Advancing biomedical applications: integrating textile innovations with tissue engineering.

Abstract

Textile technologies are significantly advancing the field of tissue engineering (TE) by providing innovative scaffolds that closely mimic the extracellular matrix and address crucial challenges in tissue regeneration. Techniques such as weaving, knitting, and braiding allow for creating structures with customizable porosity, mechanical properties, and fiber alignment, which are essential for supporting cellular behaviors such as adhesion, proliferation, and differentiation. Recent developments have incorporated bioactive materials-like growth factors, peptides, and nanoparticles-into these textile-based scaffolds, greatly enhancing their functionality for applications in wound healing, skin regeneration, and organ engineering. The emergence of smart textiles, which utilize responsive polymers and nanotechnology, facilitates the on-demand delivery of therapeutic agents and provides electrical stimulation to repair neural and muscular tissues. Additionally, combining 3D bioprinting with textile principles enables the fabrication of anatomically precise, multi-layered scaffolds, expediting advancements in complex tissue reconstruction, including vascular grafts and bone scaffolds. Utilization of materials such as polycaprolactone, collagen, and silk fibroin-often in hybrid forms-ensures that these scaffolds maintain biocompatibility, mechanical integrity, and biodegradability. As functionalized textiles are explored for applications in cardiovascular, skin, and organ engineering, leveraging techniques like electro-spun nanofibers and braided vascular grafts, a transformative approach to regenerative medicine emerges. Despite ongoing challenges with vascularization and scaling, textile-engineered scaffolds promise to enable personalized, durable, and multifunctional solutions, positioning the convergence of textile science and TE to redefine future biomedical applications.