Aging and health research最新文献

{"title":"Tooth loss and physical function among older adults related to race and ethnicity in Hawai‘i: A cross-sectional study from 2014 to 2020","authors":"Wei Zhang ,&nbsp;Yan Yan Wu ,&nbsp;Fran C. Woodworth ,&nbsp;Deborah J. Mattheus","doi":"10.1016/j.ahr.2025.100228","DOIUrl":"10.1016/j.ahr.2025.100228","url":null,"abstract":"<div><h3>Background</h3><div>Oral health and functional limitations are major health concerns among aging populations in the U.S. and globally. Although the relationship between tooth loss and physical disabilities is well documented, less is known about the role of race and ethnicity in this association. This study examined the association between tooth loss and ADL (activities of daily living) limitations across various racial/ethnic groups in Hawai‘i.</div></div><div><h3>Methods</h3><div>We examined severe tooth loss and functional limitations in relation to sociodemographic factors, including race/ethnicity, using four waves of data from the Hawaiʻi Behavioral Risk Factor Surveillance System collected between 2014 and 2020. Weighted Poisson regression was used to estimate the unadjusted and adjusted prevalence ratio of severe tooth loss and functional limitations.</div></div><div><h3>Results</h3><div>There was a significant association between severe tooth loss and the prevalence of ADL limitations among older adults in Hawai‘i. Notably, this association varied by race/ethnicity: After adjusting for sociodemographic covariates, it was stronger among White, Native Hawaiian, and Japanese respondents compared to Filipinos.</div></div><div><h3>Conclusions</h3><div>These results suggest that the relationship between severe tooth loss and physical decline is differentiated by race/ethnicity, and that socioeconomic variables (including education and income) play a complicated role in the association. Awareness of the unique challenges and inequities faced by older racially/ethnically marginalized populations is critical for policymakers to develop strategies to achieve health equity, which must entail addressing these interrelated health problems and their structural determinants at every level.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 2","pages":"Article 100228"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent validity of quantitative upper extremity function tests in Parkinson's disease: 9HPT, MDS-UPDRS, and MAM-36","authors":"Narges Azari Jafari,&nbsp;Reza Daneshvar Kakhki,&nbsp;Mohammad Shahab Shafaei","doi":"10.1016/j.ahr.2025.100225","DOIUrl":"10.1016/j.ahr.2025.100225","url":null,"abstract":"","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 2","pages":"Article 100225"},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical profile of heart failure in geriatric patients in a tertiary cardiac hospital of Bangladesh","authors":"Mahbuba Yesmin ,&nbsp;Lutfun Nahar Nizhu ,&nbsp;Afroja Alam ,&nbsp;Abdullah Al Mamun","doi":"10.1016/j.ahr.2025.100227","DOIUrl":"10.1016/j.ahr.2025.100227","url":null,"abstract":"<div><div>This study included 100 geriatric patients admitted at National Institute of Cardiovascular Diseases (NICVD) in Bangladesh having clinical features of heart failure, possible other information (Framingham Criteria) and increase in natriuretic peptide or echocardiographic findings. It was a single center, cross sectional study. Regarding functional NYHA classification, 14 % presented with class I, 30 % with class II, 35 % presented with class III, 21 % presented with class IV heart failure.</div><div>Regarding left ventricular ejection fraction (LVEF), heart failure (HF) was classified into the following categories: (1) HF with reduced EF (HFrEF) - 19 %; (2) HF with improved EF (HFmpEF) - 13 %; (3) HF with mildly reduced EF (HFmrEF) - 22 % and (4) HF with preserved EF (HFpEF) - 46 % . 23 % of the study population had iron deficiency anemia and about one-third-patient had associated renal failure (AKI/CKD). This study revealed that a significant geriatric population has unrecognized heart failure (HFpEF).</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 2","pages":"Article 100227"},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology","authors":"Vipul Sharma,&nbsp;Khadga Raj Aran","doi":"10.1016/j.ahr.2025.100226","DOIUrl":"10.1016/j.ahr.2025.100226","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is the most prevalent progressive neurodegenerative disease often characterized by memory loss, cognitive decline, and behavioral changes. The actual pathophysiology of AD remains unclear, but several factors including genetic, environmental, and lifestyle contribute significantly to the pathogenesis of AD. Even after over two decades of combined efforts to create novel interventions that can retard the progress of the disease, researchers still only have a small number of alternate medicines with poor efficacy. There is a recent growth of interest in the role of nutrients in brain health as we learn more about what nutrients are and how they impact hormonal and neurological processes that can result in a variety of neurological and psychiatric conditions. Additionally, deficiency of vitamins also gained attention for their pivotal roles in cognitive health. Vitamins, a crucial dietary supplement, regulate various physiological functions and maintain neuronal health, energy metabolism, and antioxidant defence. Vitamin B, such as B1, B6, and B12, are chief constituents for the metabolism of homocysteine and the release of neurotransmitters, a decrease in vitamin E and D may result in increased oxidative damage, which further contributes to neuronal loss. Vitamin deficiencies may make AD degenerative processes more severe as increased amyloid-beta (Aβ) plaque development and tau protein phosphorylation, are two characteristics of AD. This review explores a comprehensive summary of the most widely used vitamins and discusses the findings of recent research on the relationship between these vital micronutrients and AD.