Advances in clinical and medical research (Chandigarh, India)最新文献

{"title":"Experimental Atherosclerosis Reductions by Hypolipidemic Drugs","authors":"Silvia Saiuli Miki Ihara, Anita L R Saldanha, Leonor do Espírito Santo Almeida Pinto, Ieda Edite LanzariniLopes, J. P. Novazzi, Luis Alberto Barboza, A. Margeotto, André L Varela Gasparoto, Tania Leme da Rocha Martinez","doi":"10.52793/acmr.2022.3(3)-36","DOIUrl":"https://doi.org/10.52793/acmr.2022.3(3)-36","url":null,"abstract":"Experimental Atherosclerosis Reductions by Adv Clin Res. Abstract This article summarizes the series of experiments done in New Zealand rabbits that developed aortic lesions being fed a high cholesterol diet, varying from 0,5% to 1,5% of the chow. Planimetry in statin treated rabbits showed a","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44347519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rac1 AT1 Required For Ang2-AT2 Activities For Cardiomyocytes And ECs Where Tyr TAT And TAC Kinases Required For Preventing Glycoprotein Storage And Glycogen Accumulation","authors":"A. Tantawi","doi":"10.52793/acmr.2022.3(3)-35","DOIUrl":"https://doi.org/10.52793/acmr.2022.3(3)-35","url":null,"abstract":"Active Rac1 are so imp for improving cytoskeletal systems and for improving anti-inflammatory processes by activating Plcγ2, IFN-beta and glucocorticoid-beta (which necessary for B arrestin synthesis which necessary for activating endothelial cells function through activating ACE functions). Tyrosine kinases function (contain TAT and TAC codons) are so necessary for activating Ang2-AT2 productions for adjusting heart contractions and preventing collagen, glycoproteins, and cholesterol accumulations. Angiotensin II type 2 receptors (Ang2 bind to AT2 receptors) are produced from Ang1-AT1 by ACE regulated functions in Tyr kinases-dependent Abstract BTK and Ang1 AT1 are so necessary for IgM and IgG3 synthesis in blood serum that can be considered as so necessary for anti-inflammatory improvement, but in case of the absence of Tyr Codons TAT & TAC (kinases) the BTK will be critical for increasing the accumulated collagen (accumulated glycoprotein) in arteries which are critical for the tumor synthesis. Glycogen storage disease (GSD) and glycoprotein storage disease (GSD) are started by sever deficiency in Tyrosine TAT and TAC pyrimidine kinases (which reflect deficiency in Ang2-AT2 productions) that will lead to accumulated glycogen (increasing in Ang1 AT1 activity and glycoprotein accumulations), where, Ang2-AT2 productions are necessary for binding to the stored glycogen with metalloproteinase dependent for platelets activation mediated by releasing nitric oxide. 5-hmC are considered as the enhancers and the key regulators in heart developments, contractions, and blood vessels protections, where 5-hmC regulated by pyrimidine kinases and is so necessary for adjusting muscles contractions through methylation and demethylation processes. cause will (pyrimidine kinases) which play important roles in building dynamic promoters in Ang2-AT2 active molecules. The deficiency in pyrimidine synthesis due to deficiency in synthetase functions will cause deficiency in pyrimidine kinases and mutations in thymine kinases and in cytosine pyrimidine kinases. Also deficiency in pyrimidine kinases will lead to increasing in Ang1-AT1 activities ” that will promote maturation including allergic inflammations and tumors mediated by mutated CTGF productions and will associated with decreasing in signals productions (necessary for adjusting heart beats. Also deficiency in Estrogen productions (due to decreasing in pyrimidine kinases with increasing in purines kinases) that will lead to cholesterol accumulation and decreasing in B-arrestin that will not activate ACE for reactivate endothelial cells function. then dropping in blood pressure. Note that increasing in adverse ventricular (LV) dilatation due to inhibition or deficiency in Ang2-AT2 synthesis (deficiency in pyrimidine kinases) will lead to increasing in Myocardial relaxation time that will be main reason in hypotension which due to increasing in ventricular volume leads to an increase in the diastole of the heart ","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46427086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects