Brain & spine最新文献_第5页

Navigated percutaneous placement of cervical pedicle screws: An anatomical feasibility study

IF 1.9

Brain & spine Pub Date : 2025-01-01 DOI: 10.1016/j.bas.2025.104199

G. Schmeiser , C. Blume , N. Hecht , S. Mattes , H. Ittrich , R. Kothe

{"title":"Navigated percutaneous placement of cervical pedicle screws: An anatomical feasibility study","authors":"G. Schmeiser , C. Blume , N. Hecht , S. Mattes , H. Ittrich , R. Kothe","doi":"10.1016/j.bas.2025.104199","DOIUrl":"10.1016/j.bas.2025.104199","url":null,"abstract":"<div><h3>Introduction</h3><div>Percutaneous cervical pedicle screw placement is challenging due to complex anatomy, and requires navigation support. It is unclear how to ensure navigation accuracy in minimally invasive procedures.</div></div><div><h3>Research question</h3><div>How accurate is image-guided percutaneous pedicle screw positioning after referencing with only one clamp for the complete subaxial cervical spine?</div></div><div><h3>Materials and methods</h3><div>In six cadavers, all subaxial cervical pedicles were fitted with screws using a standardized procedure. Briefly, a reference clamp was placed via a small skin incision on spinous process C7. The procedure started from C3 and progressed towards C7, without additional imaging, using one registration for all vertebrae. Screws were placed using a navigated screwdriver. Cone-beam CT was performed at three time-points. Screw position was directly intraoperatively evaluated by the surgeons using a modified classification—from Grade 1 (perfect placement) to Grade 5 (highly inaccurate)—and these data were re-evaluated by two independent radiologists.</div></div><div><h3>Results</h3><div>In six human specimens, 10 guidewires each were placed bilaterally in C3–C7. One screw (1.7%) was intraoperatively classified as Grade 3, but as Grade 4 in the second assessment. All other screws were classified as Grades 1–2 (89.8%) or 3 (8.5%). Screw placement accuracy was not significantly impacted by distance to the clamp or side selection.</div></div><div><h3>Discussion</h3><div>In percutaneously navigated screw placement with intraoperative imaging, safe screw placement was possible with a reference clamp on C7. Clinical application of this technique has been limited to individual cases. We also propose a new classification for improving screw accuracy and clinical consequences.</div></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"Article 104199"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subgaleal drainage with one burr-hole for chronic subdural hematomas: Our two-years’ experience

IF 1.9

Brain & spine Pub Date : 2025-01-01 DOI: 10.1016/j.bas.2025.104185

Franziska A. Schmidt , Victoria Schön , Ondra Petr, Christian F. Freyschlag, Claudius Thomé

引用次数: 0

Letter to the editor regarding the response to “Multidisciplinary consensus-based statement on the current role of Middle Meningeal Artery embolization (MMAE) in chronic SubDural Hematoma (cSDH)”

IF 1.9

Brain & spine Pub Date : 2025-01-01 DOI: 10.1016/j.bas.2025.104186

M. Foppen, W.P. Vandertop, D. Verbaan

引用次数: 0

Neuropathic pain appears to be the main symptom associated with higher disease burden and lower pain alleviation in degenerative lumbar disease fusion patients

IF 1.9

Brain & spine Pub Date : 2025-01-01 DOI: 10.1016/j.bas.2025.104224

Alexander Cristea , Bart F.J. Heijnen , Seung Won Park , Aleksandr Krutko , Carlos Santos , Wolfgang Senker , Vasileios Arzoglou , Paulo Pereira

