Aging and health research最新文献

{"title":"Neighborhood physical environment satisfaction and aging attitudes in older Chinese adults: Differences by chronic condition status","authors":"Zhijing Xu ,&nbsp;Dan Zhao ,&nbsp;Weiyu Mao ,&nbsp;Jing Wang ,&nbsp;Zhongfang Yang ,&nbsp;Yaguang Zheng ,&nbsp;Bei Wu","doi":"10.1016/j.ahr.2025.100241","DOIUrl":"10.1016/j.ahr.2025.100241","url":null,"abstract":"<div><h3>Background</h3><div>With China’s aging population and rising prevalence of chronic conditions, it is crucial to understand the factors shaping aging attitudes. Satisfaction with the neighborhood physical environment may play an important role, particularly among those with chronic health issues. To examine the association between neighborhood physical environment satisfaction and aging attitudes among older Chinese adults, and to explore differences across groups with and without chronic conditions.</div></div><div><h3>Methods</h3><div>We analyzed data from 11,395 participants aged 60 and above from the 2020 China Longitudinal Aging Social Survey (CLASS). Stratified multiple regression analyses were conducted, comparing subgroups with chronic conditions (<em>n</em> = 8405, 73.76 %) and without chronic conditions.</div></div><div><h3>Results</h3><div>Among participants with chronic conditions, higher satisfaction with road conditions (β = 0.382, <em>P</em> = 0.001), environmental sanitation (β = 0.286, <em>P</em> = 0.007), and road/street lighting (β = 0.288, <em>P</em> = 0.005) was significantly associated with more positive attitudes toward aging. No significant associations were found among participants without chronic conditions.</div></div><div><h3>Conclusions</h3><div>Age-friendly neighborhood environments are important for promoting positive aging attitudes, particularly among older adults living with chronic conditions. These findings offer valuable insights for policymakers, researchers, and service providers aiming to support healthy aging in rapidly aging societies like China.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100241"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144196351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between adverse childhood experiences and frailty among middle-aged and older adults in Rural South Africa","authors":"Shengruo Zhang ,&nbsp;Markus J. Haapanen ,&nbsp;Mengyao Wang ,&nbsp;Hao Xiang ,&nbsp;Hanzhang Xu ,&nbsp;Chenkai Wu","doi":"10.1016/j.ahr.2025.100242","DOIUrl":"10.1016/j.ahr.2025.100242","url":null,"abstract":"<div><h3>Background</h3><div>Adverse childhood experiences (ACEs) negatively impact later physical and mental health. However, evidence is lacking in low- and middle-income countries. We examined the association between ACEs and frailty among middle-aged and older adults in rural South Africa.</div></div><div><h3>Methods</h3><div>We included 3825 respondents aged ≥40 years who participated in the survey, Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in rural South Africa (HAALSI). We included four ACEs: (1) parental unemployment for &gt;6 months, (2) parents who argued or fought often, (3) parents who drank, did drugs, or had mental health problems, and (4) parental physical abuse. Frailty was measured by the Fried’s frailty phenotype approach using five criteria: slowness, weakness, exhaustion, inactivity, and shrinking. We assessed the independent association between each ACE and frailty using multinomial logistic regression.</div></div><div><h3>Results</h3><div>Having experienced parents arguing or fighting often was significantly associated with frailty (prevalence ratio [PR]=1.62, 95 %CI: 1.06–2.48). After adjusting for age and sex, we found a positive association between parents unemployed for 6 or more months and frailty (PR=1.48, 95 %CI: 1.00–2.19). People having two or more ACEs were positively associated with frailty in the unadjusted (PR=1.63, 95 %CI: 1.07–2.47) and adjusted models (PR=1.60, 95 %CI: 1.05–2.45) relative to those having only one ACE.</div></div><div><h3>Conclusions</h3><div>ACEs were associated with a higher burden of frailty among middle-aged and older adults in rural South Africa. Future studies utilizing individual-centered statistical techniques such as cluster analysis and latent class analysis might be considered to offer a more in-depth understanding of the relationships between ACEs and frailty.