Acta tropica最新文献

{"title":"Toxocara canis: larvicidal activity and bioavailability analysis of 2-pyrimidinyl-hydrazone derivatives","authors":"Débora Carvalho Rodrigues ,&nbsp;Andrezza Medeiros Faria ,&nbsp;Carolina Netto de Oliveira da Cunha ,&nbsp;Maira Aparecida Trindade ,&nbsp;Lourdes Helena Rodrigues Martins ,&nbsp;Thais Cristina Mendonça Nogueira ,&nbsp;Alessandra Campbell Pinheiro ,&nbsp;Marcus Vinícius Nora de Souza ,&nbsp;Luciana Farias da Costa de Avila ,&nbsp;Daniela Fernandes Ramos ,&nbsp;Carlos James Scaini","doi":"10.1016/j.actatropica.2025.107655","DOIUrl":"10.1016/j.actatropica.2025.107655","url":null,"abstract":"<div><div>The treatment of human toxocariasis, a parasitic zoonosis with global distribution, is based on the use of benzimidazole anthelmintic, which have limited efficacy against <em>Toxocara</em> spp. larvae at the tissue level. Therefore, innovation and research into candidates for the development of new drugs for toxocariasis are essential. This study aimed to assess the efficacy of pyrimidine compounds against <em>Toxocara canis</em> larvae, as well as their cytotoxicity and bioavailability. The screening test was performed at 1 mg/mL, in duplicate, in a microplate containing 100 <em>T. canis</em> larvae in RPMI-1640 medium, and the active compound was then tested at 0.5 to 0.05 mg/mL to determine the minimum larvicidal concentration. The compound (<em>E</em>)-2-(2-((5-nitrofuran-2-yl)methylene)hydrazinyl)pyrimidine (PNAH 8) showed 100% larvicidal activity at 1 and 0.5 mg/mL and was not cytotoxic at any concentration tested. <em>In silico</em> analysis showed that the compound adhered to Lipinski's \"rule of five\" with an excellent miLogP value of 0.6, indicating the compound's high water solubility. And the larvicidal activity of the compound was confirmed by inoculating the contents of the microplates tested on Swiss mice, which showed no migration of larvae in the tissues. The absence of cytotoxicity and adequate bioavailability <em>in silico</em>, comparable to albendazole, the anthelmintic of first choice for the treatment of human toxocariasis, along with the other results, suggest the potential of this compound for future investigations in preclinical tests.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"267 ","pages":"Article 107655"},"PeriodicalIF":2.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological and molecular characterization of Triatominae bugs collected in Sonora, Mexico","authors":"Olivia Valenzuela ,&nbsp;Lesley Bogarin ,&nbsp;Idalia Paredes ,&nbsp;Mónica Resendiz-Sandoval ,&nbsp;Judith Valdez ,&nbsp;Heriberto Torres ,&nbsp;Sebastián Pita ,&nbsp;Joel Moo-Millan ,&nbsp;Etienne Waleckx","doi":"10.1016/j.actatropica.2025.107654","DOIUrl":"10.1016/j.actatropica.2025.107654","url":null,"abstract":"<div><div>Triatomines (Hemiptera: Reduviidae: Triatominae) are vectors of <em>Trypanosoma cruzi,</em> the causative agent of Chagas disease. This study aimed to assess the diversity of triatomines collected in 2023 from various regions of the State of Sonora, in Northwestern Mexico, from both wild (mainly rodent nests) and urban sites. Overall, 75 wild nests were dissected, with 36 % (27/75) positive for triatomines. A total of 180 triatomine specimens were collected, including 170 collected in wild nests, and ten collected in human dwellings. Identification was performed using taxonomic keys (for adults only) as well as sequencing of a fragment of the nuclear internal transcribed spacer 2 (ITS-2) (for both adults and nymphs). Our results confirmed the presence of at least four triatomine species: <em>Hospesneotomae sinaloensis</em> (formerly <em>Triatoma sinaloensis</em>)<em>, Triatoma rubida, Hospesneotomae protracta</em> (formerly <em>Triatoma protracta</em>)<em>, and Triatoma recurva.</em> Notably, <em>T. rubida</em> and <em>H. protracta</em> (<em>T. protracta</em>)<em>,</em> on the one hand, as well as <em>T. rubida</em> and <em>H. sinaloensis</em> (<em>T. sinaloensis</em>) on the other hand, were frequently found cohabiting in the same nest. Furthermore, this work provides the first ITS-2 molecular characterization of <em>H. sinaloensis</em> (<em>T. sinaloensis</em>), and its phylogenetic relationships with other members of the Triatomini tribe. Divergent haplotypes were found, that could be related to the presence of cryptic species in our study area.