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Vagus nerve stimulation to treat inflammatory bowel disease: a chronic, preclinical safety study in sheep 迷走神经刺激治疗炎症性肠病：绵羊的一项慢性临床前安全性研究
Bioelectronics in medicine Pub Date : 2018-12-01 DOI: 10.2217/BEM-2018-0011
Sophie C. Payne, O. Burns, M. Stebbing, Ross Thomas, An Silva, A. Sedo, F. Weissenborn, Tomoko Hyakumura, Mario Huynh, C. May, Richard A. Williams, J. Furness, J. Fallon, R. Shepherd
{"title":"Vagus nerve stimulation to treat inflammatory bowel disease: a chronic, preclinical safety study in sheep","authors":"Sophie C. Payne, O. Burns, M. Stebbing, Ross Thomas, An Silva, A. Sedo, F. Weissenborn, Tomoko Hyakumura, Mario Huynh, C. May, Richard A. Williams, J. Furness, J. Fallon, R. Shepherd","doi":"10.2217/BEM-2018-0011","DOIUrl":"https://doi.org/10.2217/BEM-2018-0011","url":null,"abstract":"Aim: Electrical stimulation of the left cervical vagus nerve is a feasible therapy for inflammatory bowel disease (IBD). However, due to the location of the electrode placement, stimulation is often associated with side effects. Methods: We developed a cuff electrode array, designed to be implanted onto the vagus nerve of the lower thorax or abdomen, below branches to vital organs, to minimize off-target effects to stimulation. Results: Following chronic implantation and electrical stimulation, electrodes remained functional and neural thresholds stable, while there were minimal off-target affects to stimulation. No nerve damage or corrosion of stimulated electrodes was observed. Conclusion: This novel electrode array, located on the vagus nerve below branches to vital organs, is a safe approach for the treatment of inflammatory bowel disease.","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/BEM-2018-0011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46508557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Innovations in electrical stimulation harness neural plasticity to restore motor function. 电刺激创新利用神经可塑性恢复运动功能。
Bioelectronics in medicine Pub Date : 2018-12-01 Epub Date: 2019-04-24 DOI: 10.2217/bem-2019-0002
Xiaoyu Peng, Jordan L Hickman, Spencer G Bowles, Dane C Donegan, Cristin G Welle
{"title":"Innovations in electrical stimulation harness neural plasticity to restore motor function.","authors":"Xiaoyu Peng, Jordan L Hickman, Spencer G Bowles, Dane C Donegan, Cristin G Welle","doi":"10.2217/bem-2019-0002","DOIUrl":"10.2217/bem-2019-0002","url":null,"abstract":"<p><p>Novel technology and innovative stimulation paradigms allow for unprecedented spatiotemporal precision and closed-loop implementation of neurostimulation systems. In turn, precise, closed-loop neurostimulation appears to preferentially drive neural plasticity in motor networks, promoting neural repair. Recent clinical studies demonstrate that electrical stimulation can drive neural plasticity in damaged motor circuits, leading to meaningful improvement in users. Future advances in these areas hold promise for the treatment of a wide range of motor systems disorders.</p>","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046169/pdf/nihms-1048067.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9664822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interview with Professor Dominique Durand: developing carbon nanotube yarn neural interfaces Dominique Durand教授访谈：开发碳纳米管纱线神经接口
Bioelectronics in medicine Pub Date : 2018-11-01 DOI: 10.2217/BEM-2018-0010
D. Durand
{"title":"Interview with Professor Dominique Durand: developing carbon nanotube yarn neural interfaces","authors":"D. Durand","doi":"10.2217/BEM-2018-0010","DOIUrl":"https://doi.org/10.2217/BEM-2018-0010","url":null,"abstract":"","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/BEM-2018-0010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47346064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Neural interfaces based on amorphous silicon carbide ultramicroelectrode arrays 基于非晶碳化硅超微电极阵列的神经接口
Bioelectronics in medicine Pub Date : 2018-11-01 DOI: 10.2217/BEM-2018-0006
Felix Deku, A. Ghazavi, S. Cogan
{"title":"Neural interfaces based on amorphous silicon carbide ultramicroelectrode arrays","authors":"Felix Deku, A. Ghazavi, S. Cogan","doi":"10.2217/BEM-2018-0006","DOIUrl":"https://doi.org/10.2217/BEM-2018-0006","url":null,"abstract":"Size and material considerations are important in the development of next-generation chronically reliable neural interface devices. In this review, we discuss the use of amorphous silicon carbide (a-SiC) for the fabrication of indwelling electrode arrays with ultrathin penetrating shanks for neural stimulation and recording. The a-SiC film is stable in saline environments and has a high intrinsic stiffness that allows fabrication of tissue-penetrating arrays with extremely small cross-sectional areas (<60 μm2). Present literature on arrays with extremely small shanks and/or ultramicroelectrode (UME) sites are reviewed. Properties of a-SiC films and their current biomedical applications are summarized. Reduced shank dimensions increase the flexibility of high Young's modulus a-SiC arrays. Iridium oxide-coated UMEs had electrochemical properties suitable for neural recording and stimulation, and recorded neural signals with high amplitudes and high signal-to-noise ratios. UMEs and a-SiC may provide a platform for next-generation high-density chronic neural interface devices.","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/BEM-2018-0006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47283295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Are ‘next generation’ bioelectronics being designed using old technologies? “下一代”生物电子学是使用旧技术设计的吗？
