Biomedical materials (Bristol, England)最新文献

{"title":"Prokaryotic/eukaryotic co-culture as a model for<i>in vitro</i>functional validation of a dual and sequential drug delivery system with antimicrobial and bone regenerative features.","authors":"Miguel A Rodrigues, Giorgia Barbolini, Maria P Ferraz, João P Borges, José D Santos, Maria A Lopes","doi":"10.1088/1748-605X/ae934c","DOIUrl":"10.1088/1748-605X/ae934c","url":null,"abstract":"<p><p>Bacteria-mammalian cell co-cultures can provide information on host-cell responses to biomaterials under bacterial challenge that is not available from separate monocultures. This study established a two-stage osteogenic cell-<i>Staphylococcus aureus</i>co-culture for assessment of a previously developed dual and sequential drug delivery system (DDS) designed to release gentamicin followed by alendronate. MG-63 cells were initially exposed toCFU/ml of<i>S. aureus</i>for different periods. An inoculum ofCFU/ml and a 2 h exposure were selected because MG-63 metabolic activity did not differ significantly from the monoculture control at this time point (<i>p</i>> 0.05). These conditions were subsequently transferred to primary human bone-marrow mesenchymal stromal cells. The DDS-containing co-culture exhibited an increasing resazurin signal over 16 d and maintained adherent cells with an organised F-actin cytoskeleton. On day 25, protein-normalised alkaline phosphatase activity was 40 mol µg^-1protein in the DDS-containing co-culture, compared with 5 mol µg^-1protein in the basal-medium control and 63 mol µg^-1protein in the osteogenic-medium control. The model supports preliminary assessment of mammalian-cell compatibility and osteogenic-associated activity during sequential drug release under an initial bacterial challenge.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural, mechanical and biological evaluation of MgO and SrO modified bioglass 45S5^®.","authors":"Mariana Gunther Borges, Alicce Reis, Paulo Soares, Liliana Ivet Sous Naasani, Thaís Casagrande Paim, Márcia Rosângela Wink, Silvio Buchner","doi":"10.1088/1748-605X/ae8ee9","DOIUrl":"10.1088/1748-605X/ae8ee9","url":null,"abstract":"<p><p>Human tissues deteriorate over time and may not regenerate naturally, motivating the development of bioactive materials capable of stimulating tissue repair. Since the discovery of Bioglass 45S5®, this material has been widely recognized as a benchmark for bone regeneration due to its high bioactivity and ability to bond with living tissues. However, its tendency to crystallize during processing can compromise bioactivity and limit mechanical performance, posing a challenge for applications requiring both biological effectiveness and structural reliability. In this context, compositional modifications have emerged as a promising strategy to overcome these limitations. This study investigates the effect of adding magnesium oxide (MgO) and strontium oxide (SrO) to the Bioglass 45S5® composition, aiming to enhance mechanical properties while preserving bioactivity. Modified bioglass compositions were synthesized by the melt-quenching method, followed by controlled thermal treatments to obtain corresponding biovitroceramics. The materials were characterized using differential thermal analysis, x-ray diffraction, Raman spectroscopy to evaluate thermal behavior, phase transformations, and structural vibration. Mechanical properties were assessed through hardness and instrumented indentation tests, while biological performance was evaluated by<i>in vitro</i>assays, including cell viability and morphological analyses. The results demonstrate that the incorporation of MgO and SrO leads to improved mechanical properties compared to the reference Bioglass 45S5®, without inducing cytotoxic effects. These findings indicate that MgO and SrO modified bioglasses are promising candidates for biomedical applications, particularly in bone tissue engineering and regenerative medicine.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic release from keratin hydrogels for use in wound healing applications.","authors":"Rachael Simmons, Seth Tomblyn, Luke Burnett, Judy S Bohnert, Neil D Danielson, Jason A Berberich, Justin M Saul","doi":"10.1088/1748-605X/ae8817","DOIUrl":"10.1088/1748-605X/ae8817","url":null,"abstract":"<p><p>Skin injuries, particularly severe injuries, such as full-thickness wounds or surgical sites, are susceptible to bacterial infection. Materials composed of keratin proteins have been investigated for use in wound dressings, and at least two products based on these materials have received FDA clearance for treating radiation dermatitis via the 510(k) mechanism. We hypothesized that hydrogels composed of oxidatively extracted keratins, known as keratose, could achieve sustained release of several classes of antibiotic drugs that might