Biomedical engineering advances最新文献

A systematic review of automated temporal bone segmentation methods 自动颞骨分割方法的系统综述

Biomedical engineering advances Pub Date : 2025-09-20 DOI: 10.1016/j.bea.2025.100195

Weijing Li , Sudanthi Wijewickrema , Jan Margeta , Reda Kamraoui , Raabid Hussain , Jean-Marc Gerard

{"title":"A systematic review of automated temporal bone segmentation methods","authors":"Weijing Li , Sudanthi Wijewickrema , Jan Margeta , Reda Kamraoui , Raabid Hussain , Jean-Marc Gerard","doi":"10.1016/j.bea.2025.100195","DOIUrl":"10.1016/j.bea.2025.100195","url":null,"abstract":"<div><div>The temporal bone is a complex anatomical structure crucial for otologic and neurotologic procedures. Accurate segmentation of the temporal bone from computed tomography (CT) and magnetic resonance imaging (MRI) is essential for surgical planning, pathology assessment, and computational modeling. Manual segmentation is time-consuming and subject to inter-observer variability, necessitating the development of automated methods. This systematic review aims to analyze the current state of automated temporal bone segmentation techniques and their performance. A comprehensive search was conducted across PubMed, IEEE Xplore for articles published from 2004 to 2024. A total of 419 articles were reviewed, from which 34 were selected for this study. Among the identified studies, deep learning, particularly convolutional neural networks (CNNs) and U-Net variants, emerged as the dominant approach, consistently outperforming SSM and atlas-based methods. Deep learning models achieved the highest Dice Similarity Coefficient (DSC) and the lowest Hausdorff Distance (HD). Deep learning-based approaches improved automated temporal bone segmentation, with strong performance in segmenting larger structures such as the labyrinth, with Dice score over 0.86. However, the segmentation of smaller anatomical structures, such as stapes and chorda tympani, remains a challenge.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"10 ","pages":"Article 100195"},"PeriodicalIF":0.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remineralization of demineralized teeth enamel with nHAp and nHAp-NaF-PEO nanocomposite nHAp和nHAp- naf - peo纳米复合材料对脱矿牙釉质的再矿化作用

Biomedical engineering advances Pub Date : 2025-09-05 DOI: 10.1016/j.bea.2025.100192

Nazifa Zaman Khan , S. Manjura Hoque , Harinarayan Das , Arup Kumar , Rafiqul Islam , Mozammal Hossain

{"title":"Remineralization of demineralized teeth enamel with nHAp and nHAp-NaF-PEO nanocomposite","authors":"Nazifa Zaman Khan , S. Manjura Hoque , Harinarayan Das , Arup Kumar , Rafiqul Islam , Mozammal Hossain","doi":"10.1016/j.bea.2025.100192","DOIUrl":"10.1016/j.bea.2025.100192","url":null,"abstract":"<div><div>Teeth enamel, composed of calcium and phosphorus, becomes demineralized in contact with beverages and food. The essential component of teeth, enamel, can be remineralized with the use of nano-hydroxyapatite (nHAp) alone or in a solution consisting of nHAp, sodium fluoride (NaF), and polyethylene oxide (PEO) nanocomposite. We divided ten sound-extracted teeth into two groups: Group A consisted of three teeth treated with nHAp colloids, while Group B consisted of seven teeth treated with nHAp-NaF-PEO nanocomposite in solution. We demineralized the teeth of both groups by soaking them in various pH-adjusted demineralizing agents for different periods. We analyzed the morphology and composition of the demineralized teeth by the scanning electron microscope (SEM) and energy-dispersive X-ray spectroscopy (EDAX). The teeth specimens were brushed two times/day for about 2 minutes each, with a 12-hours interval between brushing sessions, to remineralize them over four weeks. Periodically, the enamel specimens were placed in distilled water and maintained at 37° C in the CO<sub>2</sub> incubator. We analyzed the morphology and composition of the remineralized teeth by SEM and EDAX. The results show that the surface morphology produced by the nHAp-NaF-PEO nanocomposite solution was quite similar to the baseline enamel morphology. We observed an increase in mineral content, namely the Ca/P ratio, in the nHAp-NaF- PEO nanocomposite solution. The nHAp-NaF-PEO nanocomposite solution aids the remineralization of the decayed teeth more effectively than nHAp singly and heals carious lesions. Both nHAp and nHAp-NaF-PEO heals the morphology of carious teeth.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"10 ","pages":"Article 100192"},"PeriodicalIF":0.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wearable near-infrared spectroscopy device to quantify rehabilitation following anterior cruciate ligament reconstruction: A case study on division I collegiate football athletes 可穿戴近红外光谱装置量化前十字韧带重建后的康复：以大学橄榄球甲级运动员为例

