Aging and health research最新文献_第2页

Increased white matter hyperintensities on MRI in autosomal dominant familial compared to sporadic Alzheimer’s disease 常染色体显性家族性阿尔茨海默病与散发性阿尔茨海默病相比，MRI上白质高强度增加

IF 2

Aging and health research Pub Date : 2025-07-18 DOI: 10.1016/j.ahr.2025.100255

Alice Accorroni , Maggie R Fraser , Phoebe Walsh , Antoinette O’Connor , M Jorge Cardoso , Llwyd Prosser , Nick C Fox , Carole H Sudre , Natalie S Ryan

{"title":"Increased white matter hyperintensities on MRI in autosomal dominant familial compared to sporadic Alzheimer’s disease","authors":"Alice Accorroni , Maggie R Fraser , Phoebe Walsh , Antoinette O’Connor , M Jorge Cardoso , Llwyd Prosser , Nick C Fox , Carole H Sudre , Natalie S Ryan","doi":"10.1016/j.ahr.2025.100255","DOIUrl":"10.1016/j.ahr.2025.100255","url":null,"abstract":"<div><h3>Background</h3><div>White matter hyperintensities (WMH) on MRI may be observed in autosomal dominant familial Alzheimer’s disease (FAD) and sporadic AD (SAD), however, studies comparing WMH burden between these two groups are lacking.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, we evaluated global and local differences in WMH severity on MRI in 19 individuals with symptomatic FAD due to <em>Presenilin 1</em> mutations, 20 individuals with young-onset SAD and 19 healthy individuals, controlling for age, cerebrovascular risk factors (CVR) and <em>APOE</em>ε4 carrier status. Relationships between WMH, grey matter (GM) volumes and neuropsychological tests (NPT) were also investigated.</div></div><div><h3>Results</h3><div>Despite their young age and minimal CVR, the FAD group had higher WMH load in all areas considered, apart from juxta-cortical and periventricular layers when compared to the SAD group. The increased lobar WMH load observed in FAD was not influenced by <em>APOEε4</em> genotype or CVR. No significant associations were found between WMH and GM volumes or NPT in either AD group.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that WMH may reflect aspects of AD pathology that are particularly prominent in FAD. Notably, in our study, WMH were not simply attributable to CVR, <em>APOEε4</em> carrier status, or GM atrophy, but may instead represent independent features of the disease.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100255"},"PeriodicalIF":2.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Practical approaches to lifestyle interventions for enhancing brain health in older adults: A selective narrative review 生活方式干预增强老年人大脑健康的实用方法：选择性叙述回顾

Aging and health research Pub Date : 2025-07-17 DOI: 10.1016/j.ahr.2025.100258

Raymond L Ownby , Joshua Caballero

{"title":"Practical approaches to lifestyle interventions for enhancing brain health in older adults: A selective narrative review","authors":"Raymond L Ownby , Joshua Caballero","doi":"10.1016/j.ahr.2025.100258","DOIUrl":"10.1016/j.ahr.2025.100258","url":null,"abstract":"<div><h3>Background</h3><div>As the prevalence of Alzheimer’s disease and other dementias increases worldwide, it is increasingly important to help middle-aged and older adults develop brain health lifestyles.</div></div><div><h3>Method</h3><div>We conducted a selective review of studies on the use of shared decision-making, psychoeducation, and behavior change techniques to promote healthy behaviors in adults. We then synthesized results into a model that can be implemented in clinical practice to promote brain healthy lifestyles.</div></div><div><h3>Results</h3><div>Selected research supports the usefulness of these techniques in promoting health behaviors. The integrative model allows us to generate specific hypotheses about implementation strategies, testing of which could help in the development of a practical intervention.</div></div><div><h3>Conclusions</h3><div>Shared decision-making, psychoeducation, and behavior change techniques each could provide valuable support for individuals’ efforts at developing brain health lifestyles. The integrative model proposed here may be useful in generating specific hypotheses that can be tested in the process of developing an intervention that could be clinically implemented.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100258"},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polypharmacy and deprescribing among geriatric patients 老年患者的综合用药和处方化

