Aging and health research最新文献

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The Canadian platform for research online to investigate health, quality of life, cognition, behaviour, function, and caregiving in aging (CAN-PROTECT): Study protocol, platform description, and preliminary analyses 加拿大老龄健康、生活质量、认知、行为、功能和护理在线研究平台(CAN-PROTECT):研究方案、平台说明和初步分析
Aging and health research Pub Date : 2024-10-22 DOI: 10.1016/j.ahr.2024.100207
Zahinoor Ismail , Dylan X. Guan , Daniella Vellone , Clive Ballard , Byron Creese , Anne Corbett , Ellie Pickering , Adam Bloomfield , Adam Hampshire , Ramnik Sekhon , Pamela Roach , Eric E. Smith
{"title":"The Canadian platform for research online to investigate health, quality of life, cognition, behaviour, function, and caregiving in aging (CAN-PROTECT): Study protocol, platform description, and preliminary analyses","authors":"Zahinoor Ismail ,&nbsp;Dylan X. Guan ,&nbsp;Daniella Vellone ,&nbsp;Clive Ballard ,&nbsp;Byron Creese ,&nbsp;Anne Corbett ,&nbsp;Ellie Pickering ,&nbsp;Adam Bloomfield ,&nbsp;Adam Hampshire ,&nbsp;Ramnik Sekhon ,&nbsp;Pamela Roach ,&nbsp;Eric E. Smith","doi":"10.1016/j.ahr.2024.100207","DOIUrl":"10.1016/j.ahr.2024.100207","url":null,"abstract":"<div><h3>Background</h3><div>: Preventing or reducing the risk of cognitive decline and dementia is of great public health interest. Longitudinal data from diverse samples are needed to properly inform clinicians, researchers, and policy makers. CAN-PROTECT is a recently launched online observational cohort study that assesses factors contributing to both risk for incident cognitive decline and dementia and resilience against brain aging, in participants across the lifespan.</div></div><div><h3>Methods</h3><div>: Measures of cognition, behaviour, and quality of life administered to both participants and study partners were compared using partial Spearman correlations adjusted for participant and study partner age, sex, and education. In participants, relationships between cognition, behaviour, function, and quality of life were examined using adjusted multivariable linear and negative binomial regression models.</div></div><div><h3>Results</h3><div>: In the first three-month window, 2150 participants spanning all Canadian provinces enrolled; 637 nominated study partners had already completed assessments. Engagement with the study was excellent, with many optional assessments completed. Initial analyses demonstrated relationships between cognition, behaviour, function, and quality of life.</div></div><div><h3>Discussion</h3><div>: These preliminary results speak to the utility and feasibility of CAN-PROTECT to obtain data relevant to brain health, highlighting the public interest in participating in studies on cognition. The online portal facilitated participation of a geographically diverse sample. This group is ideal to study brain aging, dementia prevention, and early detection of neurodegenerative disease. Longitudinal data will provide additional insights. Several features of CAN-PROTECT are important to consider in terms of assessing risk and resilience in Canadians, and for further development and recruitment of a research-ready cohort.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 4","pages":"Article 100207"},"PeriodicalIF":0.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142572946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the common genes involved in autism spectrum disorder and Parkinson's disease: A systematic review 探索自闭症谱系障碍和帕金森病的共同基因:系统回顾
Aging and health research Pub Date : 2024-10-19 DOI: 10.1016/j.ahr.2024.100206
Kanchan Bala , Khadga Raj Aran
{"title":"Exploring the common genes involved in autism spectrum disorder and Parkinson's disease: A systematic review","authors":"Kanchan Bala ,&nbsp;Khadga Raj Aran","doi":"10.1016/j.ahr.2024.100206","DOIUrl":"10.1016/j.ahr.2024.100206","url":null,"abstract":"<div><div>Autism Spectrum Disorder (ASD) and Parkinson's disease (PD) are distinct neurodevelopmental disorders associated with distinct brain areas. ASD is characterized by delayed social communication skills and restricted repetitive behaviours. Conversely, PD is a progressive neurodegenerative disorder affecting basal ganglia, causing resting tremor, rigidity, postural instability, and bradykinesia. Both diseases share similarities in affected brain areas, including motor control and social behaviour. In both diseases, PARK2, SHANK3, SLC, RIT2, DRD2, and CD157/BST1 genes are involved by regulating synaptic function and dopamine neurons. Mutations in PARK2, an E3 ubiquitin ligase, can lead to dysfunctional mitophagy, causing the accumulation of damaged mitochondria and contributing to neuronal cell death, a hallmark of PD. PARK2 pathway disruptions have also been observed in some individuals with ASD, which are involved in tagging damaged or unwanted proteins for degradation, leading to the accumulation of misfolded or dysfunctional proteins that may contribute to neurodevelopmental abnormalities. PINK1 is crucial for maintaining mitochondrial quality and eliminating dysfunctional ones that produce reactive oxygen species (ROS). Mutations in this gene lead to damaged mitochondria and increased ROS production, contributing to neurodegeneration in dopamine-producing neurons. This review highlighted the various genes involved in pathogeneses of ASD and PD with their future implications.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 4","pages":"Article 100206"},"PeriodicalIF":0.0,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are physical activity and everyday mobility independently associated with quality of life at older age? 体力活动和日常行动能力与老年人的生活质量是否有独立联系?