Of HIV Infection On Cluster Of Differentiation 4 And Erythropoietin Values As Predictive Indicators In HIV Infected Patients Receiving Haart At G.H Nsukka In Enugu","authors":"Okolo Rc, Ufelle Sa, Achukwu Pu, Onah Ca, Ugwu Ib","doi":"10.52793/acmr.2022.3(3)-34","DOIUrl":"https://doi.org/10.52793/acmr.2022.3(3)-34","url":null,"abstract":"Cluster 4 And Values as Predictive Indicators in HIV Infected Abstract Aims and objectives: The study's goal is to evaluate the cluster of differentiation 4(CD4) and the erythropoietin values (EPO) in people living with HIV/AIDS in Enugu study shows the outcomes of CD4 counts in HIV patients with various ranges. The mean and standard error of CD4 counts of HIV patients before (pre) and after (post) HAART administrations showed the grand mean CD4 counts before and post HAART administration were 632.37 ± 29.24cells/ and 646.59 ± 28.9cells/ , respectively. The difference in CD4 counts between pre and post, that is, before and after HAART was given to HIV patients, demonstrated that HAART enhanced CD4 levels. The increase in CD4 counts in patients was statistically significant (P <0.05).The effects of HIV infection on EPO that is a haematopoietic cytokines in HIV infected individuals with various CD4 counts showed that the mean and standard error of erythropoietin (EPO) levels in HIV patients was 7.10±0.01mg/dl and 7.74±0.03mg/dl, respectively. The change in HIV patients' EPO levels between the two periods was significant (P <0.05). Conclusion: There is an increase in CD4 counts in patients in the study and is comparable to the work of Erb et al 2000, who found out that HIV infected individuals who received a combination of antiretroviral therapy (CART) had higher CD4 counts. The change in HIV patient's EPO levels indicated that HIV infection had the ability to decrease EPO synthesis in the body. The work of Wang et al 1993 discovered that HIV-1 appeared to suppress the synthesis of EPO and some, but not all.","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44823908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Applications Of Stem Cells For Cerebral Palsy","authors":"Owen Lewis, Vincent S. Gallicchio","doi":"10.52793/acmr.2022.3(1)-26","DOIUrl":"https://doi.org/10.52793/acmr.2022.3(1)-26","url":null,"abstract":"Cerebral palsy (CP) is an umbrella term that describes the consequences of brain injury during the neonatal period or postnatal period. Symptoms can range in severity but typically include muscular issues, cognitive impairment, and seizures. During the neonatal periods, the cause of brain injury is generally unknown. However, one of the primary known causes of CP is hypoxic ischemia (H/I). There is no cure for CP, and patients tend to rely on medication and or surgical procedures for symptom management. Recently stem cells have been an essential topic of therapeutic agents for CP due to their regenerative properties and the potential to restore motor and cognitive function. This article will discuss the various types of stem cells being studied for potential CP treatments and animal and clinical trials results.","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46549512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traumatic Penile Injuries In Children: An Experience","authors":"Emeka Ck, Nnanyereugo Ol, Patrick Al","doi":"10.52793/acmr.2022.3(1)-25","DOIUrl":"https://doi.org/10.52793/acmr.2022.3(1)-25","url":null,"abstract":"Background: Penile injuries are not uncommon in children and may be underreported. The aim of this study was to evaluate our experience with penile trauma in children in a retrospectively evaluated series. Materials and Methods: This was a retrospective study of children aged 15 years and below who were managed for traumatic penile injuries between January 2015 and December 2019 at the pediatric surgery unit of Enugu State University Teaching Hospital (ESUTH) Enugu, Nigeria. Both acute and chronic traumatic penile injuries were considered. Diagnosis of traumatic penile injury was made based on clinical and imaging findings. Results : A total of 104 cases of traumatic penile injuries were seen during the study period. The mean age of the patients was 4 months. Urethrocutaneous fistula from male circumcision was the most common traumatic penile injury. Repair