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100242"},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of regional inequalities in long-term care on health spending: evidence from dementia patients in France","authors":"Anne Penneau ,&nbsp;Zeynep Or","doi":"10.1016/j.ahr.2025.100239","DOIUrl":"10.1016/j.ahr.2025.100239","url":null,"abstract":"<div><h3>Background</h3><div>Unmet need for long-term care (LTC) could be associated with higher health care utilization and medical spending. In France funding of LTC is decentralised and there are significant disparities in accessibility of LTC. We analyse the impact of geographical variations in LTC funding and supply on healthcare expenditure focusing on dementia patients.</div></div><div><h3>Methods</h3><div>Healthcare spending of individuals is calculated from a national linked claims database. We run multilevel models exploiting the variations in spending across two geographical levels (residential areas nested in local authorities (LA)) to estimate the impact of local LTC supply and funding on health spending of patients with dementia. We estimated the generosity of LTC funding at LA with a stochastic frontier model and developed a taxonomy of LTC supply.</div></div><div><h3>Results</h3><div>Dementia patients living in LAs with most generous LTC funding have significantly lower acute (-11 %) and post-acute (-35 %) hospital spending while they have higher (+17 %) primary care spending. Moreover, people in areas with the highest LTC supply spend 3 % less on hospital care per year and per person compared to those in underserved areas.</div></div><div><h3>Conclusions</h3><div>Our results suggest that better accessibility of LTC with better funding and LTC supply can reduce hospital spending and improve overall health system efficiency.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100239"},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commercially available products for the digital tracking of biomarkers in Parkinson's Disease","authors":"Padraig Cronin ,&nbsp;Lucy M. Collins ,&nbsp;Aideen M. Sullivan","doi":"10.1016/j.ahr.2025.100240","DOIUrl":"10.1016/j.ahr.2025.100240","url":null,"abstract":"<div><h3>Background</h3><div>Parkinson’s Disease (PD) is a debilitating neurological disorder which affects 8.5 million people globally. Diagnosis of PD is made upon presentation of motor symptoms. However, there is a well-recognised prodromal phase of PD, when patients experience non-motor symptoms, and subtle motor symptoms, before the onset of the cardinal motor symptoms. Biomarkers of this prodromal phase can provide a diagnostic window into early disease processes, assisting with the differential diagnosis of PD and enabling earlier treatment. Due to increased availability of commercially-available products, both wearable devices and smartphone applications are being explored for potential to identify PD biomarkers. Such products can provide clinicians with early warning of disease progression, and supply researchers with tools for monitoring PD outside of laboratory settings.</div></div><div><h3>Methods</h3><div>This systematic review critically examined the academic literature published in the English language to identify currently-available products designed to track biomarkers of PD across 6 databases between January 2000 and March 2025.</div></div><div><h3>Results</h3><div>27 papers were identified which captured physiological biomarkers in PD patients using commercially-available products. Current products emphasise the capture of early motor dysfunction through both upper limb and eye movements. There is a lack of literature on the validation of commercially-available products for the detection of PD, despite an increase in advanced data analysis algorithms.</div></div><div><h3>Conclusion</h3><div>There is a critical need for validation of devices for the tracking of biomarkers of PD, which may be utilised for detection during the prodromal phase.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100240"},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144205026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive impairment and hearing loss in Colombian aged population","authors":"Leonardo Elías Ordóñez Ordóñez ,&nbsp;Daniela Cerón Perdomo ,&nbsp;Gloria Corredor-Rojas ,&nbsp;Jorge Medina-Parra ,&nbsp;Esther Sofía Angulo Martínez","doi":"10.1016/j.ahr.2025.100238","DOIUrl":"10.1016/j.ahr.2025.100238","url":null,"abstract":"<div><h3>Background</h3><div>Hearing loss and cognitive impairment are widely prevalent in individuals aged 60 years and above. Hearing loss is one of the main modifiable risk factors for dementia, emphasizing the importance for potentially mitigating cognitive decline.