Biomedical materials (Bristol, England)最新文献_第5页

Biomedical applications ofBombyx morisilk in skin regeneration and cutaneous wound healing.

Biomedical materials (Bristol, England) Pub Date : 2025-02-28 DOI: 10.1088/1748-605X/adb552

Mohammad Hossein Khosropanah, Alireza Ghofrani, Mahdi Alizadeh Vaghasloo, Mazyar Zahir, Afshin Bahrami, Ashkan Azimzadeh, Zahra Hassannejad, Masoumeh Majidi Zolbin

{"title":"Biomedical applications ofBombyx morisilk in skin regeneration and cutaneous wound healing.","authors":"Mohammad Hossein Khosropanah, Alireza Ghofrani, Mahdi Alizadeh Vaghasloo, Mazyar Zahir, Afshin Bahrami, Ashkan Azimzadeh, Zahra Hassannejad, Masoumeh Majidi Zolbin","doi":"10.1088/1748-605X/adb552","DOIUrl":"10.1088/1748-605X/adb552","url":null,"abstract":"A mere glance at the foundation of the sericulture industry to produce silk and the consequent establishment of the Silk Road to transport it; elucidates the significant role that this material has played in human history. Owing to its exceptional robustness, silk was introduced into medicine as a surgical suture approximately two millennia ago. During the last decades, silk has garnered attention as a possible source of biological-based materials that can be effectively used in regenerative medicine. Silk's unique characteristics, like its low immunogenicity, suitable adhesive properties, exceptional tensile strength, perfect hemostatic properties, adequate permeability to oxygen and water, resistance to microbial colonization, and most importantly, excellent biodegradability; make it an outstanding choice for biomedical applications. Although there are many different types of silk in nature,Bombyx mori(B. mori) silk accounts for about 90% of global production and is the most thoroughly investigated and the most commonly used. Silk fibroin (SF) and silk sericin (SS) are the two main protein constituents of silk. SF has been manufactured in various morphologic forms (e.g. hydrogels, sponges, films, etc) and has been widely used in the biomedical field, especially as a scaffold in tissue engineering. Similarly, SS has demonstrated a vast potential as a suitable biomaterial in tissue engineering and regenerative medicine. Initial studies on SF and SS as wound dressings have shown encouraging results. This review aims to comprehensively discuss the potential role of silk proteins in refining wound healing and skin regeneration.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and characterization of berberine-loaded nanoliposome for targeting of MAPK pathway to induce apoptosis and suppression of autophagy in glioblastoma.

Biomedical materials (Bristol, England) Pub Date : 2025-02-28 DOI: 10.1088/1748-605X/adb673

Min Xi, Somayeh Hasani Kia, Hangyu Shi, Xinya Dong, Yongqiang Shi, Luyi Zhang, Bin Jiang

{"title":"Synthesis and characterization of berberine-loaded nanoliposome for targeting of MAPK pathway to induce apoptosis and suppression of autophagy in glioblastoma.","authors":"Min Xi, Somayeh Hasani Kia, Hangyu Shi, Xinya Dong, Yongqiang Shi, Luyi Zhang, Bin Jiang","doi":"10.1088/1748-605X/adb673","DOIUrl":"10.1088/1748-605X/adb673","url":null,"abstract":"Glioblastoma (GBM), the most aggressive and lethal primary brain tumor, demands innovative therapeutic strategies to improve patient outcomes and quality of life. Addressing this urgent need, our study focuses on developing a berberine (BBR)-loaded nanoliposome (NL) as a targeted drug delivery system to combat GBM. Synthesized using the thin film hydration method and characterized through advanced physical and spectroscopic techniques, these NLs demonstrate promising potential in enhancing BBR's therapeutic efficacy. The NL formulation achieved an impressive loading efficiency of 65.71 ± 1.31% with a particle size of 83 ± 12 nm, ensuring optimal delivery. Sustained release experiments revealed that 82.65 ± 1.75% of the encapsulated BBR was consistently released over 48 h, highlighting its controlled release capabilities.In vitroassays, including cell viability, TUNEL, and western blot analysis, confirmed the potent anti-cancer effects of NL-BBR. The formulation significantly disrupted the metabolism of U-87 glioblastoma cells, inducing enhanced autophagy and apoptosis, ultimately leading to cell death via intrinsic apoptotic pathways. Additionally, western blot results demonstrated that NL-BBR effectively suppressed the mitogen-activated protein kinase signaling pathway, a critical driver of GBM progression. This study underscores the transformative potential of incorporating BBR into NLs, which not only enhances its solubility and bioavailability but also significantly amplifies its therapeutic impact. These findings pave the way for advanced nano-based interventions in GBM treatment, offering a glimmer of hope for improved outcomes in this challenging cancer landscape.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isobavachalcone-loaded electrospun polycaprolactone/gelatin nanofibers for antibacterial and antioxidant applications.

