Aging and health research最新文献

{"title":"Vitality of older adults through internal and external connectedness","authors":"Anneke G. Julien ,&nbsp;Wendy P.J. den Elzen ,&nbsp;Prof Ria Reis ,&nbsp;Dorothea P. Touwen ,&nbsp;Prof Jacobijn Gussekloo ,&nbsp;Yvonne M. Drewes","doi":"10.1016/j.ahr.2024.100185","DOIUrl":"10.1016/j.ahr.2024.100185","url":null,"abstract":"<div><h3>Background</h3><p>Vitality is a relatively unresearched concept and defined in existing literature either on the premise of one's functioning, or in terms of feeling alive. There is, however, little known about the significance of a sense of connectedness to life for vitality, especially from the perspective of older adults. This research aims to explore the association between the concept of connectedness and the perspective of vitality as a sense of aliveness, in order to formulate a theoretical understanding grounded in the subjective perceptions that older adults themselves hold of vitality.</p></div><div><h3>Methods</h3><p>Following a constructivist grounded theory approach and theoretical sampling, constant comparative analysis was performed on the transcripts of 15 semi-structured interviews, conducted in the Netherlands with older adults (mean age 73 years, eight females and seven males), regarding their vitality. Concurrently, empirical and theoretical findings were translated into a theoretical conceptualisation.</p></div><div><h3>Results</h3><p>According to the older participants, connecting to life itself enhanced their sense of vitality. This connection was achieved through internal connectedness (connecting to one's own life, intrinsic stimuli and intrinsic goals in an independent manner) and external connectedness (social connectedness, environmental connectedness, engagement with the external world). Furthermore, our findings revealed distinct interactions between internal and external connectedness and facilitating tools, such as freedom from physical constraints, financial freedom and adaptation.</p></div><div><h3>Conclusions</h3><p>Our findings provide a holistic concept of vitality and connectedness and consolidate existing perspectives on vitality into an overarching framework, which can contribute to the development of effective care policy, healthcare interventions and welfare services.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 2","pages":"Article 100185"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032124000064/pdfft?md5=df708c398f48bb57be3f8797471d1b11&pid=1-s2.0-S2667032124000064-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140276942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of heat stress on cardiovascular health outcomes of older adults: A mini review","authors":"Nomagugu Ndlovu,&nbsp;Benedicta Nkeh Chungag","doi":"10.1016/j.ahr.2024.100189","DOIUrl":"https://doi.org/10.1016/j.ahr.2024.100189","url":null,"abstract":"<div><p>Heat waves are increasingly becoming a serious threat to human health, especially for children, adults above 65 years and vulnerable populations. Older adults are already burdened with several chronic illnesses with cardiovascular diseases being the most prevalent and among the leading causes of death in that population. In this review, we explore evidence of the impact of heat stress on cardiovascular health outcomes of older adults. We further attempt to simplify the mechanisms by which aging compromises thermoregulation of individuals above the age of 65 thereby exacerbating cardiovascular diseases. Articles used in this mini review were retrieved from PubMed, Google scholar, Scopus and other academic internet databases relevant to the field of study. The keywords used in the search were ‘heat stress’, ‘cardiovascular diseases in older adults’ ‘heat stress and cardiovascular diseases’ as well as ‘heat stress and aging’. The publications included in this mini review have been carefully chosen based on their relevance, reliability, and contribution to advancing our understanding of the topic. This review reveals that heat stress in older adults may lead to increased hospitalization and death in some cases. There is a dearth of studies focusing on this area in developing countries. Therefore, this review can stimulate research interest for under studied regions or countries on the subject area considering that heat stress is a growing concern as a risk factor for cardiovascular diseases. Understanding the role of heat stress in cardiovascular diseases can help health care workers and policy makers to plan for mitigation strategies to avoid the risk of hospitalization and/or death during heat waves among older adults.