Biomedical engineering advances最新文献

{"title":"Covalent surface immobilization on metal implants: Key aspects on post-synthesis characterization","authors":"Luna Sánchez-López","doi":"10.1016/j.bea.2023.100111","DOIUrl":"https://doi.org/10.1016/j.bea.2023.100111","url":null,"abstract":"<div><p>A variety of methodologies have been applied for characterizing covalent immobilizations of biomolecules and other compounds on metal implant surfaces, due to the positive impact of functionalization and the enhancement of biomimetic signaling at covalently immobilized biomaterial surfaces. However, current challenges should be addressed, as both physically adsorbed and covalently immobilized molecules usually coexist on functionalized surfaces and covalent immobilization efficiencies greatly vary among works, in which the immobilized biomolecule size seems a determinant parameter of the efficiency.</p><p>Discrimination of the irreversible-bound covalent fraction should be assessed and advanced techniques for surface characterization must be conducted, such as quartz crystal microbalance or photon induced spectroscopy, as evaluation criteria. Verification of biomolecule activity once it is covalently immobilized on metal substrates is also required. Long-term stability and degradation resistances studies are also highly recommended for obtention of long-lasting, biomimetic-active surfaces upon covalent functionalization of metal biomaterials for medical applications.</p></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"7 ","pages":"Article 100111"},"PeriodicalIF":0.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667099223000403/pdfft?md5=3dc2be95953b8dae1217be65efdaa826&pid=1-s2.0-S2667099223000403-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139100253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic bone grafts and substitutes: A review of recent advancements and applications","authors":"Sandleen Feroz ,&nbsp;Peter Cathro ,&nbsp;Sašo Ivanovski ,&nbsp;Nawshad Muhammad","doi":"10.1016/j.bea.2023.100107","DOIUrl":"https://doi.org/10.1016/j.bea.2023.100107","url":null,"abstract":"<div><p>The demand for designing an ideal bone substitute has emerged significantly to address the clinical limitations associated with the current bone grafting materials. A thorough understanding of the complex architecture and cellular composition of natural bone is crucial to design a biomimetic bone graft that closely emulates the physiological structure of the lost bone. There is a dire need for close collaboration among clinicians, nanotechnologists, and tissue engineers to design clinically relevant bone grafts that can promote efficient osteoconduction, osteogenesis and osteoinduction. Clinically, bone grafting procedures mainly involves the utilization of xenografts, allografts or autograft, a combination of natural and synthetic materials, polymer, metals and bioceramics. The advent of 3D printing techniques has revolutionized the field of bone tissue engineering. These additive manufacturing technologies utilizing digital design features and high precision enable researchers to replicate complex anatomical structures including bone. This review aims to present an overview of the determinants of an ideal bone graft, types of available bone grafting materials, and emphasizes the recent advancements in the field of regenerative medicine for designing biomimetic bone repairing scaffolds.</p></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"6 ","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667099223000361/pdfft?md5=8f90b0319d682148fd4133b0c6c269ea&pid=1-s2.0-S2667099223000361-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134656628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the optimal design of all-on-four technique adopting finite element analysis: the aspect of framework material, kind and position of implants","authors":"Antonio Lanza ,&nbsp;Marco De Stefano ,&nbsp;Alessandro Ruggiero","doi":"10.1016/j.bea.2023.100110","DOIUrl":"10.1016/j.bea.2023.100110","url":null,"abstract":"<div><p>Nowadays, the dental implant surgery is a sophisticate and accurate sector with techniques increasingly innovative such as rapid prototyping, guided implant surgery and stem cell-based approaches. An example is certainly the use of multiple implants (4–6), instead of several prosthesis in case of human edentulous condition. The aim of this research is to investigate the mechanical behavior of the All-on-Four technique for different boundary conditions such as the value of load, framework material, type and position of implant. The goal was essentially trying to find out, by the application of structural static Finite Element Analysis (FEM), the <em>best</em> design for this specific treatment. After that, a stress-life fatigue numerical analysis was conducted for the optimal configuration in order to estimate the fatigue life in accordance with both Gerber and