{"title":"Neuropathic pain appears to be the main symptom associated with higher disease burden and lower pain alleviation in degenerative lumbar disease fusion patients","authors":"Alexander Cristea , Bart F.J. Heijnen , Seung Won Park , Aleksandr Krutko , Carlos Santos , Wolfgang Senker , Vasileios Arzoglou , Paulo Pereira","doi":"10.1016/j.bas.2025.104224","DOIUrl":"10.1016/j.bas.2025.104224","url":null,"abstract":"<div><h3>Introduction</h3><div>The role of neuropathic pain (NP) in persisting pain after degenerative lumbar disease (DLD) fusion surgery appears to be underrecognized and undertreated.</div></div><div><h3>Research question</h3><div>This study assessed NP in DLD patients before and after lumbar interbody fusion (LIF) surgery, and the NP-related burden of disease up to 12-months post-op.</div></div><div><h3>Materials and methods</h3><div>Within a prospective, multi-center, data-monitored study, a sub-cohort of 146 DLD patients underwent LIF. NP was assessed pre-op and 3-months post-op with a validated Douleur Neuropathique-4 questionnaire. Outcomes were analyzed based on NP occurrence at baseline and post-op. Medication use, back-pain, leg-pain, Oswestry Disability Index (ODI), and quality of life (QoL) were determined pre-op, 3-months and 12-months post-op. Fusion success was evaluated via x-ray and/or CT-scan. Changes were analyzed using paired t-tests and ANCOVA to test for group differences.</div></div><div><h3>Results</h3><div>NP was present pre-op in 51% of the DLD patients associated with higher back- and leg-pain, and lower QoL. LIF resulted in significant pain relief and improved QoL for all patients. Patients presenting NP post-op had significantly lower back- and leg-pain relief, ODI and QoL up to 1-year post-op. Opioid consumption was higher in the NP group, whereas DM and PVD occurrence, and fusion rates were similar.</div></div><div><h3>Discussion and conclusion</h3><div>NP occurred frequently in DLD patients, both before and after spine fusion surgery. Patients with post-operative NP reveal a significant association between NP, lower pain alleviation and higher disease burden up to 12-months post-op, despite higher opioid consumption. NP occurred independently of DM, PVD and fusion success.</div></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"Article 104224"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiological progression of medulloblastoma from non-existence to symptomatic mass in 42 days: Case report, kinetic analysis, and literature review

IF 1.9

Brain & spine Pub Date : 2025-01-01 DOI: 10.1016/j.bas.2025.104188

Yousef M. Odeibat , Mohammad Y. Hiasat , Mohammad H.M. Alhazaimeh , Ala Marji , Ammar S. Al-Omary , Ajwad Obeidat , Amer A. Alomari

{"title":"Radiological progression of medulloblastoma from non-existence to symptomatic mass in 42 days: Case report, kinetic analysis, and literature review","authors":"Yousef M. Odeibat , Mohammad Y. Hiasat , Mohammad H.M. Alhazaimeh , Ala Marji , Ammar S. Al-Omary , Ajwad Obeidat , Amer A. Alomari","doi":"10.1016/j.bas.2025.104188","DOIUrl":"10.1016/j.bas.2025.104188","url":null,"abstract":"<div><h3>Introduction</h3><div>Medulloblastoma (MB) is the most common malignant brain tumor in children, characterized by its aggressive nature and rapid growth. However, the standard practice of immediate surgical intervention limits opportunities to study the tumor's doubling time (DT), thereby restricting our understanding of its growth kinetics.</div></div><div><h3>Research question</h3><div>This study presents a pediatric case of MB that developed within 42 days of a normal MRI, with a focus on analyzing the tumor's DT and comparing it with values reported in the literature.</div></div><div><h3>Materials and methods</h3><div>Tumor kinetics were assessed using volumetric measurements obtained via 3D Slicer software. A literature review identified six studies that examined the radiological DT of medulloblastoma for comparative analysis.</div></div><div><h3>Results</h3><div>The estimated DT for the presented case ranged between 2 and 6.5 days, indicating exceptionally rapid tumor proliferation. This is shorter than previously reported cases, where DTs ranged from 6.84 to 353 days. Including the current case, the mean DT across all cases is 53.8 days.</div></div><div><h3>Discussion and conclusion</h3><div>This case highlights the potential for extremely rapid progression in MB, underscoring the aggressive nature of this tumor. The findings emphasize the importance of prompt diagnosis and intervention in MB cases. Further research into the genetic and molecular mechanisms driving its aggressive growth could support the development of targeted therapeutic strategies.</div></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"Article 104188"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammation and macrophage polarization are associated with Modic change type in lumbar radiculopathy