improve the performance of keratins as wound dressing materials. Reverse-phase high performance liquid chromatography methods were developed to quantify release of ciprofloxacin, cefazolin, and neomycin antibiotics from keratose hydrogels. Nearly 100% of ciprofloxacin and cefazolin were released from the hydrogels within 7 d, while only approximately 20% of neomycin was released. In a combination keratose hydrogel containing neomycin and cefazolin, the amount of cefazolin release decreased (compared to hydrogels with only cefazolin) to about 60% over 7 d whereas neomycin release increased (compared to hydrogels with only neomycin) to nearly 30%. The antibiotics released from the hydrogels inhibited growth of gram-positive (<i>S. aureus</i>) and gram-negative (<i>P. aeruginosa</i>) bacteria in an<i>in vitro</i>broth inhibition assay. Keratose hydrogels containing a combination of the first-line antibiotics neomycin and cefazolin inhibited<i>S. aureus</i>for 18 d and<i>P. aeruginosa</i>for 6 d which was comparable to or better than hydrogels containing broad-spectrum ciprofloxacin that had effect for 11 d. This work suggests that modification of keratin biomaterials with antibiotics may enhance their utility by inhibiting bacterial infections.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acoustic droplet ejection enables the transfer of induced pluripotent stem cells in ultra-high concentrations while preserving their pluripotency.","authors":"A Gómez Montoya, L R Breulmann, R G Tağman, C Kuckelkorn, H Fischer","doi":"10.1088/1748-605X/ae91c1","DOIUrl":"10.1088/1748-605X/ae91c1","url":null,"abstract":"<p><p>Acoustic droplet ejection (ADE) has been widely used for the precise transfer of liquids, hydrogels, and cell suspensions in different applications. One interesting advantage of this technique is its nozzle-less nature, allowing for low-shear droplet generation without the risk of clogging. This is especially relevant for printing biomimetic constructs with cell densities in different physiological ranges. To demonstrate the advantages of ADE over other drop-on-demand (DoD) bioprinting methods, cell suspensions at a concentration of at least 10⁸cells per milliliter are transferred acoustically and using a commercial piezoelectric DoD printhead as control. In addition, the impact of ADE on the post-printing behavior of induced pluripotent stem cells (iPSC) is analyzed. While the acoustic droplet transfer of the cell suspensions is reliably performed until the depletion of the reservoir, the commercial printhead fails due to nozzle clogging. Live/dead staining measurements show no significant differences between acoustically transferred and pipetted iPSC. Immunofluorescence micrographs and flow cytometry measurements confirm the preservation of the cells' biological functionality, showing that acoustically transferred iPSC remain pluripotent seven days post-printing. In conclusion, ADE allows for the transfer of cell densities in physiological ranges, while even preserving the biological functionality of delicate iPSC.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148610934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective laser melting of CoCrMo-Ti6Al4V bimetallic composites: fabrication, characterization, and cytocompatibility.","authors":"Sijing Lin, Tiantian Gao, Sung-Min Chung, In-Seop Lee, Cen Chen","doi":"10.1088/1748-605X/ae9232","DOIUrl":"10.1088/1748-605X/ae9232","url":null,"abstract":"<p><p>Bimetallic structures integrating Ti6Al4V and CoCrMo alloys present a promising strategy for advanced orthopedic implants by synergistically combining high fracture toughness with excellent wear resistance. However, the direct fabrication of these dissimilar metals via selective laser melting (SLM) is significantly hindered by metallurgical incompatibility and high residual stress, which frequently lead to interfacial delamination and edge warping. In this study, a CoCrMo-Ti6Al4V bimetallic composite was successfully fabricated using SLM. To overcome manufacturing defects, a CoCrMo transition layer printed with low laser energy density was employed as a mechanical buffer to mitigate residual stresses, while optimized external support structures provided physical anchoring to suppress geometric distortion. The microstructural evolution, elemental distribution, and phase composition were systematically characterized using field-emission scanning electron microscopy, energy-dispersive x-ray spectroscopy, and x-ray diffraction. Mechanical performance was evaluated through hardness and sliding wear tests, while the biological response was assessed using human bone marrow mesenchymal stem cells (BMSCs). The results demonstrated that the three-layer architecture effectively eliminated macroscopic defects and ensured structural integrity. Furthermore, the composite exhibited a substantial enhancement in surface hardness and wear resistance, achieving an interfacial bonding strength of 43.21 ± 1.07 MPa. Fracture analysis revealed a cohesive failure mode within the transition layer, indicating robust metallurgical bonding between the dissimilar components.