Biomedical materials (Bristol, England)最新文献

{"title":"I-PRF functionalized gelatin methacrylate microspheres for improving the proliferation and osteogenic differentiation of human periodontal ligament stem cells.","authors":"Ke Yi, Huilin Zhu, Xiaodong Lian, Zhihui Tang, Qing Li","doi":"10.1088/1748-605X/adc52a","DOIUrl":"10.1088/1748-605X/adc52a","url":null,"abstract":"<p><p>Although human periodontal ligament stem cell (hPDLSC)-based tissue engineering have been promising for regenerating periodontal bone tissue, their effectiveness is limited by the lack of an optimal delivery vehicle for these cells. Therefore, this study reports a gelatin methacryloyl microsphere system, incorporating injectable platelet-rich fibrin and nano-hydroxyapatite (nHA) as carriers for hPDLSCs. These hybrid microspheres were effectively produced using droplet microfluidics technology, achieving a size range of 100-300 μm. Importantly, the release profile of multiple growth factors (GFs) from the microspheres was significantly extended, lasting up to 28 d. Moreover, the released GFs and nHA considerably enhanced the proliferation of encapsulated hPDLSCs along with their spreading and osteogenic differentiation. The microspheres facilitated the development of Spheroid-like cell aggregates within two weeks of culture, demonstrating a promising approach for advanced periodontal bone tissue regeneration.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on pancreatic duct stents: materials and emerging trends.","authors":"Huijuan Fan, Nan Li, Xingguang Zhang, Wei Xu, Wencheng Zhang, Yangjuan Ding, Lingjian Li, Taotao Liu, Shihai Xia","doi":"10.1088/1748-605X/adcb7d","DOIUrl":"https://doi.org/10.1088/1748-605X/adcb7d","url":null,"abstract":"<p><p>Pancreatic duct strictures, which can arise from trauma, inflammation, or malignancy, often result in complications such as duct obstruction, pancreatic parenchymal hypertension, and ischemia. Endoscopic stenting is an effective therapeutic approach for managing these strictures. However, traditional plastic pancreatic duct stents fail to conform to the physiological curvature of the pancreas, while metal pancreatic duct stents with flared ends reduce migration but are associated with complications such as de novo strictures. Additionally, plastic and metal pancreatic duct stents require surgical removal. Whereas biodegradable pancreatic duct stents present a promising alternative due to their superior biocompatibility and ability to decompose into non-toxic materials, potentially eliminating the need for additional surgeries. Despite these advantages, biodegradable pancreatic duct stents remain in the experiment stage. This review assesses current materials of pancreatic duct stents, and emphasizes recent advancements in biodegradable options and emerging trends in clinical applications.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":"20 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of the advances in implant technology: accomplishments and challenges for the design of functionalized surface structures.","authors":"Ming-Feng Wang, Tao Yan, Ming-Cen Gao, Cheng-Wei Han, Zhuo-Qun Yan, Yu-Zhong Gao, Wei Zhang, Zhe Yi","doi":"10.1088/1748-605X/adca7c","DOIUrl":"10.1088/1748-605X/adca7c","url":null,"abstract":"<p><p>Biomedical implants are extensively utilized to replace hard-tissue defects owing to their biocompatibility and remarkable tissue-affinity. The materials and functional design are selected based on the resultant osseointegration level and resistance to infection, and these considerations constitute the dominant research topic in this field. However, high rates of implantation failure and peri-implantitis have been reported. Current research on biomedical-implant design encompasses enhancement of the implant surface properties, such as the roughness, nano/micro topography, and hydrophilicity, along with the realization of advanced features including antibacterial properties and cell and immunomodulation regulation. This review considers the two achievements of contemporary implant manufacturing; namely, osseointegration and the realization of antibacterial properties. Present mainstream surface modifications and coatings are discussed, along with functional design technologies and achievements. The impacts of direct surface-treatment techniques and osteogenic functional coatings on osseointegration performance and antibacterial surface structures are elucidated, considering inorganic and organic coatings with antibacterial properties as well as antibiotic-releasing coatings. Furthermore, this review highlights recent advancements in physically driven antimicrobial strategies. Expanding upon existing research, future directions for implant studies are proposed, including the realization of comprehensive functionality that integrates osseointegration and antibacterial properties, as well as patient-specific design. Our study presents a comprehensive review and offers a novel perspective on the design of biomedical implants for enhanced versatility. An in-depth exploration of future research directions will also stimulate subsequent investigations.