Associations between traditional Chinese medicine body constitution and cardiovascular disease risk in a white population

Aging and health research Pub Date : 2025-05-15 DOI:10.1016/j.ahr.2025.100235

Lihua Shu , Xiaoling Yin , Xiangzhu Zhu , Jing Zhao , Xinqing Deng , Yevheniy Eugene Shubin , Harvey J. Murff , Reid M. Ness , Chang Yu , Martha J. Shrubsole , Qi Dai

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Abstract

Background

Traditional Chinese medicine (TCM) has guided generations of practice on disease treatment and health maintenance. The TCM principles include the framework of body constitution. However, no study has assessed the body constitution in US population.

Methods

This is an ancillary study of the Personalized Prevention of Colorectal Cancer Trial which was conducted in US during 2012–2016. 191 white participants were evaluated for body constitution type using a self-administered Traditional Chinese Medicine Questionnaire (English version). The body constitution subtypes and cardiovascular disease (CVD) risk were assessed.

Results

Fifty-seven (29.8 %) were identified as balanced constitution (BC), while Blood-stasis (17.3 %), Qi-deficient (13.6 %), and inherited-special constitutions (10.5 %) were the pre-eminent pathologic subtypes. Additional analyses investigated the relationship between CVD risk and body constitution subtypes. No major types of TCM body constitution were associated with the general cardiovascular risk score and other CVD biomarkers.

Conclusions

It is important to understand the underlying mechanisms contributing to the differences by population, which may not only help to understand the underlying mechanism for TCM, but also help to identify novel factors or mechanisms for CVD risk, prevention and treatment.

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中医体质与白人心血管疾病风险的关系

中医在疾病治疗和养生方面指导了几代人的实践。中医原则包括身体构造的框架。然而，还没有研究评估过美国人的体质。方法：本研究是2012-2016年在美国进行的结直肠癌个性化预防试验的辅助研究。采用自填中医问卷（英文版）对191名白人受试者进行体质类型评估。评估身体体质亚型和心血管疾病（CVD）风险。结果平衡型体质（BC） 57例（29.8%），血瘀型（17.3%）、气虚型（13.6%）和遗传性特殊型（10.5%）为主要病理亚型。其他分析调查了心血管疾病风险与身体体质亚型之间的关系。中医体质的主要类型与一般心血管危险评分和其他CVD生物标志物无关。结论了解造成人群差异的潜在机制是重要的，这不仅有助于了解中医的潜在机制，而且有助于发现心血管疾病危险、预防和治疗的新因素或机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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