Biomedical materials (Bristol, England) Pub Date : 2025-02-28 DOI: 10.1088/1748-605X/adb8b2

Peibo Guo, Wen Zhang, Pei Zhao, Xinyi Lv, Ao Qu, Wenjing Liang, Huijing Hou, Ying Li, Zijian Wu

{"title":"Isobavachalcone-loaded electrospun polycaprolactone/gelatin nanofibers for antibacterial and antioxidant applications.","authors":"Peibo Guo, Wen Zhang, Pei Zhao, Xinyi Lv, Ao Qu, Wenjing Liang, Huijing Hou, Ying Li, Zijian Wu","doi":"10.1088/1748-605X/adb8b2","DOIUrl":"https://doi.org/10.1088/1748-605X/adb8b2","url":null,"abstract":"Antibacterial nanofibers have been widely used in the fields of biomedicine and food packaging fields. To overcome existing antibiotic resistance, this study utilized isobavachalcone (IBC), a natural compound with antibacterial and antioxidant properties, combined with polycaprolactone (PCL) and gelatin (GEL) to develop an electrospun nanofibrous antibacterial membrane. Scanning electron microscopy (SEM) analysis revealed a uniform and smooth surface structure of the nanofiber. Fourier transform infrared spectroscopy and x-ray diffraction confirmed the interactions among the components of the nanofibrous membrane PCL/GEL/IBC (PGI). Thermogravimetric analysis and contact angle measurements demonstrated the thermal stability and hydrophilic nature. Additionally, the mechanical properties of PGI membrane were that the elongation at break increased to 19.9% and the tensile strength to 2.9 MPa.In vitrorelease studies indicated at least 48% release rate of IBC from the PGI nanofibrous membrane in 12 h, and release period up to 14 d. Antioxidant results revealed PGI membranes had fine abilities for scavenging free radical. The elimination of over 99% ofStaphylococcus aureusand elimination of 54%Candida albicansdemonstrated the antibacterial capacities of the PGI membrane, indicating its potential as antibacterial and antioxidant materials. Subsequent faster wound healing, lower oxidative damage for 4-HNE and 8-OHdG, further demonstrated that PGI can reduce oxidative damage at the wound and promote wound healing. These findings also suggest the potential of PGI in the field of tissue engineering.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":"20 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring blood oxygenation through photocatalytic activity using microwave assisted hydrothermally crystallized TiO₂nanotubes.

Biomedical materials (Bristol, England) Pub Date : 2025-02-27 DOI: 10.1088/1748-605X/adb670

Raghavendra Garlapally, B Manmadha Rao

{"title":"Exploring blood oxygenation through photocatalytic activity using microwave assisted hydrothermally crystallized TiO2nanotubes.","authors":"Raghavendra Garlapally, B Manmadha Rao","doi":"10.1088/1748-605X/adb670","DOIUrl":"10.1088/1748-605X/adb670","url":null,"abstract":"Anodically crystallized TiO2nanotubes through microwave-assisted hydrothermal technique results in formation of granular morphology with anatase phase. Field emission scanning electron microscope and x-ray diffraction studies indicate the granular morphology of TiO2nanotubes while retaining the anatase phase. Diffuse reflectance and photo luminescence spectroscopy analysis reveal band gap of fabricated TiO2nanotubes as 2.90 eV and the position of defect states 0.86 eV below the conduction band. Investigations of x-ray photo-electron and electron paramagnetic resonance spectroscopy reveal the presence of oxygen vacancy related defect states. The color change of blood through photocatalytic activity indicates production of oxygen in the blood. The UV-visible absorption studies on diluted blood indicate an enhancement in blood oxygenation, which is consistent with the results of a standard hemoglobin test. The utilization of an optical microscope has facilitated the examination of the structural composition of red blood cells, which has led to the observation of no hemolysis subsequent to photocatalytic activity.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-performance affinity peptide sensor for prostate specific antigen detection.