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optomechanical evaluation of knot security in Monocryl and Maxon sutures under varying pH conditions.","authors":"Mohammed A El-Bakary, Aliaa A Nafad, Nayera M El-Sayed","doi":"10.1088/1748-605X/adcb0d","DOIUrl":"https://doi.org/10.1088/1748-605X/adcb0d","url":null,"abstract":"<p><p>Knot stability and security are crucial factors in surgical suture performance, ensuring optimal tension distribution and minimizing the risk of wound dehiscence. The mechanical behavior of surgical knots is influenced by suture material properties, knot configuration, and environmental factors such as localized pH deviations, which can accelerate material degradation. This study investigates the impact of pH-induced degradation on the mechanical and optomechanical performance of square and surgeon's knots tied with Maxon and Monocryl sutures under acidic (pH 5) and neutral (pH 7) conditions. Stress-strain analysis and Mach-Zehnder interferometry were employed to assess Young's modulus, mechanical loss percentages, tensile strength, toughness, phase maps, and 3D refractive index profiles over 20 d. Young's modulus results revealed significant reductions in acidic conditions. Maxon's surgeon knot decreased from 516 MPa to 228 MPa, while Monocryl's surgeon knot dropped from 434 MPa to 132 MPa over 20 d. Mechanical loss was notably higher in acidic conditions, with Maxon's surgeon knot exhibiting a 65.30% reduction and Monocryl's surgeon knot showing an 82.3% decrease. Toughness declined similarly, particularly in knotted configurations. Phase maps revealed substantial structural distortion, especially in Monocryl's perpendicular orientation at pH 5, indicating severe degradation. 3D refractive index profiles demonstrated that Maxon maintained greater internal uniformity, while Monocryl showed pronounced structural disruption under acidic conditions. Maxon's stability under different pH conditions makes it suitable for long-term applications, while Monocryl's rapid degradation suggests its suitability for scenarios requiring faster material breakdown. These findings provide valuable insights for suture selection in diverse wound conditions.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":"20 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequential drug release of self-ordered titania nanotubes with antibacterial function and anticancer ability for bone cancer treatments.","authors":"Chien-Chun Chang, Yuan-Shun Lo, Yu-Ping Chen, Yen-Liang Liu, Chih-Liang Wang","doi":"10.1088/1748-605X/adc9ed","DOIUrl":"10.1088/1748-605X/adc9ed","url":null,"abstract":"<p><p>The success of tumor prosthesis relies on the preclusion of deep infection and local recurrence in limb sparing surgery. The orthopedic implants enabling to simultaneously possess the antibacterial function and anticancer ability have become a desirable local therapy in the treatment of bone cancer. In this regard, we proposed a promising concept of the sequential release in a dual-drug system by combing titania nanotubes and chitosan as drug nanoreservoirs and sustained release films, respectively. An electrochemical anodization technique, controlled by anodization voltage, electrolyte composition, and processing time, was used to fabricate self-ordered titania nanotubes on the titanium surface, with their lengths simply tuned by the processing time, for drug loading. Two drugs of cisplatin and vancomycin as model anticancer and antibiotic, respectively, were sequentially loaded in nanotubes to investigate the release kinetics. The release profiles of cisplatin and vancomycin were found to be related to the spatial positioning of each drug on the nanotubes. Such a release sequence can be attributed to the anisotropic diffusion of drugs from the nanotubes, which can be further sustained for over 4 weeks through chitosan coverage. The drug release behavior was first evaluated in water using ultraviolet-visible spectroscopy for the quantitative analysis of release kinetics over time. The influence of dual-drug-loaded nanotubes on the growth of<i>Staphylococcus aureus</i>and osteogenic sarcoma<i>in vitro</i>was systematically evaluated for the therapeutic efficacy of bone cancer treatment. A high correlation between the viabilities of bacteria and cells and dual-drug release profiles was observed, indicating the feasibility of our nanotube-based concept utilizing a sequential release pattern to combat initial bacterial infection and prevent local recurrence.