Atherosclerosis plus最新文献

{"title":"Audit of transition outcomes after discharge from a paediatric familial hypercholesterolaemia service","authors":"C. Sherman, A. Cazeaux, N. Davis, J. Barratt, J. Nurse","doi":"10.1016/j.athplu.2026.100586","DOIUrl":"10.1016/j.athplu.2026.100586","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"65 ","pages":"Article 100586"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148958289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Real World Impact of Tirzepatide on dyslipidaemia in patients with Type 2 Diabetes Mellitus","authors":"Zara Linn, Baz Mukhtar, Mark Greenwood Morgan, Jose Rubio, Ngoszi Etumnu, Shazli Azmi, Maryam Ferdousi, Handrean Soran","doi":"10.1016/j.athplu.2026.100594","DOIUrl":"10.1016/j.athplu.2026.100594","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"65 ","pages":"Article 100594"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148958302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Chronic Kidney Disease on Lipoprotein(a) Levels: Insights from a multivariable analysis in an inner-city teaching hospital lipid clinic","authors":"P. Padam ∗, T. Manawadu, R. Chandra, R. Vincent, N. Rao, R. Ranasinghe","doi":"10.1016/j.athplu.2026.100584","DOIUrl":"10.1016/j.athplu.2026.100584","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"65 ","pages":"Article 100584"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148958283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intelligent commissioning to improve lipid target attainment in secondary prevention: a [region]-wide population health approach","authors":"E.T. Ojo ∗, D. Fitzgerald","doi":"10.1016/j.athplu.2026.100595","DOIUrl":"10.1016/j.athplu.2026.100595","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"65 ","pages":"Article 100595"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148958099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disclaimer page","authors":"","doi":"10.1016/j.athplu.2026.100600","DOIUrl":"10.1016/j.athplu.2026.100600","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"65 ","pages":"Article 100600"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148958097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein (a) testing- insights from the laboratory","authors":"R.S. Banerjee ∗, S. Zouwail, H. Cordy, D. Datta","doi":"10.1016/j.athplu.2026.100583","DOIUrl":"10.1016/j.athplu.2026.100583","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"65 ","pages":"Article 100583"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148958284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population-based low-density lipoprotein cholesterol (LDL-C) concentration in childhood from the Avon Longitudinal Study of Parents and Children (ALSPAC) study: developing trajectories and LDL-burden as potential safe references for treatment targets","authors":"K. Panchal., Y. Vinogradova, R. Akyea, U. Ramaswami, L. Priestley-Barnham, A. Llewellyn, S.E. Humphries, M. Fisher, M. Bains, B. Woods, J. Kai, M. Gomes, N. Qureshi, L.J. Tata","doi":"10.1016/j.athplu.2026.100578","DOIUrl":"10.1016/j.athplu.2026.100578","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"65 ","pages":"Article 100578"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148958098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Putative protective role of PCSK9 variants in a multigenerational family with familial hypercholesterolemia","authors":"Sonia Rodríguez-Nóvoa,&nbsp;Pedro Martínez Hernández,&nbsp;Irene Hidalgo Mayoral,&nbsp;Amanda Herranz Cecilia,&nbsp;Neila Rodríguez Roca,&nbsp;Ana Carazo Álvarez,&nbsp;Natividad Gallego Onís,&nbsp;Marta Duque Alcorta,&nbsp;Carmen Rodríguez Jiménez","doi":"10.1016/j.athplu.2026.100607","DOIUrl":"10.1016/j.athplu.2026.100607","url":null,"abstract":"<div><h3>Background</h3><div>Familial hypercholesterolemia (FH) is most frequently caused by pathogenic variants in <em>LDLR</em>, but phenotypic variability suggests the influence of genetic modifiers.</div></div><div><h3>Methods</h3><div>We investigated a large multigenerational family with FH, combining clinical data, lipid profiles, and genetic analysis with functional studies. <em>LDLR</em> and <em>PCSK9</em> variants were characterized according to ACMG/ClinGen guidelines. Functional assays in CHO-ldlA7 cells assessed LDLR activity, while plasma PCSK9 levels were quantified by ELISA.