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"267 ","pages":"Article 107654"},"PeriodicalIF":2.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of bacterial symbionts of the Anopheles funestus group from KwaZulu-Natal Province, South Africa","authors":"Chia-Yu Chen ,&nbsp;AshleyM Burke ,&nbsp;Givemore Munhenga ,&nbsp;Arshad Ismail ,&nbsp;Shüné V Oliver","doi":"10.1016/j.actatropica.2025.107653","DOIUrl":"10.1016/j.actatropica.2025.107653","url":null,"abstract":"<div><div><em>Anopheles funestus s.s.</em> is the anthropophilic member of a group of mosquitoes that was the only member considered a malaria vector until recently. However, <em>Anopheles parensis</em> and <em>Anopheles vaneedeni</em> have recently been suspected to be implicated in disease transmission and may contribute to the residual malaria problem in South Africa. Unlike <em>An. funestus s.s</em>, the rest of the group would be more difficult to control due to their outdoor biting and resting behaviours. Thus, alternative vector control methods efficient in controlling both outdoor and indoor biting populations would be beneficial in controlling such secondary vectors. One of these alternative efforts is paratransgenesis, a technique that aims to inhibit <em>Plasmodium</em> infection through transgenesis by bacterial symbionts. Yet, bacterial symbionts of the <em>An. funestus</em> group are poorly studied. This study characterised the microbiota of the digestive system (salivary glands and midguts) of the <em>An. funestus</em> group by sequencing the V3-V4 hypervariable region of bacterial 16S rRNA genes in F1 <em>An. rivulorum, An. vaneedeni</em> and <em>An. parensis</em> sampled from KwaZulu-Natal Province, South Africa. Although alpha diversity did not differ significantly, beta diversity, differential abundance and relative abundance varied between the different members of the <em>An. funestus</em> group. Overall, there were shared bacterial genera between the different members of the <em>An. funestus</em> group, which were <em>Agromyces, Rahnella, Acinetobacter, Microbacterium</em> and <em>Asaia</em>. The study revealed a core microbiota in the digestive system of the <em>An. funestus</em> group which could be further explored for the use of paratransgenesis for the control of members of the <em>An. funestus</em> group.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"266 ","pages":"Article 107653"},"PeriodicalIF":2.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Host-parasite interactions and their role in liver fluke-induced carcinogenesis: An evolutionary perspective","authors":"Haoran Zhong,&nbsp;Yamei Jin","doi":"10.1016/j.actatropica.2025.107651","DOIUrl":"10.1016/j.actatropica.2025.107651","url":null,"abstract":"","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"266 ","pages":"Article 107651"},"PeriodicalIF":2.1,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and zoonotic potential of pathogens in micromammals (rodents and insectivores) in the Republic of Korea","authors":"Beoul Kim,&nbsp;You-Jeong Lee,&nbsp;Insu Choi,&nbsp;Yong‑Myung Kang,&nbsp;Dongmi Kwak,&nbsp;Min-Goo Seo","doi":"10.1016/j.actatropica.2025.107649","DOIUrl":"10.1016/j.actatropica.2025.107649","url":null,"abstract":"<div><div>Micromammals (rodents and insectivores), are reservoirs of numerous zoonotic pathogens and play a critical role in infectious disease transmission. The rising prevalence of micromammals-associated pathogens in the Republic of Korea highlights the urgent need for targeted surveillance. Here, we analyzed micromammal blood samples collected from 16 nationwide sites during spring 2022, autumn 2022, and spring 2023 to investigate the following key zoonotic diseases: severe fever with thrombocytopenia syndrome, Lyme disease, Q fever, scrub typhus, anaplasmosis, ehrlichiosis, and rickettsioses. Our analysis revealed that of the 756 micromammal samples analyzed, 0.1 % had <em>Borrelia afzelii, Borrelia valaisiana</em>, and <em>Orientia tsutsugamushi</em>, 12.7 % contained <em>Anaplasma phagocytophilum</em>, and 82 % <em>Neoehrlichia mikurensis</em>. Importantly, we detected <em>Borrelia valaisiana</em> in micromammals in the Republic of Korea for the first time. Phylogenetic analysis identified close genetic links between local and global pathogen strains, highlighting potential cross-border transmission risks. The high prevalence of <em>Neoehrlichia mikurensis</em> emphasizes the zoonotic threat of micromammals. These findings provide crucial insights about enhancing micromammals-associate pathogen surveillance, inform public health strategies, and reinforce the importance of monitoring micromammal populations for zoonotic infection risk mitigation in Korea and beyond.