Aging and health research最新文献

{"title":"Advancements in TDP-43 research: Towards biomarkers and therapeutic targets for amyotrophic lateral sclerosis","authors":"Yuhan Wu ,&nbsp;Jie Wang ,&nbsp;Qianhua Zhao","doi":"10.1016/j.ahr.2024.100215","DOIUrl":"10.1016/j.ahr.2024.100215","url":null,"abstract":"<div><div>Amyotrophic lateral sclerosis (ALS) remains a devastating neurodegenerative disease characterized by progressive motor neuron degeneration, leading to paralysis and premature death. Despite advances in understanding its pathology, ALS diagnosis and treatment remain primarily symptomatic, lacking disease-specific biomarkers. TAR DNA-binding protein 43 (TDP-43) has emerged as a central player in ALS pathogenesis, undergoing pathological alterations including hyperphosphorylation, truncation, and cytoplasmic aggregation. This article reviews the physiological and pathological roles of TDP-43, its potential as a biomarker, and its candidacy as a therapeutic target. Challenges in detecting pathological forms of TDP-43 in biofluids hinder diagnostic advancements, yet recent research provides insights into its potential diagnostic and prognostic value. Moreover, ongoing efforts aim to develop targeted therapies, including genetic and proteostasis-based approaches, to mitigate TDP-43 pathology and its downstream effects. The article also discusses the need for novel animal models and antibodies to distinguish between pathological and physiological forms of TDP-43 for reliable biomarker development. Looking ahead, the article advocates for both linear and horizontal developments in TDP-43 research to advance ALS diagnosis, prognosis, and treatment paradigms.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 1","pages":"Article 100215"},"PeriodicalIF":0.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effect of smoking and education on incident dementia among older adults: The Shanghai aging study","authors":"Chengyin Xu ,&nbsp;Zhenxu Xiao ,&nbsp;Xiaowen Zhou ,&nbsp;Xiaoniu Liang ,&nbsp;Qianhua Zhao ,&nbsp;Ding Ding ,&nbsp;Wei Deng","doi":"10.1016/j.ahr.2024.100212","DOIUrl":"10.1016/j.ahr.2024.100212","url":null,"abstract":"<div><h3>Background</h3><div>The association between smoking and dementia incidence remains controversial, while education is considered a cognitive safeguard. This study aims to explore the joint effect of smoking and education on incident dementia.</div></div><div><h3>Methods</h3><div>We enrolled 1647 community-dwelling residents, and divided them into three groups: non-smoker (Smoking Index [SI, cigarette-years] = 0), mild-smoker (0 &lt; SI &lt; 265), and severe-smoker (SI ≥ 265). Their education was categorized to high or low level (formal education &gt; 9 or ≤ 9 years). Dementia diagnosis was established according to the Diagnostic and Statistical Manual of Mental Disorders IV. Cox proportional hazards models were used for the analysis, and three indicators of additive interaction between low education and severe smoking were calculated.</div></div><div><h3>Results</h3><div>We identified 167 cases (10.1 %) of incident dementia during the 8544.2 person-years of follow-up. After adjusting for age, gender, and APOE ε4, a multiplicative interaction between severe smoking and low education was observed (Hazard Ratio (HR) = 4.01, 95 % CI: 1.29-12.48, <em>P</em> = 0.017), as well as an additive interaction between the two risk factors, with Relative Excess Risk due to Interaction was 2.63 (<em>P</em> = 0.017), Attributable Proportion due to Interaction was 0.60 (<em>P</em> &lt; 0.001), and Synergy Index was 4.46 (<em>P</em> = 0.022), and compared to highly educated non-smokers, less educated severe smokers had a 3.38-fold increased risk of dementia (<em>HR</em> = 4.38, 95 %CI: 2.50-7.67, <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Severe smoking and low education may have synergistic effect on incident dementia. Targeted tobacco control interventions are crucial for dementia prevention.