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Bioelectronics in medicine最新文献

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Single neuron recording: progress towards high-throughput analysis. 单神经元记录：高通量分析的进展。
Bioelectronics in medicine Pub Date : 2020-08-01 Epub Date: 2020-09-17 DOI: 10.2217/bem-2020-0011
Andrew Alegria, Amey Joshi, Jacob O'Brien, Suhasa B Kodandaramaiah
{"title":"Single neuron recording: progress towards high-throughput analysis.","authors":"Andrew Alegria, Amey Joshi, Jacob O'Brien, Suhasa B Kodandaramaiah","doi":"10.2217/bem-2020-0011","DOIUrl":"10.2217/bem-2020-0011","url":null,"abstract":"","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604670/pdf/bem-03-33.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38679624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Designing a bioelectronic treatment for Type 1 diabetes: targeted parasympathetic modulation of insulin secretion. 设计一种治疗 1 型糖尿病的生物电子疗法：对胰岛素分泌进行有针对性的副交感神经调节。
Bioelectronics in medicine Pub Date : 2020-07-01 Epub Date: 2020-07-28 DOI: 10.2217/bem-2020-0006
Elliott W Dirr, Morgan E Urdaneta, Yogi Patel, Richard D Johnson, Martha Campbell-Thompson, Kevin J Otto
{"title":"Designing a bioelectronic treatment for Type 1 diabetes: targeted parasympathetic modulation of insulin secretion.","authors":"Elliott W Dirr, Morgan E Urdaneta, Yogi Patel, Richard D Johnson, Martha Campbell-Thompson, Kevin J Otto","doi":"10.2217/bem-2020-0006","DOIUrl":"10.2217/bem-2020-0006","url":null,"abstract":"<p><p>The pancreas is a visceral organ with exocrine functions for digestion and endocrine functions for maintenance of blood glucose homeostasis. In pancreatic diseases such as Type 1 diabetes, islets of the endocrine pancreas become dysfunctional and normal regulation of blood glucose concentration ceases. In healthy individuals, parasympathetic signaling to islets via the vagus nerve, triggers release of insulin from pancreatic β-cells and glucagon from α-cells. Using electrical stimulation to augment parasympathetic signaling may provide a way to control pancreatic endocrine functions and ultimately control blood glucose. Historical data suggest that cervical vagus nerve stimulation recruits many visceral organ systems. Simultaneous modulation of liver and digestive function along with pancreatic function provides differential signals that work to both raise and lower blood glucose. Targeted pancreatic vagus nerve stimulation may provide a solution to minimizing off-target effects through careful electrode placement just prior to pancreatic insertion.</p>","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604671/pdf/bem-03-17.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38583337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilizing prosthetic technology to improve quality of life: an interview with Ranu Jung and James Abbas. 利用假肢技术提高生活质量:采访Ranu Jung和James Abbas。
Bioelectronics in medicine Pub Date : 2020-04-01 Epub Date: 2020-04-17 DOI: 10.2217/bem-2020-0002
Ranu Jung, James Abbas
{"title":"Utilizing prosthetic technology to improve quality of life: an interview with Ranu Jung and James Abbas.","authors":"Ranu Jung,&nbsp;James Abbas","doi":"10.2217/bem-2020-0002","DOIUrl":"https://doi.org/10.2217/bem-2020-0002","url":null,"abstract":"<p><p>In this interview, we spoke with Ranu and James at SfN Neuroscience (19-23 October 2019, Chicago, IL, USA) to discover more about their collaboration on a clinical trial aiming to improve the lives of American veterans and service members who have lost limbs. The clinical trial involves the adaptive neural systems neural-enabled prosthetic hand system [1,2].</p>","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/bem-2020-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37962109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What directions of improvements in electrode designs should we expect in the next 5-10 years? 未来 5-10 年，电极设计的改进方向是什么？
Bioelectronics in medicine Pub Date : 2019-12-01 Epub Date: 2020-04-28 DOI: 10.2217/bem-2019-0023
Keying Chen, Stephanie Lam, Takashi Dy Kozai
{"title":"What directions of improvements in electrode designs should we expect in the next 5-10 years?","authors":"Keying Chen, Stephanie Lam, Takashi Dy Kozai","doi":"10.2217/bem-2019-0023","DOIUrl":"10.2217/bem-2019-0023","url":null,"abstract":"","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226723/pdf/bem-02-119.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37962108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural microphysiological systems for in vitro modeling of peripheral nervous system disorders 用于外周神经系统疾病体外建模的神经微物理系统
Bioelectronics in medicine Pub Date : 2019-06-01 DOI: 10.2217/bem-2019-0018
K. Pollard, Anup D. Sharma, M. J. Moore
{"title":"Neural microphysiological systems for in vitro modeling of peripheral nervous system disorders","authors":"K. Pollard, Anup D. Sharma, M. J. Moore","doi":"10.2217/bem-2019-0018","DOIUrl":"https://doi.org/10.2217/bem-2019-0018","url":null,"abstract":"PNS disease pathology is diverse and underappreciated. Peripheral neuropathy may result in sensory, motor or autonomic nerve dysfunction and can be induced by metabolic dysfunction, inflammatory dysfunction, cytotoxic pharmaceuticals, rare hereditary disorders or may be idiopathic. Current preclinical PNS disease research relies heavily on the use of rodent models. In vivo methods are effective but too time-consuming and expensive for high-throughput experimentation. Conventional in vitro methods can be performed with high throughput but lack the biological complexity necessary to directly model in vivo nerve structure and function. In this review, we survey in vitro PNS model systems and propose that 3D-bioengineered microphysiological nerve tissue can improve in vitro–in vivo extrapolation and expand the capabilities of in vitro PNS disease modeling.","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/bem-2019-0018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48480844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Applications of PEDOT in bioelectronic medicine PEDOT在生物电子医学中的应用
