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PYGO In Cancer Pathway PYGO在癌症通路中的作用
Advances in clinical and medical research (Chandigarh, India) Pub Date : 2023-02-06 DOI: 10.52793/acmr.2023.4(1)-48
Shihori Tanabe
{"title":"PYGO In Cancer Pathway","authors":"Shihori Tanabe","doi":"10.52793/acmr.2023.4(1)-48","DOIUrl":"https://doi.org/10.52793/acmr.2023.4(1)-48","url":null,"abstract":"Several molecules are involved in cancer molecular network. Pygopus family plant homeodomain (PHD) finger (Pygo) is a component of Wnt/  -catenin transcription complex. Pygo has two homologs, Pygo1 and Pygo2, in mammalian cells. Pygo2 has an important role as a component of  -catenin-B-cell CLL/lymphoma 9 (Bcl9)-TCF/LEF complex. In this Editorial, a role of Pygo in Wnt/  -catenin signaling related to cancer pathway is summarized.","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44481470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forgotten Right Ventricle Entity: In Post Acute Covid Symptomatic (PASC) Patients 遗忘的右心室实体:急性Covid症状(PASC)后患者
Advances in clinical and medical research (Chandigarh, India) Pub Date : 2023-01-30 DOI: 10.52793/acmr.2023.4(1)-47
A. Kapoor, G. Mahajan
{"title":"Forgotten Right Ventricle Entity: In Post Acute Covid Symptomatic (PASC) Patients","authors":"A. Kapoor, G. Mahajan","doi":"10.52793/acmr.2023.4(1)-47","DOIUrl":"https://doi.org/10.52793/acmr.2023.4(1)-47","url":null,"abstract":"Introduction World has just passed through the global pandemic of Covid-19 disease with recent reports of it resurfacing in China. Although being a disease predominantly affecting lungs the involvement of other organs like heart, brain and gut have also been seen in the acute phase. PASC (post acute SARS Covid-19) is another distinct phase of the disease seen amongst survivors from both mild and severe disease where the patients continue to suffer from symptoms of palpitations, dysnoea on exertion ,chest pain and fatigue. Few studies have been done in such patients to assess ongoing cardiac involvement. Most of these patients show normal left and right ventricle Ejection fraction, normal troponin levels with nonspecific EKG findings of sinus tachycardia. Some of these patients are made to undergo cardiac MR to rule out covid-19 myocarditis. Here also most of the imaging specialists and the cardiologists are focused on the left ventricle only and look for the Lake Loius criteria to establish or rule out diagnosis.","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41393573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mccune Albright Syndorme/Craniofacial Fibrous Dysplasia And Postcraniectomy Syndrome: Case Report And Literature Review Mccune - Albright综合征/颅面纤维发育不良和颅切除术后综合征:病例报告和文献复习
Advances in clinical and medical research (Chandigarh, India) Pub Date : 2023-01-15 DOI: 10.52793/acmr.2023.4(1)-46
Jefferson Arce Tovar, Erick E. Muñoz Rodríguez, Jhonier Osorio Valencia, Daniela Toro, Luis F Duarte Correales
{"title":"Mccune Albright Syndorme/Craniofacial Fibrous Dysplasia And Postcraniectomy Syndrome: Case Report And Literature Review","authors":"Jefferson Arce Tovar, Erick E. Muñoz Rodríguez, Jhonier Osorio Valencia, Daniela Toro, Luis F Duarte Correales","doi":"10.52793/acmr.2023.4(1)-46","DOIUrl":"https://doi.org/10.52793/acmr.2023.4(1)-46","url":null,"abstract":"","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46007194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Immunology Of Suicidal Behavior 自杀行为的免疫学
Advances in clinical and medical research (Chandigarh, India) Pub Date : 2023-01-03 DOI: 10.52793/acmr.2022.4(1)-45
A. Sfera, Christina V. Andronescu, Jonathan J. Anton, Dan O. Sfera, Sabine Hazan
{"title":"The Immunology Of Suicidal Behavior","authors":"A. Sfera, Christina V. Andronescu, Jonathan J. Anton, Dan O. Sfera, Sabine Hazan","doi":"10.52793/acmr.2022.4(1)-45","DOIUrl":"https://doi.org/10.52793/acmr.2022.4(1)-45","url":null,"abstract":"Introduction A recent study by Ahrens AP, et al. on university students with suicidal ideation has highlighted the connection between immunity and psychopathology, especially major depressive disorder (MDD) and suicidality [1-3]. This study has found that four major histocompatibility complex (MHC) alleles and the absence of oral microbe Alloprevotella rava increase the risk of suicidal behavior, emphasizing a microbial-genetic link in this pathology. Suicide is the second leading cause of mortality in young adults, contributing to more than 40,000 deaths per year in the US alone [4]. Previous studies have associated suicidal behavior with several alleles of the MHC, a network of genes encoding for the human leukocyte antigen (HLA). For example, the presence of DQB1*02 allele was reported to increase, while HLADQB1*05 to lower the odds of suicidal behavior, suggesting that genetics and immunity play a major role in the pathogenesis of this disorder [5].","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46481768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anesthetic Management In Impending Eclampsia With Intracranial Pathology 伴有颅内病理的先兆子痫的麻醉处理