Biomedical engineering advances Pub Date : 2025-09-05 DOI: 10.1016/j.bea.2025.100193

Joseph Amitrano , Milad Zarrinfar , Marco Giuliani , Kevin Cahill , Mark A. Seeley , Dhruv R. Seshadri

{"title":"Wearable near-infrared spectroscopy device to quantify rehabilitation following anterior cruciate ligament reconstruction: A case study on division I collegiate football athletes","authors":"Joseph Amitrano , Milad Zarrinfar , Marco Giuliani , Kevin Cahill , Mark A. Seeley , Dhruv R. Seshadri","doi":"10.1016/j.bea.2025.100193","DOIUrl":"10.1016/j.bea.2025.100193","url":null,"abstract":"<div><div>The anterior cruciate ligament (ACL) is critical for stabilizing the knee during high-performance activities. Anterior cruciate ligament reconstruction (ACLR) surgery, combined with rehabilitation, is the standard treatment for tears; however, determining readiness to return to sport (RTS) remains challenging. Traditional RTS assessments often fail to capture physiological recovery, emphasizing the need for precise, objective biomarkers. Near-infrared spectroscopy (NIRS) offers real-time, non-invasive insights into muscle oxygen saturation, providing an objective means to quantify recovery. This study investigated the utility of a wearable NIRS sensor to monitor muscle oxygen saturation levels in two Division 1 football athletes recovering from a torn ACL, with a focus on assessing inter-athlete recovery variability and its implications for RTS decisions. This longitudinal case study monitored muscle oxygen saturation using the Moxy Muscle Oxygen Monitor in the surgical and contralateral legs of two athletes at 1, 3-, 5-, 6-, and 7-months post-surgery during functional exercises (leg raises and quad sets). The study highlights the capacity of NIRS based wearable sensors to capture inter-individual variability over the rehabilitation continuum towards providing real-time physiological insights beyond traditional subjective or qualitative-based assessments. These findings support the integration of wearable technology into lower extremity rehabilitation protocols to enhance recovery evaluations and improve athlete RTS.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"10 ","pages":"Article 100193"},"PeriodicalIF":0.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145049341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A core needle biopsy combined with novel spectroscopic probe for in vivo tissue classification – A pilot study on piglets 核心针活检结合新型光谱探针进行体内组织分类-仔猪的初步研究

Biomedical engineering advances Pub Date : 2025-09-02 DOI: 10.1016/j.bea.2025.100191

Lukasz Surazynski , Jyri Järvinen , Martti Ilvesmäki , Markus Mäkinen , Heikki J. Nieminen , Miika T. Nieminen , Teemu Myllylä

{"title":"A core needle biopsy combined with novel spectroscopic probe for in vivo tissue classification – A pilot study on piglets","authors":"Lukasz Surazynski , Jyri Järvinen , Martti Ilvesmäki , Markus Mäkinen , Heikki J. Nieminen , Miika T. Nieminen , Teemu Myllylä","doi":"10.1016/j.bea.2025.100191","DOIUrl":"10.1016/j.bea.2025.100191","url":null,"abstract":"<div><div>Tissue sampling is a primary goal of core needle biopsies (CNB), cancer therapy evaluation, and autoimmune disease assessment. Conventional guidance methods such as ultrasound and MRI suffer from periprocedural tissue‐type insensitivity in complex biopsy targets, motion sensitivity, imaging artifacts and high costs, which may limit their usefulness. Accurate tissue classification and needle guidance during CNB are equally important. Mistakes may lead to sample inadequacies, obscured results, incorrect sampling spots, and ultimately repeated biopsies. To address these challenges, this study investigates the feasibility of a smart CNB probe integrating real-time optical spectroscopy for enhanced tissue characterization during in vivo biopsy utilizing machine learning methods. Ten fabricated probes were tested in vivo on porcine fat, liver, and kidney tissues, demonstrating potential for improving biopsy accuracy. Acquired spectral data enabled effective tissue differentiation, as indicated by the best-performing classification models. LDA classifier with MRMR feature selection reached sensitivity of 87.3 % in classification between liver and fat tissues, where SVM with linear kernel and PCA reached 86.4 % sensitivity in kidney vs fat. These findings suggest that integrating optical spectroscopy into CNB procedures may enhance diagnostic accuracy while mitigating procedural risks.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"10 ","pages":"Article 100191"},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of countermovement depth on joint coordination and ground reaction force waveform in countermovement jump 反动作深度对反动作跳跃关节配合及地面反作用力波形的影响

