BJR open最新文献

{"title":"Artificial intelligence-assisted chest X-ray for tuberculosis case finding in low- and middle-income countries: implementation experiences and impact.","authors":"Shibu Vijayan, Aswathy M Nair, Nimmy Dominic, Justy Antony Chiramal, Saniya Pawar, Latashree Goswami","doi":"10.1093/bjro/tzag007","DOIUrl":"10.1093/bjro/tzag007","url":null,"abstract":"<p><p>Medical imaging is fundamental to healthcare systems, aiding in the detection of internal abnormalities related to medical conditions beyond their physical symptoms. In low- and middle-income countries (LMICs), limited access to advanced imaging and scarcity of radiologists for image interpretation are evident. Upgrading available resources with artificial intelligence can expand the diagnostic capacity of LMICs to manage the growing prevalence and incidence of infectious diseases such as tuberculosis (TB). Chest X-rays can act as an effective triage tool for TB screening, and multiple models have been reported to improve the number of cases detected in high-burden settings. The case-finding strategies reported in literature have also demonstrated improved diagnostic accuracy and turnaround time post adoption of artificial intelligence (AI) for chest X-ray interpretation. AI assistance can help in identifying radiological involvement of TB, irrespective of their clinical symptoms. Furthermore, cost-effective, integrated workflows can also efficiently support LMICs by facilitating parallel diagnosis and appropriate linkage to care for multiple chest disorders through a unified pathway, thereby broadening the capabilities of chest X-ray based TB screening. By optimizing and strengthening LMIC health systems with AI, further scale-up and implementation can foster a supportive ecosystem for early disease diagnosis and decentralized care delivery.</p>","PeriodicalId":72419,"journal":{"name":"BJR open","volume":"8 1","pages":"tzag007"},"PeriodicalIF":2.1,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13020908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing current and future demand for PET-CT imaging in England: a comparative analysis of 2013 and 2022 Royal College of Radiologists Guidelines.","authors":"Nadia A S Smith, Rebecca Nutbrown, Alba Eisner, Raj Jena","doi":"10.1093/bjro/tzag006","DOIUrl":"10.1093/bjro/tzag006","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to provide a comprehensive analysis of the increasing demand for PET-CT imaging in England, driven by advancements in technology and updated clinical guidelines. By comparing the 2013 and 2022 guidelines issued by the Royal College of Radiologists, the analysis sought to quantify the gap between actual PET-CT provision and modeled requirements, benchmarked against international comparators, to inform strategic planning for equitable access to advanced imaging.</p><p><strong>Methods: </strong>A detailed modeling approach was developed, mapping guideline-based PET-CT scan requirements to disease incidence and stage for major oncological indications (prostate, lymphoma, neuroendocrine tumors, lung, breast, gynecological cancers) and key non-oncological conditions (dementia, cardiovascular disease). Actual scan volumes were extracted from the NHS Diagnostic Imaging Dataset and cross-referenced with provider data. Unmodeled indications were estimated using proportional scaling. Model outputs were validated against PET-CT utilization rates in Finland, adjusted for UK disease incidence. Future demand projections incorporated population growth, demographic shifts, and evolving disease prevalence.</p><p><strong>Results: </strong>For 2021, modeled estimates indicated a substantial shortfall in PET-CT provision for several high-impact indications, notably prostate cancer, dementia, neuroendocrine tumors, and breast cancer, where actual scan volumes were 2-7 times lower than modeled need. Modeled demand for England (361 900 scans/year) exceeded actual provision (239 367 scans/year) by over 50%. Comparative analysis with Finland confirmed that England's PET-CT rates lagged for most indications except lung cancer. Projections suggest continued growth in demand, particularly for dementia and neuroendocrine tumors, with overall PET-CT needs expected to rise sharply by 2040.</p><p><strong>Conclusions: </strong>England's current PET-CT capacity falls significantly short of evidence-based requirements, especially for emerging indications in neurology and oncology. Without strategic investment and expansion, this gap will widen, risking delayed diagnosis and suboptimal care. Enhanced data collection and ongoing validation are critical for responsive service planning.</p><p><strong>Advances in knowledge: </strong>This is the first study to comprehensively model PET-CT demand in England across multiple disease categories using updated clinical guidelines and international benchmarking. It provides a robust, data-driven framework for forecasting imaging needs, supporting national policy and equitable resource allocation.