Aging and health research Pub Date : 2025-07-17 DOI: 10.1016/j.ahr.2025.100256

Nokwanda Nhlanzeko Ngcobo

{"title":"Polypharmacy and deprescribing among geriatric patients","authors":"Nokwanda Nhlanzeko Ngcobo","doi":"10.1016/j.ahr.2025.100256","DOIUrl":"10.1016/j.ahr.2025.100256","url":null,"abstract":"<div><h3>Background</h3><div>Polypharmacy is increasingly common among middle-aged and geriatric patients, raising concerns about overprescribing, adverse outcomes, and healthcare costs. While appropriate polypharmacy can improve clinical outcomes when tailored to individual needs, inappropriate use heightens risks such as adverse drug reactions, falls, frailty, non-adherence, and increased mortality.</div></div><div><h3>Methods</h3><div>This review synthesises current literature examining the impact of polypharmacy in older adults. It highlights evidence-based strategies aimed at promoting appropriate prescribing practices and mitigating the risks associated with multiple medication use.</div></div><div><h3>Results</h3><div>Evidence indicates that polypharmacy in the aging population contributes to treatment non-adherence, higher incidence of adverse events, and increased healthcare expenditures. The risk of harm escalates with the number of prescribed medications and underlying comorbidities. Interventions such as medication reviews, clinician education, patient counselling, deprescribing protocols, and adherence support have shown promise in reducing medication-related harm.</div></div><div><h3>Conclusion</h3><div>Addressing polypharmacy requires a multifaceted approach, including raising clinician awareness, promoting rational prescribing, and implementing patient-centred interventions. Emphasising appropriate polypharmacy and deprescribing can significantly reduce adverse outcomes and improve overall quality of care in geriatric populations.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100256"},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Addressing disparities in caregiver training for dementia in the philippines and beyond 解决菲律宾及其他国家在痴呆症护理人员培训方面的差异

Aging and health research Pub Date : 2025-07-16 DOI: 10.1016/j.ahr.2025.100257

John Patrick C. Toledo

引用次数: 0

Health security across the spectrum: Exploring the impact of socioeconomic factors on health insurance uptake in India 全面的卫生安全：探索社会经济因素对印度医疗保险吸收的影响

Aging and health research Pub Date : 2025-06-27 DOI: 10.1016/j.ahr.2025.100244

Madhubrota Chatterjee , Alok Aditya , Prashant Kumar Choudhary

{"title":"Health security across the spectrum: Exploring the impact of socioeconomic factors on health insurance uptake in India","authors":"Madhubrota Chatterjee , Alok Aditya , Prashant Kumar Choudhary","doi":"10.1016/j.ahr.2025.100244","DOIUrl":"10.1016/j.ahr.2025.100244","url":null,"abstract":"<div><h3>Background</h3><div>To ensure that healthcare services are accessible, health insurance is receiving increased amounts of attention in debates among health experts. The current disease pattern has increased the need for people to rely on intensive care, increasing both the cost of treatment and the frequency of accessing healthcare facilities. This paper aimed to examine the demographic, socio-economic, and health-related determinants of the choice to be insured with various types of health insurance schemes among older people in India.</div></div><div><h3>Methods</h3><div>We used data from the Longitudinal Ageing Study in India (LASI) Wave-1, 2017–2018, comprising individuals aged 45 years and above. Multinomial Logistic Regression was employed to examine the association between the socio-demographic, socio-economic, and health status of respondents and their choice of opting for different types of health insurance.</div></div><div><h3>Results</h3><div>The findings revealed that adults with multimorbid conditions were more likely to choose private insurance (RRR = 1.477, <em>p</em> < 0.01), while those currently working showed a higher preference for employer-based coverage (RRR = 2.184, <em>p</em> < 0.01). Individuals from poorer households were more inclined towards government insurance (RRR = 1.565, <em>p</em> < 0.01). Furthermore, higher education and urban residence increased the likelihood of employer and private insurance, while caste and regional differences reflected disparities in access and preference.</div></div><div><h3>Conclusion</h3><div>The findings indicated that health and economic conditions play a central role in shaping health insurance choices in India. It highlighted the importance of responsive and inclusive health policies that must address both medical needs and financial vulnerability in the ageing population.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100244"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of education and work on functional limitations in later life in cohorts affected by the Cultural Revolution and economic reform 教育和工作对受文化大革命和经济改革影响的人群晚年功能限制的影响