Biomedical engineering advances Pub Date : 2025-08-21 DOI: 10.1016/j.bea.2025.100190

Mona Makita, Shinichi Kawamoto, Momoko Nagai-Tanima, Tomoki Aoyama

{"title":"The influence of countermovement depth on joint coordination and ground reaction force waveform in countermovement jump","authors":"Mona Makita, Shinichi Kawamoto, Momoko Nagai-Tanima, Tomoki Aoyama","doi":"10.1016/j.bea.2025.100190","DOIUrl":"10.1016/j.bea.2025.100190","url":null,"abstract":"<div><div>The ground reaction force (GRF) waveform during countermovement jumps (CMJs) is considered to reflect neuromuscular coordination strategies; yet the biomechanical mechanisms distinguishing unimodal from bimodal patterns remain unclear. This study investigated the influence of countermovement depth and velocity on GRF waveform shape and examined their relationship with joint moments and work. Twenty-six healthy young women (age: 22.1 ± 1.1 years; height: 160.8 ± 4.0 cm; body weight: 53.5 ± 5.6 kg) performed CMJs, and GRF waveforms were categorised as unimodal and bimodal patterns. Jump-related variables, joint moments, and work were analysed. Analysis of covariance (ANCOVA) was conducted using countermovement depth as a covariate, and correlation analyses examined the associations between depth and biomechanical parameters. Compared with the unimodal group, the bimodal group exhibited a significantly greater countermovement depth, with no significant difference in countermovement velocity. Before adjustment, knee joint work and ankle joint moments differed significantly between groups; however, these differences were no longer evident after adjusting for countermovement depth, indicating that it was a confounding factor. Correlation analyses demonstrated that a greater countermovement was associated with increased hip and knee joint work and reduced ankle joint contribution. These findings indicate that GRF waveform shape in CMJ is determined primarily by countermovement depth rather than velocity. The unimodal pattern reflected ankle-dominant simultaneous output, whereas the bimodal pattern reflected proximal joint-dominant sequential output. This study highlights the role of joint-specific coordination strategies and offers insight for developing individualised training and rehabilitation approaches.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"10 ","pages":"Article 100190"},"PeriodicalIF":0.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144892233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel frequency-domain approach to the range migration algorithm for efficient medical image processing: Application in tumor detection and identification 一种有效医学图像处理的距离迁移频域新方法：在肿瘤检测与识别中的应用

Biomedical engineering advances Pub Date : 2025-08-09 DOI: 10.1016/j.bea.2025.100189

Jaouad El Gueri , Ibtisam Amdaouch , Badiaa Ait Ahmed , Juan Ruiz-Alzola , Otman Aghzout

{"title":"A novel frequency-domain approach to the range migration algorithm for efficient medical image processing: Application in tumor detection and identification","authors":"Jaouad El Gueri , Ibtisam Amdaouch , Badiaa Ait Ahmed , Juan Ruiz-Alzola , Otman Aghzout","doi":"10.1016/j.bea.2025.100189","DOIUrl":"10.1016/j.bea.2025.100189","url":null,"abstract":"<div><div>This paper introduces a novel, computationally efficient range migration algorithm (RMA) specifically designed for medical microwave imaging applications. The proposed RMA achieves significant advancements over traditional methods, such as the Delay Multiply and Sum technique, by greatly reducing channel calculations and computational time while maintaining high image quality. The algorithm was validated using an antenna array system and a custom built phantom model. To further reduce noise and image artifacts after RMA application, Hamming, Gaussian, and Median filtering techniques were applied and compared. Notably, the Hamming filter significantly enhanced edge sharpness and improved tumor detection within human tissue compared to the other filters. A comprehensive complexity analysis was conducted to evaluate the algorithm’s efficiency and scalability, with a focus on computational time and resource utilization. Performance results offer valuable insights into the algorithm’s behavior across various operational conditions, Highlighting its potential to enhance healthcare diagnostics and improve patient outcomes, with promising prospects for future clinical adoption.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"10 ","pages":"Article 100189"},"PeriodicalIF":0.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current challenges and bioengineering aspects in the development of an in vitro model of the human intestinal epithelium 目前的挑战和生物工程方面的发展，在体外模型的人肠上皮

