Vagus nerve stimulation to treat inflammatory bowel disease: a chronic, preclinical safety study in sheep

Sophie C. Payne, O. Burns, M. Stebbing, Ross Thomas, An Silva, A. Sedo, F. Weissenborn, Tomoko Hyakumura, Mario Huynh, C. May, Richard A. Williams, J. Furness, J. Fallon, R. Shepherd
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引用次数: 13

Abstract

Aim: Electrical stimulation of the left cervical vagus nerve is a feasible therapy for inflammatory bowel disease (IBD). However, due to the location of the electrode placement, stimulation is often associated with side effects. Methods: We developed a cuff electrode array, designed to be implanted onto the vagus nerve of the lower thorax or abdomen, below branches to vital organs, to minimize off-target effects to stimulation. Results: Following chronic implantation and electrical stimulation, electrodes remained functional and neural thresholds stable, while there were minimal off-target affects to stimulation. No nerve damage or corrosion of stimulated electrodes was observed. Conclusion: This novel electrode array, located on the vagus nerve below branches to vital organs, is a safe approach for the treatment of inflammatory bowel disease.
迷走神经刺激治疗炎症性肠病:绵羊的一项慢性临床前安全性研究
目的:电刺激左颈迷走神经是治疗炎性肠病(IBD)的一种可行方法。然而,由于电极放置的位置,刺激通常与副作用有关。方法:我们开发了一种袖口电极阵列,设计用于植入下胸或腹部的迷走神经,在分支到重要器官的下方,以减少对刺激的脱靶效应。结果:在慢性植入和电刺激后,电极保持功能和神经阈值稳定,而刺激的脱靶影响最小。刺激电极未见神经损伤或腐蚀。结论:这种新型电极阵列位于迷走神经分支下的重要器官,是治疗炎症性肠病的一种安全方法。
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