Biomedical engineering advances最新文献_第2页

A new vision upon hemodialysis: A shift from synthetic to sustainable chitosan membranes 血液透析的新愿景：从合成到可持续的壳聚糖膜的转变

Biomedical engineering advances Pub Date : 2025-05-01 DOI: 10.1016/j.bea.2025.100175

Maria Martingo, Sara Baptista-Silva, Manuela Pintado, Sandra Borges

{"title":"A new vision upon hemodialysis: A shift from synthetic to sustainable chitosan membranes","authors":"Maria Martingo, Sara Baptista-Silva, Manuela Pintado, Sandra Borges","doi":"10.1016/j.bea.2025.100175","DOIUrl":"10.1016/j.bea.2025.100175","url":null,"abstract":"<div><div>The article provides a comprehensive review of chronic kidney disease (CKD), covering its epidemiology, pathophysiology, diagnosis, and management. It highlights CKD's increasing prevalence globally and its significant impact on public health due to its association with cardiovascular diseases and progression to end-stage kidney disease. The article delves into the diagnostic criteria, including the use of glomerular filtration rate (GFR) and albuminuria levels, and outlines the stages of CKD to facilitate early detection and management. It also discusses renal replacement therapies (RRT) such as dialysis and transplantation, comparing hemodialysis (HD) and peritoneal dialysis (PD) in terms of efficiency, complications, and quality of life impacts.</div><div>The transition towards sustainable dialysis involves the innovative integration of chitosan, a biopolymer into membrane technology. Current synthetic membranes, though functional, fall short in biocompatibility and sustainability. Chitosan's introduction aims to mitigate these issues by harnessing its advantageous biological and eco-friendly properties. Leveraging chitosan not only addresses environmental concerns by providing a sustainable alternative but also exploits the full potential of its properties to revolutionize RRT. The shift towards chitosan-enriched membranes represents a significant stride in advancing dialysis treatment, focusing on patient safety, environmental sustainability, and the effective management of CKD. This approach underscores the importance of innovation in healthcare, specifically in the development of dialysis technologies that prioritize both patient welfare and environmental sustainability.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"9 ","pages":"Article 100175"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-newtonian fluid lens for wearable planewave ultrasound imaging system 用于可穿戴平面波超声成像系统的非牛顿流体透镜

Biomedical engineering advances Pub Date : 2025-04-30 DOI: 10.1016/j.bea.2025.100173

Pisharody Harikrishnan Gopalakrishnan , Mahesh Raveendranatha Panicker

{"title":"Non-newtonian fluid lens for wearable planewave ultrasound imaging system","authors":"Pisharody Harikrishnan Gopalakrishnan , Mahesh Raveendranatha Panicker","doi":"10.1016/j.bea.2025.100173","DOIUrl":"10.1016/j.bea.2025.100173","url":null,"abstract":"<div><div>Ultrafast ultrasound imaging using planewaves has been found significant for many applications in the recent past. This work proposes a novel method for converging planewaves for wearable ultrafast ultrasound imaging systems using a concave non-Newtonian fluid lens. Due to the concave shape of the designed non-Newtonian fluid lens, ultrasound wave convergence on transmit can be achieved, which could enable deeper imaging with planewaves. Further, by employing multi-angle planewaves, a high-resolution high frame rate ultrasound imaging system can be developed. The proposed passive ultrasound converging lens demonstrated satisfactory performance for in vitro imaging (wire phantoms and steel screw phantoms) and in vivo imaging (human carotid artery and upper arm). The in vitro and in vivo results showed an improvement of 47.31 % of lateral resolution, 44.57 % of intensity with significant contrast to noise ratio improvement greater than 3 dB and observable drop in acoustic clutter levels at 7.6 MHz centre frequency. The proposed non-Newtonian fluid lens demonstrated 18 % of dehydration rate, suitable for continuous long period ultrasound imaging. The utility of the proposed approach was further confirmed by observing an increase in wave intensity with decreased radius of curvature values of the lens used in the system, which is of significance in focused ultrasound applications. The passive ultrasound non-Newtonian converging lens with the adjustable focusing capability, ergonomic design, and low cost of deployment without significantly altering the existing setup would open doors for upgradation of traditional systems to a wide range of applications in high frame-rate US imaging system.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"9 ","pages":"Article 100173"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Architected Materials for External Breast Prostheses 乳房外部假体结构材料的研究进展