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 2","pages":"Article 100226"},"PeriodicalIF":0.0,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is height loss in adulthood associated with health in later life among the 1946 UK Birth Cohort (NSHD) participants?","authors":"Katarina L. Matthes,&nbsp;Kaspar Staub","doi":"10.1016/j.ahr.2025.100224","DOIUrl":"10.1016/j.ahr.2025.100224","url":null,"abstract":"<div><h3>Background</h3><div>Height increases as a product of physical growth until adulthood, then is stable between the ages of 20 and about 40, after which most people lose height as they biologically age. The aim of the present study was to investigate the relationship between height in childhood and relative height loss in adulthood, and to examine the association between height loss and health at older age.</div></div><div><h3>Methods</h3><div>Data from one of the oldest ongoing cohort studies, the National Survey of Health and Development (NSHD, 1946 UK Birth Cohort) were analysed. In total, 2,119 study participants were included who completed the nurse home visit during the 24^th and most recent available follow-up examination at age 69. Linear regression models were used to estimate the association between measured height in childhood years relative height loss between ages 36 and 69. Logistic regression models using generalized additive models were calculated to estimate the probability of worse health at age 69 (chronic disease score, general health status, osteoarthritis, and pain while walking) in association with height loss.</div></div><div><h3>Results</h3><div>Between the ages of 36 and 69, men lost an average of 2.0 cm and women 2.4 cm. Women lost significantly more height than men (<em>p</em> &lt; 0.001). The taller the participants were at a young age, the more height they lost in adulthood. There was a significant association between height loss in adulthood and general health, chronic disease score (in men), osteoarthritis (in men), and walking pain at age 69. These findings largely persisted after adjusting the models for overweight, sociodemographic information, and lifestyle factors earlier in life.</div></div><div><h3>Conclusions</h3><div>Height loss seems to be associated with deteriorating health as people age. Height measurement and assessment of height loss could potentially be part of regular examinations after the age of 40 to monitor general health status, especially in the case of severe height loss.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 1","pages":"Article 100224"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143562208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventions of cognitive impairment in older adults: A comprehensive review","authors":"Shivani Chib,&nbsp;Kajal Sharma,&nbsp;Randhir Singh","doi":"10.1016/j.ahr.2025.100223","DOIUrl":"10.1016/j.ahr.2025.100223","url":null,"abstract":"","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 1","pages":"Article 100223"},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Minds in Motion, a fitness program for people living with dementia and their caregivers","authors":"Pria Nippak ,&nbsp;Jocelyn Badali ,&nbsp;Julien Meyer ,&nbsp;Housne Begum ,&nbsp;Nalini Sen ,&nbsp;Mya Rana-Nippak","doi":"10.1016/j.ahr.2025.100222","DOIUrl":"10.1016/j.ahr.2025.100222","url":null,"abstract":"<div><h3>Background</h3><div>Fitness is associated with better physical and mental outcomes in people living with dementia (PWD). This study evaluated Minds in Motion, a program designed to improve the physical fitness of PWD and their care partners (CP).</div></div><div><h3>Method</h3><div>Participants completed an 8-week program combining exercise and mindfulness recreational activities. Data were collected through a retrospective mixed-method design. Participants, staff, and volunteers completed data collection.</div></div><div><h3>Results</h3><div>Participants experienced significant improvements in chair stands (+12.9%), bicep curls (+17.2%), and 8 feet up &amp; go (+10.5%) but not in the chair sit and reach exercise. Almost all of the participants (99%) enjoyed the program and staff and volunteers (99%) self-reported improvement in their skills in working with people with dementia, with a strong reduction in the proportion of staff and volunteers disclosing “very limited skill” in dealing with PWD, from 15 to 18% to 9–12% of respondents.</div></div><div><h3>Conclusion</h3><div>This study, as an extension of the pilot, concluded that Minds in Motion program had a positive impact on PWD and CP's physical functioning following the program fitness training combined with mindfulness recreational activities, which aligned with their reported program satisfaction. The “sit and reach” exercise, may not be appropriate for them. Together, these findings highlight how fitness programs can assist PWD and CP with improved functioning through strength building.