From neuroimunomodulation to bioelectronic treatment of rheumatoid arthritis.

Alexandre Kanashiro, Gabriel Shimizu Bassi, Fernando de Queiróz Cunha, Luis Ulloa
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引用次数: 16

Abstract

Neuronal stimulation is an emerging field in modern medicine to control organ function and reestablish physiological homeostasis during illness. The nervous system innervates most of the peripheral organs and provides a fine tune to control the immune system. Most of these studies have focused on vagus nerve stimulation and the physiological, cellular and molecular mechanisms regulating the immune system. Here, we review the new results revealing afferent vagal signaling pathways, immunomodulatory brain structures, spinal cord-dependent circuits, neural and non-neural cholinergic/catecholaminergic signals and their respective receptors contributing to neuromodulation of inflammation in rheumatoid arthritis. These new neuromodulatory networks and structures will allow the design of innovative bioelectronic or pharmacological approaches for safer and low-cost treatment of arthritis and related inflammatory disorders.

Abstract Image

从神经免疫调节到类风湿关节炎的生物电子治疗。
神经刺激是现代医学的一个新兴领域,用于控制器官功能和重建疾病期间的生理稳态。神经系统支配着大部分外周器官,并为控制免疫系统提供了精细的调节。这些研究大多集中在迷走神经刺激和调节免疫系统的生理、细胞和分子机制上。在这里,我们回顾了新的研究结果,揭示了传入迷走神经信号通路、免疫调节脑结构、脊髓依赖回路、神经和非神经胆碱能/儿茶酚胺能信号及其各自的受体在类风湿关节炎炎症的神经调节中的作用。这些新的神经调节网络和结构将允许设计创新的生物电子或药理学方法,以更安全和低成本治疗关节炎和相关炎症性疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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