加拿大老龄健康、生活质量、认知、行为、功能和护理在线研究平台（CAN-PROTECT）：研究方案、平台说明和初步分析

Aging and health research Pub Date : 2024-10-22 DOI:10.1016/j.ahr.2024.100207

Zahinoor Ismail , Dylan X. Guan , Daniella Vellone , Clive Ballard , Byron Creese , Anne Corbett , Ellie Pickering , Adam Bloomfield , Adam Hampshire , Ramnik Sekhon , Pamela Roach , Eric E. Smith

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引用次数: 0

摘要

背景：预防或降低认知能力衰退和痴呆症的风险对公众健康具有重大意义。我们需要来自不同样本的纵向数据，以便为临床医生、研究人员和政策制定者提供正确的信息。CAN-PROTECT是最近启动的一项在线观察性队列研究，该研究评估了导致认知能力下降和痴呆症的风险因素，以及参与者在整个生命周期中对大脑老化的适应能力：对参与者和研究伙伴的认知、行为和生活质量进行测量，并根据参与者和研究伙伴的年龄、性别和教育程度进行调整，利用部分斯皮尔曼相关性进行比较。使用调整后的多变量线性回归模型和负二项回归模型对参与者的认知、行为、功能和生活质量之间的关系进行了研究：在第一个为期三个月的窗口期中，加拿大各省共有 2150 名参与者报名参加；637 名提名的研究伙伴已经完成了评估。参与者对研究的参与度非常高，完成了许多可选评估。初步分析表明了认知、行为、功能和生活质量之间的关系：这些初步结果表明，CAN-PROTECT 在获取与脑健康相关的数据方面具有实用性和可行性，凸显了公众对参与认知研究的兴趣。在线门户网站为不同地域的样本参与提供了便利。这一群体是研究大脑老化、痴呆症预防和神经退行性疾病早期检测的理想对象。纵向数据将提供更多的见解。CAN-PROTECT 的几个特点对于评估加拿大人的风险和适应能力，以及进一步开发和招募可用于研究的群体都非常重要。

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The Canadian platform for research online to investigate health, quality of life, cognition, behaviour, function, and caregiving in aging (CAN-PROTECT): Study protocol, platform description, and preliminary analyses

Background

: Preventing or reducing the risk of cognitive decline and dementia is of great public health interest. Longitudinal data from diverse samples are needed to properly inform clinicians, researchers, and policy makers. CAN-PROTECT is a recently launched online observational cohort study that assesses factors contributing to both risk for incident cognitive decline and dementia and resilience against brain aging, in participants across the lifespan.

Methods

: Measures of cognition, behaviour, and quality of life administered to both participants and study partners were compared using partial Spearman correlations adjusted for participant and study partner age, sex, and education. In participants, relationships between cognition, behaviour, function, and quality of life were examined using adjusted multivariable linear and negative binomial regression models.

Results

: In the first three-month window, 2150 participants spanning all Canadian provinces enrolled; 637 nominated study partners had already completed assessments. Engagement with the study was excellent, with many optional assessments completed. Initial analyses demonstrated relationships between cognition, behaviour, function, and quality of life.

Discussion

: These preliminary results speak to the utility and feasibility of CAN-PROTECT to obtain data relevant to brain health, highlighting the public interest in participating in studies on cognition. The online portal facilitated participation of a geographically diverse sample. This group is ideal to study brain aging, dementia prevention, and early detection of neurodegenerative disease. Longitudinal data will provide additional insights. Several features of CAN-PROTECT are important to consider in terms of assessing risk and resilience in Canadians, and for further development and recruitment of a research-ready cohort.

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来源期刊

Aging and health research Clinical Neurology, Public Health and Health Policy, Geriatrics and Gerontology

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

12 weeks