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 2","pages":"Article 100189"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032124000106/pdfft?md5=2a90edd51f88e4c0f26761162bf9aa9c&pid=1-s2.0-S2667032124000106-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140341468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between healthcare use and migration background in persons with dementia: A cohort study in the Netherlands","authors":"Bianca T. Strooij ,&nbsp;Marieke T. Blom ,&nbsp;Hein P.J. van Hout ,&nbsp;Otto R. Maarsingh ,&nbsp;Petra J.M. Elders ,&nbsp;Jos P.C.M. van Campen ,&nbsp;Iris van der Heide ,&nbsp;Karlijn J. Joling","doi":"10.1016/j.ahr.2024.100191","DOIUrl":"https://doi.org/10.1016/j.ahr.2024.100191","url":null,"abstract":"<div><h3>Background</h3><p>: Qualitative research shows barriers in access to healthcare for persons with a migration background, possibly leading to healthcare inequalities. We aimed to compare healthcare use between older community-dwelling persons with a migration background and native Dutch persons with dementia.</p></div><div><h3>Methods</h3><p>: Observational cohort study using electronic health records of NIVEL Primary Care Database (2013–2014) linked to nationwide administrative registries managed by Statistics Netherlands. We included all community-dwelling persons with dementia in the Netherlands aged 65 years and older. Negative binomial and logistic regression analyses were conducted to assess differences in healthcare use outcomes. The largest migrant groups (persons born in Surinam, Turkey and Morocco) were studied separately.</p></div><div><h3>Results</h3><p>: 138,864 persons with dementia were included in the study, whereof 3,991 persons with a migration background and 132,477 native Dutch persons. Moroccan-born persons showed 1.46 higher odds of having an unplanned hospital admission compared to native Dutch persons (95 % Confidence Interval [CI] 1.22–1.74). Persons with a migration background used less professional home care (Odds Ratio [OR] 0.55, 95 %CI 0.51–0.59), and received less home visits from their general practitioner (OR 0.50, 95 %CI 0.43–0.57) than native Dutch persons. Moroccan-born persons had more often an out-of-hours general practitioner consultation compared to native Dutch persons (Incidence Rate Ratio 1.36, 95 %CI 1.18–1.57).</p></div><div><h3>Conclusions</h3><p>: We found significant quantitative differences in healthcare use between persons with a migration background and native Dutch persons with dementia. Further research is needed to gain insight into the reasons of these differences, with consideration of specific migration background.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 2","pages":"Article 100191"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266703212400012X/pdfft?md5=916be7ee51e7298fae4b48d79917c733&pid=1-s2.0-S266703212400012X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140631773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term consequences after COVID-19 in older people with epilepsy","authors":"Yiling Chen ,&nbsp;Zhenxu Xiao ,&nbsp;Xiaowen Zhou ,&nbsp;Luxin Jiang ,&nbsp;Jianhong Wang ,&nbsp;Ding Ding ,&nbsp;Guoxing Zhu","doi":"10.1016/j.ahr.2024.100184","DOIUrl":"https://doi.org/10.1016/j.ahr.2024.100184","url":null,"abstract":"<div><h3>Background</h3><p>This study aims to investigate the clinical characteristics and the short-term consequences of COVID-19 in older people with epilepsy.</p></div><div><h3>Methods</h3><p>From January 28 to March 6,2023,a telephone follow-up survey was conducted to a group of older people with epilepsy after COVID-19 outbreak in Shanghai. Data on infection symptoms,duration,COVID-19 vaccination, and clinical characteristics and management of epilepsy were collected.</p></div><div><h3>Results</h3><p>Eighty-two participants aged ≥50 years with SARS-CoV-2 infection were recruited. Common symptoms included fever (72.0%) and cough (63.4%).Overall, anti-seizure medication(ASM) accessibility was sufficient (95.1%),and medication adherence was good (93.9%).Three participants (3.7%)reported 1–3 seizures after virus infection. No statistically significant differences were observed in terms of clinical characteristics and consequences of COVID-19 in subgroups with participants aged &lt;63 and ≥63years,with and without fever, antipyretic drugs users and non-users, and with ≥4 and &lt;4 seizures/year before COVID-19.</p></div><div><h3>Conclusion</h3><p>Our study found few cases of seizure onset and good ASM adherence after SARS-CoV-2 infection in older people with epilepsy. Further prospective studies are needed to understand the long-term consequences of COVID-19.