IF 1.9

Brain & spine Pub Date : 2025-01-01 DOI: 10.1016/j.bas.2025.104249

Wensen Li , Niek Djuric , Christiaan Mink , Carmen L.A. Vleggeert-Lankamp

{"title":"Inflammation and macrophage polarization are associated with Modic change type in lumbar radiculopathy","authors":"Wensen Li , Niek Djuric , Christiaan Mink , Carmen L.A. Vleggeert-Lankamp","doi":"10.1016/j.bas.2025.104249","DOIUrl":"10.1016/j.bas.2025.104249","url":null,"abstract":"<div><h3>Introduction</h3><div>Lumbar disc herniation (LDH) typically manifests as sciatica, attributed to nerve root mechanical compression and/or inflammation. Modic changes (MC), classified as type I or type II, are deemed to represent endplate vascular insufficiency and are hypothesized to create an inflammatory environment. Macrophages infiltrating disc tissue can be polarized into pro-inflammatory M1 or anti-inflammatory M2 phenotypes.</div></div><div><h3>Research question</h3><div>This study aims to investigate the interplay among inflammatory cells, including M1 and M2 macrophages, Modic Changes, and hernia size and type in patients suffering from sciatica due to a LDH.</div></div><div><h3>Material and methods</h3><div>This prospective cohort study selected patients undergoing microdiscectomy for LDH. Macrophage infiltration (CD68, CD192, CD163), MC classification on MRI, and hernia parameters were analyzed.</div></div><div><h3>Results</h3><div>132 out of 187 patients demonstrated macrophages in the lumbar disc tissue. Most samples demonstrated severe inflammation (50 %), and most macrophages were of the M1 phenotype (48 %). MC were present in 45 % of patients, and only 19 % of these demonstrated MC type I. MC type I were highly associated with both severe (p = 0.016) and M1 macrophage-dominant inflammation (p = 0.048). Larger and non-contained herniations associated with increased inflammation (p = 0.029/p = 0.002), while larger herniations associated with the presence of MC type II (p = 0.027).</div></div><div><h3>Discussion and conclusions</h3><div>This study elucidates a close association of MC type I and M1 macrophage. MC type II were observed more often in patients with larger HNPs. This is indicative for MC typing as an important factor in prediction modelling and it suggests the potential for personalized treatment strategies.</div></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"Article 104249"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

nTMS in spinal cord injury: Current evidence, challenges and a future direction

IF 1.9

Brain & spine Pub Date : 2025-01-01 DOI: 10.1016/j.bas.2025.104234

Josephine Jung , Sabina Patel , Azharul Khan , Alba Diaz Baamonde , Ana Mirallave-Pescador , Yasir A. Chowdhury , David Bell , Irfan Malik , Nick Thomas , Gordan Grahovac , Francesco Vergani , Aminul I. Ahmed , José Pedro Lavrador

{"title":"nTMS in spinal cord injury: Current evidence, challenges and a future direction","authors":"Josephine Jung , Sabina Patel , Azharul Khan , Alba Diaz Baamonde , Ana Mirallave-Pescador , Yasir A. Chowdhury , David Bell , Irfan Malik , Nick Thomas , Gordan Grahovac , Francesco Vergani , Aminul I. Ahmed , José Pedro Lavrador","doi":"10.1016/j.bas.2025.104234","DOIUrl":"10.1016/j.bas.2025.104234","url":null,"abstract":"<div><div>Spinal Cord Injury (SCI) has devastating consequences for patients and their families. Over the last few decades, a renewed interest in the utilization of non-invasive and cost-effective therapeutic technologies in the management of patients with SCI has emerged. This includes stimulation with navigated transcranial magnetic stimulation (nTMS) in order to improve the outcome for these patients alongside with existing clinical tools. nTMS has shown encouraging preliminary results in both clinical assessment and rehabilitation (motor and pain) of patients with SCI. However, different protocols – stimulation parameters, length of treatment and combination with other modalities – and patient selection criteria hampered definitive conclusions. So far, none of these have been adapted in regular clinical practice. In this article, we provide an overview on different assessment and therapeutic strategies using nTMS and review their effectiveness.</div></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"Article 104234"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suicidal ideation after subthalamic stimulation in Parkinson's Disease: A critical concern