Biomedical engineering advances Pub Date : 2025-07-04 DOI: 10.1016/j.bea.2025.100188

Jhonatan Rafael de Oliveira Bianchi , Ana Letícia Rodrigues Costa , Hernandes F. Carvalho , Lucimara Gaziola de La Torre

{"title":"Current challenges and bioengineering aspects in the development of an in vitro model of the human intestinal epithelium","authors":"Jhonatan Rafael de Oliveira Bianchi , Ana Letícia Rodrigues Costa , Hernandes F. Carvalho , Lucimara Gaziola de La Torre","doi":"10.1016/j.bea.2025.100188","DOIUrl":"10.1016/j.bea.2025.100188","url":null,"abstract":"<div><div>The human intestinal epithelium is a multitasking tissue with different cell types and a complex architecture responsible for molecules/nutrient absorption during food digestion, and working as a physical barrier to the infection of pathogens. Symbiosis with the microbiota regulates metabolic pathways accountable for developing diseases, for example diabetes, obesity, and cancer. Therefore, several <em>in vitro</em> biology-inspired physiological models have been developed to humanize drug tests and study cell behavior. This review uses a design approach to discuss the essential bioengineering parameters required to design an intestinal epithelium microphysiological system (MPS) rationally. Important project parameters are discussed, considering the biological question in hands, hydrogel microenvironment, and relevant engineering criteria to observe and quantify the functionality of this epithelium. Thus, we will focus on recent bioengineering aspects related to the fabrication of the intestine model, such as how the biomaterial (matrix) proprieties (porosity, mechanical force, and curvature) affect the cell behavior and, consequently, the characteristics of <em>in vitro</em> intestinal models. Moreover, the technological approaches used to create a villus-like microarchitecture, lithography, and 3D bioprinting are introduced. Finally, combining villi-crypt microarchitecture with fluid perfusion and hypoxia is discussed to create a more complex intestine-MPS.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"10 ","pages":"Article 100188"},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BLVQE: Blind Laparoscopic Video Quality Evaluator using spatio-temporal interdependency and textural cues 使用时空相互依赖和纹理线索的盲腹腔镜视频质量评估器

Biomedical engineering advances Pub Date : 2025-06-16 DOI: 10.1016/j.bea.2025.100184

Sria Biswas, Rohini Palanisamy

{"title":"BLVQE: Blind Laparoscopic Video Quality Evaluator using spatio-temporal interdependency and textural cues","authors":"Sria Biswas, Rohini Palanisamy","doi":"10.1016/j.bea.2025.100184","DOIUrl":"10.1016/j.bea.2025.100184","url":null,"abstract":"<div><div>Quality assessment of laparoscopic videos is critical for ensuring accurate diagnostics and surgical precision. Traditional quality assessment methods typically focus on either spatial or textural features independently, limiting their effectiveness in handling composite distortions like motion blur, noise, defocus blur, uneven illumination, and smoke. To address this, leveraging spatio-temporal interdependencies and textural features offers a more comprehensive approach in replicating the human visual system to improve the robustness of video quality assessment. This work introduces Blind Laparoscopic Video Quality Evaluator (BLVQE) that models the statistical interdependencies between spatial, temporal and texture features. For this, laparoscopic videos obtained from a public database are used to estimate the Luminance and motion vector maps, which are then analyzed using bivariate generalized Gaussian distribution to capture spatio-temporal interdependency. Scene texture complexity is further quantified using statistical energy measures. These feature vectors are used for end-to-end training of an LSTM framework for frame quality predictions. The training and validation loss curves of the model saturate around 50 epochs, indicating prediction proficiency. BLVQE predictions show a high correlation with subjective scores exhibiting robust and competitive performance against other state-of-the-art methods. Ablation studies highlight the contribution of individual feature elements, confirming the superiority of the selected features. These findings enhance the understanding of the spatial, temporal and textural variations that influence video quality and highlight the potential of joint dependencies in accurately estimating the diagnostic quality of laparoscopic videos.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"10 ","pages":"Article 100184"},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144471198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Technological enhancements in personalized dietary management for chronic conditions 慢性病个性化饮食管理的技术改进