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 1","pages":"Article 100212"},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting digital inclusion through public-private partnerships for older adults in Nigeria: A review","authors":"Judith Ifunanya ANI,&nbsp;Kezia Batisai","doi":"10.1016/j.ahr.2024.100211","DOIUrl":"10.1016/j.ahr.2024.100211","url":null,"abstract":"<div><div>In the face of global demographic shifts and rapid digitalization, ensuring digital inclusion for the aging population is imperative. Projected to reach 1.5 billion by 2050, older adults stand at the intersection of societal challenges and digital opportunities. The review emphasizes the multifaceted role of digital inclusion, aligning with the World Health Organization's Global Strategy on Ageing and Health and supporting Sustainable Development Goals 3, 4, and 10. Despite the potential benefits, the digital divide persists in developing countries like Nigeria, accentuated by limited technology access. Urgent research is needed to understand technology acceptance among older adults, highlighting the necessity for public-private partnerships to bridge these gaps. The comprehensive approach advocates for inclusive policies, technological advancements, and collaborative efforts, ensuring older adults are not left behind in the evolving digital landscape.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 4","pages":"Article 100211"},"PeriodicalIF":0.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142664089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assistance with oral hygiene care among family dementia caregivers in Chinese American Communities in New York City","authors":"Weiyu Mao ,&nbsp;Bei Wu ,&nbsp;Yaolin Pei","doi":"10.1016/j.ahr.2024.100210","DOIUrl":"10.1016/j.ahr.2024.100210","url":null,"abstract":"<div><h3>Background</h3><div>Oral hygiene care is instrumental to maintaining optimal oral health. As dementia progresses, individuals face challenges performing adequate oral hygiene care and become dependent on their caregivers. The role of family caregivers in assisting with oral hygiene care becomes increasingly critical. This study explored the association between caregiving circumstances, care recipient characteristics, and assistance in oral hygiene care among dementia caregivers in Chinese American communities.</div></div><div><h3>Methods</h3><div>Data came from a pilot study on Chinese dementia caregivers in New York City collected between November 2021 and June 2022. Purposive sampling was used to recruit family caregivers to participate in a survey (online or via telephone). Current caregivers (<em>n</em> = 76) were included. Caregiver assistance with oral hygiene care was measured by assistance with toothbrushing (yes or no) and assistance with flossing (yes or no). Descriptive analyses, group comparisons, and logistic regressions were conducted.</div></div><div><h3>Results</h3><div>Female caregivers tended to assist with toothbrushing. Caregivers with an average of 2.4 years in providing care tended to assist with flossing. Care recipients with tooth pain were 5.12 times more likely to receive assistance with toothbrushing. Care recipients with more natural teeth were 1.07 times more likely to receive assistance with toothbrushing. Care recipients with severe dementia were 94 % less likely to receive assistance with flossing.</div></div><div><h3>Conclusions</h3><div>The findings underscore the importance of understanding the factors that influence caregivers’ assistance with oral hygiene care. This study is a crucial first step toward developing effective, caregiver-led interventions to improve the oral hygiene of individuals with dementia.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 1","pages":"Article 100210"},"PeriodicalIF":0.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing biological information and mood for video exercise and intervention exercise in older adults a pilot study","authors":"Yutaka Yoshida ,&nbsp;Yoshifumi Moriyama ,&nbsp;Hiroyuki Sakano ,&nbsp;Tomoki Ando ,&nbsp;Emi Yuda","doi":"10.1016/j.ahr.2024.100208","DOIUrl":"10.1016/j.ahr.2024.100208","url":null,"abstract":"<div><h3>Background</h3><div>Light exercise for older adults is effective in preventing dementia and maintaining independent living. However, difference in effectiveness between person supported intervention exercise and exercise by video watching is not clear. In this study, we compare these differences using biological information and subjective evaluation by Profile of Mood States (POMS).