OR = 0.21, p < 0.001; OR = 0.34, p = 0.009, respectively). Prolonged ICU stay correlated with worse recovery (OR = 0.90, p = 0.002).</p><p><strong>Discussion and conclusion: </strong>Early decompressive surgery, thorough assessment of injury characteristics, and minimizing ICU stay duration are critical for improving neurological recovery. These findings highlight the importance of timely surgery and strategic clinical management in enhancing recovery outcomes in traumatic cervical SCI patients.</p>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"104326"},"PeriodicalIF":1.9,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sylvian fissure meningioma: A case report and systematic review of clinical and surgical insights.","authors":"Mohammed A Azab, Khalid Sarhan, Oday Atallah, Ahmed Sabra, Brahim Kammoun, Ahmed Hazim, Sara Hamed, Mohsen Nabih Shama","doi":"10.1016/j.bas.2025.104310","DOIUrl":"10.1016/j.bas.2025.104310","url":null,"abstract":"<p><strong>Background: </strong>Meningothelial cells within the arachnoid of the Sylvian fissure give rise to a rare subtype of non-dural based tumors known as Sylvian fissure meningiomas (SFMs). The clinical presentations and management of these lesions need to be further explained.</p><p><strong>Methods: </strong>We followed the PRISMA statement guidelines when reporting this systematic review and meta-analysis. We conducted a literature search through PubMed, Embase, and Web of Science.</p><p><strong>Databases: </strong>We performed a quantitative summary of all included studies. We also describe an additional case report of a grade II Sylvian fissure meningioma (SFM).</p><p><strong>Results: </strong>A total of 40 patients with sylvian fissure meningioma were analyzed. The mean (range) age was 23.4 (1.5-73) years, 24 were adults and 16 were children with a female-to-male ratio of 15:25. Most patients with Sylvian fissure meningioma (SFM) presented with seizures 28 (70 %). According to the WHO histological grading of meningiomas, a total of 32 (80 %) tumors were diagnosed as grade I meningiomas and 8 (20 %) were WHO grade II. Pterional craniotomy was the most frequently employed approach, 21 (67.7 %). In 35 studies reporting surgical resection outcomes, gross total resection was achieved in 25 (71.4 %) patients, whereas subtotal resection was necessary in 10 (28.6 %) patients. Postoperative complications were present in 10 out of 40 patients.</p><p><strong>Conclusion: </strong>WHO grade II SFMs are a rare subset of supratentorial meningiomas. The most common symptom is seizure. Imaging reveals no dural tail like other typical meningioma characteristics. The cornerstone of therapy is surgery. It is necessary to assess whether such a location has a positive or negative predictive value in larger case series cohorts.</p>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"104310"},"PeriodicalIF":1.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrathecal baclofen therapy in patients with spastic paraplegia: retrospective evaluation of pretreatment drugs, test dosage, dose increments and final therapy.","authors":"Stephan Kurz, Linda Maria Marth, Christoph-Heinrich Hoffmann, Jonas Hermann Maria Kummerant, Frederik Wilhelm Schneckmann","doi":"10.1016/j.bas.2025.104323","DOIUrl":"10.1016/j.bas.2025.104323","url":null,"abstract":"<p><strong>Introduction: </strong>Intrathecal baclofen therapy (ITB) is an effective alternative for severe generalized spasticity after unsuccessful oral spasmolytic therapy.</p><p><strong>Research question: </strong>What degree of severity, type and duration of pretreatment indicated ITB? What are safe test, starting and effective treatment dose? How common are complications?</p><p><strong>Material and methods: </strong>Descriptive retrospective analysis. Variables: age, gender, etiology, ASIA Impairment Scale (AIS), neurological level, Ashworth Scale (AS). Time of implantation after onset of paralysis. Baclofen test dose, escalation, effective treatment. Type of complications.</p><p><strong>Results: </strong>27 patients (21 male, 6 female) were examined. 80 % were classified AIS A. Neurological levels: 55 % cervical, 45 % thoracic. Median onset of paralysis: 12 months prior. 31 % were previously treated with triple, 54 % with double and 15 % monotherapy. In 42 %, 50 μg intrathecal baclofen test dose was sufficient; 34 % required over 100 μg. Mean increase in daily flow rate from implantation was approx. 180 μg. Effective dose averaged 360 μg per day. All patients started at AS IV°, with 40 % improving to AS I° and 60 % to AS II° under ITB. Complications occurred in 25 % (infection, skin perforation, catheter occlusion, pump malfunction). 