</p>","PeriodicalId":72419,"journal":{"name":"BJR open","volume":"8 1","pages":"tzag006"},"PeriodicalIF":2.1,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13020349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the gap between radiologic and manometric criteria to diagnose esophageal motility disorders: a pictorial review for radiologists.","authors":"Ahmed O El Sadaney, D Chamil Codipilly, David J Bartlett, Kristina T Flicek, Michael L Wells, Safa Hoodeshenas, Jay Heiken, Karthik Ravi, Joel G Fletcher, Avinash K Nehra","doi":"10.1093/bjro/tzag005","DOIUrl":"https://doi.org/10.1093/bjro/tzag005","url":null,"abstract":"<p><p>Dysphagia is defined as a subjective sensation of difficulty swallowing and can result from oropharyngeal or esophageal etiologies based upon patient symptoms. Dysphagia affects approximately 16% of adults in the general population, with prevalence increasing with age. Esophagogastroduodenuoscopy (EGD) is initially performed to assess for structural abnormalities resulting in esophageal dysphagia. However, if EGD reveals no pathologic abnormalities, high-resolution manometry (HRM) and barium esophagography are performed in order to assess for underlying causes of dysmotility. Esophageal motility disorders (EMDs) are an underrecognized cause of dysphagia and can be characterized by impaired esophageal peristalsis or lower esophageal sphincter dysfunction. High-resolution manometry (HRM) measures key metrics such as integrated relaxation pressure (IRP), which is the deglutitive relaxation across the LES, and metrics of esophageal body peristalsis based on distal contractile integral (DCI) and distal latency (DL). The Chicago Classification version 4 (CCv4.0), published in 2021, provides a standardized classification scheme for differentiating EMDs using metrics from HRM. Additionally, barium esophagography has remained an important adjunctive diagnostic modality, as this may identify strictures, neoplasms, or hiatal hernias, but can also identify major motility disorders such as achalasia and distal esophageal spasm. The combined use of HRM with timed barium esophagram can enhance the diagnostic accuracy of EMDs, particularly when HRM demonstrates inconclusive findings. Therefore, radiologists should be familiar with how imaging findings from barium esophagram integrate with findings noted on HRM. The aim of this review is to highlight the findings of EMDs noted on HRM in conjunction with barium esophagography, thereby illustrating characteristic patterns of primary and secondary EMDs.</p>","PeriodicalId":72419,"journal":{"name":"BJR open","volume":"8 1","pages":"tzag005"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12987765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal time for MRI response evaluation in squamous cell carcinoma of the anus.","authors":"Bettina A Hanekamp, Ellen Viktil, Johann Baptist Dormagen, Nils E Kløw, Cathrine Brunborg, Eirik Malinen, Marianne G Guren, Anselm Schulz","doi":"10.1093/bjro/tzag004","DOIUrl":"https://doi.org/10.1093/bjro/tzag004","url":null,"abstract":"<p><strong>Objectives: </strong>To identify the optimal time for MRI response evaluation after chemoradiotherapy (CRT) in squamous cell carcinoma of the anus (SCCA) and to employ combined T2+diffusion-weighted MRI tumour regression grade (comrTRG).</p><p><strong>Methods: </strong>We assessed the positive and negative predictive values (PPV, NPV) of post-treatment MRI in a retrospective mono-centre diagnostic accuracy study that prospectively included consecutive patients treated between 2013 and 2017. Index tests were MRI at 6-, 12-, and 24-weeks post-treatment (6w, 12w, and 24w) to detect locoregional treatment failures (LRTF). Clinical outcome served as reference standard. Tumour regression was assessed using comrTRG based on radiological reports. Mixed-effects logistic regression was used to compare the comrTRG score across time points. The analyses were stratified by patients' T/N stage and human papillomavirus (HPV) status.</p><p><strong>Results: </strong>For 127 included patients (62 years ± 11 [mean ± SD]; 92 women), 261 post-treatment MRI reports (6w: <i>n</i> = 45, 12w: <i>n</i> = 125, 24w: <i>n</i> = 91) were scored using comrTRG. LRTF occurred in 13 patients; 12/13 were high-risk patients (T3/T4, N+, or HPV-negative); 1/13 progressed early (<24 weeks). The rate of radiologic complete response (comrTRG1) increased over time (6w: 27%, 12w: 66%, 24w: 75%), while the rate of indeterminate (comrTRG2) and minor definite tumour (comrTRG3) decreased. PPV of MRI increased over time: 6w: 33% (95%CI: 9.9%-65.1%), 12w: 46% (16.7%-76.6%), and 24w: 88% (47.3%-99.7%). NPV was stable high >90%.