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 2","pages":"Article 100184"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032124000052/pdfft?md5=dd78ca96fbc91778e4f1d4799f8cbff1&pid=1-s2.0-S2667032124000052-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140191812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lingering Effects of COVID-19 Stressors on Mental Health and Alcohol Use in Middle Aged to Older Adults","authors":"Tracy W. Lin ,&nbsp;Judith A. Richman ,&nbsp;Timothy P. Johnson ,&nbsp;Kathleen M. Rospenda","doi":"10.1016/j.ahr.2023.100178","DOIUrl":"https://doi.org/10.1016/j.ahr.2023.100178","url":null,"abstract":"<div><h3>Background</h3><p>Older adults have faced not only health threats but grave mental health challenges since the emergence of the Coronavirus disease 2019 (COVID-19) pandemic. Using factor analysis, this study is the first to identify the underlying dimensions of COVID-19-related stressors, then examine the relationship between these factors and mental health and alcohol use/misuse longitudinally in a middle aged to older adult sample in the United States.</p></div><div><h3>Methods</h3><p>As part of a long-term follow-up study, 921 survey participants completed measures of COVID-related stressors, psychological distress, and alcohol use/misuse in a 2020 survey. An exploratory factor analysis was conducted to examine the dimensionality of COVID-related stress. Regression models were utilized to examine relationships between the extracted factors and depression, anxiety, and alcohol-related outcomes measured approximately one year later, in 2021.</p></div><div><h3>Results</h3><p>Four dimensions of COVID-19 stressors were extracted, including 1) jobs, finances and loss of routine; 2) practical difficulties; 3) social worries and challenges; and 4) supply shortages. Practical difficulties were associated with higher depression at follow-up, while jobs, finances and loss of routine were associated with past 12 month frequency of intoxication at follow-up. <strong>Conclusions:</strong> Challenges from the pandemic may have longer-term implications for mental health in older adults past the acute phase of the pandemic. It is important to allocate sufficient attention and resources to the prevention of late life depression and mental health as policymakers and health professionals continue to deal with the pandemic and future variants of the virus.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 1","pages":"Article 100178"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032123000628/pdfft?md5=b12b2e0f63fcc7209f146ad4b41d4cc0&pid=1-s2.0-S2667032123000628-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139100169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to vaccination among older adults: Demographic variation and links to vaccine acceptance","authors":"Heather R. Fuller ,&nbsp;Andrea Huseth-Zosel ,&nbsp;Bryce Van Vleet ,&nbsp;Paul J. Carson","doi":"10.1016/j.ahr.2023.100176","DOIUrl":"https://doi.org/10.1016/j.ahr.2023.100176","url":null,"abstract":"<div><h3>Background</h3><p>Despite risks of vaccine-preventable infectious diseases, many older adults are under vaccinated. The present study investigates possible barriers to acceptance of vaccines recommended for older adults and considers demographic variation and links to acceptance for distinct vaccines.</p></div><div><h3>Methods</h3><p>A mailed survey was conducted with 901 older adults (aged 65+) across the state of North Dakota, oversampling for rural regions. The survey addressed demographic characteristics, barriers to vaccination (including needle phobia, cost, lacking doctor recommendation, transportation, and scheduling uncertainty), and vaccine acceptance (including provider guidance acceptance and uptake for influenza, shingles, pneumococcal, and COVID-19 vaccines).</p></div><div><h3>Results</h3><p>Cost (27.2 %) and needle phobia (24.1 %) were the most prevalent barriers. Rural, lower educated, non-white, and living alone older adults experienced increased risks of barriers such as cost, lacking a doctor recommendation, transportation, and uncertainty how to schedule. Cost was associated with shingles vaccine uptake, whereas lacking doctor recommendation was associated with uptake for all vaccines except shingles. Needle phobia was associated with uptake of all vaccines except COVID-19. Transportation barrier was only associated with pneumococcal vaccine uptake.