Aging and health research最新文献

{"title":"Age accelerated effect of tooth loss on cognitive function among Chinese older adults","authors":"Huashuai Chen ,&nbsp;Yan Yan Wu ,&nbsp;Wei Zhang","doi":"10.1016/j.ahr.2022.100099","DOIUrl":"10.1016/j.ahr.2022.100099","url":null,"abstract":"<div><h3>Objectives</h3><p>Focusing on older adults in China, this study aims to examine the association between tooth loss and cognitive impairment.</p></div><div><h3>Methods</h3><p>This study used six waves of data from the Chinese Longitudinal Healthy Longevity Survey across 16 years and applied generalized estimation equation regression models.</p></div><div><h3>Results</h3><p>Severe tooth loss was significantly related to cognitive impairment after adjusting for sociodemographic characteristics, health behaviors, and self-rated poor health. The adjusted prevalence ratios of cognitive impairment were 1.35 (95%CI: 1.30, 1.40) for edentulousness vs. no or mild tooth loss (0–9), and 1.25 (95%CI: 1.20, 1.30) for severe tooth loss (10 or more) vs. no or mild tooth loss. The effect of tooth loss increased with age from &lt;1% for all three groups to 50.9% for edentulousness, 35.6% for severe tooth loss and 30.7% for no or mild tooth loss.</p></div><div><h3>Discussion</h3><p>This study lends support to the hypothesis that oral health is an important covariate of cognitive impairment. Future studies should continuously explore this topic by adding more objective oral health assessments and speculate potential pathways that may underlie the relationship using high quality longitudinal data.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"2 4","pages":"Article 100099"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032122000452/pdfft?md5=0ca9b47d17bb1b32e02bb23c3cdc6e13&pid=1-s2.0-S2667032122000452-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48748559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in Parkinson's disease with dementia and dementia with Lewy bodies","authors":"Lidadi L. Agbomi ,&nbsp;Chika P. Onuoha ,&nbsp;Samuel I. Nathaniel ,&nbsp;Oreoluwa O. Coker-Ayo ,&nbsp;Melissa J. Bailey-Taylor ,&nbsp;Laurie Theriot Roley ,&nbsp;Nicolas Poupore ,&nbsp;Richard L. Goodwin ,&nbsp;Thomas I. Nathaniel","doi":"10.1016/j.ahr.2022.100096","DOIUrl":"10.1016/j.ahr.2022.100096","url":null,"abstract":"<div><h3>Background</h3><p>Gender differences for dementia with Lewy bodies (DLB), usually considered an intermediate disease between Alzheimer disease (AD), Parkinson disease (PD), and Parkinson disease with dementia (PDD), is controversial. The present study investigated gender differences in DLB and PDD using demographic and pharmacologic treatment strategies in a retrospective data analysis.</p></div><div><h3>Method</h3><p>Data of confirmed cases of DLB and PDD between 2015 and 2020 were collected from the PRISMA dementia data-base registry. Data from 7594 PDD patients and 608 DLB patients were analyzed using logistic regression analysis to determine demographic and pharmacologic factors associated with DLB and PDD patients.</p></div><div><h3>Result</h3><p>In the adjusted analysis, central acetylcholinesterase inhibitors (ChEIs) including donepezil, galantamine, rivastigmine were associated with DLB. Second generation antipsychotics (SGAs) such as risperidone (odd ratio(OR)=1.900, 95% confidence interval (CI),1.192–3.030, <em>P</em> = 0.007) was associated with females with DLB while aripiprazole (OR=0.195,95% CI,0.06–0.631, <em>P</em>&lt;0.006), and a selective serotonin receptor inhibitor (SSRIs) including escitalopram (OR=0.651, 95% CI,0.468–0.906, <em>P</em> = 0.011), and demographic factors including tobacco use (OR=0.620, 95% CI,0.444–0.866, <em>P</em>&lt;0.005) and increasing age (OR =1.042, 95% CI, 1.025–1.058, <em>P</em>&lt;0.001), were associated with females that present with PDD. Olanzapine (OR=2.871, 95% CI, 1.902–4.334, <em>P</em>&lt;0.001), escitalopram (OR=1.444, 95% CI, 1.079–1.932) and tobacco use (OR=1.424, 95%CI, 1.075–1.887, <em>P</em> = 0.014) were associated with males with DLB. African American males (OR= 0.249, 95% CI, 0.088–0.703, <em>P</em> = 0.009) with a history of ethyl alcohol (ETOH) use (OR= 0.371, 95% CI, 0.260–0.531, <em>P</em>&lt;0.001) treated with aripiprazole (OR=0.581, 95%CI, (0.302–1.118), <em>P</em> = 0.004) were associated with PDD.