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical adhesives for soft tissue wound repair with good biocompatibility, flexibility, and high adhesive strength.","authors":"Jinju Ding, Xuehua Zhao, Chengkai Xuan, Jiayi Lin, Cuiping Zhang, Xuetao Shi","doi":"10.1088/1748-605X/adc529","DOIUrl":"10.1088/1748-605X/adc529","url":null,"abstract":"<p><p>Compared with traditional soft tissue wound closure methods such as sutures and staplers, bioadhesives have significant advantages in terms of tissue compatibility, ease of use, and wound adaptability, making them a hot topic among current wound repair materials. This study aimed to select polyurethane materials with good biocompatibility and high mechanical strength, optimize the prepolymer formula, develop new curing agents, and obtain a new dual-component polyurethane bioadhesive. Furthermore, key research will be conducted on its mechanical properties and tissue adhesion performance. The results show that through the optimization of prepolymer formulations and the development of novel curing agents, a dual-component polyurethane bioadhesive with good biocompatibility, flexibility, and high adhesive strength was obtained. This adhesive can quickly and effectively bond common soft tissue (skin, muscle) traumatic wounds, with an adhesive strength of up to 72 kPa. This adhesive matches well with the mechanical properties of soft tissues and safely and tightly adheres to the surface of soft tissues. Additionally, this dual-component polyurethane adhesive holds promise for repairing other soft tissues, such as the lungs and intestines, with broad application prospects.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the solvent on the green synthesis of NIR active polymeric nanoparticles and their<i>in vitro</i>photothermal therapeutic validation.","authors":"Anusha Srivastava, Vibha Choudhary, Priyanka Payal, Maxim Shevtsov, Sharad Gupta","doi":"10.1088/1748-605X/adc865","DOIUrl":"10.1088/1748-605X/adc865","url":null,"abstract":"<p><p>Nanoparticle-mediated drug delivery has revolutionized nano-therapeutics. It ensures improved biodistribution, longer blood circulation, and improved bioavailability inside the body. The loading efficiency and stability of the drug within the carrier are the major challenges for ideal drug delivery. In this study, we have synthesized indocyanine green (ICG) loaded Poly-L-Lysine (PLL) nanoparticles by a two-step self-assembly process using a green chemistry approach, where water-based solvents were used for fabrication such as phosphate-buffered saline (PBS, pH 7.4), deionized water (DI), and Milli-Q water (MQ). The effect of these solvents on the morphology, stability and loading efficiency of ICG was investigated using UV-visible spectroscopy, fluorescence spectroscopy, scanning electron microscopy, and dynamic light scattering. The results demonstrated that nanoparticles can be fabricated using all the three solvents, however, there was a huge difference between their functional and morphological properties. These functional and morphological properties play important role in their biomedical applications. It was found that PBS-based NPs showed the maximum loading of ICG followed by DI water and MQ water respectively. The PBS suspended ICG-loaded PLL nanoparticles were highly monodispersed with the mean diameter of ∼200 nm and showed highest photothermal efficiency. The green synthesized biocompatible and biodegradable NPs were designed to treat solid tumors via local hyperthermia due to photothermal property of these NPs. The photothermal cytotoxicity assessment of PBS-based PLL-ICG NPs in both 2D and 3D<i>in vitro</i>cultures displayed notable efficacy. Therefore, we conclusively demonstrate that selection of right solvent is crucial to realize the full potential of green-synthesized polymeric nanoparticles.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of naturally derived hydrogels containing anti-inflammatory melittin for sustained drug delivery to treat osteoarthritis disease.","authors":"Jun Yao, Sunfang Chen, Zaihua Zhu, Jianjiang Chen, Jiajie Xia, Bin Fang, Jingjing Guo, Bing Wu, Gaoxiang Ma","doi":"10.1088/1748-605X/adc864","DOIUrl":"10.1088/1748-605X/adc864","url":null,"abstract":"<p><p>Osteoarthritis (OA) has become a common degenerative joint disease, lacking clinical means to alleviate this disease. Melittin, taken from natural honeybee venom, possesses outstanding anti-inflammatory properties and has great potential to treat OA. However, its high toxicity and hemolytic properties limit its application. In this work, a biocompatible hydrogel was prepared from extracellular matrix (ECM) of rib cartilage, possessing fibrous mesh structure characteristics, which was beneficial for melittin loading. It was found that the use of ECM hydrogel loaded with melittin can reduce the intrinsic toxicity of melittin and prolong the release behavior, simultaneously. The<i>in vitro</i>study demonstrated that melittin-hydrogel could effectively inhibit phosphorylation-ERK/JNK, prevent the exacerbation of TNF-<i>α</i>-induced apoptosis in ATDC5 cells, and reduce their inflammatory markers, effectively alleviating OA and preventing cartilage degradation. Subsequently,<i>in vivo</i>studies have demonstrated that injecting melittin-hydrogel into the joint cavity of OA mice can effectively reduce cartilage degeneration. These findings suggest that melittin-hydrogel plays a critical role in the development of OA and may provide a therapeutic option for the treatment of OA disease.