</div></div><div><h3>Methods</h3><div>Participants were 10 older adults in the healthy group (aged 69±5 years) and 5 in the musculoskeletal disease group (aged 72±7 years). Each participant performed 30 min of video exercise on the first day and 30 min of intervention exercise the next day. Biological information such as pulse rate, physical activity, skin temperature and conversation time were measured during the exercise using a wearable sensors. Subjective evaluation by POMS was performed before and after exercise. In addition, psychomotor vigilance test was performed and reaction time of fingertips was measured before and after exercise.</div></div><div><h3>Results</h3><div>In both groups, physical activity was significantly decreased with intervention exercise (<em>P</em> &lt; 0.01), and conversation time was significantly increased with intervention exercise (<em>P</em> &lt; 0.01). In the healthy group, skin temperature decreased significantly with both exercise therapies (<em>p</em> &lt; 0.01). Especially, video exercise decrease skin temperature more than intervention exercise. Reaction time of fingertip became significantly faster after intervention exercise in the healthy group (<em>P</em> &lt; 0.05). POMS results showed that intervention exercise resulted in significantly more positive mood.</div></div><div><h3>Conclusions</h3><div>Resistance training using elastic tubes as an intervention exercise is effective in preventing a decrease in skin temperature and improving fingertip reaction time in the healthy older adults. Intervention exercise is effective in improving mood of older adults, moreover it is suggested that intervention and conversation during the exercise may have an effect on improving mood.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 4","pages":"Article 100208"},"PeriodicalIF":0.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive syndrome, cognitive impairment, and associated factors among community-dwelling aged persons in Cameroon","authors":"Gustave Mabiama ,&nbsp;Dieudonné Adiogo ,&nbsp;Pierre Marie Preux ,&nbsp;Jean-Claude Desport ,&nbsp;Philippe Fayemendy ,&nbsp;Pierre Jésus","doi":"10.1016/j.ahr.2024.100209","DOIUrl":"10.1016/j.ahr.2024.100209","url":null,"abstract":"<div><h3>Background</h3><div>Depressive syndrome (DS) and cognitive impairment (CI) are associated with unsuccessful aging. However, little is known about Cameroon. This study aimed to assess the factors associated with DS and CI among older adults in Cameroon.</div></div><div><h3>Methods</h3><div>A representative sample of 599 individuals aged ≥ 60 years was selected for this cross-sectional study. Sociodemographic and health data were also collected. DS and CI were assessed using the Center for Epidemiologic Studies-Depression Scale (CES-D) and Mini-Mental State Examination (MMSE), respectively. The Rosow Mobility Scale, Activities of Daily Living (ADL), and Instrumental Activities of Daily Living (IADL) scales were used to evaluate functional abilities. Chi-2, ANOVA, and multiple regression analyses were performed to assess the factors associated with DS and CI. The threshold of statistical significance was 5 %.</div></div><div><h3>Results</h3><div>The average age was 68.9 ± 7.2 years, sex ratio M/<em>F</em> = 0.93, and weight 68.5 ± 14.7 kg. DS affected 14.5 % of the population and the CI was 21.4 %. In the multivariate analysis, DS was positively associated with male gender (Odds Ratio (OR) = 1.7 [95 % Confidence Interval (CI):1.1–2.7], <em>p</em> = 0.031) and inactivity (OR = 1.7 [95 % CI:1.0–3.0], <em>p</em> = 0.043). CI was positively associated with lack of education (OR = 6.5 [95 % CI:3.5–12.2], <em>p</em> &lt; 0.001), inactivity (OR = 5.3 [95 % CI:1.6–17.9], <em>p</em> = 0.008), single (OR = 3.7 [95 % CI:1.2–11.3], <em>p</em> = 0.023), and widowhood (OR = 3.3 [95 % CI:1.6–6.5], <em>p</em> = 0.001), and negatively associated with no IADL (OR = 0.3 [95 % CI:0.2–0.6], <em>p</em> = 0.001) and ADL disability (OR = 0.5 [95 % CI:0.2–0.9], <em>p</em> = 0.032) limitations.</div></div><div><h3>Conclusions</h3><div>The associated factors suggest that it might be of interest to fight inactivity and encourage early and long-term education to prevent DS and/or CI among older adults.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 4","pages":"Article 100209"},"PeriodicalIF":0.