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"266 ","pages":"Article 107649"},"PeriodicalIF":2.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological, clinical and etiological treatment aspects in the Chagas clinic of the municipality of Comapa - Jutiapa, Guatemala","authors":"Elsa Berganza ,&nbsp;Rafael Herazo ,&nbsp;Esdras García ,&nbsp;Andrea Marchiol ,&nbsp;Marianela Menes ,&nbsp;Estuardo Alvarado ,&nbsp;Ranferí Trampe ,&nbsp;María Jesús Pinazo","doi":"10.1016/j.actatropica.2025.107648","DOIUrl":"10.1016/j.actatropica.2025.107648","url":null,"abstract":"<div><div>Chagas disease (CD) is a major public health problem in Guatemala, where an estimated 166,000 people are infected with <em>Trypanosoma cruzi</em> and 1.4 million are at risk of infection. The municipality of Comapa (department of Jutiapa) is in a “hot spot” for CD control in Central America. To improve access to CD healthcare, the Departmental Directorate of Integrated Health Services Networks of Jutiapa, with support from the Drugs for Neglected Diseases initiative Latin America, set up a Chagas clinic in Comapa; This study describes epidemiological and clinical aspects of the population attended in the clinic. Using a descriptive observational study design, based on the review of a database with 590 care records between 2019 and 2024. The mean age was 44.1 years; 61.9 % were women and 7.1 % were pregnant women. 32 % exhibited the cardiac form of chronic CD. Trypanocidal treatment was started in 77.5 %, and of these, 7.6 % did not complete the prescribed regimen. All patients were treated with nifurtimox. 71.5 % of those treated reported adverse reactions (ADR). The most frequent ADRs were neuropsychiatric (67.6 %), followed by digestive (47.1 %); in 59 % of cases, between two and four ADRs occurred simultaneously. This characterization is one of the few descriptions of the Guatemalan population with <em>T. cruzi</em> infection/ CD. In general, the clinical data are similar to those reported in other publications. The Comapa Chagas Clinic provides a new model which can facilitate access at the primary health care level for people with CD.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"266 ","pages":"Article 107648"},"PeriodicalIF":2.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlling deltamethrin-resistant Rhipicephalus microplus with a phytoformulation of Annona muricata and Piper longum","authors":"Macha Vijay ,&nbsp;Mood Rajitha ,&nbsp;M Krishnagaanth ,&nbsp;Nitin D. Jadhav ,&nbsp;Gajanan Chigure ,&nbsp;Anand Srivastava","doi":"10.1016/j.actatropica.2025.107644","DOIUrl":"10.1016/j.actatropica.2025.107644","url":null,"abstract":"<div><div>Ticks are one of the most significant vectors for transmitting diseases in livestock. Synthetic acaricides are the primary method for controlling tick populations; however, their indiscriminate application has led to widespread acaricide resistance and environmental concerns. In response to these challenges, this research has focused on developing eco-friendly herbal acaricides that ensure animal safety while minimizing environmental contamination and residual toxicity. Plants produce secondary metabolites, some of which possess insecticidal properties and have potential as natural acaricides. In the present study, the acaricidal properties of five plant extracts were evaluated against <em>Rhipicephalus microplus</em>. The hexane extracts of <em>Annona muricata</em> leaves and <em>Piper longum</em> seeds demonstrated significant acaricidal activity, with IC₅₀ values of 0.34 % and 0.184 % in larval immersion tests and 1.39 % and 0.71 % in adult immersion tests, respectively. A stable phytoformulation was developed incorporating these extracts, and its physicochemical properties were monitored over 12 