</p></div><div><h3>Conclusion</h3><p>Our findings reveal similarities and differences in demographic and pharmacologic factors associated with DLB and PDD. Investigating the effect of identified factors on DLB or PDD in future studies can help improve the care of DLB and PDD patients.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"2 4","pages":"Article 100096"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032122000427/pdfft?md5=717795420f8f428ebd2f3a26df163573&pid=1-s2.0-S2667032122000427-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46766430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differential in chronic diseases among older adults in India: Does living arrangement has a role to play?","authors":"Shekhar Chauhan ,&nbsp;Shubham Kumar ,&nbsp;Nayan Jyoti Nath ,&nbsp;Divya Dosaya ,&nbsp;Ratna Patel","doi":"10.1016/j.ahr.2022.100106","DOIUrl":"10.1016/j.ahr.2022.100106","url":null,"abstract":"<div><h3>Background</h3><p>This study examined the prevalence and related factors of four major chronic diseases among older adults in India with a focus on living arrangement and gender.</p></div><div><h3>Methods</h3><p>Longitudinal Ageing Study in India survey data (LASI- Wave I) conducted in 2017–18 was used. This study is based on 31,464 older people aged 60+ years in India. The outcome variables for this study are four chronic diseases namely; Hypertension, Diabetes, Chronic lung diseases, and Chronic heart diseases. Binary logistic regression was used to evaluate the association of diagnosed chronic diseases with socio-demographic and health characteristics.</p></div><div><h3>Results</h3><p>Prevalence rates of chronic heart diseases (5.8% vs. 4.6%), chronic lung diseases (9% vs. 8%), and diabetes (14.6% vs. 13.9%) were higher among the male older adults than in the female older adults. In contrast, the prevalence of hypertension was higher among the female older adults (37.1% vs. 28%) than in the male older adults. The odds of diabetes were lower among the older adults living with spouse and/or others [Odds Ratio (OR)=0.54, 95% Confidence Interval (CI)=0.32–0.91] and living with spouse and children (OR=0.48, 95% CI=0.29–0.81) than living alone. The odds of chronic lung diseases (OR=0.62, 95% CI=0.50–0.78) and chronic heart diseases (OR=0.72, 95% CI=0.54–0.96) were lower among females than in males.</p></div><div><h3>Conclusions</h3><p>Given the higher prevalence of chronic diseases among older adults, there is a need to set-up the geriatric clinics to cater to the needs of the older adult population. Furthermore, special attention should be given to the older adults living alone.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"2 4","pages":"Article 100106"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266703212200052X/pdfft?md5=964f2ad1d32b4b6c00636862246af8c7&pid=1-s2.0-S266703212200052X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42891849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using a systems perspective to understand hospital falls among patients with dementia","authors":"Mary Duah-Owusu White ,&nbsp;Fiona Kelly ,&nbsp;Michael Vassallo ,&nbsp;Samuel R. Nyman","doi":"10.1016/j.ahr.2022.100109","DOIUrl":"10.1016/j.ahr.2022.100109","url":null,"abstract":"<div><h3>Background</h3><p>Falls are a frequent event among older adults with dementia during their hospital stay. This qualitative study explores the factors contributing to falls in this population using a systems perspective.</p></div><div><h3>Methods</h3><p>Semi-structured interviews were conducted with 32 carers of patients with dementia and 20 hospital staff who worked on medical wards. Interview transcripts were analysed thematically using a systems framework.</p></div><div><h3>Results</h3><p>The themes generated from this falls research were factors related to the: patient (e.g. their physical health), carer (e.g. their ability to re-call a patient's past medical history), staff (e.g. teamwork), hospital policies (e.g. transfer of patients between wards), the hospital environment (e.g. lack of observation side rooms for infectious patients who are at risk of falls on some wards) and the use of hospital equipment (e.g. walking aid).</p></div><div><h3>Conclusion</h3><p>We recommend that future hospital falls intervention programmes need to be supported by a credible systems approach aiming to improve patient outcomes in relation to falls prevention.