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 1","pages":"Article 100222"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premorbid and current intellectual performance reflects different backgrounds in patients with Parkinson's disease","authors":"Hidetomo Murakami,&nbsp;Machiko Kezuka,&nbsp;Junnosuke Ozawa,&nbsp;Kaoru Matsuoka,&nbsp;Tatsuya Nakanishi,&nbsp;Atsushi Ishida,&nbsp;Naohito Ito,&nbsp;Mizuki Kanemoto,&nbsp;Mitsuru Kawamura","doi":"10.1016/j.ahr.2025.100221","DOIUrl":"10.1016/j.ahr.2025.100221","url":null,"abstract":"<div><h3>Background</h3><div>There is growing interest in targeting Parkinson's Disease (PD) at an earlier stage, especially before emergence of motor symptoms. Cognitive dysfunction is a non-motor symptom in PD, whereas the Japanese version of the National Adult Reading Test (JART) is a validated battery to estimate the premorbid intellectual quotient (IQ). Therefore, the results of JART and current cognitive assessment after onset of PD may reflect different background factors. The goal of the study was to compare factors correlated with estimated premorbid intellectual performance using JART and current cognitive function after onset of PD.</div></div><div><h3>Methods</h3><div>Current motor symptoms (Unified Parkinson's Disease Rating Scale; UPDRS Part III) and cognitive function (Montreal Cognitive Assessment; MoCA) were assessed in 48 patients with PD. Premorbid IQs (verbal IQ: VIQ, performance IQ: PIQ, and full scale IQ: FIQ) were estimated using JART. Spearman correlation coefficients were calculated for background factors (current age, years of education, UPDRS Part III, and levodopa equivalent dose of prescribed drugs (LED)) with MoCA scores and estimated IQs.</div></div><div><h3>Results</h3><div>Estimated VIQ (<em>r</em> = 0.451, <em>p</em> = 0.001), PIQ (<em>r</em> = 0.445, <em>p</em> = 0.002) and FIQ (<em>r</em> = 0.453, <em>p</em> = 0.001) were significantly correlated with years of education that was fixed until adolescence (i.e. 20 s). MoCA was significantly correlated with current age (<em>r</em>=−0.401, <em>p</em> = 0.005) and UPDRS part III (<em>r</em>=−0.374, <em>p</em> = 0.009), both of which continue to progress gradually after onset of PD. In multiple regression analyses, these correlations were significant and independent.</div></div><div><h3>Conclusion</h3><div>Premorbid and current intellectual performance reflect different background factors in patients with PD.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 1","pages":"Article 100221"},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143204997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline shock index and baroreflex function in older adults","authors":"Kenneth M. Madden ,&nbsp;Boris Feldman ,&nbsp;Graydon S. Meneilly","doi":"10.1016/j.ahr.2025.100220","DOIUrl":"10.1016/j.ahr.2025.100220","url":null,"abstract":"<div><div>Elevations in shock index (SI), defined as heart rate (HR)/systolic blood pressure (BP) are less discriminative of impending shock in older adults. We hypothesized baroreflex dysfunction as a potential explanation for lower baseline SI in older adults. 52 older adults (29 women, 23 men, age ≥ 65; mean age 77.8 ± 0.9 years) were recruited. SI, the modified shock index (MSI, HR/mean BP), and the age corrected SI (Age * SI) as well as baroreflex function (using the sequence method) was measured at baseline. SI (Standardized <strong>β</strong> = 0.392, <em>p</em> = 0.005), MSI (Standardized <strong>β</strong> = 0.385, <em>p</em> = 0.006) and Age * SI (Standardized <strong>β</strong> = 0.431, <em>p</em> = 0.002) showed significant positive associations with BRS_up. Age * SI also showed a significant positive association with BRS (Standardized <strong>β</strong> = 0.329, <em>p</em> = 0.019). Autonomic dysfunction is associated with lower SI in older adults, potentially masking circulatory instability.</div><div>ClinicalTrials.gov ID <span><span>NCT01914133</span><svg><path></path></svg></span></div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 1","pages":"Article 100220"},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The deprivation cascade hypothesis of dementia","authors":"Timothy Daly","doi":"10.1016/j.ahr.2024.100219","DOIUrl":"10.1016/j.ahr.2024.100219","url":null,"abstract":"<div><div>There are significant disparities in dementia risk and care burden in the global population. This review provides evidence of the effects of deprivation, understood as the absence of environmental resources required for brain health. Deprivation increases dementia risk and care burden due to biological, environmental, and social dimensions of risk. It is hypothesized that the major mediator between deprivation and dementia is reduced educational and professional attainment. It argues for structural interventions centered around improved attainment, particularly for girls and women across the globe, improved funding for primary and social care, and a rights-based approach to brain health to improve access to these resources and thereby reduce dementia disparities.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 1","pages":"Article 100219"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}