Goodman mean stress theory. The coupling involved the implants supported by an arch and a human mandible composed of cortical and cancellous part. After the simulations, it was found that the stress/strain field was very sensitive to the boundary conditions imposed. In particular, the position of the implants and the material framework yielded different responses depending on the implant design. Finally the use of ultrashort implants provided a significant decrease in the developed efforts than the long ones if the first premolar position was assumed. More specific, the stress peaks were in the range 100–225MPa for the implants, 300–537MPa for the framework, 50–124MPa for the cortical bone and 3–35MPa for the cancellous bone and they were located essentially in the abutment-framework connection as much as in implant neck-bone coupling. The best design saw the presence of ultra-short implant, first premolar position and Co-Cr alloy as framework material. The fatigue test confirmed the stability of the structure even with dynamic loads, but critical spots were present in the framework. In conclusion, the All-on-Four technique is a valid and safe alternative, even in case of ultrashort implants, for human edentulism care.</p></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"6 ","pages":"Article 100110"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667099223000397/pdfft?md5=212557d95a2c5ffe10f2f0226b7f7983&pid=1-s2.0-S2667099223000397-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135764266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An in vitro study of micromechanics, cellular proliferation and viability on both decellularized porcine dura grafts and native porcine dura grafts","authors":"Ashma Sharma ,&nbsp;Erika Moore ,&nbsp;Lakiesha N. Williams","doi":"10.1016/j.bea.2023.100108","DOIUrl":"https://doi.org/10.1016/j.bea.2023.100108","url":null,"abstract":"<div><p>Damage to the dura mater may occur during intracranial or spinal surgeries, which can result in cerebrospinal fluid leakage and other potentially fatal physiological changes. As a result, biological and synthetic derived scaffolds are typically used to repair dura mater post intracranial or spinal surgeries. The extracellular matrix of xenogeneic dura scaffolds has been shown to exhibit increased cell infiltration and regeneration than synthetic dura materials. In this study, we investigated the biocompatibility of native and decellularized porcine dura by seeding rat fibroblast cells onto the constructs. Cell proliferation, cell viability, and the mechanical properties of these dural grafts were evaluated post-re-seeding on days 3,7 and 14. Live-dead staining and resazurin salts were used to quantify cell viability and cell proliferation, respectively. Micro indentation was conducted to quantify the mechanical integrity of the native and acellular dura graft. The findings indicate that the acellular porcine dura graft creates a beneficial setting for infiltrating rat fibroblast cells. Cell viability, proliferation, and micro indentation results on the acellular grafts are comparable with the native control porcine dura tissue. In conclusion, the porcine scaffold material showed increased cell viability at each time point evaluated. The sustained mechanical response and favorable viability of the cells on the decellularized grafts provide promising insight into the potential use of porcine dura in clinical cranial dura mater graft applications.</p></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"6 ","pages":"Article 100108"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667099223000373/pdfft?md5=ff36dfc6bd9142f2afddeadf99cebdd5&pid=1-s2.0-S2667099223000373-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134656627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in robot-assisted surgical systems","authors":"Pradipta Biswas,&nbsp;Sakura Sikander ,&nbsp;Pankaj Kulkarni","doi":"10.1016/j.bea.2023.100109","DOIUrl":"https://doi.org/10.1016/j.bea.2023.100109","url":null,"abstract":"<div><p>In recent years there has been a steady growth in the number of new robotic devices developed for surgical intervention. The market has rapidly grown into a multibillion-dollar industry. A significant number of commercial robots have been developed for several surgical procedures. Considering the recent developments in surgical robotics and its significant market potential we have studied the existing commercially available robotic surgical systems. The purpose of this review is to understand the current trends and existing gaps in this field to provide the developers with proper insight about the future direction. We reviewed the systems based on their target anatomical location and summarized the working principle for each robot, including their regulatory status.