of urethrocutaneous fistula and recurrent urethrocutaneous fistula were the most performed surgical procedure and most post-operative complication respectively. Majority of the patients achieved good cosmetic and functional outcome. Conclusio n: Traumatic penile injuries in children occur infrequently but could be a significant cause of penile disfigurement and morbidity. Urethrocutaneous fistula and bleeding problems from male circumcision are the most common traumatic penile injuries. Traumatic penile injuries can be minimized by better training and good practice. genitalia the 2016 National Commission of Statistics, population of 4 people and a population density of 2 . The hospital referrals neighboring states. Information was extracted from the case notes, operation notes, and operation register and admission-discharge records. The information extracted included the of the patient, presenting duration of symptoms before presentation, time interval between presentation and clinical diagnosis, operative procedure performed complications of treatment, duration of hospital stay and outcome of treatment. Diagnosis of traumatic penile injury was made based on clinical and imaging findings. The follow-up period was 12 months. Ethical approval was obtained from the ethics and research committee of ESUTH. Informed consent was not obtained from the patients’ caregivers because of the retrospective nature of the study and the identities of the patients were not revealed. Statistical Package for Social (SPSS) was used for data entry and analysis. Data were expressed as percentages, mean, median and range.","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46093824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental Finding Of Migrated Intra-Uterine Device During Elective Robotic-Assist Laparoscopic Hysterectomy","authors":"Cash C Sterling, Francis Lake, James Chambers","doi":"10.52793/acmr.2022.3(1)-24","DOIUrl":"https://doi.org/10.52793/acmr.2022.3(1)-24","url":null,"abstract":"Device Abstract Migration of Intra-uterine devices (IUDs) a rare, yet serious complication associated with a well-accepted means of contraception. IUDs have long been a safe and effective option for women of child-bearing age to prevent pregnancy. We present a 48-year-old female with known symptomatic uterine fibroids undergoing a robot-assist laparoscopic hysterectomy in the elective setting. She was found to have a previously placed IUD that migrated through her uterus and was adherent and invading into her rectum. This IUD was removed without complication and without","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44988371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Mouthwash on Oral Cytomegalovirus, Epstein-Barr Virus, Herpes Simplex Virus Type-1.","authors":"Hessam Nowzari,&nbsp;Petra Wilder-Smith","doi":"10.52793/acmr.2022.3(4)-44","DOIUrl":"https://doi.org/10.52793/acmr.2022.3(4)-44","url":null,"abstract":"<p><strong>Background: </strong>Cytomegalovirus (HCMV), Epstein-Barr virus (EBV), and herpes simplex virus type-1 (HSV-1) are pathogens.</p><p><strong>Objectives: </strong>The goal of the present double-blinded, randomized study was to compare the effect on oral viral load of twice daily use over 60 days of Lumineux Mouthwash^Rvs. de-ionized water. The main composition of the mouthwash was Dead Sea salt.</p><p><strong>Methods: </strong>30 participants were randomized to test or control. For 60 days, participants rinsed for 60s twice daily with 20ml of their allocated mouthwash, after morning and evening meals. On Day 0 and 60, before eating and oral hygiene and at least 60 minutes after drinking, unstimulated saliva was collected. Samples underwent mRNA analysis. Study endpoints were changes in Log Salivary Viral Load.</p><p><strong>Result: </strong>After adjusting for baseline differences, the reduction in viral load was significantly greater for the test group, all p-values <0.001. Baseline differences did not have an effect on the differences between groups in change over time.</p><p><strong>Conclusion: </strong>After adjusting for baseline differences, the reduction in viral load was significantly greater for the test group, all <i>p</i>-values <0.001. Baseline differences did not have an effect on the differences between groups in change over time.