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142664088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Canadian platform for research online to investigate health, quality of life, cognition, behaviour, function, and caregiving in aging (CAN-PROTECT): Study protocol, platform description, and preliminary analyses","authors":"Zahinoor Ismail ,&nbsp;Dylan X. Guan ,&nbsp;Daniella Vellone ,&nbsp;Clive Ballard ,&nbsp;Byron Creese ,&nbsp;Anne Corbett ,&nbsp;Ellie Pickering ,&nbsp;Adam Bloomfield ,&nbsp;Adam Hampshire ,&nbsp;Ramnik Sekhon ,&nbsp;Pamela Roach ,&nbsp;Eric E. Smith","doi":"10.1016/j.ahr.2024.100207","DOIUrl":"10.1016/j.ahr.2024.100207","url":null,"abstract":"<div><h3>Background</h3><div>: Preventing or reducing the risk of cognitive decline and dementia is of great public health interest. Longitudinal data from diverse samples are needed to properly inform clinicians, researchers, and policy makers. CAN-PROTECT is a recently launched online observational cohort study that assesses factors contributing to both risk for incident cognitive decline and dementia and resilience against brain aging, in participants across the lifespan.</div></div><div><h3>Methods</h3><div>: Measures of cognition, behaviour, and quality of life administered to both participants and study partners were compared using partial Spearman correlations adjusted for participant and study partner age, sex, and education. In participants, relationships between cognition, behaviour, function, and quality of life were examined using adjusted multivariable linear and negative binomial regression models.</div></div><div><h3>Results</h3><div>: In the first three-month window, 2150 participants spanning all Canadian provinces enrolled; 637 nominated study partners had already completed assessments. Engagement with the study was excellent, with many optional assessments completed. Initial analyses demonstrated relationships between cognition, behaviour, function, and quality of life.</div></div><div><h3>Discussion</h3><div>: These preliminary results speak to the utility and feasibility of CAN-PROTECT to obtain data relevant to brain health, highlighting the public interest in participating in studies on cognition. The online portal facilitated participation of a geographically diverse sample. This group is ideal to study brain aging, dementia prevention, and early detection of neurodegenerative disease. Longitudinal data will provide additional insights. Several features of CAN-PROTECT are important to consider in terms of assessing risk and resilience in Canadians, and for further development and recruitment of a research-ready cohort.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 4","pages":"Article 100207"},"PeriodicalIF":0.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142572946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the common genes involved in autism spectrum disorder and Parkinson's disease: A systematic review","authors":"Kanchan Bala ,&nbsp;Khadga Raj Aran","doi":"10.1016/j.ahr.2024.100206","DOIUrl":"10.1016/j.ahr.2024.100206","url":null,"abstract":"<div><div>Autism Spectrum Disorder (ASD) and Parkinson's disease (PD) are distinct neurodevelopmental disorders associated with distinct brain areas. ASD is characterized by delayed social communication skills and restricted repetitive behaviours. Conversely, PD is a progressive neurodegenerative disorder affecting basal ganglia, causing resting tremor, rigidity, postural instability, and bradykinesia. Both diseases share similarities in affected brain areas, including motor control and social behaviour. In both diseases, PARK2, SHANK3, SLC, RIT2, DRD2, and CD157/BST1 genes are involved by regulating synaptic function and dopamine neurons. Mutations in PARK2, an E3 ubiquitin ligase, can lead to dysfunctional mitophagy, causing the accumulation of damaged mitochondria and contributing to neuronal cell death, a hallmark of PD. PARK2 pathway disruptions have also been observed in some individuals with ASD, which are involved in tagging damaged or unwanted proteins for degradation, leading to the accumulation of misfolded or dysfunctional proteins that may contribute to neurodevelopmental abnormalities. PINK1 is crucial for maintaining mitochondrial quality and eliminating dysfunctional ones that produce reactive oxygen species (ROS). Mutations in this gene lead to damaged mitochondria and increased ROS production, contributing to neurodegeneration in dopamine-producing neurons. This review highlighted the various genes involved in pathogeneses of ASD and PD with their future implications.