months to ensure consistency and quality. HPTLC profiling identified piperine and α-caryophyllene as marker compounds for quality control. <em>In vitro</em> assays using phytoformulation showed lower IC₅₀ values than individual plant extracts in deltamethrin-resistant ticks at the larval stage. Also, at the adult stage, the phytoformulation inhibited egg hatchability and disrupted ovarian structures. Toxicity studies confirmed the phytoformulation's safety for animal use. Field trials on natural tick-infested cattle demonstrated a mean efficacy of 83.3 ± 3.5 % within 48 h of application. This study suggests that phytoformulation could serve as a sustainable, safe, and effective way to manage deltamethrin-resistant <em>Rhipicephalus microplus</em> infestations.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"266 ","pages":"Article 107644"},"PeriodicalIF":2.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lidocaine exhibits antileishmanial and immunomodulatory activities in an in vitro model of tegumentary leishmaniasis","authors":"Juliane Pereira Rocha ,&nbsp;Priscila de Cássia da Silva ,&nbsp;Marcelo Antônio Pascoal-Xavier ,&nbsp;Kelly Alves Bicalho ,&nbsp;Érica Alessandra Rocha Alves","doi":"10.1016/j.actatropica.2025.107645","DOIUrl":"10.1016/j.actatropica.2025.107645","url":null,"abstract":"<div><div>Local anesthetics have been shown to inhibit or delay the progression of tegumentary leishmaniasis (TL) in hamster models, although the mechanisms underlying this clinical improvement remain unclear. This study aimed to determine whether lidocaine reduces intracellular parasitism through a direct antiparasitic effect and/or by modulating macrophage functions. To achieve this, <em>Leishmania (L.) amazonensis</em> promastigotes were exposed to increasing concentrations (0.078 to 5.0 mg/mL) of lidocaine for up to 72 hours, followed by assessments of parasite proliferation and viability. Next, human macrophages were incubated for 24 and 72 hours with escalating concentrations (0.078 to 5.0 mg/mL) of lidocaine to determine the maximum non-cytotoxic concentration (MNCC). Subsequently, <em>L. (L.) amazonensis</em>-infected human macrophages were treated with the MNCC of lidocaine for 24 and 72 hours, and the infection index, nitric oxide (NO) and cytokine levels, and intracellular parasite viability were measured. The results showed that lidocaine caused a dose-dependent reduction in the proliferation and viability of <em>L. (L.) amazonensis</em> promastigotes. The IC₅₀ values for proliferation decreased from 0.69 mg/mL at 24 hours to 0.13 mg/mL at 72 hours, while the IC₅₀ values for viability declined from 1.08 mg/mL at 24 hours to 0.30 mg/mL at 72 hours. These findings indicate that prolonged exposure enhances the parasite’s susceptibility to lidocaine’s antiproliferative and cytotoxic effects. The MNCC of lidocaine for human macrophages was determined to be 0.625 mg/mL. After incubating infected macrophages with this concentration, the mean ± standard deviation of the infection index was reduced by over 66% after both 24-hour and 72-hour treatments. Additionally, after 72 hours of exposure to lidocaine, there was an 89.6% increase in NO production by infected macrophages. Infected macrophages exposed to lidocaine produced 7.9-fold less IL-1β after 24 hours of treatment, and 35.2-fold, 12.9-fold, and 1.6-fold less TNF-α, IL-6, and IL-8, respectively, after 72 hours of treatment. The number of promastigotes that proliferated from intracellular amastigotes was significantly lower following treatment with lidocaine for both 24 and 72 hours, indicating that lidocaine significantly reduces the viability of intracellular parasites. In conclusion, lidocaine exhibits potent anti-<em>Leishmania</em> activity and modulates macrophage functions crucial to the immunity against <em>Leishmania</em> and immunopathogenesis of TL. These findings support its potential as an alternative or adjunctive therapeutic strategy for the treatment of this disease.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"266 ","pages":"Article 107645"},"PeriodicalIF":2.