85 % of them could be further treated intrathecally after revision.</p><p><strong>Discussion and conclusion: </strong>ITB requires close clinical care and individual coordination depending on the level of pretreatment. Further analysis of complications needs larger case numbers.</p>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"104323"},"PeriodicalIF":1.9,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12272870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of chronic subdural hematoma in spontaneous intracranial hypotension.","authors":"Manou Overstijns, Amir El Rahal, Katharina Wolf, Niklas Lützen, Urs Würtemberger, Lucas Becker, Horst Urbach, Daniel Casanova Martinez, Jürgen Beck, Florian Volz","doi":"10.1016/j.bas.2025.104320","DOIUrl":"10.1016/j.bas.2025.104320","url":null,"abstract":"<p><strong>Introduction: </strong>There is no accepted algorithm for the management of chronic subdural hematoma (cSDH) caused by spinal CSF leaks in spontaneous intracranial hypotension (SIH).</p><p><strong>Research question: </strong>This study analyses characteristics of cSDH in SIH to establish a practicable management algorithm.</p><p><strong>Material and methods: </strong>This retrospective cohort study included all patients with spinal CSF leak closure from April 2018 to April 2024. Demographics, leak type, treatment modalities, as well as cSDH characteristics, prevalence, and risk factors were analyzed.</p><p><strong>Results: </strong>Among 272 SIH patients, 85 (31 %) concomitantly had cSDH, predominantly bilateral (88 %). Hematoma width ranged from 2 to 30 mm. cSDH prevalence was highest in CSF-venous fistulas (43 %), followed by ventral (31 %) and lateral leaks (22 %). Male sex (OR = 4; p < 0.001) and age >70 years (OR = 6; p = 0.008) were significant risk factors. Surgical evacuation was performed in 23 patients, with symptoms attributable to cSDH in 17/23 patients. The biggest cSDH without surgical treatment was 20 mm. No neurological deterioration occurred during diagnostics or treatment of CSF leaks. After leak closure, no cSDH, regardless of initial size or previous treatment, required additional treatment, and no recurrence occurred in the 3-month follow-up.</p><p><strong>Discussion and conclusion: </strong>Primary localization and targeted treatment of the spinal leak is safe in asymptomatic patients and cSDH ≤10 mm (\"leak first\" strategy). Immediate evacuation of the cSDH is mandatory in symptomatic patients (\"subdural first\" strategy). We consider the CSF leak closure as a causal treatment for cSDH resulting in a markedly low, close to zero, recurrence rate. Prospective validation of these findings is needed.</p>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"104320"},"PeriodicalIF":1.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12272930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging advances in spinal cord injury: An introductory overview.","authors":"Michael G Fehlings, Shintaro Honda, Peter Vajkoczy, Narihito Nagoshi","doi":"10.1016/j.bas.2025.104307","DOIUrl":"10.1016/j.bas.2025.104307","url":null,"abstract":"<p><p>Spinal cord injury (SCI) remains a devastating condition with limited treatment options. This Focus Issue highlights recent clinical and translational advances across the continuum of SCI care from prehospital coordination to novel therapeutics. The articles cover multidisciplinary strategies during the early post-injury phase, including acute pre-hospital care and pragmatic alternatives for settings with limited medical resources. A historical perspective on the evolution of surgical timing and a comprehensive reappraisal of the pathophysiology of central cord syndrome provide valuable clinical context. Emerging diagnostic innovations are prominently featured, including novel biomarkers such as cerebrospinal fluid pressure dynamics, quantitative MRI, and navigated transcranial magnetic stimulation, which offer the potential to refine diagnosis and personalize prognostication. In parallel, emerging therapeutic technologies such as 3D-printed surgical guides and clinical applications of stem cell therapies represent significant advances in addressing long-standing challenges. The issue also includes comprehensive reviews of current classification systems and diagnostic criteria for both spine fractures and degenerative cervical myelopathy. Together, these contributions provide a multidisciplinary overview of the evolving landscape in SCI research and care, bridging basic science with clinical practice across diverse healthcare settings.