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 4","pages":"Article 100206"},"PeriodicalIF":0.0,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are physical activity and everyday mobility independently associated with quality of life at older age?","authors":"Jane Elliott ,&nbsp;Judith Green","doi":"10.1016/j.ahr.2024.100204","DOIUrl":"10.1016/j.ahr.2024.100204","url":null,"abstract":"<div><h3>Background</h3><p>Physical activity and everyday mobility are concepts that overlap but tend to be located in different disciplinary fields. We used the English Longitudinal Study of Ageing (ELSA) to: identify whether physical activity and everyday mobility are separate constructs at younger (60–69) and/or older (&gt;=70) age bands, and for men and women; derive measures of the two constructs from variables in the ELSA; and assess whether they are independently associated with quality of life (QoL).</p></div><div><h3>Methods</h3><p>We derived composite measures for physical activity and everyday mobility from ELSA variables. ‘Physical Activity’ combined items recording directly-measured activity for movement (walk-speed) and self-report measures of physical mobility difficulties and amount of vigorous, moderate and mild physical activity undertaken. ‘Everyday Mobility’ combined self-report responses about activities likely to involve leaving the house. QoL was measured using the ‘CASP-19′ scale. Using Wave 9 of ELSA (data collection in 2018–2020), we used a factor analysis to explore the constructs, and a regression analysis to examine associations with QoL.</p></div><div><h3>Results</h3><p>The factor analysis confirmed that these were discrete constructs, which explained between them 36% of the variance. This was robust across age bands, and in factor analyses for men and women separately. The regression analysis identified that lower physical activity and everyday mobility are independently associated with lower QoL, when controlling for a range of contextual variables including age.</p></div><div><h3>Conclusions</h3><p>Findings suggest that a social model of QoL at older age should focus on the broader mobility determinants of QoL as well as individual levels of physical activity.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 3","pages":"Article 100204"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032124000258/pdfft?md5=7f861c845abfba84a8064d01e80b7c6c&pid=1-s2.0-S2667032124000258-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142148432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping research landscapes on frailty in stroke from 2001 to 2023: A bibliometric analysis","authors":"Qinqin Liu ,&nbsp;Jian Du ,&nbsp;Yongmei Bai ,&nbsp;Huaxin Si ,&nbsp;Yaru Jin ,&nbsp;Cuili Wang","doi":"10.1016/j.ahr.2024.100205","DOIUrl":"10.1016/j.ahr.2024.100205","url":null,"abstract":"<div><h3>Background</h3><p>Frailty and stroke are strongly related to the health of older people. This study aimed to map the research hotspots and frontiers, as well as quantitatively and comprehensively characterize the landscapes of publications on frailty in stroke over past decades.</p></div><div><h3>Methods</h3><p>The articles and reviews related to frailty in stroke, published from 2001 to 2023 were retrieved in the Web of Science Core Collection. CiteSpace and VOSviewer were used to identify the research hotspots, research frontiers, and the basic characteristics (such as top countries, institutions, journals and keywords) in this field.</p></div><div><h3>Results</h3><p>The publications’ growth rate on frailty in stroke was increasing over time. Four research hotspot clusters (geriatric syndrome, adverse outcomes prediction, cognitive function and mental health, as well as cardiovascular diseases management) were identified for frailty in stroke research over the past decades. The burst detection analysis showed that recovery, body mass index and oropharyngeal dysphagia were the research trends.</p></div><div><h3>Conclusion</h3><p>These findings will help scholars better understand current research progress and predict future directions related to frailty in stroke. Health providers could pay close attention to the development of scientific research in this field to maintain good health status of older people by geriatric care delivery.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 3","pages":"Article 100205"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266703212400026X/pdfft?md5=0422cdba71392bc0d1ffb46cb1f5bdfd&pid=1-s2.0-S266703212400026X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}