</p><p><strong>Conclusions: </strong>MRI performed more reliably after 24 weeks. Timely assessment may aid early LRTF detection. Tailoring follow-up with frequent MRI scans may be sufficient for high-risk patients. Combined mrTRG is practical for describing response in SCCA.</p><p><strong>Advances in knowledge: </strong>Post-treatment MRI assessment at later time points is preferable in SCCA to avoid inconclusive imaging and unnecessary salvage surgery. The introduced comrTRG is a practical tool for response evaluation.</p><p><strong>Registration: </strong>ClinicalTrials.gov: NCT01937780.</p>","PeriodicalId":72419,"journal":{"name":"BJR open","volume":"8 1","pages":"tzag004"},"PeriodicalIF":2.1,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triple-bolus CT urography: an optimized approach for vascular assessment in ureteropelvic junction obstruction.","authors":"Po-Ting Lin, Chia-Yu Lin, Hsien-Tzu Liu, Jia-An Hong, Chih-Chien Li, Shan-Su Huang, Shu-Huei Shen","doi":"10.1093/bjro/tzag003","DOIUrl":"https://doi.org/10.1093/bjro/tzag003","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the diagnostic value of triple-bolus computed tomography urography (TB-CTU) for ureteropelvic junction obstruction (UPJO) in comparison with split-bolus CTU (SB-CTU).</p><p><strong>Methods: </strong>In this single-centre retrospective study, patients under clinical suspicion of UPJO referred from the urology clinic for CTU examination from January 1, 2017 to January 31, 2022, were included. CTU examinations were performed with SB or TB protocols. The images were reviewed by 2 radiologists for assessment of arterial and venous renal pelvis enhancement and arteriovenous differentiation. Interobserver agreement on arteriovenous differentiation was calculated.</p><p><strong>Results: </strong>A total of 23 TB-CTU and 70 SB-CTU examinations were included. The Hounsfield unit (HU) values for the renal artery, renal vein, and upper urinary tract were all significantly higher in the TB group. The proportion of high enhancement of arteries and veins was also significantly higher in the TB group (<i>P </i>< .001). Both radiologists evaluated TB-CTU as providing greater arteriovenous differentiation with strong interobserver agreement (κ = 0.77).</p><p><strong>Conclusions: </strong>TB-CTU exhibited superior arteriovenous differentiation in comparison with SB-CTU, with an acceptable radiation dose.</p><p><strong>Advances in knowledge: </strong>For patients with suspicion of UPJO, TB-CTU may be the imaging modality of choice for evaluating anatomical structures for further management.</p>","PeriodicalId":72419,"journal":{"name":"BJR open","volume":"8 1","pages":"tzag003"},"PeriodicalIF":2.1,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12937586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medico-legal considerations in post-mortem imaging data: governance, ethics, and evidential use.","authors":"Natasha Davendralingam, Susan C Shelmerdine, Amy-Lee Brookes, Imogen Jones","doi":"10.1093/bjro/tzag002","DOIUrl":"10.1093/bjro/tzag002","url":null,"abstract":"<p><p>Post-mortem imaging, in particular CT (PMCT), is increasingly used for death investigation in England and Wales, yet unlike \"live\" clinical imaging, this data falls outside traditional health-record legislation, creating uncertainty around data ownership, access rights, and disclosure obligations. This review examines the current data governance landscape surrounding post-mortem imaging data, identifying critical gaps requiring national guidance. We explore fundamental questions of data control between coroners and commercial service providers, noting how the absence of standardized frameworks has resulted in substantial regional variation in practice. Key challenges include inconsistent approaches to data storage, whether on clinical or dedicated PACS systems, varying data-retention periods, and disparate policies for third-party access by researchers, legal teams, and bereaved families. The evolving role of radiologists as expert witnesses in coronial and criminal proceedings presents additional complexities, particularly regarding who is best placed to explain imaging findings in court. We propose recommendations including national standards for data governance, standardized contractual frameworks clarifying data-controller relationships, protocols for secure storage and access controls, and defined competencies for radiologists presenting evidence in legal settings. Establishing robust governance foundations for post-mortem imaging data is essential to ensure this technology serves the public interest effectively, while maintaining legal defensibility and ethical integrity.