A. Sfera, Dan O. Sfera, Sarvin Sasannia, Sabine Hazan
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引用次数: 0
摘要
我们饶有兴趣地阅读了Ambati BK等人在2022年2月21日发表在《Frontiers in Virology》上的文章《MSH3同源性和潜在重组链接到SARS-CoV-2 Furin切割位点》。这篇前瞻性论文强调了一个包含SARS-CoV-2蛋白切割位点(FCS)的19个核苷酸的基因序列，这是人类MSH3基因的反向补体。由于该序列(SEQ ID11652)于2016年由Moderna获得专利(美国专利9,587,003)，一些人认为FCS可能在COVID-19大流行之前就已经知道了。
The MSH3 Gene From A Neuropsychiatrist’s Perspective
Introduction We read with great interest the article by Ambati BK, et al. “MSH3 Homology and Potential Recombination Link to SARS-CoV-2 Furin Cleavage Site” published on February 21st, 2022 in Frontiers in Virology. This perspective paper highlights a 19-nucleotide genetic sequence, a reverse complement of the human MSH3 gene, that contains the SARS-CoV-2 furin cleavage site (FCS). As this sequence (SEQ ID11652) was patented by Moderna in 2016 (US patent 9,587,003), some have suggested that the FCS may have been known prior to the COVID-19 pandemic [1].
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