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"2 4","pages":"Article 100109"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032122000555/pdfft?md5=371dbe5f7b88e8796548d406e58ed05e&pid=1-s2.0-S2667032122000555-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41519398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catastrophic health spending among older adults in India: Role of multiple deprivation","authors":"Basant Kumar Panda ,&nbsp;Sanjay K. Mohanty","doi":"10.1016/j.ahr.2022.100100","DOIUrl":"10.1016/j.ahr.2022.100100","url":null,"abstract":"<div><h3>Background</h3><p>Previous studies have assessed catastrophic health spending (CHS) is high among households with older member, but no studies have examined its association with multiple deprivation. The purpose of this study is to compare the incidence and determinants of CHS between multiple deprived and non-deprived households in India.</p></div><div><h3>Methods</h3><p>Data for this paper was obtained from the 75th round of the National Sample Survey (NSS), a cross-sectional household survey conducted in 2017-18. The multiple deprivation index was estimated using Alkire and Foster method while CHS was estimated using the capacity to pay approach. Logistic regression analysis was used to identify the determinants of CHS in both types of households.</p></div><div><h3>Results</h3><p>The study found 43% of households with an older member were deprived in multiple dimensions. We found the incidence of CHS was 19% among households with an older adults; 22% among multiple deprived and 16% among the multiple non-deprived older adult households. Regression analysis result suggest that the odds ratio of incurring CHS was 1.84 (<em>p</em> &lt; 0.001) for the deprived older adult households than that of non-deprived households. Apart from multiple deprivation, any member being hospitalized or any member suffering from chronic diseases significantly associated with CHS in both type of households.</p></div><div><h3>Conclusion</h3><p>This study established the higher financial catastrophes among the deprived older adult households. Therefore, there is an utmost need for the government and policymakers to focus on multiple aspects of geriatric wellbeing at one hand and improving financial mechanisms to reduce the CHS at other hand.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"2 4","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032122000464/pdfft?md5=90ab2fdb2806f27c116397631cf07b0b&pid=1-s2.0-S2667032122000464-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47878527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normative values of hand grip strength of older Filipinos aged 60 to 85 years","authors":"Sanny Boy Afable ,&nbsp;Grace Cruz ,&nbsp;Yasuhiko Saito ,&nbsp;Rahul Malhotra","doi":"10.1016/j.ahr.2022.100108","DOIUrl":"10.1016/j.ahr.2022.100108","url":null,"abstract":"<div><h3>Background</h3><p>Hand grip strength (HGS) is associated with a range of health outcomes in older persons. Interpretation of an individual older person's HGS requires comparison with normative values of HGS for the population the older person belongs to, but normative values of HGS for older Filipinos are not established.</p></div><div><h3>Methods</h3><p>Using data on a subset (<em>n</em> = 3406) of ‘healthy’ persons aged 60 to 85 years from the baseline survey of the nationally representative Longitudinal Study of Ageing and Health in the Philippines (LSAHP), we established normative values of HGS and determined the association of older person characteristics with the normative values. We also compared the health status of mutually exclusive groups, defined using the normative values among all LSAHP participants aged 60 to 85 years with measured HGS, to assess the efficiency of the normative values. HGS was measured using a Smedley spring-type dynamometer, in a standing position with elbows extended, thrice for each hand.</p></div><div><h3>Results</h3><p>Single-year age, gender-, and hand-specific values and graphs for the normative values (5th, 20th, 50th, 80th, and 95th percentiles) of HGS were delineated. Height, weight, education, and occupation of the older person were associated with the normative values. Individuals classified into groups representing weaker HGS had a poorer health status.