</p></div><div><h3>Conclusions</h3><p>These findings highlight relatively low prevalence of barriers, yet variability by older adults’ demographic characteristics. Further, the influence of barriers on acceptance varied by vaccine type. By better understanding the nuanced role of barriers to older adults’ vaccination, strategies to increase vaccination rates can be developed.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 1","pages":"Article 100176"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032123000604/pdfft?md5=59b0575f51a0acb88edde5b56089d64c&pid=1-s2.0-S2667032123000604-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138501753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-decade changes in dementia mortality in a Chinese community","authors":"Ding Ding ,&nbsp;Wanqing Wu ,&nbsp;Zhenxu Xiao ,&nbsp;Jianfeng Luo ,&nbsp;Qianhua Zhao ,&nbsp;Zhen Hong","doi":"10.1016/j.ahr.2024.100182","DOIUrl":"https://doi.org/10.1016/j.ahr.2024.100182","url":null,"abstract":"<div><h3>Background</h3><p>Evidence for the time trend of mortality with dementia from low- and middle-income countries is scarce.</p></div><div><h3>Objective</h3><p>To explore the secular trend of dementia mortality in a Chinese community over 2 decades.</p></div><div><h3>Methods</h3><p>The Shanghai Epidemiological Survey of Dementia and Alzheimer's Disease (SESD) and the Shanghai Aging Study (SAS) are community-based studies established in the same resident district in 1987 and 2010. We examined changes in 5-year mortality of dementia (i.e. Alzheimer's disease [AD], vascular dementia [VD], and all dementia) by analyzing survival data of participants aged≥65 years from the prospective stages of SESD (1987–1992) and SAS (2010–2015). Mortality rate (MR), case fatality rate (CFR), and standardized mortality ratio (SMR) in SAS were adjusted by the sex, age, and education-structured population data in SESD.</p></div><div><h3>Result</h3><p>The adjusted 5-year MRs of AD (0.76% vs. 2.24 %; OR, 95 %CI 0.34, 0.20–0.57), VD (0.37% vs. 1.16 %; OR 0.33,0.16–0.68), and all dementia (1.23% vs. 3.74 %; OR 0.32, 0.22–0.48) in SAS were lower than that in SESD. The same trend of the 5-year CFRs was also observed in AD (23.3% vs. 62.2 %; OR 0.19, 0.10–0.35), VD (48.7% vs. 77.4 %; OR 0.29, 0.10–0.90), and all dementia (61.0% vs. 70.6 %; OR 0.21, 0.12–0.35). The 2-year SMR in individuals with VD increased significantly (3.18 vs<em>.</em> 15.31), but the 5-year SMR increased gently (3.81 vs<em>.</em> 5.32) during the 2 decades.</p></div><div><h3>Conclusion</h3><p>We observed a decreasing trend of dementia mortality, and VD still induced a higher threat to life loss over 20 years in this older Chinese population.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 1","pages":"Article 100182"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032124000039/pdfft?md5=288ae82fd1d7d584d602b46528cf6d70&pid=1-s2.0-S2667032124000039-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139993605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal subfields volume changes and its correlation with memory functions in patients with mild cognitive impairment","authors":"Sadhana Singh,&nbsp;Palash Kumar Malo,&nbsp;Albert Stezin,&nbsp;Abhishek L. Menesgere,&nbsp;Thomas Gregor Issac","doi":"10.1016/j.ahr.2024.100183","DOIUrl":"https://doi.org/10.1016/j.ahr.2024.100183","url":null,"abstract":"<div><h3>Background</h3><p>This study examined hippocampal subfields volumes in patients with mild cognitive impairment (MCI) as potential non-invasive predictive neuroimaging markers of cognitive decline.</p></div><div><h3>Methods</h3><p>T1-weighted images and Addenbrooke's cognitive examination III (ACE-III) data were obtained from 36 healthy controls and 27 MCI patients. The hippocampal subfields volumes were extracted using Freesurfer software, and group differences and correlation were assessed using general linear model (GLM) with age, sex, and total intracranial volume (TIV) as covariates.</p></div><div><h3>Results</h3><p>MCI participants exhibited significant decrease in memory scores and notable volumetric changes in hippocampal subfields, including the bilateral hippocampal tail, subiculum, CA1, CA3, molecular layer, as well as the left presubiculum, parasubiculum, CA4, GC-ML-DG, and HATA. Moreover, the left presubiculum, left parasubiculum, and left GC-ML-DG showed significant positive correlations with ACE memory scores in MCI patients.</p></div><div><h3>Conclusions</h3><p>The alterations in hippocampal subfields in MCI patients may indicate underlying neurodegenerative processes associated with Alzheimer's disease (AD) pathology.