Aging and health research Pub Date : 2025-06-26 DOI: 10.1016/j.ahr.2025.100243

Chengming Han

{"title":"The effect of education and work on functional limitations in later life in cohorts affected by the Cultural Revolution and economic reform","authors":"Chengming Han","doi":"10.1016/j.ahr.2025.100243","DOIUrl":"10.1016/j.ahr.2025.100243","url":null,"abstract":"<div><h3>Background</h3><div>This study examines the moderation effect of work on education level in terms of functional limitations across different People’s Republic of China (PRC) cohorts born around 1949, who experienced the Cultural Revolution and economic reform.</div></div><div><h3>Methods</h3><div>Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS). Multilevel Tobit regression models were used to analyze the effects of education and work on functional limitations from 2011 to 2018 across cohorts. The interaction effects of education and work were used to examine how work moderates the effect of education level on functional limitations.</div></div><div><h3>Results</h3><div>Interrupted education during the Cultural Revolution decreased the proportion of PRC cohort members receiving college education. The protective effects of education were found only among those with rural jobs. In the late-PRC cohort, higher returns to education after the economic reform in China were associated with the effect of higher education level on functional limitations.</div></div><div><h3>Conclusion</h3><div>The Cultural Revolution and Economic Reform shaped the education and work for cohorts, which in turn, impact the functional limitations in later life.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100243"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neighborhood physical environment satisfaction and aging attitudes in older Chinese adults: Differences by chronic condition status 中国老年人邻里自然环境满意度与老龄态度：慢性病状态的差异

Aging and health research Pub Date : 2025-05-30 DOI: 10.1016/j.ahr.2025.100241

Zhijing Xu , Dan Zhao , Weiyu Mao , Jing Wang , Zhongfang Yang , Yaguang Zheng , Bei Wu

{"title":"Neighborhood physical environment satisfaction and aging attitudes in older Chinese adults: Differences by chronic condition status","authors":"Zhijing Xu , Dan Zhao , Weiyu Mao , Jing Wang , Zhongfang Yang , Yaguang Zheng , Bei Wu","doi":"10.1016/j.ahr.2025.100241","DOIUrl":"10.1016/j.ahr.2025.100241","url":null,"abstract":"<div><h3>Background</h3><div>With China’s aging population and rising prevalence of chronic conditions, it is crucial to understand the factors shaping aging attitudes. Satisfaction with the neighborhood physical environment may play an important role, particularly among those with chronic health issues. To examine the association between neighborhood physical environment satisfaction and aging attitudes among older Chinese adults, and to explore differences across groups with and without chronic conditions.</div></div><div><h3>Methods</h3><div>We analyzed data from 11,395 participants aged 60 and above from the 2020 China Longitudinal Aging Social Survey (CLASS). Stratified multiple regression analyses were conducted, comparing subgroups with chronic conditions (<em>n</em> = 8405, 73.76 %) and without chronic conditions.</div></div><div><h3>Results</h3><div>Among participants with chronic conditions, higher satisfaction with road conditions (β = 0.382, <em>P</em> = 0.001), environmental sanitation (β = 0.286, <em>P</em> = 0.007), and road/street lighting (β = 0.288, <em>P</em> = 0.005) was significantly associated with more positive attitudes toward aging. No significant associations were found among participants without chronic conditions.</div></div><div><h3>Conclusions</h3><div>Age-friendly neighborhood environments are important for promoting positive aging attitudes, particularly among older adults living with chronic conditions. These findings offer valuable insights for policymakers, researchers, and service providers aiming to support healthy aging in rapidly aging societies like China.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100241"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144196351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between adverse childhood experiences and frailty among middle-aged and older adults in Rural South Africa 不良童年经历与南非农村中老年人身体虚弱之间的关系

Aging and health research Pub Date : 2025-05-29 DOI: 10.1016/j.ahr.2025.100242

Shengruo Zhang , Markus J. Haapanen , Mengyao Wang , Hao Xiang , Hanzhang Xu , Chenkai Wu

{"title":"The association between adverse childhood experiences and frailty among middle-aged and older adults in Rural South Africa","authors":"Shengruo Zhang , Markus J. Haapanen , Mengyao Wang , Hao Xiang , Hanzhang Xu , Chenkai Wu","doi":"10.1016/j.ahr.2025.100242","DOIUrl":"10.1016/j.ahr.2025.100242","url":null,"abstract":"<div><h3>Background</h3><div>Adverse childhood experiences (ACEs) negatively impact later physical and mental health. However, evidence is lacking in low- and middle-income countries. We examined the association between ACEs and frailty among middle-aged and older adults in rural South Africa.</div></div><div><h3>Methods</h3><div>We included 3825 respondents aged ≥40 years who participated in the survey, Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in rural South Africa (HAALSI). We included four ACEs: (1) parental unemployment for >6 months, (2) parents who argued or fought often, (3) parents who drank, did drugs, or had mental health problems, and (4) parental physical abuse. Frailty was measured by the Fried’s frailty phenotype approach using five criteria: slowness, weakness, exhaustion, inactivity, and shrinking. We assessed the independent association between each ACE and frailty using multinomial logistic regression.</div></div><div><h3>Results</h3><div>Having experienced parents arguing or fighting often was significantly associated with frailty (prevalence ratio [PR]=1.62, 95 %CI: 1.06–2.48). After adjusting for age and sex, we found a positive association between parents unemployed for 6 or more months and frailty (PR=1.48, 95 %CI: 1.00–2.19). People having two or more ACEs were positively associated with frailty in the unadjusted (PR=1.63, 95 %CI: 1.07–2.47) and adjusted models (PR=1.60, 95 %CI: 1.05–2.45) relative to those having only one ACE.</div></div><div><h3>Conclusions</h3><div>ACEs were associated with a higher burden of frailty among middle-aged and older adults in rural South Africa. Future studies utilizing individual-centered statistical techniques such as cluster analysis and latent class analysis might be considered to offer a more in-depth understanding of the relationships between ACEs and frailty.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100242"},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of regional inequalities in long-term care on health spending: evidence from dementia patients in France 长期护理方面的地区不平等对卫生支出的影响：来自法国痴呆症患者的证据