Advances in clinical and medical research (Chandigarh, India) Pub Date : 2022-10-25 DOI: 10.52793/acmr.2022.3(4)-43
Srashti Singh, Sandeep Kadam
{"title":"Anesthetic Management In Impending Eclampsia With Intracranial Pathology","authors":"Srashti Singh, Sandeep Kadam","doi":"10.52793/acmr.2022.3(4)-43","DOIUrl":"https://doi.org/10.52793/acmr.2022.3(4)-43","url":null,"abstract":"Introduction Intracranial bleed is rare yet devastating event in pregnancy. There are risk of maternal mortality/morbidity and poor fetal outcome. Intracranial hemorrhage can be subdural, extradural, subarachnoid, intraparenchymal. Causes of bleeding include trauma, jaundice, preeclampsia, eclampsia, venous thrombosis. Urgent neurosurgical, obstetrician and anesthetic intervention needs to be taken for better maternal and fetal outcome.","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48615190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship Between Immune Checkpoint Inhibitors And Myocarditis 免疫检查点抑制剂与心肌炎的关系
Advances in clinical and medical research (Chandigarh, India) Pub Date : 2022-10-20 DOI: 10.52793/acmr.2022.3(4)-41
Shihori Tanabe
{"title":"Relationship Between Immune Checkpoint Inhibitors And Myocarditis","authors":"Shihori Tanabe","doi":"10.52793/acmr.2022.3(4)-41","DOIUrl":"https://doi.org/10.52793/acmr.2022.3(4)-41","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) induce anti-cancer immunity. Several reports have indicated that treatment with ICIs is involved in myocarditis. In this Editorial, the relationship between ICIs and myocarditis is reviewed. The ICIs include ipilimumab, which is an anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) antibody, and nivolumab, pembrolizumab, and cemiplimab, which are anti-programmed cell death protein 1 (PD-1) antibodies, and avelumab, atezolizumab, and durvalumab, which are anti-programmed cell death-ligand 1 (PD-L1) antibodies. Myocarditis, defined as inflammation of the muscular walls of the heart, is induced by several infectious diseases and molecules. The investigation into ICI-related myocarditis is ongoing.","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41419859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The MSH3 Gene From A Neuropsychiatrist’s Perspective 从神经心理学家的角度看MSH3基因
Advances in clinical and medical research (Chandigarh, India) Pub Date : 2022-10-20 DOI: 10.52793/acmr.2022.3(4)-40
A. Sfera, Dan O. Sfera, Sarvin Sasannia, Sabine Hazan
{"title":"The MSH3 Gene From A Neuropsychiatrist’s Perspective","authors":"A. Sfera, Dan O. Sfera, Sarvin Sasannia, Sabine Hazan","doi":"10.52793/acmr.2022.3(4)-40","DOIUrl":"https://doi.org/10.52793/acmr.2022.3(4)-40","url":null,"abstract":"Introduction We read with great interest the article by Ambati BK, et al. “MSH3 Homology and Potential Recombination Link to SARS-CoV-2 Furin Cleavage Site” published on February 21st, 2022 in Frontiers in Virology. This perspective paper highlights a 19-nucleotide genetic sequence, a reverse complement of the human MSH3 gene, that contains the SARS-CoV-2 furin cleavage site (FCS). As this sequence (SEQ ID11652) was patented by Moderna in 2016 (US patent 9,587,003), some have suggested that the FCS may have been known prior to the COVID-19 pandemic [1].","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48682869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-Pharmacological Interventions For The Appetite And Eating Disorders In Patients With Dementia: A Cross-Over RCT 痴呆患者食欲和饮食障碍的非药物干预：随机对照试验
Advances in clinical and medical research (Chandigarh, India) Pub Date : 2022-10-03 DOI: 10.52793/acmr.2022.3(4)-39
Dimitriou Tatiana-Danai, Papatriantafyllou John, Konsta Anastasia, K. Dimitrios, A. Loukas, Ioannidis Panagiotis, Koutsouraki Efrosini, Tegos Thomas, Sofia Loukou, T. Magda