</div></div><div><h3>Methods</h3><div>This study performed a secondary analysis of the database of Survey on Health, Well-Being, and Aging in Colombia (SABE Colombia). Hearing loss and cognitive impairment were assessed by self-report and the abbreviated Folstein version of the Mini Mental State Examination validated in Latin American Spanish. Information was searched on hearing rehabilitation and access barriers. A logistic regression model was used to assess the impact factors of cognitive impairment.</div></div><div><h3>Results</h3><div>Among 23,694 participants, the estimated prevalence of hearing loss was 31.73 % and for cognitive impairment was 19.79 %, which is similar with global reports. A significant proportion of individuals with hearing loss (93.13 %) remain untreated. There was a statistically significant association between the presence of hearing loss and risk of cognitive impairment (<em>p</em> &lt; 0.001). Older age, fewer years of education, gender (women) and affiliation to subsidized scheme/not being affiliated were also found having significant associations with cognitive impairment (<em>p</em> &lt; 0.001)<strong>.</strong></div></div><div><h3>Conclusions</h3><div>This study offers valuable insights into cognitive impairment and hearing loss and their interrelation in Colombia, thereby assisting government authorities and health system stakeholders in making informed decisions regarding public health policies and resource allocation.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100238"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with receipt of caregiver training among family and unpaid caregivers of people living with dementia","authors":"Jihye Kim ,&nbsp;Yue Li ,&nbsp;Sungchul Park ,&nbsp;Hyunjee Kim ,&nbsp;Yeunkyung Kim","doi":"10.1016/j.ahr.2025.100237","DOIUrl":"10.1016/j.ahr.2025.100237","url":null,"abstract":"<div><h3>Background</h3><div>To investigate factors associated with the receipt of caregiver training among informal caregivers for people living with dementia in the community.</div></div><div><h3>Methods</h3><div>Using three waves of the National Health and Aging Trends Study and the National Study of Caregiving data (2015, 2017, and 2021), the sample included 2606 family/unpaid caregivers who provided care assistance to community-dwelling older adults living with dementia. We conducted a multivariate logistic regression analysis with sampling weights to examine the factors associated with the receipt of training among caregivers for people living with dementia.</div></div><div><h3>Results</h3><div>Findings indicated that 8.3 % of the caregivers received caregiver training. Non-Hispanic Black (odds ratio [OR], 2.02; 95 % confidence interval [CI]: 1.30–3.15) and caregivers of other races (OR, 2.94; 95 % CI: 1.57–5.49) were more likely to receive training than non-Hispanic White caregivers. Spouse of care recipient (OR, 3.11; 95 % CI: 1.32–7.30), Medicaid-enrolled caregivers (OR, 2.52; 95 % CI: 1.44–4.41), caregivers who worked in the past week (OR, 2.12; 95 % CI: 1.21–3.70), and caregivers for those who needed assistance for multiple self-care or mobility tasks (OR, 2.22; 95 % CI: 1.24–4.00) were more likely to receive caregiver training than their respective counterparts.</div></div><div><h3>Conclusions</h3><div>Given the challenges of dementia caregiving and the potential beneficial effect of training, it is imperative for policy makers to promote both overall uptake rate of caregiver training and the rate among high-risk subgroups, to relieve caregiver burden and improve outcomes of both caregivers and care recipients.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100237"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights from recruiting individuals with mild dementia and care partners for a multi-site oral hygiene intervention","authors":"Jing Wang ,&nbsp;Shahrzad Siamdoust ,&nbsp;Zhijing Xu ,&nbsp;Catharine Mott ,&nbsp;Brenda L. Plassman ,&nbsp;Ruth A. Anderson ,&nbsp;Jessica Zwerling ,&nbsp;Bei Wu","doi":"10.1016/j.ahr.2025.100236","DOIUrl":"10.1016/j.ahr.2025.100236","url":null,"abstract":"<div><h3>Background</h3><div>Maintaining oral health is essential for individuals with dementia, yet they often need support. We sought to identify insights gained during the recruitment process for an intervention designed to teach care partners skills to guide individuals with mild dementia in proper oral hygiene techniques and provide reminders to practice oral hygiene care.