Biomedical engineering advances Pub Date : 2025-04-27 DOI: 10.1016/j.bea.2025.100168

Sibo Zhang , Jennifer Xue , Xiao Yu , Yunlan Zhang

{"title":"Development of Architected Materials for External Breast Prostheses","authors":"Sibo Zhang , Jennifer Xue , Xiao Yu , Yunlan Zhang","doi":"10.1016/j.bea.2025.100168","DOIUrl":"10.1016/j.bea.2025.100168","url":null,"abstract":"<div><div>Breast cancer remains the most prevalent cancer among women, with mastectomy often performed as a standard treatment or preventive measure. Post-surgery, breast prostheses are essential for restoring appearance, balance, and confidence. However, conventional silicone external prostheses often fall short in addressing key challenges such as comfort, weight, heat management, and personalization. This study presents a new design framework for External Breast Prostheses (EBPs) utilizing gyroid-based architected materials fabricated through additive manufacturing. By mimicking the density, thermal conductivity, and mechanical properties of natural breast tissue, the proposed design achieves advancements in realism and functionality. Tailored gyroid unit cell geometries enable precise control over weight distribution, thermal regulation, and stiffness, aligning with the properties of natural tissue. Guided by numerical simulations and validated through experimental testing, this approach produces a lightweight, breathable, and realistic prosthesis that can enhance comfort and functionality. This approach highlights the transformative potential of advanced imaging and 3D printing technologies in creating customizable, high-performance solutions to improve the quality of life for breast cancer patients.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"10 ","pages":"Article 100168"},"PeriodicalIF":0.0,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144272191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of fluid-structure interaction: blood flow in arteries 流固相互作用：动脉血流的研究进展

Biomedical engineering advances Pub Date : 2025-04-27 DOI: 10.1016/j.bea.2025.100171

Zubeir Allum Saib , Farid Abed , Mergen H. Ghayesh , Marco Amabili

{"title":"A review of fluid-structure interaction: blood flow in arteries","authors":"Zubeir Allum Saib , Farid Abed , Mergen H. Ghayesh , Marco Amabili","doi":"10.1016/j.bea.2025.100171","DOIUrl":"10.1016/j.bea.2025.100171","url":null,"abstract":"<div><div>Over the past decade, Fluid-Structure Interaction studies related to blood vessels have been an active area of research, as they adequately capture the multiphysics of blood flow within the circulatory system. Despite the growing interest, only few state-of-the-art reviews have been published in the literature, each focusing individually on the coronary artery, carotid artery, aorta, heart valves and peripheral arteries. This systematic review assesses the current research and implications of Fluid-Structure Interaction implementation strategies in relation to human arteries. It is meant to comprehensively amalgamate research studies on an array of arteries coupled with cardiovascular complications such as atherosclerosis, plaque calcification, aneurysms, aortic dissections and valve dysfunction. It additionally covers computational finite element and finite volume solver demands, coupling schemes, inlet and outlet boundary conditions specifications, Newtonian and non-Newtonian blood rheological properties, laminar and turbulent flow types, as well as the modelling of the vessel wall’s hyperelastic and viscoelastic mechanical behavior. The research information is retrieved from the last ten years and summarized in a tabulated format, to help researchers in easily extracting useful information for future investigations and reviews.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"9 ","pages":"Article 100171"},"PeriodicalIF":0.0,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ECG-based cardiac arrhythmia classification using fuzzy encoded features and deep neural networks 基于模糊编码特征和深度神经网络的心电心律失常分类

Biomedical engineering advances Pub Date : 2025-04-25 DOI: 10.1016/j.bea.2025.100167

Kiruthika Balakrishnan , Durgadevi Velusamy , Karthikeyan Ramasamy , Lisiane Pruinelli

