Aging and health research最新文献_第3页

Impact of regional inequalities in long-term care on health spending: evidence from dementia patients in France 长期护理方面的地区不平等对卫生支出的影响：来自法国痴呆症患者的证据

Aging and health research Pub Date : 2025-09-01 Epub Date: 2025-05-28 DOI: 10.1016/j.ahr.2025.100239

Anne Penneau , Zeynep Or

{"title":"Impact of regional inequalities in long-term care on health spending: evidence from dementia patients in France","authors":"Anne Penneau , Zeynep Or","doi":"10.1016/j.ahr.2025.100239","DOIUrl":"10.1016/j.ahr.2025.100239","url":null,"abstract":"<div><h3>Background</h3><div>Unmet need for long-term care (LTC) could be associated with higher health care utilization and medical spending. In France funding of LTC is decentralised and there are significant disparities in accessibility of LTC. We analyse the impact of geographical variations in LTC funding and supply on healthcare expenditure focusing on dementia patients.</div></div><div><h3>Methods</h3><div>Healthcare spending of individuals is calculated from a national linked claims database. We run multilevel models exploiting the variations in spending across two geographical levels (residential areas nested in local authorities (LA)) to estimate the impact of local LTC supply and funding on health spending of patients with dementia. We estimated the generosity of LTC funding at LA with a stochastic frontier model and developed a taxonomy of LTC supply.</div></div><div><h3>Results</h3><div>Dementia patients living in LAs with most generous LTC funding have significantly lower acute (-11 %) and post-acute (-35 %) hospital spending while they have higher (+17 %) primary care spending. Moreover, people in areas with the highest LTC supply spend 3 % less on hospital care per year and per person compared to those in underserved areas.</div></div><div><h3>Conclusions</h3><div>Our results suggest that better accessibility of LTC with better funding and LTC supply can reduce hospital spending and improve overall health system efficiency.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100239"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring age-related influences on COVID-19 severity and therapeutic approaches for older patients 探讨年龄对COVID-19严重程度的影响及老年患者的治疗方法

IF 2

Aging and health research Pub Date : 2025-09-01 Epub Date: 2025-08-14 DOI: 10.1016/j.ahr.2025.100259

Shafaat Hossain , Shaumik Islam , Mohammad Kamruzzaman , Hossain Uddin Shekhar

{"title":"Exploring age-related influences on COVID-19 severity and therapeutic approaches for older patients","authors":"Shafaat Hossain , Shaumik Islam , Mohammad Kamruzzaman , Hossain Uddin Shekhar","doi":"10.1016/j.ahr.2025.100259","DOIUrl":"10.1016/j.ahr.2025.100259","url":null,"abstract":"<div><h3>Background</h3><div>Older adults experience higher rates of COVID-19-related morbidity and mortality compared to younger populations. This increased vulnerability is driven by age-associated biological changes affecting immune function and inflammatory regulation. This review aimed to synthesize current evidence on the biological mechanisms underlying the heightened risk of severe COVID-19 in older adults and to explore therapeutic strategies from a geroscience perspective.</div></div><div><h3>Methods</h3><div>A narrative literature review was conducted using PubMed, Scopus, and Google Scholar to identify peer-reviewed articles published between January 2020 and December 2024. Studies were included if they focused on aging-related biological factors, immunological changes, or therapeutic interventions relevant to COVID-19 in adults aged 60 and older.</div></div><div><h3>Results</h3><div>The review identified key mechanisms including immunosenescence, inflammaging, altered human angiotensin-converting enzyme 2 (ACE2) expression, increased oxidative stress, and reduced autophagic activity that contribute to COVID-19 severity in older adults. The presence of comorbid conditions, particularly cardiovascular disease and diabetes, further amplifies this vulnerability. Several therapeutic approaches, including senolytics, antioxidants, vitamin D supplementation, and precision medicine guided by biological aging, show potential to mitigate adverse outcomes.</div></div><div><h3>Conclusion</h3><div>Aging-related biological changes play a critical role in the pathogenesis of COVID-19 among older adults. Integrating geroscience-based interventions into COVID-19 management may help reduce severity and improve outcomes in this vulnerable population.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100259"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Short-term consequences after COVID-19 in older people with epilepsy” [Aging and Health Research Vol 4 Issue 2 (June 2024) 100184] “COVID-19对老年癫痫患者的短期后果”的更正[老龄化与健康研究第4卷第2期（2024年6月）100184]

IF 2

Aging and health research Pub Date : 2025-09-01 Epub Date: 2025-08-10 DOI: 10.1016/j.ahr.2025.100254

Yiling Chen , Zhenxu Xiao , Xiaowen Zhou , Luxin Jiang , Jianhong Wang , Ding Ding , Guoxing Zhu