Aging and health research Pub Date : 2025-05-28 DOI: 10.1016/j.ahr.2025.100239

Anne Penneau , Zeynep Or

{"title":"Impact of regional inequalities in long-term care on health spending: evidence from dementia patients in France","authors":"Anne Penneau , Zeynep Or","doi":"10.1016/j.ahr.2025.100239","DOIUrl":"10.1016/j.ahr.2025.100239","url":null,"abstract":"<div><h3>Background</h3><div>Unmet need for long-term care (LTC) could be associated with higher health care utilization and medical spending. In France funding of LTC is decentralised and there are significant disparities in accessibility of LTC. We analyse the impact of geographical variations in LTC funding and supply on healthcare expenditure focusing on dementia patients.</div></div><div><h3>Methods</h3><div>Healthcare spending of individuals is calculated from a national linked claims database. We run multilevel models exploiting the variations in spending across two geographical levels (residential areas nested in local authorities (LA)) to estimate the impact of local LTC supply and funding on health spending of patients with dementia. We estimated the generosity of LTC funding at LA with a stochastic frontier model and developed a taxonomy of LTC supply.</div></div><div><h3>Results</h3><div>Dementia patients living in LAs with most generous LTC funding have significantly lower acute (-11 %) and post-acute (-35 %) hospital spending while they have higher (+17 %) primary care spending. Moreover, people in areas with the highest LTC supply spend 3 % less on hospital care per year and per person compared to those in underserved areas.</div></div><div><h3>Conclusions</h3><div>Our results suggest that better accessibility of LTC with better funding and LTC supply can reduce hospital spending and improve overall health system efficiency.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100239"},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144222892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commercially available products for the digital tracking of biomarkers in Parkinson's Disease 用于帕金森病生物标志物数字跟踪的市售产品

Aging and health research Pub Date : 2025-05-28 DOI: 10.1016/j.ahr.2025.100240

Padraig Cronin , Lucy M. Collins , Aideen M. Sullivan

{"title":"Commercially available products for the digital tracking of biomarkers in Parkinson's Disease","authors":"Padraig Cronin , Lucy M. Collins , Aideen M. Sullivan","doi":"10.1016/j.ahr.2025.100240","DOIUrl":"10.1016/j.ahr.2025.100240","url":null,"abstract":"<div><h3>Background</h3><div>Parkinson’s Disease (PD) is a debilitating neurological disorder which affects 8.5 million people globally. Diagnosis of PD is made upon presentation of motor symptoms. However, there is a well-recognised prodromal phase of PD, when patients experience non-motor symptoms, and subtle motor symptoms, before the onset of the cardinal motor symptoms. Biomarkers of this prodromal phase can provide a diagnostic window into early disease processes, assisting with the differential diagnosis of PD and enabling earlier treatment. Due to increased availability of commercially-available products, both wearable devices and smartphone applications are being explored for potential to identify PD biomarkers. Such products can provide clinicians with early warning of disease progression, and supply researchers with tools for monitoring PD outside of laboratory settings.</div></div><div><h3>Methods</h3><div>This systematic review critically examined the academic literature published in the English language to identify currently-available products designed to track biomarkers of PD across 6 databases between January 2000 and March 2025.</div></div><div><h3>Results</h3><div>27 papers were identified which captured physiological biomarkers in PD patients using commercially-available products. Current products emphasise the capture of early motor dysfunction through both upper limb and eye movements. There is a lack of literature on the validation of commercially-available products for the detection of PD, despite an increase in advanced data analysis algorithms.</div></div><div><h3>Conclusion</h3><div>There is a critical need for validation of devices for the tracking of biomarkers of PD, which may be utilised for detection during the prodromal phase.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100240"},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144205026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0