Aging and health research Pub Date : 2024-09-01 DOI: 10.1016/j.ahr.2024.100204
Jane Elliott , Judith Green
{"title":"Are physical activity and everyday mobility independently associated with quality of life at older age?","authors":"Jane Elliott ,&nbsp;Judith Green","doi":"10.1016/j.ahr.2024.100204","DOIUrl":"10.1016/j.ahr.2024.100204","url":null,"abstract":"<div><h3>Background</h3><p>Physical activity and everyday mobility are concepts that overlap but tend to be located in different disciplinary fields. We used the English Longitudinal Study of Ageing (ELSA) to: identify whether physical activity and everyday mobility are separate constructs at younger (60–69) and/or older (&gt;=70) age bands, and for men and women; derive measures of the two constructs from variables in the ELSA; and assess whether they are independently associated with quality of life (QoL).</p></div><div><h3>Methods</h3><p>We derived composite measures for physical activity and everyday mobility from ELSA variables. ‘Physical Activity’ combined items recording directly-measured activity for movement (walk-speed) and self-report measures of physical mobility difficulties and amount of vigorous, moderate and mild physical activity undertaken. ‘Everyday Mobility’ combined self-report responses about activities likely to involve leaving the house. QoL was measured using the ‘CASP-19′ scale. Using Wave 9 of ELSA (data collection in 2018–2020), we used a factor analysis to explore the constructs, and a regression analysis to examine associations with QoL.</p></div><div><h3>Results</h3><p>The factor analysis confirmed that these were discrete constructs, which explained between them 36% of the variance. This was robust across age bands, and in factor analyses for men and women separately. The regression analysis identified that lower physical activity and everyday mobility are independently associated with lower QoL, when controlling for a range of contextual variables including age.</p></div><div><h3>Conclusions</h3><p>Findings suggest that a social model of QoL at older age should focus on the broader mobility determinants of QoL as well as individual levels of physical activity.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 3","pages":"Article 100204"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032124000258/pdfft?md5=7f861c845abfba84a8064d01e80b7c6c&pid=1-s2.0-S2667032124000258-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142148432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mapping research landscapes on frailty in stroke from 2001 to 2023: A bibliometric analysis 绘制 2001 年至 2023 年有关中风虚弱的研究图景:文献计量分析
Aging and health research Pub Date : 2024-09-01 DOI: 10.1016/j.ahr.2024.100205
Qinqin Liu , Jian Du , Yongmei Bai , Huaxin Si , Yaru Jin , Cuili Wang
{"title":"Mapping research landscapes on frailty in stroke from 2001 to 2023: A bibliometric analysis","authors":"Qinqin Liu ,&nbsp;Jian Du ,&nbsp;Yongmei Bai ,&nbsp;Huaxin Si ,&nbsp;Yaru Jin ,&nbsp;Cuili Wang","doi":"10.1016/j.ahr.2024.100205","DOIUrl":"10.1016/j.ahr.2024.100205","url":null,"abstract":"<div><h3>Background</h3><p>Frailty and stroke are strongly related to the health of older people. This study aimed to map the research hotspots and frontiers, as well as quantitatively and comprehensively characterize the landscapes of publications on frailty in stroke over past decades.</p></div><div><h3>Methods</h3><p>The articles and reviews related to frailty in stroke, published from 2001 to 2023 were retrieved in the Web of Science Core Collection. CiteSpace and VOSviewer were used to identify the research hotspots, research frontiers, and the basic characteristics (such as top countries, institutions, journals and keywords) in this field.</p></div><div><h3>Results</h3><p>The publications’ growth rate on frailty in stroke was increasing over time. Four research hotspot clusters (geriatric syndrome, adverse outcomes prediction, cognitive function and mental health, as well as cardiovascular diseases management) were identified for frailty in stroke research over the past decades. The burst detection analysis showed that recovery, body mass index and oropharyngeal dysphagia were the research trends.</p></div><div><h3>Conclusion</h3><p>These findings will help scholars better understand current research progress and predict future directions related to frailty in stroke. Health providers could pay close attention to the development of scientific research in this field to maintain good health status of older people by geriatric care delivery.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 3","pages":"Article 100205"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266703212400026X/pdfft?md5=0422cdba71392bc0d1ffb46cb1f5bdfd&pid=1-s2.0-S266703212400026X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“[It's the] first time I have felt so acutely that I am 'less' because of my age.”: Aging in the time of COVID-19 "[这是我]第一次如此敏锐地感觉到,我因为年龄而'逊色'了":COVID-19 时代的老龄化