引用次数: 0

Practical approaches to lifestyle interventions for enhancing brain health in older adults: A selective narrative review 生活方式干预增强老年人大脑健康的实用方法：选择性叙述回顾

Aging and health research Pub Date : 2025-09-01 Epub Date: 2025-07-17 DOI: 10.1016/j.ahr.2025.100258

Raymond L Ownby , Joshua Caballero

{"title":"Practical approaches to lifestyle interventions for enhancing brain health in older adults: A selective narrative review","authors":"Raymond L Ownby , Joshua Caballero","doi":"10.1016/j.ahr.2025.100258","DOIUrl":"10.1016/j.ahr.2025.100258","url":null,"abstract":"<div><h3>Background</h3><div>As the prevalence of Alzheimer’s disease and other dementias increases worldwide, it is increasingly important to help middle-aged and older adults develop brain health lifestyles.</div></div><div><h3>Method</h3><div>We conducted a selective review of studies on the use of shared decision-making, psychoeducation, and behavior change techniques to promote healthy behaviors in adults. We then synthesized results into a model that can be implemented in clinical practice to promote brain healthy lifestyles.</div></div><div><h3>Results</h3><div>Selected research supports the usefulness of these techniques in promoting health behaviors. The integrative model allows us to generate specific hypotheses about implementation strategies, testing of which could help in the development of a practical intervention.</div></div><div><h3>Conclusions</h3><div>Shared decision-making, psychoeducation, and behavior change techniques each could provide valuable support for individuals’ efforts at developing brain health lifestyles. The integrative model proposed here may be useful in generating specific hypotheses that can be tested in the process of developing an intervention that could be clinically implemented.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100258"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Synergistic effect of smoking and education on incident dementia among older adults: The Shanghai aging study” [Aging and Health Research Vol 5 Issue 1 (March 2025) 100212] “吸烟和教育对老年人痴呆发病率的协同效应：上海老龄化研究”的更正[老龄化与健康研究第5卷第1期（2025年3月）100212]

IF 2

Aging and health research Pub Date : 2025-09-01 Epub Date: 2025-07-24 DOI: 10.1016/j.ahr.2025.100253

Chengyin Xu , Zhenxu Xiao , Xiaowen Zhou , Xiaoniu Liang , Qianhua Zhao , Ding Ding , Wei Deng

引用次数: 0

Commercially available products for the digital tracking of biomarkers in Parkinson's Disease 用于帕金森病生物标志物数字跟踪的市售产品

Aging and health research Pub Date : 2025-09-01 Epub Date: 2025-05-28 DOI: 10.1016/j.ahr.2025.100240

Padraig Cronin , Lucy M. Collins , Aideen M. Sullivan

{"title":"Commercially available products for the digital tracking of biomarkers in Parkinson's Disease","authors":"Padraig Cronin , Lucy M. Collins , Aideen M. Sullivan","doi":"10.1016/j.ahr.2025.100240","DOIUrl":"10.1016/j.ahr.2025.100240","url":null,"abstract":"<div><h3>Background</h3><div>Parkinson’s Disease (PD) is a debilitating neurological disorder which affects 8.5 million people globally. Diagnosis of PD is made upon presentation of motor symptoms. However, there is a well-recognised prodromal phase of PD, when patients experience non-motor symptoms, and subtle motor symptoms, before the onset of the cardinal motor symptoms. Biomarkers of this prodromal phase can provide a diagnostic window into early disease processes, assisting with the differential diagnosis of PD and enabling earlier treatment. Due to increased availability of commercially-available products, both wearable devices and smartphone applications are being explored for potential to identify PD biomarkers. Such products can provide clinicians with early warning of disease progression, and supply researchers with tools for monitoring PD outside of laboratory settings.</div></div><div><h3>Methods</h3><div>This systematic review critically examined the academic literature published in the English language to identify currently-available products designed to track biomarkers of PD across 6 databases between January 2000 and March 2025.</div></div><div><h3>Results</h3><div>27 papers were identified which captured physiological biomarkers in PD patients using commercially-available products. Current products emphasise the capture of early motor dysfunction through both upper limb and eye movements. There is a lack of literature on the validation of commercially-available products for the detection of PD, despite an increase in advanced data analysis algorithms.</div></div><div><h3>Conclusion</h3><div>There is a critical need for validation of devices for the tracking of biomarkers of PD, which may be utilised for detection during the prodromal phase.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100240"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144205026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between adverse childhood experiences and frailty among middle-aged and older adults in Rural South Africa 不良童年经历与南非农村中老年人身体虚弱之间的关系