{"title":"ECG-based cardiac arrhythmia classification using fuzzy encoded features and deep neural networks","authors":"Kiruthika Balakrishnan , Durgadevi Velusamy , Karthikeyan Ramasamy , Lisiane Pruinelli","doi":"10.1016/j.bea.2025.100167","DOIUrl":"10.1016/j.bea.2025.100167","url":null,"abstract":"<div><div>Cardiac arrhythmia, characterized by an irregular heart rhythm, is a leading cause of sudden and unexpected deaths among patients with cardiovascular diseases. The electrocardiogram (ECG) is a widely utilized non-invasive tool for detecting cardiac arrhythmias. This study investigates the effectiveness of ECG signals in diagnosing various irregular heart rhythms and proposes a novel framework integrating a fuzzy system with deep neural networks. Our approach combines Fourier–Bessel Series Expansion (FBSE)-Tunable Q Wavelet Transform (TQWT) and Principal Component Analysis (PCA) for automatic arrhythmia classification. Compared to conventional deep learning models that rely on raw ECG signals, our method enhances interpretability and feature extraction by incorporating time–frequency analysis and fuzzy feature encoding. Experimental validation using the MIT-BIH dataset demonstrated that our approach outperforms state-of-the-art models in classifying five arrhythmia categories (N, SVEB, VEB, Q, and F) based on the Association for the Advancement of Medical Instrumentation (AAMI) standards. Our model achieved precision scores of 0.98 (N), 0.95 (F), 0.98 (VEB), 0.90 (SVEB), and 0.99 (Q), with corresponding recall values of 1.00 (N), 0.74 (F), 0.93 (VEB), 0.72 (SVEB), and 0.98 (Q). The integration of FBSE-TQWT with a fuzzy deep neural network represents a substantial advancement in ECG-based arrhythmia detection, offering improved accuracy, robustness, and clinical applicability, particularly in distinguishing minority classes such as supraventricular ectopic beats (SVEB) and fusion beats (F).</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"9 ","pages":"Article 100167"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Negative magnetophoresis guided unidirectional cell patterning on culture surface 负磁泳引导培养表面的单向细胞图案

Biomedical engineering advances Pub Date : 2025-04-22 DOI: 10.1016/j.bea.2025.100169

Melike Cagan-Algan , Muge Anil-Inevi , Seren Kecili , Ece Inal , H. Cumhur Tekin , Gulistan Mese , Engin Ozcivici

{"title":"Negative magnetophoresis guided unidirectional cell patterning on culture surface","authors":"Melike Cagan-Algan , Muge Anil-Inevi , Seren Kecili , Ece Inal , H. Cumhur Tekin , Gulistan Mese , Engin Ozcivici","doi":"10.1016/j.bea.2025.100169","DOIUrl":"10.1016/j.bea.2025.100169","url":null,"abstract":"<div><div>Cell patterning is a significant tool in tissue engineering, enabling the directed deposition of cells into specific locations to achieve biological relevance. Conventional cell patterning techniques often involve time-consuming modifications or bioprinting, potentially affecting cell viability. This study presents a novel, single-step magnetic patterning system for label-free linear cell patterning using negative magnetophoresis. A custom magnetic system and culture chamber enabled the rapid (3 h) imprinting of cells on a surface without substrate modification. This approach achieved linear patterns with a thickness of ∼1 mm using a safe concentration of a paramagnetic agent (5 mM Gadolinium chelate, Gadobutrol). The patterns maintained structural integrity for 48 h and were successfully combined with osteogenic and adipogenic differentiation protocols. This cost-effective and contactless manipulation technique holds promise for diverse applications in tissue engineering, drug discovery, and fundamental cell biology research.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"9 ","pages":"Article 100169"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D printed titanium TPMS for personalised tibial bone implant 用于个性化胫骨植入的3D打印钛TPMS

Biomedical engineering advances Pub Date : 2025-04-19 DOI: 10.1016/j.bea.2025.100166