Biomedical engineering advances Pub Date : 2025-06-13 DOI: 10.1016/j.bea.2025.100181

Tania Tahtouh , Hadil Salman , Nermin Eissa , Najla Al Nassar , Sofyan Maghaydah , Marah Alhalabi , Maha Yaghi , Abdalla Gad , Dana Abdallah , Salma Elberry , Aysha Alhosani , Shaikha Alshehhi , Mohammad Alkhedher , Mohamad Ramadan , Mohammed Ghazal

{"title":"Technological enhancements in personalized dietary management for chronic conditions","authors":"Tania Tahtouh , Hadil Salman , Nermin Eissa , Najla Al Nassar , Sofyan Maghaydah , Marah Alhalabi , Maha Yaghi , Abdalla Gad , Dana Abdallah , Salma Elberry , Aysha Alhosani , Shaikha Alshehhi , Mohammad Alkhedher , Mohamad Ramadan , Mohammed Ghazal","doi":"10.1016/j.bea.2025.100181","DOIUrl":"10.1016/j.bea.2025.100181","url":null,"abstract":"<div><div>Dietary compliance plays a vital role in the control of chronic diseases and influences response to therapy. The rapid development experienced nowadays through smart technology has enabled the personalization of dietary advice to meet individual needs. This paper provides an overview of the current technological solutions to dietary adherence among patients with chronic conditions. With the increasing prevalence of chronic diseases requiring diet-specific interventions, this review encompasses mobile apps and wearables to IoT-based devices and generative intelligence tools, including chatbots, aimed at offering specific guidance as well as providing individualized support for dietary requirements. This review provides an overview of the strengths and limitations of these approaches in real world applications, as well as emerging methodologies that attempt to improve this by focusing on means to personalize dietary management more effectively. The study suggests that technology-enabled dietary interventions can be useful to support chronic disease management and generative artificial intelligence may have a profound effect on the further personalization of dietary guidance. However, issues surrounding regulatory alignment, content validity and long-term user engagement remain to be resolved in order to maximize the tools’ functionality in clinical and home settings.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"10 ","pages":"Article 100181"},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noninvasive monitoring of changes in intracranial fluid and tissue composition 颅内液体和组织成分变化的无创监测

Biomedical engineering advances Pub Date : 2025-06-13 DOI: 10.1016/j.bea.2025.100187

Andrea Boraschi , Andreas Spiegelberg , Vartan Kurtcuoglu

{"title":"Noninvasive monitoring of changes in intracranial fluid and tissue composition","authors":"Andrea Boraschi , Andreas Spiegelberg , Vartan Kurtcuoglu","doi":"10.1016/j.bea.2025.100187","DOIUrl":"10.1016/j.bea.2025.100187","url":null,"abstract":"<div><div>Continuous assessment of changes in the fluid and tissue composition of the brain, as they occur with certain space-occupying disorders, is currently not possible. Recently, the noninvasive acquisition of the head’s dielectric properties has been proposed as the basis for monitoring such changes. The analysis of the corresponding electric signal, referred to as W, focused so far on intracranial fluid volume changes induced by cardiorespiratory action. Here, we report on a novel approach to acquire changes of W also in the 0 to 0.1 Hz frequency range, which would allow capturing slower processes such as edema formation. Six healthy male volunteers were tilted head-up, head-down, and subjected to bilateral jugular vein compression. W decreased during head-up tilting, while it increased during head-down tilting and jugular vein compression. These findings are consistent with anticipated changes in intracranial volume due to these maneuvers, notably the reduction of intracranial blood volume during head-up tilt and its augmentation during head-down tilt and jugular vein compression. This study provides a proof of principle for the detection of changes in W within the 0–0.1 Hz frequency range, broadening the potential clinical utility of noninvasive monitoring of cranial dielectric properties in diagnosing and managing space-occupying disorders.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"10 ","pages":"Article 100187"},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0