{"title":"Non-Pharmacological Interventions For The Appetite And Eating Disorders In Patients With Dementia: A Cross-Over RCT","authors":"Dimitriou Tatiana-Danai, Papatriantafyllou John, Konsta Anastasia, K. Dimitrios, A. Loukas, Ioannidis Panagiotis, Koutsouraki Efrosini, Tegos Thomas, Sofia Loukou, T. Magda","doi":"10.52793/acmr.2022.3(4)-39","DOIUrl":"https://doi.org/10.52793/acmr.2022.3(4)-39","url":null,"abstract":"Objectives: The most common appetite/ eating problems in patients with dementia (PWD) are loss or increase of appetite, loss or gain of weight, changes in eating behaviour, changes in the preferences of the food, developing specific eating behaviours, eating in an appropriate way or eating non-food items, and frequently demanding food or drinks, because they forget that they have eaten. Appetite/ eating disorder is an essential and common behavioral and psychological symptom of dementia (BPSD) that leads to poor quality of life, institutionalization, and affects the physiological function of many systems of the patient. Methods/ Design: 60 patients with dementia and appetite problems and their caregivers were included. The participants were suffering from all different types and stages of dementia. The study is a cross-over randomized controlled trial. The measurements used were: Mini Mental State Examination (MMSE), Addenbrooke’s Cognitive Examination Revised (ACE-R), Geriatric Scale of Depression (GDS), Functional Rating Scale for Symptoms in Dementia (FRSSD), and Neuropsychiatric Inventory (NPI). The three non-pharmacological interventions that were used: Physical Activity (PA), Music Therapy (MT), and Psycho-Educational Programme for the Caregivers (PEPC). Results: The most effective combination for the reduction of appetite problems was found in group 6: PEPC (structure routine in the hours that the food is served) (p=0.004), followed by MT (p=0.027), followed by PA (p=0.036). The same combination was the most effective for the reduction of caregivers’ burden, as well. Conclusions: There is a combination of non-pharmacological interventions (PEPC+MT+PA) that can effectively reduce the appetite/eating problems in PwD. The same combination is the most effective in reducing the caregivers’ burden, as well.","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49482214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Insight On Primary Aldosteronism Vagenete 原发性醛固酮增多症阴道的新认识
Advances in clinical and medical research (Chandigarh, India) Pub Date : 2022-10-03 DOI: 10.52793/acmr.2022.3(3)-38
Adel Ekladious, Beisi Jiang
{"title":"New Insight On Primary Aldosteronism Vagenete","authors":"Adel Ekladious, Beisi Jiang","doi":"10.52793/acmr.2022.3(3)-38","DOIUrl":"https://doi.org/10.52793/acmr.2022.3(3)-38","url":null,"abstract":"Primary Hyperaldosteronism is not an uncommon cause of secondary hypertension and labeled before as difficult to treat hypertension, especially in the absence of hypokalaemia which leads to sustained uncontrolled hypertension on polypharmacy and development of many vascular complications leading to early death, Identification of aldosterone secreting adenoma leads to permanent cure with surgical intervention. Diagnosing glucocorticoid remediable hypertension leads to permanent cure with glucocorticoid. Timely diagnosis of familial genetic hyperaldosteronism could prevent haemorrhagic stroke in males and preeclampsia in females.","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49291652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship Between Corona Virus Infection And Immune Checkpoint Inhibitors 冠状病毒感染与免疫检查点抑制剂的关系
Advances in clinical and medical research (Chandigarh, India) Pub Date : 2022-08-30 DOI: 10.52793/acmr.2022.3(3)-37
Shihori Tanabe
{"title":"Relationship Between Corona Virus Infection And Immune Checkpoint Inhibitors","authors":"Shihori Tanabe","doi":"10.52793/acmr.2022.3(3)-37","DOIUrl":"https://doi.org/10.52793/acmr.2022.3(3)-37","url":null,"abstract":"The severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) causes infectious disease, COVID-19, and the relationship between COVID-19 and cancer immunotherapy such as immune checkpoint inhibitors (ICIs) is not fully understood. Recent rapid progress in ICI therapy has reported their immune response-related reaction, which demonstrates the importance of studies on the relationship between ICIs and COVID-19. In this Editorial, the application of ICIs in COVID-19 is focused on.","PeriodicalId":72085,"journal":{"name":"Advances in clinical and medical research (Chandigarh, India)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43788254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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