Bioelectronics in medicine Pub Date : 2019-06-01 DOI: 10.2217/BEM-2019-0014
C. Boehler, Z. Aqrawe, M. Asplund
{"title":"Applications of PEDOT in bioelectronic medicine","authors":"C. Boehler, Z. Aqrawe, M. Asplund","doi":"10.2217/BEM-2019-0014","DOIUrl":"https://doi.org/10.2217/BEM-2019-0014","url":null,"abstract":"The widespread use of conducting polymers, especially poly(3,4-ethylene dioxythiophene) (PEDOT), within the space of bioelectronics has enabled improvements, both in terms of electrochemistry and functional versatility, of conventional metallic electrodes. This short review aims to provide an overview of how PEDOT coatings have contributed to functionalizing existing bioelectronics, the challenges which meet conducting polymer coatings from a regulatory and stability point of view and the possibilities to bring PEDOT-based coatings into large-scale clinical applications. Finally, their potential use for enabling new technologies for the field of bioelectronics as biodegradable, stretchable and slow-stimulation materials will be discussed.","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/BEM-2019-0014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47439802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 64
What impact could transcutaneous vagal nerve stimulation have on an aging population? 经皮迷走神经刺激对老年人有什么影响?
Bioelectronics in medicine Pub Date : 2019-06-01 DOI: 10.2217/bem-2019-0022
Beatrice Bretherton, J. Deuchars, S. Deuchars
{"title":"What impact could transcutaneous vagal nerve stimulation have on an aging population?","authors":"Beatrice Bretherton, J. Deuchars, S. Deuchars","doi":"10.2217/bem-2019-0022","DOIUrl":"https://doi.org/10.2217/bem-2019-0022","url":null,"abstract":"eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Items deposited in White Rose Research Online are protected by copyright, with all rights reserved unless indicated otherwise. They may be downloaded and/or printed for private study, or other acts as permitted by national copyright laws. The publisher or other rights holders may allow further reproduction and re-use of the full text version. This is indicated by the licence information on the White Rose Research Online record for the item.","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/bem-2019-0022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42063746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Biomimicry for injectable mesh nanoelectronics 可注射网状纳米电子学的仿生
Bioelectronics in medicine Pub Date : 2019-06-01 DOI: 10.2217/BEM-2019-0017
Clementene Clayton, B. Tian
{"title":"Biomimicry for injectable mesh nanoelectronics","authors":"Clementene Clayton, B. Tian","doi":"10.2217/BEM-2019-0017","DOIUrl":"https://doi.org/10.2217/BEM-2019-0017","url":null,"abstract":"","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/BEM-2019-0017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48499606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rodent model for long-term vagus nerve stimulation experiments 长期迷走神经刺激实验的啮齿动物模型
Bioelectronics in medicine Pub Date : 2019-06-01 DOI: 10.2217/bem-2019-0016
Farid Yaghouby, Benjamin Shafer, Srikanth Vasudevan
{"title":"A rodent model for long-term vagus nerve stimulation experiments","authors":"Farid Yaghouby, Benjamin Shafer, Srikanth Vasudevan","doi":"10.2217/bem-2019-0016","DOIUrl":"https://doi.org/10.2217/bem-2019-0016","url":null,"abstract":"Aim: Investigations into the benefits of vagus nerve stimulation (VNS) using rodents have led to promising findings for treating clinical disorders. However, the majority of research has been limited to acute timelines. We developed a rodent model for longitudinal assessment of VNS and validated it with a long-term experiment incorporating continuous physiological monitoring. While the primary aim was not to investigate the effects of VNS on the cardiovascular system, we analyzed cardiovascular parameters to demonstrate the model's capabilities in a long-term stimulation-and-recording setup. Materials & methods: Rats were implanted with a cuff electrode around the cervical vagus nerve and electrocardiogram monitoring devices were implanted in the peritoneal cavity. We also designed a connector mount for seamless access to the cuff electrode for VNS in awake-behaving rats. Results & conclusion: Results signified easy-to-interface VNS system, electrode robustness and discernible physiological signals in a long-term setup. Analysis of the cardiovascular parameters revealed some transient effects during VNS. Our proposed model enables long-term VNS experiments along with physiological monitoring in unanesthetized rats.","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/bem-2019-0016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42717047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Electrical stimulation–fracture treatment: new insights into the underlying mechanisms 电刺激-骨折治疗:对潜在机制的新见解
Bioelectronics in medicine Pub Date : 2019-03-01 DOI: 10.2217/BEM-2019-0010
M. Bhavsar, L. Leppik, K. M. Oliveira, J. Barker
{"title":"Electrical stimulation–fracture treatment: new insights into the underlying mechanisms","authors":"M. Bhavsar, L. Leppik, K. M. Oliveira, J. Barker","doi":"10.2217/BEM-2019-0010","DOIUrl":"https://doi.org/10.2217/BEM-2019-0010","url":null,"abstract":"","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/BEM-2019-0010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45151942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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