Martin Appiah , Abul Arafat , Abhishek Gupta , Arun Arjunan , Ahmad Baroutaji , John Robinson , Chameekara T. Wanniarachchi , Manpreet Singh , Neil Ashwood , Aaron Vance

{"title":"3D printed titanium TPMS for personalised tibial bone implant","authors":"Martin Appiah , Abul Arafat , Abhishek Gupta , Arun Arjunan , Ahmad Baroutaji , John Robinson , Chameekara T. Wanniarachchi , Manpreet Singh , Neil Ashwood , Aaron Vance","doi":"10.1016/j.bea.2025.100166","DOIUrl":"10.1016/j.bea.2025.100166","url":null,"abstract":"<div><div>Porous titanium scaffolds offer hope for reducing stress shielding and encouraging new bone growth, moving the field closer to personalised load bearing implants. This study explores four triply periodic minimal surface (TPMS) tibial scaffolds informed by Gyroid (GSC), Lidinoid (LSC), Diamond (DSC), and Schwartz Primitive (SSC) unit cells. These scaffolds were made using Laser Powder Bed Fusion (L-PBF) 3D printing, with a targeted porosity of 60 % to closely match the mechanical behaviour of natural tibial bone. Mechanical testing of these scaffolds revealed an elastic modulus of 10.42 to 13.62 GPa and compressive strengths ranging from 209 to 393 MPa, meeting the requirements for load-bearing tibial implants. Multi-criteria decision-making (MCDM) methods, AHP and TOPSIS, were applied to evaluate the designs, considering four favourable factors of relative importance in the order porosity>yield strength>elastic modulus>ultimate strength. This analysis identified SSC scaffold featuring Schwartz Primitive architecture as the most promising candidate for load-bearing applications. The biological compatibility of these scaffolds was also found to be equally compelling. In vitro testing with U-2OS osteosarcoma cells confirmed high cell viability, underscoring the cytocompatibility of these TPMS designs and reinforcing their potential for biomedical applications. Together, these findings offer a path toward the use of titanium scaffolds in orthopaedics, setting the stage for further in vivo studies and a potential breakthrough in functional bone implant design.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"9 ","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143860146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical design of 3D printed bone tissue scaffolds with tunable anisotropy 各向异性可调3D打印骨组织支架的力学设计

Biomedical engineering advances Pub Date : 2025-04-18 DOI: 10.1016/j.bea.2025.100170

Abdullah Al Masud , Amit Arefin , Nava Raj Khatri , AKM Ahasun Habib , Ming-Chien Chyu , Paul F. Egan

{"title":"Mechanical design of 3D printed bone tissue scaffolds with tunable anisotropy","authors":"Abdullah Al Masud , Amit Arefin , Nava Raj Khatri , AKM Ahasun Habib , Ming-Chien Chyu , Paul F. Egan","doi":"10.1016/j.bea.2025.100170","DOIUrl":"10.1016/j.bea.2025.100170","url":null,"abstract":"<div><div>Additive manufacturing is enabling the design of intricate biomedical structures with tuned mechanics for bone tissue engineering. Tuning structures to mimic the effective anisotropic mechanical properties of bone, however, remains challenging due to difficulties in recreating bone’s hierarchical geometry and porous structure. Here, we introduce beam-based lattices with tunable unit cell aspect ratios and hierarchical pores to tailor the biomechanics of tissue engineering scaffolds for interbody spine fusion cages. BC-Tetra unit cells with beams along edges and diagonally from each corner to the center of a tetragonal unit volume were selected due to their mechanical efficiency and favorable geometry for tissue growth. Unit cells were designed with 500 and 800 µm diameter beams, porosities of 50 % and 70 %, and adjustable aspect ratios by tuning unit cell height. Scaffolds were printed using digital light processing with a biocompatible methacrylic polymer. Uniaxial mechanical compression experiments demonstrated that larger unit cell aspect ratios resulted in higher effective mechanical properties in the loading direction. Finite element analysis matched experimental trends and highlighted stress distributions for each tested lattice. Dimensional characterization demonstrated beams were printed larger than expected towards the center of the scaffold, that in turn decreased scaffold porosity while increasing stiffness. Large hierarchical voids were introduced to improve the consistency of printed beams throughout scaffolds and facilitate biological functioning. Mechanical testing demonstrated scaffolds of 40 % to 80 % porosity had stiffness from 3.9 to 8.4 kN/mm, suitable for vertebral bone fusion. These results enable improved design and fabrication of tissue scaffolds by providing new strategies for controlling anisotropy and hierarchy that could widely enhance regenerative medicine treatments.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"9 ","pages":"Article 100170"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decision support systems for lower limb rehabilitation using electrical stimulation—A review 电刺激下肢康复决策支持系统综述