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ortholinea paraensis n. sp. (Myxosporea: Ortholineidae) infecting the urinary bladder of Ageneiosus ucayalensis Castelnau, 1855 (Siluriformes: Auchenipteridae) in the Amazon region of Brazil","authors":"Camila Maria Barbosa Pereira ,&nbsp;Jhonata Eduard ,&nbsp;José Francisco Berrêdo Reis da Silva ,&nbsp;Maria do Perpétuo Socorro Progene Vilhena ,&nbsp;José Ledamir Sindeaux Neto ,&nbsp;Michele Velasco","doi":"10.1016/j.actatropica.2025.107642","DOIUrl":"10.1016/j.actatropica.2025.107642","url":null,"abstract":"<div><div>The present study describes a new parasite species of the myxozoan genus <em>Ortholinea</em>, based on the interpretation of morphological and molecular parameters. This species was found infecting the urinary bladder of the driftwood catfish <em>Ageneiosus ucayalensis</em>, captured in the region of Santo Antônio and Guajará bays, in the Amazonian state of Pará, Brazil. Plasmodia and myxospores were observed in pairs in the urinary bladder, either floating freely or adhered to the mucosa. The myxospores are spherical in the frontal view and valvular, with two equal, sub-spherical polar capsules, oriented divergently, containing 6–7 coils of the polar tubule. Scanning electron microscopy revealed ridges on the surface of the spore, which confer it with the appearance of a ball of wool, covering the entire surface of the valve, a slightly undulating suture line, and the presence of discharge pores for the polar tubule on opposite sides of the suture, that permit the extrusion of the polar tubule. The new species presents morphological characteristics typical of the genus <em>Ortholinea</em>. In the phylogenetic analysis, <em>Ortholinea paraensis</em> n. sp. occupied a basal position within a clade of species from the Amazon region. The sum of the morphological and molecular evidence clearly supports the description of a new species, denominated <em>Ortholinea paraensis</em> n. sp., which is the first <em>Ortholinea</em> species reported from Brazil.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"266 ","pages":"Article 107642"},"PeriodicalIF":2.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143931495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of American tegumentary leishmaniasis in Bahia, Brazil (2007–2023)","authors":"Thiago Soares Rocha ,&nbsp;Luanna Chácara Pires ,&nbsp;Gisele Lopes de Oliveira ,&nbsp;Sebastião Rodrigo Ferreira","doi":"10.1016/j.actatropica.2025.107646","DOIUrl":"10.1016/j.actatropica.2025.107646","url":null,"abstract":"<div><div>American tegumentary leishmaniasis (ATL) is a neglected zoonotic disease, endemic in Brazil, with variable clinical forms. In Bahia, ATL significantly impacts public health, requiring epidemiological surveillance and effective control measures. This study is intended to provide a detailed epidemiological and spatial analysis of ATL in the state of Bahia, Brazil, between 2007 and 2023. A retrospective approach was used to analyze ATL cases in Bahia through Notifiable Diseases Information System and Brazilian Institute of Geography and Statistics data. Methods included Bayesian smoothing, spatial autocorrelation analysis (Moran’s index), and thematic mapping with QGIS, complemented by statistical analysis using chi-squared tests and graphic tools in RStudio and SAS. Between 2007 and 2023, Bahia recorded approximately 44,427 ATL cases, with an average annual incidence rate of 17.62 cases per 100,000 inhabitants. The highest incidences rate occurred between 2010 and 2012, predominantly affecting males (59.98%) and individuals aged 15 to 34. The cutaneous form predominated (96.34%), in socially vulnerable populations, particularly those with low education. Spatial analysis identified critical clusters in municipalities, particularly during 2015–2023, with significant positive autocorrelation. Although ATL incidence rate in Bahia has declined, geographic expansion and critical clusters persist, requiring targeted surveillance. Incomplete records and treatment abandonment highlight gaps that require professional training and improved public health strategies. Integrated actions addressing socio-economic and environmental factors remain essential for effective disease control and management.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"266 ","pages":"Article 107646"},"PeriodicalIF":2.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143931639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}