Aging and health research Pub Date : 2024-08-16 DOI: 10.1016/j.ahr.2024.100203
Allie Peckham , Molly Maxfield , M.Aaron Guest
{"title":"“[It's the] first time I have felt so acutely that I am 'less' because of my age.”: Aging in the time of COVID-19","authors":"Allie Peckham ,&nbsp;Molly Maxfield ,&nbsp;M.Aaron Guest","doi":"10.1016/j.ahr.2024.100203","DOIUrl":"10.1016/j.ahr.2024.100203","url":null,"abstract":"<div><h3>Background</h3><p>Initially, many of the measures implemented to promote public health and stop the spread of COVID-19 explicitly targeted older adults. Public discourse, media coverage, and government policy at the beginning stages of the COVID-19 pandemic perpetuated views that older adults are frail, vulnerable, and dispensable. Understanding how the framing of pandemics impacts older adults’ experiences can inform strategies to reduce ageism in the future.</p></div><div><h3>Methods</h3><p>Participants completed an online survey that captured their experiences during COVID-19. At the end of the survey, we asked participants, “What else would you like to share about your experience of living through COVID-19?” One thousand forty-six individuals responded to this open-ended question across all three survey waves with 1700 comments included in the analysis. We conducted an inductive descriptive analysis.</p></div><div><h3>Results</h3><p>The inductive analysis revealed broader implications of age-related overgeneralizations and benevolent ageism. Three implications of public health messaging were identified: intergenerational conflict, age-based vulnerability, and distrust of leadership and information. The results highlight that age-based public health messaging leads to feelings and experiences of prejudice and increases generational divides.</p></div><div><h3>Conclusions</h3><p>The coverage of the COVID-19 pandemic and the open discourse around vulnerability when contracting COVID-19 was framed in terms of age. Experiences with age-based framing perpetuate ‘othering’ between generations and even within generations. Public health messaging and decision-makers must consider intergenerational conflict frames before instituting social policies.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 3","pages":"Article 100203"},"PeriodicalIF":0.0,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032124000246/pdfft?md5=d10bee93dd2d053332384c0c7e346ea1&pid=1-s2.0-S2667032124000246-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142040333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive geriatric assessment-based frailty clinic in a low middle income country: Time to act 一个中低收入国家以老年病综合评估为基础的虚弱诊所:行动起来
Aging and health research Pub Date : 2024-08-15 DOI: 10.1016/j.ahr.2024.100202
Urza Bhattarai , Robin Maskey , Manisha Shrestha , Anusha Rayamajhi , Rohan Basnet , Arun Gautam , Bhupendra Shah , Sanjib Kumar Sharma
{"title":"Comprehensive geriatric assessment-based frailty clinic in a low middle income country: Time to act","authors":"Urza Bhattarai ,&nbsp;Robin Maskey ,&nbsp;Manisha Shrestha ,&nbsp;Anusha Rayamajhi ,&nbsp;Rohan Basnet ,&nbsp;Arun Gautam ,&nbsp;Bhupendra Shah ,&nbsp;Sanjib Kumar Sharma","doi":"10.1016/j.ahr.2024.100202","DOIUrl":"10.1016/j.ahr.2024.100202","url":null,"abstract":"<div><p>Comprehensive Geriatric Assessment (CGA) is a process of care that involves a holistic, multidimensional, interdisciplinary assessment of an older individual and has been demonstrated to be the choice of management for frailty. By 2050, it is expected that 80 % of the aging population will be living in low and low-middle income countries (LMICs). The implementation of geriatric programs is scarce in LMICs. CGA based frailty clinics could help facilitate early screening for impairment in physical and psychological capacities among pre-frail and frail older individuals allowing for suggestions for targeted interventions. Creating a sound healthcare model which addresses issues of older adults living with frailty is the need of the hour, especially in LMICs. Establishing frailty clinics in low-middle income countries could thus help to create a sustainable age-friendly healthcare model for the vulnerable and poor aging population. It is now the time to act.