</p></div><div><h3>Conclusion</h3><p>The established normative values provide a reference for interpreting HGS values, measured using Smedley spring-type dynamometers, in older Filipinos aged 60 to 85 years.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"2 4","pages":"Article 100108"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032122000543/pdfft?md5=aa56e8994ec51cd039ddd53a48a79e50&pid=1-s2.0-S2667032122000543-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42711390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A “death-laden society”: The next stage of a hyper-aged Japan and health challenges ahead","authors":"Masa Higo","doi":"10.1016/j.ahr.2022.100110","DOIUrl":"10.1016/j.ahr.2022.100110","url":null,"abstract":"<div><p>From the next decade onward through the foreseeable future, Japan will become a “death-laden society,” in which the whole society is overwhelmed with the lasting trend of the ballooning deaths of those in advanced age at a scale unparalleled in history. In following with the country's decades-long experience as the world's leader in population aging, Japan will phase into this next stage of aging society, preceding the rest of the aging world. Based on administrative survey data and original interview data, this paper discusses main characteristics, causes, and consequences of a death-laden society and highlights key challenges in relation to medicine and health with which Japan will contend in the decades to come. On top of the enduring issues from preceding stages of aging society, a death-laden Japan will contend with a variety of unprecedented challenges including (1) shortages in basic medical resources; (2) possible dilemma between “dying in place” and “lonely death”; and (3) urgency to develop a national framework for end-of-life decisions. The coming of a death-laden society will significantly hinder Japan's national efforts to protect the wellbeing, safety, and dignity of its citizens, particularly those about to die as well as their relatives. This paper calls for further research to explore policy suggestions that would contribute to future policymaking not only of Japan but also of other countries that will likely follow Japan's path to become death-laden societies in the decades ahead.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"2 4","pages":"Article 100110"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032122000567/pdfft?md5=7673eb0110e456c1fa92fc19073559eb&pid=1-s2.0-S2667032122000567-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41775899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of mild cognitive impairment and physical activity level in older persons in Chile","authors":"Pedro Olivares-Tirado ,&nbsp;Felipe Alfonso Sandoval Garrido","doi":"10.1016/j.ahr.2022.100107","DOIUrl":"10.1016/j.ahr.2022.100107","url":null,"abstract":"<div><h3>Background</h3><p>Understanding the association between cognitive impairment and low physical activity is a useful way to proactively prevent MCI or delay the onset of dementia. This study aims to explore the association between MCI and physical activity (PA) levels in Chilean persons aged 60 and over.</p></div><div><h3>Methods</h3><p>Data came from the 2016–17 Chilean National Health Survey data. MCI was evaluated with Mini-Mental State Examination and Pfeffer Functional Activities Questionnaire, excluding individuals with suspected dementia. The Global Physical Activity Questionnaire was used to assess PA levels. The association between MCI and PA levels was examined using logistic regression analysis, including overall and sex stratified models.</p></div><div><h3>Results</h3><p>A total of 1981 participants were analysed. The mean age was 70.7 years (SD: 7.77), and 63% were women. The MCI prevalence was 10%, increasing with age. The overall MCI model for low PA level showed an Odds Ratio (OR): 1.95 (95% Confidence Interval (95% CI): 1.18; 3.20, <em>p</em> = 0.009), meaning that a low PA level has a significant association with the risk of having MCI. The MCI model for PA levels in women was not statistically significant; however, the model for men showed an OR of 2.44 (95% CI: 1.17; 5.11, <em>p</em> = 0.018).</p></div><div><h3>Conclusions</h3><p>A low PA level significantly increases the likelihood of developing MCI, and the risk was significantly higher among men. Therefore, promoting PA for older persons should be considered as a valuable prevention strategy among healthy older adults or those with initial symptoms of MCI.