Effects Of HIV Infection On Cluster Of Differentiation 4 And Erythropoietin Values As Predictive Indicators In HIV Infected Patients Receiving Haart At G.H Nsukka In Enugu

Abstract

Cluster 4 And Values as Predictive Indicators in HIV Infected Abstract Aims and objectives: The study's goal is to evaluate the cluster of differentiation 4(CD4) and the erythropoietin values (EPO) in people living with HIV/AIDS in Enugu study shows the outcomes of CD4 counts in HIV patients with various ranges. The mean and standard error of CD4 counts of HIV patients before (pre) and after (post) HAART administrations showed the grand mean CD4 counts before and post HAART administration were 632.37 ± 29.24cells/ and 646.59 ± 28.9cells/ , respectively. The difference in CD4 counts between pre and post, that is, before and after HAART was given to HIV patients, demonstrated that HAART enhanced CD4 levels. The increase in CD4 counts in patients was statistically significant (P <0.05).The effects of HIV infection on EPO that is a haematopoietic cytokines in HIV infected individuals with various CD4 counts showed that the mean and standard error of erythropoietin (EPO) levels in HIV patients was 7.10±0.01mg/dl and 7.74±0.03mg/dl, respectively. The change in HIV patients' EPO levels between the two periods was significant (P <0.05). Conclusion: There is an increase in CD4 counts in patients in the study and is comparable to the work of Erb et al 2000, who found out that HIV infected individuals who received a combination of antiretroviral therapy (CART) had higher CD4 counts. The change in HIV patient's EPO levels indicated that HIV infection had the ability to decrease EPO synthesis in the body. The work of Wang et al 1993 discovered that HIV-1 appeared to suppress the synthesis of EPO and some, but not all.