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 3","pages":"Article 100202"},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032124000234/pdfft?md5=fc60ad7be441493ce4a3a943f8442534&pid=1-s2.0-S2667032124000234-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142058013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between social network and mental health in family-oriented older migrants: A study in two cities in China 以家庭为导向的老年移民的社会网络与心理健康之间的相关性:中国两个城市的研究
Aging and health research Pub Date : 2024-08-14 DOI: 10.1016/j.ahr.2024.100201
Shan Gan , Xiuyu Yao , Zheng Li
{"title":"Correlation between social network and mental health in family-oriented older migrants: A study in two cities in China","authors":"Shan Gan ,&nbsp;Xiuyu Yao ,&nbsp;Zheng Li","doi":"10.1016/j.ahr.2024.100201","DOIUrl":"10.1016/j.ahr.2024.100201","url":null,"abstract":"<div><h3>Background</h3><p>Family-oriented mobility has become increasingly prevalent in recent years, leading to the emergence of a new demographic: older migrants. These individuals, who are often accompanied by their family members, relocate to another place of residence while retaining their household registration in their original location. The existing literature has largely neglected the social perspective on the mental health of this population group.</p></div><div><h3>Methods</h3><p>This study recruited participants from five communities in two cities and employed the Geriatric Social Network Scale, the Self-Rating Anxiety Scale, and the Geriatric Depression Scale to assess their mental health and social networks.</p></div><div><h3>Results</h3><p>Among the 317 qualified participants, 31.23 % reported experiencing anxiety and 15.77 % reported experiencing depression. The mean social network score was 3.83 ± 0.54 points. A negative correlation was observed between social network scores and both anxiety (<em>r</em> = −0.272, <em>P</em> &lt; 0.001) and depression (<em>r</em> = −0.338, <em>P</em> &lt; 0.001). Two distinct types of social networks were identified through latent profile analysis, with a low level of social support and a low-level social network being significantly correlated with depression (<em>P</em> &lt; 0.001)<em>.</em></p></div><div><h3>Conclusions</h3><p>Mental health issues are prevalent among family-oriented older migrants. A medium-level social network was found to be negatively correlated with anxiety and depression. The presence of a low-level social network was found to be associated with depression. It is imperative to prioritize the mental health status of family-oriented older migrants. Collaboration between community nurses and social workers should be encouraged to aid in exploring more effective ways of promoting the mental health status and social networks of this population.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 3","pages":"Article 100201"},"PeriodicalIF":0.0,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032124000222/pdfft?md5=b70e8b288f28038d4fa34a278647fe5d&pid=1-s2.0-S2667032124000222-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary variety and nutrient intake among Japanese community-dwelling older adults: A cross-sectional study 日本社区老年人的饮食多样性和营养摄入量:横断面研究
Aging and health research Pub Date : 2024-08-06 DOI: 10.1016/j.ahr.2024.100200
Mika Kimura , Ai Moriyasu , Ryo Miyazaki
{"title":"Dietary variety and nutrient intake among Japanese community-dwelling older adults: A cross-sectional study","authors":"Mika Kimura ,&nbsp;Ai Moriyasu ,&nbsp;Ryo Miyazaki","doi":"10.1016/j.ahr.2024.100200","DOIUrl":"10.1016/j.ahr.2024.100200","url":null,"abstract":"<div><h3>Background</h3><p>Maintaining good nutritional status through a varied diet is key to healthy aging.</p></div><div><h3>Methods</h3><p>This cross-sectional study investigated the association between dietary variety based on the food frequency score (FFS, the score of the frequency of daily intake of 10 food groups, range 0–30) and nutrient intake based on a brief self-administered diet history questionnaire. Data from 130 older adults were analyzed. In addition, the association between FFS and estimated average requirement (EAR) deficiency in the Dietary Reference Intakes for Japanese was investigated.