Biomedical engineering advances Pub Date : 2025-04-15 DOI: 10.1016/j.bea.2025.100162

Tiago Franco , Pedro Rangel Henriques , Paulo Alves , Maria João Varanda Pereira

{"title":"Decision support systems for lower limb rehabilitation using electrical stimulation—A review","authors":"Tiago Franco , Pedro Rangel Henriques , Paulo Alves , Maria João Varanda Pereira","doi":"10.1016/j.bea.2025.100162","DOIUrl":"10.1016/j.bea.2025.100162","url":null,"abstract":"<div><div>This paper presents a comprehensive review of Decision Support Systems (DSS) for lower limb rehabilitation using Electrical Stimulation (ES), employing a rigorous two-part methodology. The first part involves a bibliometric analysis of articles from 1980 to 2023, while the second part is a systematic review of studies from 2019 to 2023, addressing six key research questions. The review identifies the main characteristics of DSS, such as data usage, sensitive data protection, reasoning techniques, and validation processes. It highlights the development focus on joint control systems, increasing interest in biofeedback and AI applications, and significant interest in FES-Cycling. Despite advancements, “decision support” remains in the early stages with simple architectures and limited data handling. Conversely, studies show advanced ES control models validated with neurological patients. This article emphasizes the need for sophisticated DSS that integrate data protection, reasoning methods, and patient monitoring to enhance rehabilitation outcomes and identifies significant gaps for future research.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"9 ","pages":"Article 100162"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ion release and antibacterial assessment of copper-containing hydroxyapatite and biphasic calcium phosphates 含铜羟基磷灰石和双相磷酸钙的离子释放及抗菌评价

Biomedical engineering advances Pub Date : 2025-04-09 DOI: 10.1016/j.bea.2025.100165

Sierra K. Kucko , Danielle L. Perry , Randall E. Youngman , Timothy J. Keenan

{"title":"Ion release and antibacterial assessment of copper-containing hydroxyapatite and biphasic calcium phosphates","authors":"Sierra K. Kucko , Danielle L. Perry , Randall E. Youngman , Timothy J. Keenan","doi":"10.1016/j.bea.2025.100165","DOIUrl":"10.1016/j.bea.2025.100165","url":null,"abstract":"<div><div>Copper-containing hydroxyapatite (CuHA) is hypothesized to be an effective approach to hinder orthopedic infection. Copper (Cu) is well regarded for its antibacterial potential yet remains understudied in bioceramics. Herein, a series of CuHA were evaluated by probing the Cu<sup>2+</sup> ion using electron paramagnetic resonance (EPR). Additionally, particle size, surface area, and crystallinity measurements were performed. CuHA was heat-treated to form Cu-containing biphasic calcium phosphate (CuBCP), which enabled Cu release in aqueous solution to reach a maximum of 0.108 + 0.004 mg/L per 1m<sup>2</sup> powder compared to its CuHA counterpart, which showed no Cu release per 1m<sup>2</sup> powder. Agar diffusion and time-based bacterial broth analyses were conducted against gram-positive and gram-negative strains of bacteria for CuHA and CuBCP with results indicating potential bacteriostatic effects. The material that released the highest amount of Cu into aqueous solution also exhibited the largest inhibitory effect against <em>S. Aureus</em> (broth analyses) indicating a potential correlation.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"9 ","pages":"Article 100165"},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0