Aging and health research Pub Date : 2025-09-01 Epub Date: 2025-05-29 DOI: 10.1016/j.ahr.2025.100242

Shengruo Zhang , Markus J. Haapanen , Mengyao Wang , Hao Xiang , Hanzhang Xu , Chenkai Wu

{"title":"The association between adverse childhood experiences and frailty among middle-aged and older adults in Rural South Africa","authors":"Shengruo Zhang , Markus J. Haapanen , Mengyao Wang , Hao Xiang , Hanzhang Xu , Chenkai Wu","doi":"10.1016/j.ahr.2025.100242","DOIUrl":"10.1016/j.ahr.2025.100242","url":null,"abstract":"<div><h3>Background</h3><div>Adverse childhood experiences (ACEs) negatively impact later physical and mental health. However, evidence is lacking in low- and middle-income countries. We examined the association between ACEs and frailty among middle-aged and older adults in rural South Africa.</div></div><div><h3>Methods</h3><div>We included 3825 respondents aged ≥40 years who participated in the survey, Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in rural South Africa (HAALSI). We included four ACEs: (1) parental unemployment for >6 months, (2) parents who argued or fought often, (3) parents who drank, did drugs, or had mental health problems, and (4) parental physical abuse. Frailty was measured by the Fried’s frailty phenotype approach using five criteria: slowness, weakness, exhaustion, inactivity, and shrinking. We assessed the independent association between each ACE and frailty using multinomial logistic regression.</div></div><div><h3>Results</h3><div>Having experienced parents arguing or fighting often was significantly associated with frailty (prevalence ratio [PR]=1.62, 95 %CI: 1.06–2.48). After adjusting for age and sex, we found a positive association between parents unemployed for 6 or more months and frailty (PR=1.48, 95 %CI: 1.00–2.19). People having two or more ACEs were positively associated with frailty in the unadjusted (PR=1.63, 95 %CI: 1.07–2.47) and adjusted models (PR=1.60, 95 %CI: 1.05–2.45) relative to those having only one ACE.</div></div><div><h3>Conclusions</h3><div>ACEs were associated with a higher burden of frailty among middle-aged and older adults in rural South Africa. Future studies utilizing individual-centered statistical techniques such as cluster analysis and latent class analysis might be considered to offer a more in-depth understanding of the relationships between ACEs and frailty.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100242"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights from recruiting individuals with mild dementia and care partners for a multi-site oral hygiene intervention 从招募轻度痴呆患者和护理伙伴的多站点口腔卫生干预的见解

Aging and health research Pub Date : 2025-09-01 Epub Date: 2025-05-21 DOI: 10.1016/j.ahr.2025.100236

Jing Wang , Shahrzad Siamdoust , Zhijing Xu , Catharine Mott , Brenda L. Plassman , Ruth A. Anderson , Jessica Zwerling , Bei Wu

{"title":"Insights from recruiting individuals with mild dementia and care partners for a multi-site oral hygiene intervention","authors":"Jing Wang , Shahrzad Siamdoust , Zhijing Xu , Catharine Mott , Brenda L. Plassman , Ruth A. Anderson , Jessica Zwerling , Bei Wu","doi":"10.1016/j.ahr.2025.100236","DOIUrl":"10.1016/j.ahr.2025.100236","url":null,"abstract":"<div><h3>Background</h3><div>Maintaining oral health is essential for individuals with dementia, yet they often need support. We sought to identify insights gained during the recruitment process for an intervention designed to teach care partners skills to guide individuals with mild dementia in proper oral hygiene techniques and provide reminders to practice oral hygiene care.</div></div><div><h3>Methods</h3><div>Throughout the study, research team members from two research sites met regularly to discuss their experiences in recruiting participants. Notes from these meetings served as the basis for identifying key challenges and effective strategies.</div></div><div><h3>Results</h3><div>Recruitment involved direct patient engagement, collaboration with dementia research centers and community organizations, and the use of electronic health record systems, including MyChart. Recruitment coordinators connected study personnel with organizations and support groups, thereby broadening the recruitment base. Barriers to recruitment included the reduced frequency of patient visits to clinics during the COVID-19 pandemic, which limited in-person recruitment opportunities, as well as the time required to establish new relationships with non-affiliated hospitals and community organizations. Recruitment efforts successfully integrated long-standing relationships with dementia research centers and healthcare providers alongside the establishment of new partnerships with community organizations and non-affiliated hospitals.</div></div><div><h3>Conclusion</h3><div>Flexibility, participant-centered communication, and a multifaceted approach were critical for overcoming pandemic-related challenges and addressing recruitment barriers, ensuring diverse and well-retained participation in this study.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100236"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased white matter hyperintensities on MRI in autosomal dominant familial compared to sporadic Alzheimer’s disease 常染色体显性家族性阿尔茨海默病与散发性阿尔茨海默病相比，MRI上白质高强度增加