</p></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"6 ","pages":"Article 100109"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667099223000385/pdfft?md5=0975dec3c98061fdd1e9861673f46bc8&pid=1-s2.0-S2667099223000385-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138475188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling of aneurysm progression in anterior cerebral arteries to estimate rupture risk: A computational study","authors":"Gurpreet Singh,&nbsp;Prem Nath Yadav,&nbsp;Shubham Gupta,&nbsp;Arnab Chanda","doi":"10.1016/j.bea.2023.100106","DOIUrl":"https://doi.org/10.1016/j.bea.2023.100106","url":null,"abstract":"<div><p>A cerebral aneurysm is a medical disorder that occurs when the wall of the cerebral artery ruptures as a result of abnormally high blood pressure. The imaging techniques that are now in use, such as CT and MRI scans, can only show the geometrical information about an aneurysm and cannot determine the risk of rupture that relates to the progression of an aneurysm. In this work, computational modeling was performed to simulate aneurysm progression and to analyze the stress development for a variety of different pressure loading conditions. Image segmentation was utilized to segment one anterior cerebral artery and one anterior communicating artery, both of which were rebuilt to generate aneurysm models at susceptible locations of the aneurysm progression simulation. To represent the various phases of aneurysm development, five different aneurysm sizes with two varying wall thicknesses were identified. The diastolic pressure, the systolic pressure, and the hypertensive pressure were applied to simulate the actual pressure conditions for the anterior cerebral arteries. The rupture risk was determined by analyzing the stress distributions across all of the models. It was estimated that the stresses around the walls of aneurysm varies with an incremental change in both the diameter of the aneurysm and the magnitude of the blood pressure. Aneurysms that were observed to have significant rupture risks were those that had a large diameter and a thin wall and were simulated at high blood pressures. The findings of this research are anticipated to assist medical practitioners in estimating rupture risks with known imaging, based on the diameters of aneurysms, and in early decision making for the treatment of aneurysms.</p></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"6 ","pages":"Article 100106"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49761364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benchtop impaction device replicates cadaveric loading conditions of the transforaminal lumbar interbody fusion (TLIF) procedure","authors":"Alexis Graham ,&nbsp;Caitlin Luke ,&nbsp;Frank Brinkley ,&nbsp;Jaden Bennett ,&nbsp;Cody Gressett ,&nbsp;Micah Foster ,&nbsp;Zach Hooper ,&nbsp;Jerald Redmond ,&nbsp;Daniel Woods ,&nbsp;MeLeah A. Henson ,&nbsp;Rex Armstrong ,&nbsp;Lauren B. Priddy ,&nbsp;Matthew W. Priddy","doi":"10.1016/j.bea.2023.100105","DOIUrl":"https://doi.org/10.1016/j.bea.2023.100105","url":null,"abstract":"<div><h3>Background context</h3><p>Lumbar spine disc pathologies often necessitate removal of the intervertebral disc and implantation of a lumbar interbody fusion (LIF) device. Herein, the objective was to measure use condition forces while simulating intra-operative loading conditions of transforaminal lumbar interbody fusion (TLIF) procedures.</p></div><div><h3>Methods</h3><p>In this work, we developed a transferable method to measure impact forces in a cadaveric intra-operative setting and designed a drop weight benchtop device equipped with force and displacement sensors to replicate cadaveric impact conditions, including number of strikes required for interbody device insertion, peak force, initial slope of the impact waveform, impact duration, and area under the force-time curve (impulse). Following cadaveric testing, a benchtop biomechanical study varying interbody device height, drop height, and drop weight was performed to evaluate the utility of the benchtop device to replicate impact loading conditions which occurred in the cadaveric model.</p></div><div><h3>Results</h3><p>Several benchtop test groups replicated the cadaver group in number of strikes required for device insertion. The average cadaveric peak force, 13.03 kN, was replicated by three benchtop groups: 12 mm device height, 60 cm drop height, 0.75 lb drop weight; 12 mm device height, 60 cm drop height, 1.0 lb drop weight; and 14 mm device height, 60 cm drop height, 0.50 lb drop weight. The initial slope of the impact waveform was replicated best by 12 mm devices. Both the impact duration and impulse were lower in all benchtop groups than in cadaver testing.</p></div><div><h3>Conclusions</h3><p>This work validated the outfitting of an impact force sensor onto an interbody device insertion instrument as a reproducible, quantifiable method for collecting impact loading data in a cadaveric model. This benchtop device and methodology will aid in testing interbody devices relative to anticipated use conditions, enhance interbody device designs, and accelerate surgical technique refinement.