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"2 4","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032122000531/pdfft?md5=955e91ca6334ae7c59f6896b485b8290&pid=1-s2.0-S2667032122000531-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45962189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with elevated Per- and Polyfluoroalkyl substances serum levels in older adults","authors":"Emmanuel Obeng-Gyasi","doi":"10.1016/j.ahr.2022.100086","DOIUrl":"10.1016/j.ahr.2022.100086","url":null,"abstract":"<div><p>Per- and Polyfluoroalkyl substances (PFAS) are highly persistent synthetic chemicals that have been produced for more than seven decades. This study examined 6,018 eligible older adults (aged≥ 60 years) using the National Health and Nutrition Examination Survey (NHANES),to assess seven PFAS by sociodemographic and water source data to (a) determine factors most linked with elevated PFAS levels and (b) evaluate the differences by race and ethnicity. The results of this study indicated that among older adults, PFAS levels were more elevated in men than women (<em>p &lt; 0.05)</em>, non-Hispanic Blacks than other ethnicities <em>(p &lt; 0.05)</em>, among those using well water (<em>p &lt; 0.05)</em>, and those with lower education (<em>p &lt; 0.05)</em>. Income was not a significant factor among this group. These findings offer insight into the factors associated with elevated PFAS levels in older adults. With this knowledge, it is necessary to target education about PFAS among the most vulnerable.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"2 3","pages":"Article 100086"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40469050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early life factors associated with old age physical frailty: evidence from India","authors":"CV Irshad ,&nbsp;T Muhammad ,&nbsp;Arun Balachandran ,&nbsp;TV Sekher ,&nbsp;Umakant Dash","doi":"10.1016/j.ahr.2022.100089","DOIUrl":"10.1016/j.ahr.2022.100089","url":null,"abstract":"<div><h3>Background</h3><p>Physical frailty is one of the most important phenotypes used to understand the vulnerable nature of older adults. The paper examined the association of childhood factors, including birth order, childhood socioeconomic status, and other exposures with old age physical frailty. The study further explored the gender dimensions of physical frailty prevalence.</p></div><div><h3>Methods</h3><p>Data from the Longitudinal Ageing Study in India (LASI, 2017-18), wave-1 were used. The sample size for the study was 24,513 older adults aged 60 years and above (12,510 females and 12,003 males). Physical frailty was assessed using the measurement approach proposed by Fried and colleagues.</p></div><div><h3>Results</h3><p>The results indicated significant gender difference in the prevalence of physical frailty with 39.03% of older women and 32.49% of men being frail. Older adults with lower levels of mothers’ (adjusted odds ratio (aOR): 1.26; 95% confidence interval (CI):1.01–1.58) or fathers’ education (aOR: 1.33; 95% CI:1.18–1.50) or poor childhood health status (aOR: 1.48; 95% CI:1.27–1.71) had higher odds of physical frailty. Compared to older women with a well-off childhood financial condition, women with average childhood financial status had 38% (aOR: 1.38, 95% CI:1.01-1.89) higher odds of reporting physical frailty. In contrast, older men with poor childhood financial status had lower odds (aOR: 0.73; 95% CI:0.56-0.96) of physical frailty than older men with well-off childhood financial status.</p></div><div><h3>Conclusion</h3><p>Early life disadvantages in health, financial condition and lack of parental education had significant positive associations with old age physical frailty. The findings suggest the importance of childhood factors in policy and practice in terms of addressing old age physical frailty.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"2 3","pages":"Article 100089"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266703212200035X/pdfft?md5=cb8b0ec6293fe6cc41c437adea306820&pid=1-s2.0-S266703212200035X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45051417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}