</p>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"104307"},"PeriodicalIF":1.9,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-reported challenges in spinal cord injury rehabilitation and integration within the community of a lower middle-income country: opportunities for changing lives.","authors":"Rajani Mullerpatan, Aamreen Ryain, Neha Padia, K R Salgotra","doi":"10.1016/j.bas.2025.104299","DOIUrl":"10.1016/j.bas.2025.104299","url":null,"abstract":"<p><strong>Introduction: </strong>Rehabilitation of individuals with spinal cord injury (SCI) is improving in tertiary-healthcare settings of low-middle-income countries (LMICs). However, rehabilitation and integration within the community is yet a distant target.</p><p><strong>Research question: </strong>What are the patients-reported challenges in rehabilitation and community-integration which open opportunities to change lives of individuals with SCI.</p><p><strong>Material and methods: </strong>Clinical-records and interviews of 24 adults with SCI were examined to report socio-demographic information, functioning, disability, cost-of-care, health-related- quality-of-life and environmental-barriers.</p><p><strong>Results: </strong>Fifty-percent individuals belonged to lower-middle socio-economic strata. Functioning independence (SCIM) was highest in indoor (9.0 ± 1.4); and least in outdoor-mobility (9.3 ± 4.0) 7.8yr after injury. Individuals from lower-income-strata had no access to indoor water(n = 5) and toilet(n = 8) facilities. WHO-QoL was lowest (39.5 ± 15.0) in environmental domain. Seventy-percent individuals employed before SCI, could not return to previous jobs. Post-injury, 8 were employed in alternate lesser paid jobs; whereas 16 were dependent on family. Cost-of-care was covered either by self(n = 1), government health-insurance (n = 1); private health-insurance (n = 3); employer (n = 5); NGO (n = 2), family (n = 12).</p><p><strong>Discussion and conclusion: </strong>Patient-reported challenges in rehabilitation and community-integration of individuals with SCI, highlight gaps in access to basic amenities in houses, inaccessible transport and public spaces and financial-hardships caused by lack of coverage of rehabilitation costs and unemployment in the low socioeconomic strata despite numerous health policies and schemes. These challenges prompt urgent research in the health system and open opportunities for strategic-planning of context-specific, participatory, sustainable, climate-resilient measures to rebuild lives and facilitate respectful integration in society and alleviation of socio-economic burden of SCI.</p>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"104299"},"PeriodicalIF":1.9,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment practices for geriatric type II odontoid fractures - A survey by the European Association of Neurosurgical Societies Spine Section.","authors":"Ralph T Schär, Jefferson R Wilson, Marcel Ivanov, Giuseppe Barbagallo, Yana Petrova, Carla Reizinho, Maria Luisa Gandia González, Enrico Tessitore, Andrzej Maciejczak, Nikolay Gabrovsky, Bart Depreitre, Ehab Shiban, Andreas K Demetriades, Florian Ringel","doi":"10.1016/j.bas.2025.104295","DOIUrl":"10.1016/j.bas.2025.104295","url":null,"abstract":"<p><strong>Introduction: </strong>Controversy exists regarding the optimal management of type II odontoid fractures in the geriatric population. The objective of this study was to determine the current treatment patterns of spine surgeons for geriatric patients (≥70 years) with type II odontoid fractures.</p><p><strong>Research question: </strong>How much do treatment practices for type II odontoid fractures in the geriatric population differ amongst spine surgeons?</p><p><strong>Methods: </strong>The European Association of Neurosurgical Societies (EANS) Spine Section distributed a 39-items web-based survey among spine surgeons between July 2024 and February 2025.</p><p><strong>Results: </strong>A total of 154 responses were collected from 119 neurosurgeons (77.8 %) and 34 orthopedic surgeons (22.2 %). Participants were predominantly from Europe (92.7 %), and 63.2 % have been in practice >10 years. Fracture displacement, comorbidities and age were the most influential factors for decision-making. For non-displaced fractures, 78.8 % of respondents recommended conservative treatment for patients aged 70-80 years, and 83.7 % for those aged 80-90 years. For displaced fractures, 70.9 % preferred surgery for patients aged 70-80 years, whereas this preference decreased to 47.9 % for those aged 80-90 years. Posterior C1-2 fixation was the most common technique for 67.3 % of respondents, and 48.3 % prescribe a collar postoperatively. 51.3 % routinely order CT imaging postoperatively to assess for bony fusion. For conservative treatment, 59.3 % prescribe an external orthosis for 3 months.