</p></div><div><h3>Results</h3><p>FFS significantly correlated with most of 29 nutrients investigated, except for carbohydrate and sodium, and inversely correlated with alcohol. FFS categorized into tertiles was significantly associated with many of 29 nutrients, except for carbohydrates, n-3 unsaturated fat, vitamin D, vitamin B12, sodium, and manganese, and inversely associated with alcohol. Multiple logistic regression analysis showed that a higher FFS significantly decreased the odds of EAR deficiencies of vitamin A, thiamine, vitamin C, calcium, magnesium, and zinc. The calculated cutoff values of FFS for EAR deficiencies were 17 for vitamin A, vitamin C, and calcium or 18 for thiamine, magnesium, and zinc.</p></div><div><h3>Conclusion</h3><p>Based on FFS, this study found that dietary variety was significantly associated with various nutrients and inversely associated with EAR deficiency rates among community-dwelling older adults. These results indicate that improving FFS may help maintain nutritional status, and the simple recommendation of a daily intake of 10 food groups may be useful for community-dwelling older adults.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 3","pages":"Article 100200"},"PeriodicalIF":0.0,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032124000210/pdfft?md5=425959fed96516a88a25bab60089065e&pid=1-s2.0-S2667032124000210-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141963303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Balance and strength measures are associated with incident dementia in older men 平衡和力量测量与老年男性痴呆症发病率有关
Aging and health research Pub Date : 2024-07-28 DOI: 10.1016/j.ahr.2024.100199
Jack Paterson , Michelle Trevenen , Keith Hill , Osvaldo P. Almeida , Bu B. Yeap , Jonathan Golledge , Graeme J. Hankey , Leon Flicker
{"title":"Balance and strength measures are associated with incident dementia in older men","authors":"Jack Paterson ,&nbsp;Michelle Trevenen ,&nbsp;Keith Hill ,&nbsp;Osvaldo P. Almeida ,&nbsp;Bu B. Yeap ,&nbsp;Jonathan Golledge ,&nbsp;Graeme J. Hankey ,&nbsp;Leon Flicker","doi":"10.1016/j.ahr.2024.100199","DOIUrl":"10.1016/j.ahr.2024.100199","url":null,"abstract":"<div><h3>Background</h3><p>As people age the risk of dementia increases. Balance and strength deteriorate with ageing, but their associations with dementia are not clear. We aimed to determine relationships of balance and strength performance with incident dementia in the Health in Men Study (HIMS) cohort.</p></div><div><h3>Methods</h3><p>We used wave 4 of the HIMS as baseline for analyses (2011–2013), following 1261 men until December 2017 via data linkage to determine incident dementia. Balance was measured using a modified Balance Outcome Measure for Elder Rehabilitation (mBOOMER) Score and strength with the knee extension test. Cox proportional hazards regression was used, adjusting for sociodemographic and health data. Strength and balance scores were analysed non-linearly using restricted cubic splines.</p></div><div><h3>Results</h3><p>13.7% of men were diagnosed with dementia over a mean period of 4.7 (SD 1.5) years. Higher baseline mBOOMER scores were associated with a reduced risk of incident dementia, with greater changes in risk at higher mBOOMER scores (9 vs 8: HR 0.80, 95% CI 0.73–0.88; 12 vs 11: 0.49, 95% HR 0.36–0.68). Higher baseline lower limb strength was associated with a reduced risk of incident dementia, with greater changes occurring at lower scores, plateauing at around 25 kg (5 vs 4: HR 0.93, 95% CI 0.89–0.98; 25 vs 24: HR 0.99, 95% CI 0.95–1.03).</p></div><div><h3>Conclusions</h3><p>This study demonstrated a non-linear association of better performance in both strength and balance with reduced likelihood of incident dementia. These results raise the hypothesis that strategies to improve strength and balance could reduce the incidence of dementia in older men.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 3","pages":"Article 100199"},"PeriodicalIF":0.0,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032124000209/pdfft?md5=58c6ab653c866f4daad40d93953bdacc&pid=1-s2.0-S2667032124000209-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141841878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virtual frailty screening: A quality improvement project to enhance community-based assessment 虚拟虚弱筛查:旨在加强社区评估的质量改进项目
Aging and health research Pub Date : 2024-07-14 DOI: 10.1016/j.ahr.2024.100198
Titus A. Chan , Anne H.J. Summach , Tammy O'Rourke
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