</div></div><div><h3>Methods</h3><div>Throughout the study, research team members from two research sites met regularly to discuss their experiences in recruiting participants. Notes from these meetings served as the basis for identifying key challenges and effective strategies.</div></div><div><h3>Results</h3><div>Recruitment involved direct patient engagement, collaboration with dementia research centers and community organizations, and the use of electronic health record systems, including MyChart. Recruitment coordinators connected study personnel with organizations and support groups, thereby broadening the recruitment base. Barriers to recruitment included the reduced frequency of patient visits to clinics during the COVID-19 pandemic, which limited in-person recruitment opportunities, as well as the time required to establish new relationships with non-affiliated hospitals and community organizations. Recruitment efforts successfully integrated long-standing relationships with dementia research centers and healthcare providers alongside the establishment of new partnerships with community organizations and non-affiliated hospitals.</div></div><div><h3>Conclusion</h3><div>Flexibility, participant-centered communication, and a multifaceted approach were critical for overcoming pandemic-related challenges and addressing recruitment barriers, ensuring diverse and well-retained participation in this study.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100236"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between traditional Chinese medicine body constitution and cardiovascular disease risk in a white population","authors":"Lihua Shu ,&nbsp;Xiaoling Yin ,&nbsp;Xiangzhu Zhu ,&nbsp;Jing Zhao ,&nbsp;Xinqing Deng ,&nbsp;Yevheniy Eugene Shubin ,&nbsp;Harvey J. Murff ,&nbsp;Reid M. Ness ,&nbsp;Chang Yu ,&nbsp;Martha J. Shrubsole ,&nbsp;Qi Dai","doi":"10.1016/j.ahr.2025.100235","DOIUrl":"10.1016/j.ahr.2025.100235","url":null,"abstract":"<div><h3>Background</h3><div>Traditional Chinese medicine (TCM) has guided generations of practice on disease treatment and health maintenance. The TCM principles include the framework of body constitution. However, no study has assessed the body constitution in US population.</div></div><div><h3>Methods</h3><div>This is an ancillary study of the Personalized Prevention of Colorectal Cancer Trial which was conducted in US during 2012–2016. 191 white participants were evaluated for body constitution type using a self-administered Traditional Chinese Medicine Questionnaire (English version). The body constitution subtypes and cardiovascular disease (CVD) risk were assessed.</div></div><div><h3>Results</h3><div>Fifty-seven (29.8 %) were identified as balanced constitution (BC), while Blood-stasis (17.3 %), Qi-deficient (13.6 %), and inherited-special constitutions (10.5 %) were the pre-eminent pathologic subtypes. Additional analyses investigated the relationship between CVD risk and body constitution subtypes. No major types of TCM body constitution were associated with the general cardiovascular risk score and other CVD biomarkers.</div></div><div><h3>Conclusions</h3><div>It is important to understand the underlying mechanisms contributing to the differences by population, which may not only help to understand the underlying mechanism for TCM, but also help to identify novel factors or mechanisms for CVD risk, prevention and treatment.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100235"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144105596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations between multimorbidity, healthcare resource utilisation and costs in individuals with Alzheimer's disease dementia","authors":"Sophie Edwards ,&nbsp;Marc Evans ,&nbsp;Craig Ritchie ,&nbsp;Julie Hviid Hahn-Pedersen ,&nbsp;Mei Sum Chan ,&nbsp;Benjamin D Bray ,&nbsp;Alice Clark ,&nbsp;Christian Ahmad Wichmann ,&nbsp;Dominic Trepel","doi":"10.1016/j.ahr.2025.100234","DOIUrl":"10.1016/j.ahr.2025.100234","url":null,"abstract":"<div><h3>Background</h3><div>Multimorbidity (having two or more comorbidities), is common among people with dementia and associated with lower survival and increased healthcare use. We aimed to identify comorbidity clusters in people living with Alzheimer’s disease (AD) dementia in the UK, describe comorbidity-cluster prevalence and patterns, and estimate associations of clusters with healthcare resource utilisation (HCRU) and costs.