IF 1.9

Brain & spine Pub Date : 2025-01-01 DOI: 10.1016/j.bas.2025.104247

Gideon Sorlelodum Alex , Oluwatobiloba Israel Popoola , Inibehe Ime Okon

引用次数: 0

Comparative analysis of mini-open trans-thoracic transpleural and posterior approaches in thoracic disc herniation surgery: A 10-year retrospective review

IF 1.9

Brain & spine Pub Date : 2025-01-01 DOI: 10.1016/j.bas.2025.104244

Ali Baram , Giorgio Cracchiolo , Marco Riva , Gabriele Capo , Leonardo Anselmi , Carlo Brembilla , Stefania Radice , Maria Pia Tropeano , Carla Anania , Emanuela Morenghi , Maurizio Fornari , Federico Pessina

{"title":"Comparative analysis of mini-open trans-thoracic transpleural and posterior approaches in thoracic disc herniation surgery: A 10-year retrospective review","authors":"Ali Baram , Giorgio Cracchiolo , Marco Riva , Gabriele Capo , Leonardo Anselmi , Carlo Brembilla , Stefania Radice , Maria Pia Tropeano , Carla Anania , Emanuela Morenghi , Maurizio Fornari , Federico Pessina","doi":"10.1016/j.bas.2025.104244","DOIUrl":"10.1016/j.bas.2025.104244","url":null,"abstract":"<div><h3>Introduction</h3><div>Thoracic disc herniations (TDHs) are rare, and surgery is typically reserved for patients with radiculopathy, myelopathy, or intractable back pain. Despite established algorithms, the optimal surgical strategy remains debated.</div></div><div><h3>Research question</h3><div>What are the clinical, surgical, and radiological outcomes of anterior and posterior surgical approaches for TDHs over a 10-year period?</div></div><div><h3>Material and methods</h3><div>A retrospective analysis of 54 patients who underwent surgery for TDHs (2013–2022) was performed. Patients were grouped by surgical approach: anterior (34 patients) and posterior (20 patients). Data included preoperative and postoperative outcomes such as operative times, hospital stays, complications, reoperations, and assessments using the Frankel scale, Nurick score, and Visual Analog Scale (VAS) for pain.</div></div><div><h3>Results</h3><div>Both approaches improved clinical outcomes. No significant differences in postoperative Nurick or VAS pain scores were observed. However, the anterior approach showed better Frankel score improvements but was associated with longer operative times and hospital stays. Complications were more frequent in the anterior group.</div></div><div><h3>Discussion and conclusion</h3><div>Both approaches effectively alleviate symptoms in symptomatic TDHs. The anterior approach offers greater neurological improvement but carries higher complication risks. Surgical strategy should be tailored based on herniation characteristics and surgeon expertise. Anterior approaches are ideal for central, large, or calcified herniations, while posterior approaches are preferable for lateral ones.</div></div>","PeriodicalId":72443,"journal":{"name":"Brain & spine","volume":"5 ","pages":"Article 104244"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143792762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter-to-the-editor to the study by Bartek J et al “Multidisciplinary consensus-based statement on the current role of Middle Meningeal Artery embolization (MMAE) in chronic SubDural Hematoma (cSDH)” – A letter from the international CSDH research group committee, iCORIC Bartek等人的研究“基于多学科共识的脑膜中动脉栓塞（MMAE）在慢性硬膜下血肿（cSDH）中的作用”的致编辑信- iCORIC国际CSDH研究小组委员会的一封信。

IF 1.9

Brain & spine Pub Date : 2025-01-01 DOI: 10.1016/j.bas.2024.104169

T.S.R. Jensen , J. Duerinck , D. Holl , C. Iorio-Morin , J. Soleman , E. Edlmann , iCORIC steering committee

引用次数: 0