<i>In vitro</i>assessments confirmed excellent cytocompatibility, exhibiting high cell viability (>95%) and proliferation on the composite surfaces. Ultimately, this research establishes a reliable fabrication methodology for complex bimetallic components, offering broad application prospects in personalized medical devices, joint replacements, and tissue engineering.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In situ</i>synthesized silver nanoparticle-loaded poly(vinyl alcohol)/gelatin composite films for burn wound dressing applications: antibacterial activity and<i>in vivo</i>wound-healing evaluation.","authors":"Zehra Gün Gök, Beste Çağdaş, Yaşar Şahin, Yasin Özkabadayı, Ayfer Koyuncu","doi":"10.1088/1748-605X/ae8f98","DOIUrl":"10.1088/1748-605X/ae8f98","url":null,"abstract":"<p><p>This study aimed to develop and evaluate poly(vinyl alcohol)/gelatin (PVA/Gel/AgNPs) composite films containing silver nanoparticles (AgNPs), which have the potential to be used as burn wound dressings. In the present study, AgNPs at different concentration were fabricated by a green hyrodthermel method with the help of functional groups of gelatin and PVA in the mixture of these polymers. Then, PVA/Gel composite surfaces containing<i>in situ</i>synthesized AgNPs were obtained in a simple and single step with solvent casting method. The chemical composition of the films was confirmed by Fourier-transform infrared spectroscopy, verifying the presence of both gelatin and PVA. Morphological and elemental analyses performed by field emission scanning electron microscopy and energy-dispersive x-ray spectroscopy revealed a heterogeneous structure in AgNP-containing films, with uniformly distributed nanoparticles and characteristic silver peaks. X-ray diffraction further confirmed AgNP incorporation, while thermogravimetric analysis indicated enhanced thermal stability with increased residual mass at 900 °C. Physicochemical evaluations demonstrated that the films were hydrophilic, exhibited high water retention capacity, and enabled sustained release of AgNPs. Additionally, AgNP incorporation improved the mechanical properties of the films. The AgNP-containing films exhibited concentration-dependent antibacterial activity, and formulations containing 5 and 10 mM AgNPs achieved complete bacterial growth inhibition (100%) against both<i>Escherichia coli</i>and<i>Staphylococcus aureus.</i>Cytotoxicity analysis performed using the MTT assay on L929 fibroblast cells confirmed that all films were non-toxic. The results obtained provide preliminary evidence of cytocompatibility.<i>In vivo</i>studies using third-degree burn wounds on Sprague-Dawley rats demonstrated effective wound healing over 21 d compared to commercial dressings. Overall, the developed PVA/Gel/AgNPs films exhibit strong potential as antibacterial wound dressings, with advantages including biocompatibility, ease of fabrication, and suitability for large-scale production.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable charge-complementary hyaluronic acid/<i>ϵ</i>-Poly-L-lysine hydrogel loaded with BMP-2 for potential antibacterial and osteogenic management of peri-implantitis.","authors":"Siqi Zhao, Xiao Li","doi":"10.1088/1748-605X/ae9231","DOIUrl":"10.1088/1748-605X/ae9231","url":null,"abstract":"<p><p>Peri-implantitis is a biofilm-associated infectious disorder marked by progressive peri-implant bone loss and remains a major cause of late implant failure. To achieve simultaneous antibacterial treatment and bone regeneration, an injectable charge-complementary hydrogel (BMP-2@HA/<i>ϵ</i>-PL) was fabricated using anionic hyaluronic acid (HA), cationic<i>ϵ</i>-poly-L-lysine (<i>ϵ</i>-PL), and positively charged bone morphogenetic protein-2 (BMP-2). Its structural and physicochemical features were examined by Fourier-transform infrared spectroscopy, scanning electron microscopy (SEM), rheological testing, compression analysis, and swelling-degradation behavior assessments. BMP-2 release was quantified by enzyme-linked immunosorbent assay.<i>In vitro</i>, cytocompatibility of the BMP-2@HA/<i>ϵ</i>-PL hydrogel with rat bone marrow mesenchymal stem cells (BMSCs) was evaluated by CCK-8 and live/dead staining, whereas osteogenic differentiation was assessed by alkaline phosphatase activity, calcium deposition, and expression of osteogenesis-related genes. Antibacterial activity<i>in vitro</i>was evaluated against<i>S. aureus</i>(<i>S. aureus</i>) and<i>E. coli</i>(<i>E. coli</i>). The results demonstrated the successful synthesis of the hydrogels, and BMP-2 incorporation optimized the physicochemical properties (a densely packed network, higher compressive strength, and slower degradation) of the BMP-2@HA/<i>ϵ</i>-PL hydrogel, which also showed effective BMP-2 release.