IF 2

Aging and health research Pub Date : 2025-09-01 Epub Date: 2025-07-18 DOI: 10.1016/j.ahr.2025.100255

Alice Accorroni , Maggie R Fraser , Phoebe Walsh , Antoinette O’Connor , M Jorge Cardoso , Llwyd Prosser , Nick C Fox , Carole H Sudre , Natalie S Ryan

{"title":"Increased white matter hyperintensities on MRI in autosomal dominant familial compared to sporadic Alzheimer’s disease","authors":"Alice Accorroni , Maggie R Fraser , Phoebe Walsh , Antoinette O’Connor , M Jorge Cardoso , Llwyd Prosser , Nick C Fox , Carole H Sudre , Natalie S Ryan","doi":"10.1016/j.ahr.2025.100255","DOIUrl":"10.1016/j.ahr.2025.100255","url":null,"abstract":"<div><h3>Background</h3><div>White matter hyperintensities (WMH) on MRI may be observed in autosomal dominant familial Alzheimer’s disease (FAD) and sporadic AD (SAD), however, studies comparing WMH burden between these two groups are lacking.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, we evaluated global and local differences in WMH severity on MRI in 19 individuals with symptomatic FAD due to <em>Presenilin 1</em> mutations, 20 individuals with young-onset SAD and 19 healthy individuals, controlling for age, cerebrovascular risk factors (CVR) and <em>APOE</em>ε4 carrier status. Relationships between WMH, grey matter (GM) volumes and neuropsychological tests (NPT) were also investigated.</div></div><div><h3>Results</h3><div>Despite their young age and minimal CVR, the FAD group had higher WMH load in all areas considered, apart from juxta-cortical and periventricular layers when compared to the SAD group. The increased lobar WMH load observed in FAD was not influenced by <em>APOEε4</em> genotype or CVR. No significant associations were found between WMH and GM volumes or NPT in either AD group.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that WMH may reflect aspects of AD pathology that are particularly prominent in FAD. Notably, in our study, WMH were not simply attributable to CVR, <em>APOEε4</em> carrier status, or GM atrophy, but may instead represent independent features of the disease.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100255"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with receipt of caregiver training among family and unpaid caregivers of people living with dementia 与痴呆症患者的家庭和无偿照顾者接受照顾者培训相关的因素

Aging and health research Pub Date : 2025-09-01 Epub Date: 2025-05-22 DOI: 10.1016/j.ahr.2025.100237

Jihye Kim , Yue Li , Sungchul Park , Hyunjee Kim , Yeunkyung Kim

{"title":"Factors associated with receipt of caregiver training among family and unpaid caregivers of people living with dementia","authors":"Jihye Kim , Yue Li , Sungchul Park , Hyunjee Kim , Yeunkyung Kim","doi":"10.1016/j.ahr.2025.100237","DOIUrl":"10.1016/j.ahr.2025.100237","url":null,"abstract":"<div><h3>Background</h3><div>To investigate factors associated with the receipt of caregiver training among informal caregivers for people living with dementia in the community.</div></div><div><h3>Methods</h3><div>Using three waves of the National Health and Aging Trends Study and the National Study of Caregiving data (2015, 2017, and 2021), the sample included 2606 family/unpaid caregivers who provided care assistance to community-dwelling older adults living with dementia. We conducted a multivariate logistic regression analysis with sampling weights to examine the factors associated with the receipt of training among caregivers for people living with dementia.</div></div><div><h3>Results</h3><div>Findings indicated that 8.3 % of the caregivers received caregiver training. Non-Hispanic Black (odds ratio [OR], 2.02; 95 % confidence interval [CI]: 1.30–3.15) and caregivers of other races (OR, 2.94; 95 % CI: 1.57–5.49) were more likely to receive training than non-Hispanic White caregivers. Spouse of care recipient (OR, 3.11; 95 % CI: 1.32–7.30), Medicaid-enrolled caregivers (OR, 2.52; 95 % CI: 1.44–4.41), caregivers who worked in the past week (OR, 2.12; 95 % CI: 1.21–3.70), and caregivers for those who needed assistance for multiple self-care or mobility tasks (OR, 2.22; 95 % CI: 1.24–4.00) were more likely to receive caregiver training than their respective counterparts.</div></div><div><h3>Conclusions</h3><div>Given the challenges of dementia caregiving and the potential beneficial effect of training, it is imperative for policy makers to promote both overall uptake rate of caregiver training and the rate among high-risk subgroups, to relieve caregiver burden and improve outcomes of both caregivers and care recipients.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100237"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0