</p>","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":"3 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10534892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Involvement Of Reactive Oxygen Species (ROS) And Coagulation In Coronaviral Infection","authors":"Shihori Tanabe","doi":"10.52793/acmr.2021.2(2)-21","DOIUrl":"https://doi.org/10.52793/acmr.2021.2(2)-21","url":null,"abstract":"Coronaviral infection induces various molecular network pathways. Coronavirus pathogenesis pathway is involved in molecules in production of reactive oxygen species (ROS), oxidative stress responses and coagulation system. Several literatures have revealed the association of ROS and coagulation in infection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this Editorial, the involvement of ROS and coagulation in coronavirus infectious disease (COVID)-19 pathogenesis is summarized.","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41589239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collation Of Hydroxychloroquine Virological Clearance, Effectiveness, Safety In Covid-19 Patients With Control Group (Conventional Therapy) – A Systematic Review And Meta-Analysis","authors":"Athira Mohan S, Shaiju S. Dharan","doi":"10.52793/acmr.2021.2(2)-18","DOIUrl":"https://doi.org/10.52793/acmr.2021.2(2)-18","url":null,"abstract":"Objectives: Destitute of an effective treatment, several potential repurposed drugs have been tried in COVID-19. Despite unavailability of anecdotal evidence, several guidelines granted both Chloroquine (CQ) and Hydroxychloroquine (HCQ) in treatment. Clinical studies relating to those in COVID-19 disease has reported conflicting results. We sought to systematically evaluate the clinical effects contact, mainly in health workers [8]. On March 30, 2020 FDA issued an Emergency Use Authorization (EUA) in order to use both CQ and HCQ in the treatment of COVID-19. FDA issued EUA for the second time in the history. Formerly it was given for an investigational neuraminidase inhibitor, Peramivir during 2009-2010 to treat severely ill patients with H1N1 influenza [9]. The meta-analysis of 5 studies that reported rate of virological clearance or PCR negativity (n=312) found no benefit in HCQ arm. {OR, 1.863; 95% CI, 1.024 to 3.389; p=0.041} with a moderate heterogeneity (I 2 =70.3%, P=0.009). meta-analysis of 5 studies (n=1710) that reported about ADR outcomes found that, there exist an increased risk of ADRs in HCQ arm. {OR, 2.648; 95% CI, 2.068 to 7.717; p=0.000}, with no heterogeneity (I 2 = 0%, P=0.417). 6 studies (n=4,341) showed a significant increase in mortality in HCQ arm when compared with control arm {OR, 1.182; 95% CI, 0.981 to 1.425; p=0.079}, with substantial heterogeneity (I 2 = 82.0%, P=0.000). Conclusions: The systematic review and meta-analysis revealed a reduced antiviral efficacy in reducing mortality, ADR occurrence and has a decreased virological clearance in patients with COVID-19. in COVID-19 patients.","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44986371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RNA Signaling In Microenvironment","authors":"Shihori Tanabe","doi":"10.52793/acmr.2021.2(2)-19","DOIUrl":"https://doi.org/10.52793/acmr.2021.2(2)-19","url":null,"abstract":"Various forms of RNAs exist in the extracellular vesicles, which are mRNA, microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and RNAs These RNAs in extracellular vesicles play important roles in intercellular RNA signaling. Inter- and intra-cellular travel of RNAs in cancer microenvironment LncRNAs in exosomes mediate cell-to-cell communication in cancer microenvironment affecting tumor Abstract RNA signaling has emerged to be focused in several diseases. Multiple types of RNAs including microRNA, long non-coding RNA, and circular RNA mediate the signals among cells in cancer microenvironment. These RNAs travel in the microenvironment via extracellular vesicles or exosomes. The messages carried by RNAs transactivate the cells in different organs, which may cause cancer metastasis or the amplification of diseases. Intercellular RNA signaling in microenvironment is of interest.","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45702178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}