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generation of induced pluripotent stem cell-derived anterior foregut endoderms on integrin-binding short peptide-based synthetic substrates.","authors":"Shujun Wu, Huan Wang, Yanbei Ren, Ying Liu, Xuejun Wen","doi":"10.1088/1748-605X/adc52b","DOIUrl":"10.1088/1748-605X/adc52b","url":null,"abstract":"<p><p>Anterior foregut endoderms (AFEs) derived from induced pluripotent stem cells (iPSCs) are an important cell source in stem cell technology as they give rise to some important lineages like lung progenitors and thyroid cells. Coating substrates plays a critical role in AFE generation. Currently, conventional large molecule proteins like Matrigel are used in most differentiation protocols. However, the complex components and mechanisms of these coatings have limited both the exploration of cell-extracellular matrix (ECM) interaction and potential clinical applications. In this study, we identified eight pure synthetic integrin-binding short peptides as effective coatings for iPSC growth and AFE generation with an integrin-binding peptide array. Our results showed that integrin<i>α</i>5<i>β</i>1-,<i>α</i>V<i>β</i>8-, and<i>α</i>IIb<i>β</i>3-binding peptides supported the adhesion and expansion of iPSCs and AFE generation by guided differentiation via a definitive endoderm (DE) in a full-anchorage-dependent manner. AFE generation was also found on coatings based on integrin<i>α</i>3<i>β</i>1-,<i>α</i>6<i>β</i>1-,<i>α</i>V<i>β</i>1-,<i>α</i>V<i>β</i>6-, and<i>α</i>M<i>β</i>2-binding peptides following a process with temporal suspension growth in the DE-inducing stage, with lower AFE generation efficiency compared to the full-anchorage-dependent peptide groups and Matrigel. According to the results, the integrin<i>α</i>5<i>β</i>1-binding peptide is the most promising defined substrate for inducing AFEs because of its equivalent efficiency with traditional Matrigel coating in supporting iPSC expansion and differentiation toward AFEs. Additionally, the other seven peptide-based coatings also exhibit potential and could be further investigated for developing synthetic-coating strategies in future studies involving AFEs. Our findings provide valuable insights into the role of integrin and ECM function and hold great potential for disease modeling as well as therapeutic exploration of AFE origin organs.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of novel antibacterial bio-adhesive for the treatment of periodontitis.","authors":"Yin Xu, Yixian Zhou, Shengjin Meng, Chengchao Zhou, Nannan Yang, Luhan Bao, Weizhong Lu","doi":"10.1088/1748-605X/adc6df","DOIUrl":"10.1088/1748-605X/adc6df","url":null,"abstract":"<p><p>Periodontitis seriously affects people's daily health, and the development of a non-antibiotic bio-adhesive with antimicrobial and periodontitis regeneration for periodontal pockets will effectively promote the treatment of periodontitis. In this study, we constructed a hybrid hydrogel (GelMA-BC-PL) by introducing aldehyde bacterial cellulose (BC) short nanofibers into the photosensitive hydrogel gelatin methacryloyl (GelMA), which binds to periodontal tissues to play an adhesive role through the Schiff base reaction, and further introducing ϵ-polylysine (PL), which could achieve the adhesive, antibacterial, and regenerative effect. Pigskin adhesion experiments showed that the adhesion of GelMA hydrogel to pigskin was only 0.39 N, while that of GelMA-BC-PL reached 1.42 N. The adhesion performance of the hydrogel was significantly improved by adding aldehyde BC nanofibers. Due to the introduction of PL, the antimicrobial properties of the hybrid hydrogel against two typical periodontitis bacteria (porphyromanas gingivalis and fusobacterium nucleatum), were significantly improved. Experiments with human periodontal membrane fibroblasts showed that the hybrid hydrogel had excellent cell spreading and proliferation promotion properties. The hybrid hydrogel simultaneously achieves adhesion, antimicrobial properties and promotes periodontal regeneration, which has great potential for application in the treatment of periodontitis diseases.</p>","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}