Validity and reliability of the Persian version of Alzheimer's disease-related quality of life (P-ADRQL) questionnaire among older Iranian adults

Aging and health research Pub Date : 2025-04-07 DOI:10.1016/j.ahr.2025.100229

Masoud Gharib , Jafar Hajghani , Hamed Cheraghmakani , Vahid Rashedi

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Abstract

Background

Assessing quality of life (QOL) in individuals with Alzheimer's disease (AD) is particularly challenging due to the subjective nature of the concept and the cognitive deficits associated with the condition. This study aimed to translate the AD-Related QOL (ADRQL) questionnaire into Persian and rigorously evaluate its reliability and validity in this population.

Methods

This cross-sectional methodological study was conducted between March 2021 and August 2022, involving 220 patients diagnosed with AD according to DSM-IV criteria, along with their primary caregivers. The Persian version of the ADRQL (P-ADRQL) and the QOL in Late-Stage Dementia (QUALID) scales were used to collect data, allowing for a thorough assessment of QOL across multiple domains.

Results

The P-ADRQL demonstrated excellent psychometric properties, with an overall Cronbach's alpha of 0.92, indicating strong internal consistency. This suggests that the items reliably measure the construct of QOL in patients with AD. Additionally, test-retest analysis revealed consistent scores across all subscales, confirming the stability of caregiver assessments over time. Significant correlations between P-ADRQL and QUALID further supported the convergent validity of the instrument, affirming its ability to measure QOL in alignment with established dementia assessment tools.

Conclusion

The P-ADRQL is a robust and reliable instrument for evaluating QOL in older Iranian adults with AD. Its strong psychometric properties ensure accurate and consistent assessments, addressing a critical need within Iran's healthcare system.

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波斯语版阿尔茨海默病相关生活质量（P-ADRQL）问卷在伊朗老年人中的效度和可靠性

评估阿尔茨海默病（AD）患者的生活质量（QOL）尤其具有挑战性，因为这一概念的主观性以及与该疾病相关的认知缺陷。本研究旨在将ad相关生活质量（ADRQL）问卷翻译成波斯语，并严格评估其在该人群中的信度和效度。该横断面方法学研究于2021年3月至2022年8月进行，涉及220名根据DSM-IV标准诊断为AD的患者及其主要护理人员。使用波斯语版本的ADRQL （P-ADRQL）和晚期痴呆（QUALID）量表收集数据，允许对多个领域的生活质量进行全面评估。结果P-ADRQL具有良好的心理测量特性，总体Cronbach's alpha为0.92，表明内部一致性强。这表明这些项目可靠地衡量了AD患者生活质量的构成。此外，测试-重测分析显示所有子量表的得分一致，证实了护理人员评估随时间的稳定性。P-ADRQL和QUALID之间的显著相关性进一步支持了该工具的收敛效度，证实了其测量生活质量的能力与已建立的痴呆评估工具一致。结论P-ADRQL是评估伊朗老年AD患者生活质量的可靠工具。其强大的心理测量特性确保了准确和一致的评估，解决了伊朗医疗保健系统内的关键需求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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