</div></div><div><h3>Methods</h3><div>This was a cohort study using Discover dataset (electronic health records from approximately 2.8 million North-West London residents). We identified individuals with AD dementia using diagnostic codes, and estimated HCRU and total healthcare costs (including primary and hospital-based care). Individuals were grouped based on comorbidity profile using k-medoids clustering. Multivariable modelling was used to estimate associations between comorbidity clusters and healthcare costs.</div></div><div><h3>Results</h3><div>Among 18,116 individuals with AD dementia, eight comorbidity clusters were identified. The three highest-cost clusters incurred mean costs per patient year(ppy) of £6355, £5560, and £5284 respectively. The highest-cost cluster had a high burden of comorbidities with the most prevalent: frailty (83.2 %), hypertension (81.8 %), type 2 diabetes mellitus (81.4 %), and chronic kidney disease (69.7 %). Costs in the three highest-cost clusters were 1.7 to 2.0 times higher than the lowest-cost cluster (mean cost £3160ppy), which featured the lowest overall comorbidity burden. The lowest median survival times were in the two highest-cost clusters. Cluster membership was strongly associated with costs even after adjusting for a wide range of demographic and clinical factors. Compared with the lowest-cost cluster the average marginal increases in costs for the clusters ranged between £1072 (95 %CI:£478-£1666) and £3531ppy (95 %CI: £2850-£4212).</div></div><div><h3>Conclusions</h3><div>HCRU and costs in individuals with AD dementia show notable differences, with a large proportion of costs attributable to a minority of individuals with multiple comorbidities (particularly cardiometabolic diseases and frailty). Health systems should ensure initiatives to improve timely diagnosis and treatment of people with AD taking account of the high multimorbidity prevalence in this population.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 2","pages":"Article 100234"},"PeriodicalIF":0.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual reality-based robotic training for lower limb rehabilitation in stroke patients with Hemiplegia: A pilot study","authors":"Lijing Chen ,&nbsp;Huanzhi Zhu ,&nbsp;Jing Wang ,&nbsp;Rongrong Lu ,&nbsp;Jing Tian ,&nbsp;Bei Wu ,&nbsp;Jing Chu ,&nbsp;Juan Li","doi":"10.1016/j.ahr.2025.100233","DOIUrl":"10.1016/j.ahr.2025.100233","url":null,"abstract":"<div><h3>Background</h3><div>More than half of stroke survivors suffer from movement disorders after receiving routine rehabilitation treatment. Evidence suggests that virtual reality (VR)-based robotic training for lower limb rehabilitation is a promising approach for improving motor function recovery.</div></div><div><h3>Methods</h3><div>A pilot open-label randomized controlled trial was conducted to explore the feasibility and preliminary effects of VR-based robotic training for lower limb rehabilitation in stroke patients with hemiplegia. We enrolled 42 stroke patients with hemiplegia, 21 received VR-based robotic training for lower limb rehabilitation and conventional rehabilitation treatment as the intervention, and 21 only received conventional rehabilitation treatment as the control.</div></div><div><h3>Results</h3><div>Forty participants completed the trial. We found a statistically significant difference in lower limb motor function scores from baseline to week 4 between the intervention and control group (mean difference (MD): 6.5 vs 3.3, <em>p</em>&lt;0.001). At week 4, participants in the intervention group demonstrated significant enhancements in balancing function, walking ability, activities of daily living, and quality of life (<em>p</em>&lt;0.05). However, the intervention group did not show a significant improvement in global cognitive function compared to the control group (MD: 3.8 vs 3.7, <em>p</em> = 0.873). No adverse events were observed during the trial.</div></div><div><h3>Conclusion</h3><div>The VR-based robotic training for lower limb rehabilitation showed promise in improving motor function, activities of daily living, and quality of life in stroke patients with hemiplegia. These preliminary findings support the feasibility of this approach and highlight the need for large-scale studies to validate its effectiveness.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 2","pages":"Article 100233"},"PeriodicalIF":0.0,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}