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 1","pages":"Article 100183"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032124000040/pdfft?md5=3d62cc7a662b2b08b8bc46704871ed34&pid=1-s2.0-S2667032124000040-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140062408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real world outcomes, healthcare utilisation and costs of Alzheimer's disease in England","authors":"Sophie Edwards ,&nbsp;Dominic Trepel ,&nbsp;Craig Ritchie ,&nbsp;Julie Hviid Hahn-Pedersen ,&nbsp;Danielle E Robinson ,&nbsp;Mei Sum Chan ,&nbsp;Benjamin D Bray ,&nbsp;Alice Clark ,&nbsp;Milana Ivkovic ,&nbsp;Wojciech Michalak ,&nbsp;Christian Ahmad Wichmann ,&nbsp;Marc Evans","doi":"10.1016/j.ahr.2024.100180","DOIUrl":"10.1016/j.ahr.2024.100180","url":null,"abstract":"<div><h3>Background</h3><p>Evidence on health and social care resource utilisation and associated costs, and how this varies across people with Alzheimer's disease (AD) dementia is limited.</p></div><div><h3>Methods</h3><p>Retrospective cohort, using the Discover dataset, which includes linked health and social care records for approximately 2.5 million people in North-West London. Individuals were followed up from the latter of 2010 or from diagnosis of AD dementia (index) up to 2019. Outcomes were overall survival, care home admission, health and social care utilisation and associated costs, and cardiovascular outcomes. Variation was explored in subpopulations and by stratifying by cost quintile. Generalised linear modelling was used to estimate the association between clinical and demographic characteristics and healthcare costs.</p></div><div><h3>Results</h3><p>The cohort included 18,116 people diagnosed with AD dementia whose mean age at index was 81 years, 62 % were female and 65 % were of white ethnicity. Median survival from index was 4.9 years (95 %CI: 4.8–5.0). Mean healthcare costs were £4,548(£4,491–£4,604) per person year(ppy). Healthcare costs for the 48 % who used social care were £5,433ppy(£5,353–£5,514) and social care costs were £24,374ppy(£24,372–£24,376). In the overall cohort costs in the highest cost quintile were £13,665ppy(£13,420–£13,911), of which 70 % was from inpatient hospitalisation. Subpopulations admitted to care home (£7,535 £7,362–£7,709), with cardiovascular disease (£6,106;£5,990–£6,222) and with type 2 diabetes (£6,049;£5,901–£6,198) accrued the highest healthcare costs. Factors most strongly associated with cost were dying during follow up (+£2,224;£2,010–£2,493), being frail (+£1,246;£1,051–£1,440) and prior stroke (+£1,207;£908–£1,507).</p></div><div><h3>Conclusion</h3><p>Characteristics of individuals with high healthcare costs include requirement for social care and cardiometabolic comorbidities. Identifying individuals early in their disease course may improve health outcomes and reduce the cost of AD dementia in later life.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 1","pages":"Article 100180"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032124000015/pdfft?md5=275512798c53d5577ce7f5e70a834464&pid=1-s2.0-S2667032124000015-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139634793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An overview about neurological diseases in India – A theranostics approach","authors":"Balachandar Vellingiri","doi":"10.1016/j.ahr.2023.100177","DOIUrl":"10.1016/j.ahr.2023.100177","url":null,"abstract":"<div><p>With the current global population expansion and increasing life expectancy, more people are living in their later years, when neurological issues are most common. Both environmental and geographical factors contribute to the incidence of various neurological diseases (NDs) in India. These diseases involve the gradual or complete loss of structure and function of neurons, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), epilepsy, stroke, and amyotrophic lateral sclerosis (ALS). The exact cause of these illnesses is still unknown in medicine. Still, it may be linked to protein deterioration, oxidative stress, inflammation, environmental factors, mitochondrial deficiencies, familial history, and abnormal protein build-up. In this review, we have discussed briefly the pathophysiology of various neurological diseases from Indian studies as well as possible diagnostic markers, drugs used, traditional Indian medicinal plants, and alternative therapeutic approaches for detecting and treating these NDs.</p></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"4 1","pages":"Article 100177"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667032123000616/pdfft?md5=3bdab0f4cc8ca8b36946d091feb70e13&pid=1-s2.0-S2667032123000616-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}