Biomedical materials (Bristol, England) Pub Date : 2025-02-27 DOI: 10.1088/1748-605X/adb7b0

Ao Cheng, Shuangjia Guo, Zhehang Wang, Kuibo Lan, Zihao Liu, Yong Wang, Ruibing Chen, Guoxuan Qin

{"title":"High-performance affinity peptide sensor for prostate specific antigen detection.","authors":"Ao Cheng, Shuangjia Guo, Zhehang Wang, Kuibo Lan, Zihao Liu, Yong Wang, Ruibing Chen, Guoxuan Qin","doi":"10.1088/1748-605X/adb7b0","DOIUrl":"10.1088/1748-605X/adb7b0","url":null,"abstract":"Prostate-specific antigen (PSA) is the best serum biomarker for prostate cancer (PCa), and the detection of PSA concentration can be used to assess the risk of malignancy. Given the current lack of effective treatment options for PCa, early detection and intervention are particularly important. To address this, we developed a novel electronic biosensor aimed at highly sensitive detection of PSA. The core materials of this sensor consist of the receptor material, PSA-affinity peptides, and the support material, single-walled carbon nanotubes. These materials are cost-effective, can operate at room temperature, and exhibit good stability, which aids in optimizing the sensor's performance and stability. We attached the carbon nanotubes to a gold fork electrode and successfully fabricated the device by chemically linking the peptides to the carbon nanotubes. PSA was subsequently detected through the binding of PSA molecules to specific peptide sequences in standard solution. The sensor achieved a detection limit as low as 10-13μg μL-1, which is lower than that of currently used detection methods, demonstrating exceptional sensitivity. This biosensor offers advantages such as low cost, high efficiency, and strong specificity, indicating its broad application prospects in medical diagnostics, particularly in PCa screening.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prospects of black phosphorus nanosheets in the treatment of peri-implantitis.

Biomedical materials (Bristol, England) Pub Date : 2025-02-26 DOI: 10.1088/1748-605X/adb66e

Ailin Wu, Jun Su, Yongzhi Zhang, Dongjiao Zhang, Yanhua Chen

引用次数: 0

A coaxial electrospun PLLA/PPDO/NAR mesh for abdominal wall hernia repair.

Biomedical materials (Bristol, England) Pub Date : 2025-02-24 DOI: 10.1088/1748-605X/adb554

Yifan Xv, Li Xu, Dandan Wei, Yinghua Tao, Tianzhu Zhang, Zhenling Ji

{"title":"A coaxial electrospun PLLA/PPDO/NAR mesh for abdominal wall hernia repair.","authors":"Yifan Xv, Li Xu, Dandan Wei, Yinghua Tao, Tianzhu Zhang, Zhenling Ji","doi":"10.1088/1748-605X/adb554","DOIUrl":"10.1088/1748-605X/adb554","url":null,"abstract":"This study aims to employ poly-L-lactic acid (PLLA) and poly(p-dioxanone) (PPDO), loaded with naringin (NAR) to fabricate a functionalized degradable mesh which can promote abdominal wall hernia (AWH) repair. Three meshes named PPDO, PLLA/PPDO, and PLLA/PPDO/NAR were fabricated by electrospinning. The physical and chemical properties of the meshes were evaluated from the aspects of morphology, wettability, chemical composition, mechanical properties, andin vitrodegradation. Then, the meshes were implanted into rats to evaluate their repair effects on abdominal wall defect models. The mechanical properties of PLLA/PPDO/NAR mesh were superior to the other two meshes, with a fixed tensile strength of 36.47 ± 2.40 N cm-1and an elongation at break of 287.98% ± 51.67%, which adequately met the mechanical strength required for the human abdominal wall. The core-shell structure effectively delayed the degradation of PLLA/PPDO as well as PLLA/PPDO/NAR mesh, and drug release of PLLA/PPDO/NAR mesh. On the 7th, 14th, and 28th day after implantation, more neovascularization and tissue formation were observed in the PLLA/PPDO/NAR group and the newborn collagen was arranged in a regular and neat manner compared to the other two groups. The immunohistochemical results showed that the PLLA/PPDO/NAR mesh promoted abdominal wall repair by inhibiting the expression of matrix metalloproteinase2 as well as interleukin-6, and increasing the expression of vascular endothelial growth factor. The PLLA/PPDO/NAR mesh is promising for application in AWH repair.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A tannic acid coated silk fibroin sponge loaded with bioglass for noncompressible hemostasis.