<i>In vitro</i>evaluation further indicated that the BMP-2@HA/<i>ϵ</i>-PL hydrogel exhibited favorable cytocompatibility, enhanced osteogenic differentiation of BMSCs due to the synergistic effect of HA and BMP-2, and robust antibacterial effects against both<i>S. aureus</i>and<i>E. coli</i>. These findings indicate that the injectable BMP-2@HA/<i>ϵ</i>-PL hydrogel features dual antibacterial and osteoinductive functions, offering a promising minimally invasive strategy for peri-implantitis treatment.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a chromium doped zinc gallate composite nano drug loading platform for enhancing anti-tumor efficacy through the combination of chemotherapy and photothermal therapy.","authors":"Yan Liu, Jiahui Chen, Fang Li, Wei Lv, Xiuyun Zhang, Tingting Zheng","doi":"10.1088/1748-605X/ae8d68","DOIUrl":"10.1088/1748-605X/ae8d68","url":null,"abstract":"<p><p>In recent years, nanoparticles have become key carriers for cancer diagnosis and therapy. In this study, chromium-doped zinc gallium oxide nanomaterials (ZnGa₂O₄:Cr³⁺, ZGC) with uniform morphology were synthesized via a one-step hydrothermal method. A nano drug delivery platform (mZGC/DOX/ICG; mZGC: ZnGa₂O₄:Cr³⁺@ SiO₂; DOX: Doxorubicin, ICG: Indocyanine Green) was successfully constructed based on ZGC, using Stöber method and electrostatic layer-by-layer self-assembly to enhance anti-tumor effect. The drug loading capacities (DLC%) for DOX and ICG were (54.11 ± 0.21)% and (45.9 ± 0.68)%, and the encapsulation efficiencies (EE%) were (56.18 ± 0.77)% and (94.01 ± 0.13)%, respectively. More notably, the release behavior of DOX from mZGC/DOX/ICG exhibited pH and temperature responsive characteristics. Meanwhile, the platform demonstrated good photothermal properties, drug release performance, blood compatibility, and anti-tumor effects superior to chemotherapy or photothermal therapy alone. It holds great potential for localized tumor therapy and is expected to be used in further anti-tumor research.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148537852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dual-functional 3D scaffold with an imidazolium-based interface for non-antibiotic therapy and enhanced osseointegration in infected bone defect.","authors":"Zeyuan Li, Guosheng Hua, Ziqi Liu, Hanbing Chen, Tao Luo, Kan Li, Guangsen Zheng, Dalin Wu, Liangtao Yang, Shuaishuai Cao","doi":"10.1088/1748-605X/ae8ee8","DOIUrl":"10.1088/1748-605X/ae8ee8","url":null,"abstract":"<p><p>Infected bone defects pose a significant clinical challenge due to the need for prolonged antibiotic therapy and multiple bone grafting procedures, which often lead to antibiotic overuse and increased patient burden. In this study, we developed a multifunctional 3D-printed polycaprolactone (PCL)/<i>β</i>-tricalcium phosphate (TCP) composite scaffold functionalized with a novel imidazolium-based cationic polymer (PIm⁺) encapsulated within a gelatin methacryloyl (GelMA) hydrogel interface. The resulting PCL/TCP+ scaffold exhibits optimized hydrophilicity and mechanical strength for bone regeneration. The early, sustained release of PIm⁺provides potent broad-spectrum bactericidal activity against both<i>Staphylococcus aureus</i>(<i>S. aureus</i>) and<i>Escherichia coli</i>(<i>E. coli</i>) by efficiently disrupting bacterial membranes. Simultaneously, the TCP component facilitates long-term osteogenic differentiation of bone marrow mesenchymal stem cells through the sustained release of calcium and phosphate ions. In a clinically relevant rat infected calvarial defect model, the scaffold achieves near-complete bacterial clearance by day 7 and promotes robust bone bridging within 12 weeks. This integrated platform offers a promising, personalized strategy for infected bone repair by significantly reducing reliance on systemic antibiotics and providing a highly effective dual-functional microenvironment for infected bone regeneration.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148564005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CORRIGENDUM: Optimizing fibrin hydrogel toward effective neural progenitor cell delivery in spinal cord injury (2022<i>Biomed. Mater.</i> 17 014102).","authors":"Tara Sudhadevi, Harikrishnan S Vijayakumar, Easwer V Hariharan, Samavedam Sandhyamani, Lissy K Krishnan","doi":"10.1088/1748-605X/ae8c9b","DOIUrl":"https://doi.org/10.1088/1748-605X/ae8c9b","url":null,"abstract":"","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":"21 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148674613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}