</div></div><div><h3>Results</h3><div>The <em>LDLR</em> c.2479G &gt; A variant was associated with the FH phenotype in the family and showed borderline functional impairment <em>in vitro</em>. The presence of the established loss-of-function <em>PCSK9</em> c.137G&gt;T variant, together with the rare <em>PCSK9</em> c.2023del variant with a predicted deleterious effect, was identified in a normocholesterolemic carrier of the <em>LDLR</em> variant who showed markedly low circulating PCSK9 levels.</div></div><div><h3>Conclusions</h3><div>These findings suggest the potential relevance of investigating gene–gene interactions and variants with opposing effects on the lipid phenotype in FH. Integrating clinical, biochemical, genetic, and functional data may help explain intrafamilial variability and support more precise interpretation of inherited dyslipidemias.</div></div>","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"65 ","pages":"Article 100607"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149004354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between carotid macrovascular and retinal microvascular alterations in diabetes: Evidence synthesis and implications for risk assessment","authors":"Gentian Bajraktari,&nbsp;Fisnik Jashari,&nbsp;Per Wester,&nbsp;Dren Boshnjaku,&nbsp;Edita Pllana,&nbsp;Ardian Sermaxhaj,&nbsp;Pranvera Ibrahimi","doi":"10.1016/j.athplu.2026.100608","DOIUrl":"10.1016/j.athplu.2026.100608","url":null,"abstract":"<div><div>Diabetes mellitus is characterized by progressive vascular injury affecting both the microcirculation and large arteries. Diabetic retinopathy is a major microvascular complication and has been associated in observational studies with several carotid vascular phenotypes, including increased carotid intima-media thickness, focal plaque burden, arterial stiffness, plaque vulnerability markers, and, in selected cohorts, carotid stenosis. However, these carotid endpoints differ in measurement protocol, biological meaning, and prognostic implications, and most available evidence is cross-sectional. Retinal imaging modalities, including optical coherence tomography and optical coherence tomography angiography, provide quantitative measures such as vessel density, foveal avascular-zone size, retinal nerve fiber layer thickness, and choroidal thickness that may parallel systemic vascular injury, but validated thresholds for carotid disease detection have not been established. Shared mechanisms, including chronic hyperglycemia, endothelial dysfunction, inflammation, oxidative stress, dyslipidemia, and hypoxia-driven angiogenic signaling, may contribute to both retinal and carotid abnormalities; insulin resistance is particularly relevant to type 2 diabetes and metabolic syndrome, whereas diabetes duration and glycemic exposure are central across diabetes types. This narrative review therefore summarizes the associations between retinal microvascular changes and specific carotid vascular changes, while emphasizing that many findings may be influenced by shared risk factors and that most studies show association rather than causation or proven clinical utility. Current evidence supports multidisciplinary awareness and comprehensive cardiovascular risk-factor management in people with diabetes, but it does not yet justify retinal findings or OCTA metrics as validated triggers for screening asymptomatic patients with carotid ultrasonography. Prospective studies are needed to show whether combined retinal and carotid assessment improves diagnosis, risk prediction, cost-effectiveness, and patient outcomes before it can be recommended as a routine screening strategy.</div></div>","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"65 ","pages":"Article 100608"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149004352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CALON-FH: AlphaFold3-Derived Structural Severity Score Enables Domain-Specific ASCVD Penetrance Prediction and Mutation-Guided Treatment Selection in Familial Hypercholesterolaemia","authors":"N. Genedy","doi":"10.1016/j.athplu.2026.100591","DOIUrl":"10.1016/j.athplu.2026.100591","url":null,"abstract":"","PeriodicalId":72324,"journal":{"name":"Atherosclerosis plus","volume":"65 ","pages":"Article 100591"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148958292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}