Sophie C. Payne, O. Burns, M. Stebbing, Ross Thomas, An Silva, A. Sedo, F. Weissenborn, Tomoko Hyakumura, Mario Huynh, C. May, Richard A. Williams, J. Furness, J. Fallon, R. Shepherd
{"title":"Vagus nerve stimulation to treat inflammatory bowel disease: a chronic, preclinical safety study in sheep","authors":"Sophie C. Payne, O. Burns, M. Stebbing, Ross Thomas, An Silva, A. Sedo, F. Weissenborn, Tomoko Hyakumura, Mario Huynh, C. May, Richard A. Williams, J. Furness, J. Fallon, R. Shepherd","doi":"10.2217/BEM-2018-0011","DOIUrl":null,"url":null,"abstract":"Aim: Electrical stimulation of the left cervical vagus nerve is a feasible therapy for inflammatory bowel disease (IBD). However, due to the location of the electrode placement, stimulation is often associated with side effects. Methods: We developed a cuff electrode array, designed to be implanted onto the vagus nerve of the lower thorax or abdomen, below branches to vital organs, to minimize off-target effects to stimulation. Results: Following chronic implantation and electrical stimulation, electrodes remained functional and neural thresholds stable, while there were minimal off-target affects to stimulation. No nerve damage or corrosion of stimulated electrodes was observed. Conclusion: This novel electrode array, located on the vagus nerve below branches to vital organs, is a safe approach for the treatment of inflammatory bowel disease.","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/BEM-2018-0011","citationCount":"13","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioelectronics in medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2217/BEM-2018-0011","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 13
Abstract
Aim: Electrical stimulation of the left cervical vagus nerve is a feasible therapy for inflammatory bowel disease (IBD). However, due to the location of the electrode placement, stimulation is often associated with side effects. Methods: We developed a cuff electrode array, designed to be implanted onto the vagus nerve of the lower thorax or abdomen, below branches to vital organs, to minimize off-target effects to stimulation. Results: Following chronic implantation and electrical stimulation, electrodes remained functional and neural thresholds stable, while there were minimal off-target affects to stimulation. No nerve damage or corrosion of stimulated electrodes was observed. Conclusion: This novel electrode array, located on the vagus nerve below branches to vital organs, is a safe approach for the treatment of inflammatory bowel disease.