</p>","PeriodicalId":72419,"journal":{"name":"BJR open","volume":"8 1","pages":"tzag002"},"PeriodicalIF":2.1,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12820887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146031700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are radiology residents safe to report feeding nasogastric (NG) tubes on chest X-rays?","authors":"Cindy Chew, Lucy McGuire, Patrick J O'Dwyer, David Young","doi":"10.1093/bjro/tzag001","DOIUrl":"10.1093/bjro/tzag001","url":null,"abstract":"<p><strong>Objectives: </strong>The task of issuing reports on whether nasogastric (NG) tubes are safe for enteral nutrition on chest X-ray (CXR) often falls to radiology residents. The aims of this study are to evaluate whether radiology residents are formally trained and their performance in interpreting NG tube position on CXR.</p><p><strong>Methods: </strong>Radiology residents were invited to participate in an online study evaluating NG tube position on CXR. The CXR images comprised 20 NG tubes, 14 of which were correctly sited, while 4 were in the distal oesophagus and 2 in the lung.</p><p><strong>Results: </strong>Twenty-eight (of 185, 15%) radiology residents responded-despite incentives to participate and directed by Training Program Directors/Heads of School. Of those, only 10 (35.7%) correctly identified all NG tube positions on CXR. The most common error was reporting a <i>correctly sited</i> NG tube as mal-positioned for enteral nutrition. Global error rate was 8.9%. Radiology residents who correctly interpreted all 20 NG tube CXRs were significantly more confident in their abilities on a 5-point Likert scale than those who got at least 1 NG tube CXR wrong [4.4 (0.52) versus 3.8 (0.79), <i>P</i> = .02].</p><p><strong>Conclusions: </strong>This study suggests that radiology residents may not be adequately trained to interpret the position of NG tubes on CXRs. Early and compulsory training in this important skill should be instituted urgently.</p><p><strong>Advances in knowledge: </strong>There is a critical gap in radiology training. Radiology residents may not be adequately prepared to safely interpret NG tube position on chest X-rays. New DHSC memorandum of understanding mandates competency-based education across all training programs.</p>","PeriodicalId":72419,"journal":{"name":"BJR open","volume":"8 1","pages":"tzag001"},"PeriodicalIF":2.1,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12872581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiomic analysis of contrast-enhanced CT for the prediction of microvascular invasion in hepatocellular carcinoma: literature analysis and practical challenges.","authors":"Sara Viganò, Pietro Andrea Bonaffini, Elisabetta De Bernardi, Andrea Corsi, Claudio Bandini, Eleonora Piccin, Clarissa Valle, Paolo Marra, Domenico Pinelli, Sandro Sironi","doi":"10.1093/bjro/tzaf032","DOIUrl":"10.1093/bjro/tzaf032","url":null,"abstract":"<p><strong>Background: </strong>Microvascular invasion (MVI) is considered an independent risk factor for early recurrence after curative resection of hepatocellular carcinoma (HCC). The ability to preoperatively predict MVI could lead to personalized treatment options in high-risk patients.</p><p><strong>Aims: </strong>To identify radiomic features from CE-CT that correlate with MVI in patients with HCC and evaluate the robustness and reproducibility of radiomic assessment by manual segmentation between readers with different experience.</p><p><strong>Methods: </strong>Clinical, CT imaging, and histological parameters were recorded. Sixty-two HCC lesions were manually contoured by three radiologists. Radiomic features were extracted. Features best correlating with angioinvasion were selected and assessed in univariate and multivariate models by means of 100 trials of 5-fold stratified cross-validation in terms of AUC, sensitivity, and specificity. The model identified on contours from the most experienced operator was then tested on contours from the other operators to assess inter-reader reproducibility.</p><p><strong>Results: </strong>Feature selection identified LI-RADS category and four arterial-phase radiomic texture features, with GLCM-ClusterShade and its high-frequency wavelet variant showing the highest predictive value for MVI. A bivariate logistic regression model combining these two features achieved an AUC of 79%, with 78% sensitivity and 64% specificity. The robustness of manual segmentation was strongly dependent on reader experience, and inter-operator reproducibility was suboptimal when the model was applied to contours from less experienced readers.</p><p><strong>Conclusion: </strong>Radiomics analysis may be able to predict MVI in patients with HCC. However, segmentation methods remain a practical challenge affecting reproducibility in radiomic studies.