</p><p><strong>Discussion and conclusion: </strong>Our survey found both variability and consistency in treatment practices of geriatric type II odontoid fractures, reflecting the ongoing debate and lack of consensus in clinical decision-making.</p>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"104295"},"PeriodicalIF":1.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Hounsfield units on adjacent fracture risk after kyphoplasty.","authors":"Nazeer Aboud, Niklas Eckardt, Sergio Calero Martinez, Aaron Lawson McLean, Christian Senft, Falko Schwarz","doi":"10.1016/j.bas.2025.104296","DOIUrl":"10.1016/j.bas.2025.104296","url":null,"abstract":"<p><strong>Study design: </strong>retrospective cohort study.</p><p><strong>Objective: </strong>This study aims to assess the utility of Hounsfield units (HU) derived from computed tomography (CT) scans as a predictive marker for the risk of adjacent fractures (AF) following kyphoplasty.</p><p><strong>Methods: </strong>In a retrospective analysis at a high-volume care hospital, 93 patients who underwent single-level kyphoplasty between January 2012 and December 2020 were included. The study focused on the correlation between HU values in vertebrae adjacent to the operated level and the occurrence of AF. Patient demographics, fracture characteristics, and time to AF occurrence were recorded. Bone density was assessed using HU measurements from CT scans, focusing on the trabecular bone.</p><p><strong>Results: </strong>The median time to AF occurrence was 10 weeks, with no significant correlation to patient demographics or fracture location. A marked association was observed between reduced bone density, as measured by HU in the vertebrae adjacent to the kyphoplasty site, and the incidence of AF. Particularly, the bone density in the vertebra immediately superior to the operated site showed a statistically significant relationship with the occurrence of AF.</p><p><strong>Conclusion: </strong>This study underscores the potential of HU measurements in CT scans as a predictive tool for AF risk post-kyphoplasty. Reduced bone density in adjacent vertebrae emerged as a significant risk factor. These findings highlight the necessity for vigilant postoperative monitoring and a proactive approach in managing bone health in patients undergoing kyphoplasty for osteoporotic fractures.</p>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"104296"},"PeriodicalIF":1.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential applications of focused ultrasound for spinal cord diseases: a narrative review of preclinical studies.","authors":"Ryan Nguyen, Victor Gabriel El-Hajj, Umberto Battistin, Karl J Habashy, Victor E Staartjes, Adrian Elmi-Terander, Jingke Zhang, Abdul Karim Ghaith","doi":"10.1016/j.bas.2025.104298","DOIUrl":"10.1016/j.bas.2025.104298","url":null,"abstract":"<p><p>Focused ultrasound (FUS) technology provides unique advantages as a therapy targeting the central nervous system (CNS). We aimed to investigate and summarize the potential applications of FUS in the context of spinal cord diseases. Search strategies were created using a combination of keywords and standardized index terms. Searches were run in April 2025 in the Ovid Cochrane Central Register of Controlled Trials, EBSCO MegaFILE, Ovid Embase, Ovid Medline, Ovid PsycINFO, Scopus, and Web of Science Core Collection to retrieve all relevant studies from inception until 2024. A narrative and comprehensive summary of the current body of evidence was performed. Current preclinical studies indicate the potential use of spinal cord FUS in blood-spinal cord barrier (BSCB) disruption, neuromodulation, and inflammatory regulation following spinal cord injury. Targeted CNS drug delivery with BSCB disruption using FUS has proven promising in the context of neuro-oncology and neurotrauma. Additionally, FUS has been explored for neuromodulation in managing neuropathic pain and spasticity. FUS to the spinal cord may also provide anti-inflammatory effects and alter the local cellular response to injury. While therapeutic FUS ablation of brain structures has been extensively studied, research on similar applications within the spinal cord was less prevalent and faces multiple challenges. FUS is a highly promising technique with multiple advantages and potential applications in the treatment of spinal cord diseases. Current research efforts have shifted focus towards translational studies, while human trials are currently limited.</p>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"104298"},"PeriodicalIF":1.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}