Bioelectronics in medicine Pub Date : 2018-11-01 DOI: 10.2217/BEM-2018-0008
R. Green
{"title":"Are ‘next generation’ bioelectronics being designed using old technologies?","authors":"R. Green","doi":"10.2217/BEM-2018-0008","DOIUrl":"https://doi.org/10.2217/BEM-2018-0008","url":null,"abstract":"","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/BEM-2018-0008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42335495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Methods for powering bioelectronic microdevices 为生物电子微型设备供电的方法
Bioelectronics in medicine Pub Date : 2018-11-01 DOI: 10.2217/BEM-2018-0005
Pui Mun Lee, Ze Xiong, J. S. Ho
{"title":"Methods for powering bioelectronic microdevices","authors":"Pui Mun Lee, Ze Xiong, J. S. Ho","doi":"10.2217/BEM-2018-0005","DOIUrl":"https://doi.org/10.2217/BEM-2018-0005","url":null,"abstract":"Bioelectronic microdevices are an emerging class of biomedical devices miniaturized at the scale of a millimeter or less, which promise new capabilities for monitoring and treating human disease. Although rapid progress has been made in the sensing and actuation capabilities of microdevices, a major technological challenge remains in the way that these devices are powered within the body. In this review, we revisit the power requirements of microdevices, describe current methods for storing, transferring or harvesting energy in microdevices, provide an overview of emerging powering approaches and discuss the promise of microdevices in biomedicine.","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/BEM-2018-0005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45906036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Light-triggered biological modulation with silicon-based materials and devices 硅基材料和器件的光触发生物调制
Bioelectronics in medicine Pub Date : 2018-11-01 DOI: 10.2217/BEM-2018-0012
Naomi Yamamoto, B. Tian
{"title":"Light-triggered biological modulation with silicon-based materials and devices","authors":"Naomi Yamamoto, B. Tian","doi":"10.2217/BEM-2018-0012","DOIUrl":"https://doi.org/10.2217/BEM-2018-0012","url":null,"abstract":"","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/BEM-2018-0012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48044100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting bioelectronically the carotid sinus nerve in Type 2 diabetes: strengths, drawbacks and challenges for the future 生物电子靶向颈动脉窦神经治疗2型糖尿病:优势、缺点和未来的挑战
Bioelectronics in medicine Pub Date : 2018-11-01 DOI: 10.2217/BEM-2018-0007
S. Conde, M. Guarino
{"title":"Targeting bioelectronically the carotid sinus nerve in Type 2 diabetes: strengths, drawbacks and challenges for the future","authors":"S. Conde, M. Guarino","doi":"10.2217/BEM-2018-0007","DOIUrl":"https://doi.org/10.2217/BEM-2018-0007","url":null,"abstract":"","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/BEM-2018-0007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45455250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Interview with Dr Theodoros Zanos: untangling the inflammatory reflex Theodoros Zanos博士访谈：解开炎症反射
Bioelectronics in medicine Pub Date : 2018-11-01 DOI: 10.2217/BEM-2018-0009
Theodoros P. Zanos
{"title":"Interview with Dr Theodoros Zanos: untangling the inflammatory reflex","authors":"Theodoros P. Zanos","doi":"10.2217/BEM-2018-0009","DOIUrl":"https://doi.org/10.2217/BEM-2018-0009","url":null,"abstract":"","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/BEM-2018-0009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41393445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From neuroimunomodulation to bioelectronic treatment of rheumatoid arthritis. 从神经免疫调节到类风湿关节炎的生物电子治疗。
Bioelectronics in medicine Pub Date : 2018-05-01 DOI: 10.2217/bem-2018-0001
Alexandre Kanashiro, Gabriel Shimizu Bassi, Fernando de Queiróz Cunha, Luis Ulloa
{"title":"From neuroimunomodulation to bioelectronic treatment of rheumatoid arthritis.","authors":"Alexandre Kanashiro,&nbsp;Gabriel Shimizu Bassi,&nbsp;Fernando de Queiróz Cunha,&nbsp;Luis Ulloa","doi":"10.2217/bem-2018-0001","DOIUrl":"https://doi.org/10.2217/bem-2018-0001","url":null,"abstract":"<p><p>Neuronal stimulation is an emerging field in modern medicine to control organ function and reestablish physiological homeostasis during illness. The nervous system innervates most of the peripheral organs and provides a fine tune to control the immune system. Most of these studies have focused on vagus nerve stimulation and the physiological, cellular and molecular mechanisms regulating the immune system. Here, we review the new results revealing afferent vagal signaling pathways, immunomodulatory brain structures, spinal cord-dependent circuits, neural and non-neural cholinergic/catecholaminergic signals and their respective receptors contributing to neuromodulation of inflammation in rheumatoid arthritis. These new neuromodulatory networks and structures will allow the design of innovative bioelectronic or pharmacological approaches for safer and low-cost treatment of arthritis and related inflammatory disorders.</p>","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/bem-2018-0001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36948875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
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