</p></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"6 ","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49761362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Production Floor Temperature on Weaving: A Case Study of Bangladesh","authors":"Samiha Tanni, Rohani Us Shams Zaman, Md. Robiul","doi":"10.26855/ea.2023.08.019","DOIUrl":"https://doi.org/10.26855/ea.2023.08.019","url":null,"abstract":"Weaving is a method of fabric production in which two distinct sets of yarns or threads are interlaced at right angles to form a fabric or cloth Temperature variation is common in Bangladesh from season to season. This research is about the temperature effect on the weaving industry. To reach the goal of this research, we have to do the work in a non-chiller weaving floor because we face the huge temperature variation in Bangladesh during winter and summer season. We tried to find out this two season’s differences on each steps of weaving process, such as sizing cost, production performance, fabrics quality, maintenance cost, machine lifetime etc. Reducing cost, increase productivity and better quality plays a vital role to survive in today’s competitive market. Though the initial investment is high, but considering the both short term (fabric quality, maintenance cost, increased production etc.) and long term (machine lifetime, quick return on investment, safety etc.) benefit. Chiller and voltage stabilizer is the best solution to con-trol the temperature and overcome from these problems.","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"2015 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136100553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on the Morphology of Lithium Aluminate Films Prepared by Laser Chemical Vapor Deposition","authors":"Chi Chen","doi":"10.26855/ea.2023.08.018","DOIUrl":"https://doi.org/10.26855/ea.2023.08.018","url":null,"abstract":"The Li-Al-O system has three compounds of LiAl 5 O 8 , LiAlO 2 and Li 5 AlO 4 . Among them, LiAlO 2 attracts increasing attention as a potential substrate for growing GaN semiconductor due to low lattice mismatch and removability. It is also of interest as a solid tritium breeding material to produce tritium fuel by the nuclear reaction of Li(n, a)T in a fusion reactor, since LiAlO 2 shows high-temperature stability and good compatibility with structural materials under irradiation with neutrons. Additionally, LiAlO 2 is thermochemically stable even at 973 K so that it is usually used as the support for the polymer electrolyte to form the diaphragm transporting CO 32-in molten carbonate fuel cells (MCFC). In this paper, (110) and (004)-oriented γ -LiAlO 2 films were prepared on poly-crystalline AlN substrates by laser chemical vapor deposition atdeposition temperature (T dep ) of 1000–1300 K, molar ratio of Li/Al (R Li/Al ) of 1.0–10 and lowtotal pressure (P tot ) of 100–200 Pa. The (004)-oriented γ -LiAlO 2 films consisted of pyramidal grains with acolumnar structure while (110)-oriented γ -LiAlO 2 films showed granular and polygonal column. The deposition rate of γ -LiAlO 2 films reached to 60–90 µ m h -1 .","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136025557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analytic Theory of the Evolution of Circle Pearcey Beam","authors":"Minghan Liu, Gouhua Fu","doi":"10.26855/ea.2023.08.017","DOIUrl":"https://doi.org/10.26855/ea.2023.08.017","url":null,"abstract":"With the research of abrupt autofocusing beams deeper than ever before, the application of that turns wider, such as the particle manipulation, biomedicine, optical communication, vortex beams and so on, arousing scientists’ interest further. However, the analytical solution of circle Pearcey beams (CPBs) in paraxial propagation has not yet been proposed so far. In this work, we first propose the analytical solution of circle Pearcey beams (CPBs) transmitting on axi, and obtain semi-analytical solution of which transmitting off axis under paraxial condition. Particularly, The complex amplitude and analytical expressions of the circle Pear-cey beam (CPB) at any point in the free space under the paraxial approximation are obtained by means of the stationed phase method, the asymptotic theory and decouple theory–separation variable method, which contains separation variable method. It’s fantastic that the analytical solution we acquire is well consistent with the numerical solution gained by three-step Fourier algorithm. Furthermore, compared with the three-step method, we theoretically get the self-focusing distance of circle Pearcey beams (CPBs), expounding the phenomena of autofocusing and the law of spatial evolution under paraxial approximation","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136025558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}