Biomedical materials (Bristol, England) Pub Date : 2025-02-24 DOI: 10.1088/1748-605X/adb553

Shanshan Chu, Xu Fang, Junfeng Xu, Wenwen Yuan

引用次数: 0

Analgesic effect of microneedle with 3-acetylaconitine for neuropathic pain. 含有 3-乙酰乌头碱的微针对神经病理性疼痛的镇痛效果。

Biomedical materials (Bristol, England) Pub Date : 2025-02-24 DOI: 10.1088/1748-605X/adb671

Juan Huang, Yanhui Li, Mengru Zhu, Jigang Luo, Zhuoyue Song, Shijie Li, Tao Liu, Chunzhi Tang, Nenggui Xu, Shihui Liu

{"title":"Analgesic effect of microneedle with 3-acetylaconitine for neuropathic pain.","authors":"Juan Huang, Yanhui Li, Mengru Zhu, Jigang Luo, Zhuoyue Song, Shijie Li, Tao Liu, Chunzhi Tang, Nenggui Xu, Shihui Liu","doi":"10.1088/1748-605X/adb671","DOIUrl":"10.1088/1748-605X/adb671","url":null,"abstract":"Neuropathic pain is a worldwide problem that causes physical and psychological pain to many patients. 3-acetylaconitine (AAC) is a kind of non-narcotic analgesic with long-lasting action, non-tolerant and non-addiction. However, it has some cardiac toxicity and can easily cause toxic organ damage. To solve these problems, dissolvable microneedle (MN) patches were prepared and delivered subcutaneously through the skin barrier. The results showed that the solid dispersion made with AAC and polyvinyl pyrrolidone (PVP) effectively changed the solubility of AAC and improved its bioavailability. The MN shape was conical and the bending forces of AAC/PVP-MN were all approximately 1.2 N/needle, which was enough to penetrate the stratum corneum of the skin. Through the use of the neuropathic pain model (spared nerve injury) test, it was found that the soluble MN mediated AAC hypodermic delivery provided effective analgesic activity. Compared with the model group, AAC/PVP-MN could increase mechanical pain threshold and hind legs load-bearing capacity, reduce the inflammation in the body, and have certain protective effect to spinal cord neurons. This study provided an idea for the clinical treatment of neuropathic pain and also a new approach for the safe use of toxic drugs with a narrow range.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thiolated gellan gum/polyethylene glycol diacrylate hydrogels containing timolol maleate-loaded chitosan nanoparticles for ophthalmic delivery.

Biomedical materials (Bristol, England) Pub Date : 2025-02-21 DOI: 10.1088/1748-605X/adb555

Golnaz Shajari, Hamid Erfan-Niya, Marziyeh Fathi, Nazanin Amiryaghoubi

{"title":"Thiolated gellan gum/polyethylene glycol diacrylate hydrogels containing timolol maleate-loaded chitosan nanoparticles for ophthalmic delivery.","authors":"Golnaz Shajari, Hamid Erfan-Niya, Marziyeh Fathi, Nazanin Amiryaghoubi","doi":"10.1088/1748-605X/adb555","DOIUrl":"10.1088/1748-605X/adb555","url":null,"abstract":"The combination of hydrogels with nanoformulations can significantly enhance the delivery and effectiveness of drugs in ophthalmic drug delivery systems. In the current study, the polyethylene glycol diacrylate (PEGDA)/thiolated gellan gum (GGSH) hydrogels based on GGSH and PEGDA were prepared via thiol-ene reaction using Irgacure 2959 as a photoinitiator. To this end, the modification of GG was achieved by esterification of the hydroxyl groups of GG with the carboxyl group of mercaptopropionic acid with a free thiol amount of 95.5 μmol g-1. To provide sustained release, chitosan nanoparticles (CSNPs) containing timolol maleate (TM) with 56.4% entrapment efficiency were synthesized by the desolvation method and encapsulated in the developed hydrogel. The values of zeta potential and particle size of CSNPs were +26.0 mV and 182.4 nm, respectively. The physico/chemical properties of the hydrogels were investigated via texture analyzer, FT-IR, XRD, and SEM. Thein vitrodegradation, swelling behavior, rheological assessments, cell viability testing, and porosity determination were evaluated. With the increase in PEGDA concentration, the mechanical properties were increased. While the rate of swelling, degradation, and drug release were decreased. Thein vitrobiocompatibility of hydrogels was confirmed using the MTT test. According to anex vivostudy, ocular drug delivery using the obtained transparent hydrogels is promising due to improved drug permeation and sustained release of TM via CSNPs.","PeriodicalId":72389,"journal":{"name":"Biomedical materials (Bristol, England)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0