</p><p><strong>Advances in knowledge: </strong>This study, in agreement with the literature, identifies a radiomic model based on two textural features that could correlate with MVI in HCC. Furthermore, it aims to investigate some of the limitations in the application of radiomics in clinical practice, which still restrict it to a research setting, identifying an important limitation in manual segmentation methods. This aspect has not yet been sufficiently investigated in the literature.</p>","PeriodicalId":72419,"journal":{"name":"BJR open","volume":"8 1","pages":"tzaf032"},"PeriodicalIF":2.1,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12812215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Getting to the heart of Carotid and Vertebral imaging in acute ischemic stroke: an all-encompassing cross-sectional comparative analysis of Colour Doppler Ultrasound, CT Angiography, and MR Angiography.","authors":"Komal Verma Saluja, Mahesh Kumar Swami, Drishya Pillai, Manisha Meena, Dharm Raj Meena","doi":"10.1093/bjro/tzaf031","DOIUrl":"10.1093/bjro/tzaf031","url":null,"abstract":"<p><strong>Objectives: </strong>This study presents a comprehensive comparison of minimally-invasive extracranial neck imaging modalities-Colour Doppler ultrasound (CDUS), CT angiography (CTA), and MR angiography (MRA)-in acute ischaemic stroke (AIS) patients. The aim was to evaluate vessel stenosis, its related parameters, and assess the role of early CTA/MRA in AIS.</p><p><strong>Methods: </strong>Categorical and continuous data were compared with Chi-square and independent Sample <i>t</i>-test, respectively. Spearman rank correlation matrix was performed for non-linear CDUS variables. The agreement between various imaging modalities was calculated with kappa (<i>k</i>) coefficient.</p><p><strong>Results: </strong>AIS was most common in males, aged 61-70 years, associated with hypertension and smoking (<i>P</i>-value < .05). Seventy-four plaques were identified in 50 patients, with good agreement between the 3 imaging (<i>k</i> > 0.6). CDUS was limited in evaluating Vertebral Arteries and plaque characterization. CTA/MRA showed higher sensitivity for defining stenosis and plaques, with good-excellent agreement between them (<i>k</i> > 0.6). CTA and MRA identified 40 and 43 vulnerable plaques, respectively.</p><p><strong>Conclusions: </strong>Colour Doppler ultrasound is subjective, comprehensive assessment of anatomic and hemodynamic parameters but lacks sensitivity in identifying vulnerable plaques. CTA/MRA have better sensitivity with good soft tissue differentiation especially in lesser stenosed vessels.</p><p><strong>Advances in knowledge: </strong>Our results support preferred use of MRA/CTA as first-line modalities in time-sensitive scenarios like acute stroke and need to move beyond CDUS-based assessment. These show promise in detecting vulnerable plaque and predicting AIS risk/recurrence; in patient triage, and to guide early intensive treatment. Longitudinal studies are required to assess risk reduction by early advanced imaging.</p>","PeriodicalId":72419,"journal":{"name":"BJR open","volume":"8 1","pages":"tzaf031"},"PeriodicalIF":2.1,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12812217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the therapeutic potential of localized alpha irradiation for cancer: from DNA damage to immune activation.","authors":"Saskia Hazout, Daniel Zwahlen, Christoph Oehler, Ambroise Champion, David Benzaquen, Daniel Taussky","doi":"10.1093/bjro/tzaf030","DOIUrl":"10.1093/bjro/tzaf030","url":null,"abstract":"<p><p>Alpha radiation has emerged as a promising modality in cancer treatment due to its unique physical and biological properties. Among these, diffusing alpha-emitters radiation therapy (DaRT) delivers alpha radiation directly into solid tumours using inserted seeds. This review synthesizes both the biological mechanisms and therapeutic implications of alpha irradiation, with a focus on DaRT. We explore how alpha particles induce complex DNA damage, modulate the tumour microenvironment, and interact with immune therapies. Emphasis is placed on preclinical and early clinical findings that suggest DaRT's potential to improve outcomes, especially in difficult-to-treat malignancies. The high linear energy transfer (LET) radiation induces complex DNA damage in tumour cells, leading to increased cell death compared to conventional radiotherapy. Alpha particles have a short range in tissue, allowing for highly localized treatment with minimal damage to surrounding healthy tissue. Recent studies have demonstrated that alpha radiation can stimulate antitumor immune responses, potentially enhancing treatment efficacy. Clinical trials utilizing alpha-emitting radioisotopes have shown encouraging results in various cancer types, particularly for metastatic disease.</p>","PeriodicalId":72419,"journal":{"name":"BJR open","volume":"7 1","pages":"tzaf030"},"PeriodicalIF":2.1,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12694430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}